UNIVPM: Pubblicazioni di Andrea BRENCIANI

Andrea BRENCIANI

AREA MIN. 06 - Scienze mediche
Dipartimento Scienze Biomediche e Sanita' Pubblica
Facolta' di MEDICINA e CHIRURGIA

111 pubblicazioni

Anno

Pubblicazioni

2026

Citrus reticulata Essential Oil as a Bioactive Food Ingredient: Composition Variability, Extraction, Functional Bioactivities, and Cross‐Study Quantitative Analysis
Anno: 2026
Rivista: FOOD SCIENCE & NUTRITION
Autori/autrici: Zhang, Jiaojiao; Zhou, Peng; Chen, Yongxian; Brenciani, Andrea; Zhou, Jing; Zarei, Iman; Nasim, Amnah
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/363252
Citazioni:
Citrus reticulata Essential Oil as a Bioactive Food Ingredient: Composition Variability, Extraction, Functional Bioactivities, and Cross‐Study Quantitative Analysis / Zhang, J., Zhou, P., Chen, Y., Brenciani, A., Zhou, J., Zarei, I., Nasim, A.. - In: FOOD SCIENCE & NUTRITION. - ISSN 2048-7177. - 14:9(2026). [10.1002/fsn3.72380]
Abstract:
Citrus reticulata essential oil (CrEO) is a complex mixture of volatile and aroma-active phytochemicals mainly obtained from the peel oil glands of C. reticulata. Its chemical composition is dominated by monoterpene hydrocarbons, particularly limonene, together with other representative constituents...
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2026

Tn7860, a novel chromosomal pseudo-compound transposon carrying the OptrA gene in Enterococcus faecalis
Anno: 2026
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Massacci, Francesca Romana; Simoni, Serena; Albini, Elisa; D'Achille, Gloria; Paoletti, Claudia; Morroni, Gianluca; Mingoia, Marina; Zhu, Yao; Zhang, Wanjiang; Du, Xiang-Dang; Krüger-Haker, Henrike; Schwarz, Stefan; Vignaroli, Carla; Magistrali, Chiara Francesca; Giovanetti, Eleonora; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357974
Citazioni:
Tn7860, a novel chromosomal pseudo-compound transposon carrying the OptrA gene in Enterococcus faecalis / Massacci, F.R., Simoni, S., Albini, E., D'Achille, G., Paoletti, C., Morroni, G., Mingoia, M., Zhu, Y., Zhang, W., Du, X., Krüger-Haker, H., Schwarz, S., Vignaroli, C., Magistrali, C.F., Giovanetti, E., Brenciani, A.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - 81:3(2026). [10.1093/jac/dkag046]

2026

Characterization of a ST412-K57 colistin-resistant hypervirulent Klebsiella pneumoniae strain of chicken origin
Anno: 2026
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Xu, Qiu; Zhu, Yao; Schwarz, Stefan; Xie, Shuangyu; Chai, Jiyun; Lin, Longhua; Sun, Hongfei; Du, Susu; Liu, Simeng; Hou, Jie; Song, Yongshan; Brenciani, Andrea; Zhang, Wanjiang
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/355112
Citazioni:
Characterization of a ST412-K57 colistin-resistant hypervirulent Klebsiella pneumoniae strain of chicken origin / Xu, Q., Zhu, Y., Schwarz, S., Xie, S., Chai, J., Lin, L., Sun, H., Du, S., Liu, S., Hou, J., Song, Y., Brenciani, A., Zhang, W.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 81:4(2026). [10.1093/jac/dkag114]
Abstract:
Background: The emergence and spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious and growing challenge to public health worldwide. However, the knowledge regarding hvKp of animal origin remains very limited. In this study, we characterized a colistin-resistant hvKp isolate obtained...
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2026

Spread of oxazolidinone-resistant enterococci in an Italian pig slaughterhouse
Anno: 2026
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Massacci, Francesca Romana; Albini, Elisa; Cucco, Lucilla; Russo, Elisa; Nigro, Maria Elena; Binucci, Giorgia; Coccitto, Sonia Nina; Cinthi, Marzia; Simoni, Serena; Scoccia, Eleonora; Maresca, Carmen; Giovanetti, Eleonora; Pezzotti, Giovanni; Magistrali, Chiara Francesca; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/360792
Citazioni:
Spread of oxazolidinone-resistant enterococci in an Italian pig slaughterhouse / Massacci, F.R., Albini, E., Cucco, L., Russo, E., Nigro, M.E., Binucci, G., Coccitto, S.N., Cinthi, M., Simoni, S., Scoccia, E., Maresca, C., Giovanetti, E., Pezzotti, G., Magistrali, C.F., Brenciani, A.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - 17:(2026). [10.3389/fmicb.2026.1894422]
Abstract:
The swine production chain represents a critical point for the spread of antimicrobial resistance, with slaughterhouses acting as potential hotspots for cross-contamination. The veterinary use of phenicols may promote resistance to oxazolidinones, a last-resort class of antibiotics. This study inves...
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2026

Anaerobic bacteria: a neglected reservoir of mobile oxazolidinone resistance genes
Anno: 2026
Rivista: GUT MICROBES
Autori/autrici: Liu, Simeng; Xie, Shuangyu; Song, Yongshan; Li, Ruichao; Brenciani, Andrea; Schwarz, Stefan; Zhang, Wanjiang; Zhu, Yao
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/363132
Citazioni:
Anaerobic bacteria: a neglected reservoir of mobile oxazolidinone resistance genes / Liu, S., Xie, S., Song, Y., Li, R., Brenciani, A., Schwarz, S., Zhang, W., Zhu, Y.. - In: GUT MICROBES. - ISSN 1949-0976. - 18:1(2026). [10.1080/19490976.2026.2734670]
Abstract:
Oxazolidinones are critical last-resort antimicrobials against severe infections caused by Gram-positive bacteria, whereas mobile oxazolidinone resistance genes (MORGs, including cfr, optrA, poxtA) severely compromise their clinical efficacy. To date, most surveillance and mechanistic studies focusi...
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2026

Heteroresistance in vancomycin-variable Enterococcus faecium ST80 isolate
Anno: 2026
Rivista: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Autori/autrici: Simoni, Serena; Di Gregorio, Alessandra; Caucci, Sara; Brenciani, Andrea; Giovanetti, Eleonora; Vignaroli, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/352392
Citazioni:
Heteroresistance in vancomycin-variable Enterococcus faecium ST80 isolate / Simoni, S., Di Gregorio, A., Caucci, S., Brenciani, A., Giovanetti, E., Vignaroli, C.. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - (2026). [Epub ahead of print] [10.1007/s10096-026-05416-5]
Abstract:
Purpose: To investigate the gradual genetic changes occurred in heteroresistant vancomycin-variable (VVE) Enterococcus faecium ST80 isolate - belonging to the vanA ST80 nosocomial clone although recovered from marine environment - contributing to its reversion to a resistant phenotype after exposure...
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2026

Occurrence of oxazolidinone resistance genes in enterococci, staphylococci, and Mammaliicoccus sciuri from swine slaughterhouse wastewater, Italy
Anno: 2026
Rivista: WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Autori/autrici: Massacci, Francesca Romana; Simoni, Serena; Albini, Elisa; Nigro, Maria Elena; Russo, Elisa; D'Achille, Gloria; Paoletti, Claudia; Morroni, Gianluca; Mingoia, Marina; Zhu, Yao; Zhang, Wanjiang; Vignaroli, Carla; Magistrali, Chiara Francesca; Giovanetti, Eleonora; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/355933
Citazioni:
Occurrence of oxazolidinone resistance genes in enterococci, staphylococci, and Mammaliicoccus sciuri from swine slaughterhouse wastewater, Italy / Massacci, F.R., Simoni, S., Albini, E., Nigro, M.E., Russo, E., D'Achille, G., Paoletti, C., Morroni, G., Mingoia, M., Zhu, Y., Zhang, W., Vignaroli, C., Magistrali, C.F., Giovanetti, E., Brenciani, A.. - In: WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY. - ISSN 1573-0972. - 42:5(2026). [10.1007/s11274-026-04968-0]
Abstract:
Unlabelled: Oxazolidinones (linezolid and tedizolid) are last-resort antibiotics used to treat severe infections caused by multidrug-resistant Gram-positive bacteria. Although linezolid is not approved for veterinary use, resistant bacteria—particularly enterococci—have increasingly been...
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2026

Toxin gene profiles, antibiotic resistance, and genetic diversity of Clostridium perfringens from food-producing animals: a whole-genome sequencing study with implications for food safety
Anno: 2026
Rivista: CURRENT RESEARCH IN FOOD SCIENCE
Autori/autrici: Xie, Shuangyu; Liu, Simeng; Schwarz, Stefan; Sun, Hongfei; Xu, Qiu; Chai, Jiyun; Lin, Longhua; Du, Susu; Hou, Jie; Song, Yongshan; Brenciani, Andrea; Zhu, Yao; Zhang, Wanjiang
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/358492
Citazioni:
Toxin gene profiles, antibiotic resistance, and genetic diversity of Clostridium perfringens from food-producing animals: a whole-genome sequencing study with implications for food safety / Xie, S., Liu, S., Schwarz, S., Sun, H., Xu, Q., Chai, J., Lin, L., Du, S., Hou, J., Song, Y., Brenciani, A., Zhu, Y., Zhang, W.. - In: CURRENT RESEARCH IN FOOD SCIENCE. - ISSN 2665-9271. - 12:(2026). [10.1016/j.crfs.2026.101460]
Abstract:
Clostridium perfringens is a significant zoonotic foodborne pathogen. To systematically assess the potential risks associated with food-producing animals as a reservoir of C. perfringens in the early stages of the food production chain, we conducted whole-genome sequencing (WGS) and phenotypic analy...
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2026

Transferable optrA-mediated linezolid resistance in enterococci from high-altitude river sediments of Gilgit-Baltistan, Pakistan
Anno: 2026
Rivista: APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Autori/autrici: Simoni, Serena; Brenciani, Andrea; Di Gregorio, Alessandra; Massacci, Francesca Romana; Cucco, Lucilla; Nafees, Maisoor Ahmed; Din, Saif Ud; Hanif, Nelofar; Gorbi, Stefania; Regoli, Francesco; Giovanetti, Eleonora; Vignaroli, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/362593
Citazioni:
Transferable optrA-mediated linezolid resistance in enterococci from high-altitude river sediments of Gilgit-Baltistan, Pakistan / Simoni, S., Brenciani, A., Di Gregorio, A., Massacci, F.R., Cucco, L., Nafees, M.A., Din, S.U., Hanif, N., Gorbi, S., Regoli, F., Giovanetti, E., Vignaroli, C.. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 0099-2240. - 92:9(2026). [10.1128/aem.01129-26]
Abstract:
Environmental dissemination of antimicrobial resistance is a growing global concern. This study investigated the occurrence, genetic context, and mobility of the oxazolidinone resistance genes in enterococci isolated from high-altitude river sediments in the Gilgit-Baltistan region of Pakistan. A to...tal of 17 florfenicol-resistant enterococci were recovered from 3 of the 12 sampling sites analyzed. Four multidrug-resistant strains (two Enterococcus faecium, one E. faecalis, and one E. hirae) harboring the optrA gene were selected for whole-genome sequencing using Illumina and Nanopore platforms. Genomic analyses showed that optrA was plasmid-borne in all isolates and co-localized with additional resistance genes, including macrolide, phenicol, and tetracycline resistance determinants. The optrA genetic context was frequently associated with insertion sequences, suggesting their role in the mobilization of multidrug-resistance elements. Mini-translocatable units of the optrA genetic context were detected as circular forms in two of four strains, further supporting their mobility potential. Conjugation assays demonstrated successful horizontal transfer of the optrA gene mediating linezolid resistance, with transfer frequencies ranging from 2.03 × 10⁻⁶ to 6.36 × 10⁻⁴ transconjugants per recipient cell. optrA-carrying plasmids remained stable after serial passages without antibiotic pressure. Phylogenetic analysis showed that isolates belonged to distinct sequence types and clustered with strains of diverse geographic and ecological origins, suggesting dissemination of optrA across different genetic backgrounds rather than clonal expansion. The occurrence of linezolid-resistant enterococci in high-altitude river sediments suggests their widespread distribution and emphasizes the need for broader environmental surveillance programs to monitor clinically relevant resistances even in remote ecosystems. IMPORTANCE: This study provides important insights into the environmental dissemination of antimicrobial resistance by demonstrating the occurrence and genetic diversity of clinically relevant resistance determinants in enterococci isolated from remote high-altitude river sediments. The findings emphasize that natural environments could serve as reservoirs and exchange hubs for antimicrobial resistance, even in ecosystems with limited direct anthropogenic impact. Therefore, integrated One Health surveillance strategies that include environmental compartments alongside human and animal populations are required to better monitor and mitigate the emergence of clinically significant resistant bacteria.
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2026

Genomic insights into an optrA-carrying plasmid associated with linezolid resistance in clinical Enterococcus faecalis isolates, Argentina
Anno: 2026
Rivista: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Autori/autrici: Schell, Celia Marìa; Magi, Gloria; Simoni, Serena; Massacci, Francesca Romana; Albini, Elisa; D'Achille, Gloria; Paoletti, Claudia; Carriera, Filomena; Morroni, Gianluca; Mingoia, Marina; Zhu, Yao; Zhang, Wanjiang; Du, Xiang-Dang; Krüger-Haker, Henrike; Schwarz, Stefan; Bernstein, Judith Celina; Giovanetti, Eleonora; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/362192
Citazioni:
Genomic insights into an optrA-carrying plasmid associated with linezolid resistance in clinical Enterococcus faecalis isolates, Argentina / Schell, C.M., Magi, G., Simoni, S., Massacci, F.R., Albini, E., D'Achille, G., Paoletti, C., Carriera, F., Morroni, G., Mingoia, M., Zhu, Y., Zhang, W., Du, X., Krüger-Haker, H., Schwarz, S., Bernstein, J.C., Giovanetti, E., Brenciani, A.. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - (2026). [Epub ahead of print] [10.1007/s10096-026-05657-4]
Abstract:
The spread of the transferable optrA gene poses an increasing threat to the clinical efficacy of oxazolidinones. Here, we characterized a novel optrA-carrying plasmid, pEfa-optrA-Arg, from a linezolid-resistant Enterococcus faecalis clinical isolate from Argentina. The 68,653-bp conjugative plasmid ...
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2026

Diffusion of OXA-48- and NDM-5-producing Klebsiella pneumoniae ST383 clone in Central Italy
Anno: 2026
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: D'Achille, Gloria; Cotoloni, Giulia; Nunzi, Ilaria; Brescini, Lucia; Fioriti, Simona; Armiento, Maria; Pocognoli, Antonella; Giovanetti, Eleonora; Paoletti, Claudia; Menzo, Stefano; Brenciani, Andrea; Mingoia, Marina; Morroni, Gianluca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/361592
Citazioni:
Diffusion of OXA-48- and NDM-5-producing Klebsiella pneumoniae ST383 clone in Central Italy / D'Achille, G., Cotoloni, G., Nunzi, I., Brescini, L., Fioriti, S., Armiento, M., Pocognoli, A., Giovanetti, E., Paoletti, C., Menzo, S., Brenciani, A., Mingoia, M., Morroni, G.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 81:1(2026). [10.1093/jac/dkaf397]

2025

A New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine: A Promising Approach for the Treatment of Urinary Tract Infections
Anno: 2025
Rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Autori/autrici: Recinella, Lucia; Pinti, Morena; Di Lodovico, Silvia; Brenciani, Andrea; Giovanetti, Eleonora; Diban, Firas; Di Giulio, Mara; Brunetti, Luigi; Leone, Sheila
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/343732
Citazioni:
A New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine: A Promising Approach for the Treatment of Urinary Tract Infections / Recinella, L., Pinti, M., Di Lodovico, S., Brenciani, A., Giovanetti, E., Diban, F., Di Giulio, M., Brunetti, L., Leone, S.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 26:10(2025). [10.3390/ijms26104639]
Abstract:
Biofilm plays a crucial role in the pathogenesis and chronicity of urinary tract infections (UTIs). The present work aimed to evaluate the anti-biofilm effects of Formulation (DIF17BRO® plus NAC) in combination with ciprofloxacin (CPX) on Escherichia coli strains. The antimicrobial activity of c...
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2025

Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population
Anno: 2025
Rivista: TRANSBOUNDARY AND EMERGING DISEASES
Autori/autrici: Wu, Liangliang; Zhang, Likuan; Wang, Xiaoqi; Huang, Wei; Schwarz, Stefan; Brenciani, Andrea; Li, Chenglong; Du, Xiang-Dang
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/346832
Citazioni:
Streptococcus suis Serotype 14: A Nonnegligible Zoonotic Population / Wu, L., Zhang, L., Wang, X., Huang, W., Schwarz, S., Brenciani, A., Li, C., Du, X.. - In: TRANSBOUNDARY AND EMERGING DISEASES. - ISSN 1865-1674. - 2025:1(2025). [10.1155/tbed/5779652]
Abstract:
Streptococcus suis is an important zoonotic pathogen that can cause severe infections in both humans and pigs. The prevalence of S. suis serotype 14 in sporadic cases in China has been gradually increasing during recent years. However, the current understanding of S. suis serotype 14 is limited. In ...
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2025

Novel integrative and conjugative elements carrying cfr(B) and cfr(C) linezolid resistance genes in Clostridioides difficile isolates from calves, Italy
Anno: 2025
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Romana Massacci, Francesca; Albini, Elisa; Cucco, Lucilla; Russo, Elisa; Elena Nigro, Maria; Coccitto, Sonia Nina; Cinthi, Marzia; Simoni, Serena; Paniccià, Marta; Morroni, Gianluca; Mingoia, Marina; Francesca Magistrali, Chiara; Vignaroli, Carla; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/345292
Citazioni:
Novel integrative and conjugative elements carrying cfr(B) and cfr(C) linezolid resistance genes in Clostridioides difficile isolates from calves, Italy / Brenciani, A., Romana Massacci, F., Albini, E., Cucco, L., Russo, E., Elena Nigro, M., Coccitto, S.N., Cinthi, M., Simoni, S., Paniccià, M., Morroni, G., Mingoia, M., Francesca Magistrali, C., Vignaroli, C., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 80:8(2025), pp. 2280-2284. [10.1093/jac/dkaf202]
Abstract:
Objectives: To clarify the genetic basis of high-level linezolid resistance in three Clostridioides difficile strains from calves. Methods: A WGS approach was used to comprehensively characterize C. difficile A501, A505 and A516 strains exhibiting high linezolid MICs, and to clarify their phylogenet...
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2025

The optrA, cfr(D) and vanA genes are co-located on linear plasmids in linezolid- and vancomycin-resistant enterococcal clinical isolates in Italy
Anno: 2025
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Simoni, Serena; Gherardi, Giovanni; Palamara, Anna Teresa; Di Lodovico, Silvia; Di Giulio, Mara; Du, Xiang-Dang; Vignaroli, Carla; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/343395
Citazioni:
The optrA, cfr(D) and vanA genes are co-located on linear plasmids in linezolid- and vancomycin-resistant enterococcal clinical isolates in Italy / Cinthi, M., Coccitto, S.N., Simoni, S., Gherardi, G., Palamara, A.T., Di Lodovico, S., Di Giulio, M., Du, X., Vignaroli, C., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 80:5(2025), pp. 1362-1370. [10.1093/jac/dkaf082]
Abstract:
Objectives To characterize the optrA-, cfr(D)- and vanA-carrying linear plasmids detected in three MDR enterococcal clinical isolates.Methods Enterococcus faecium (868), E. faecium (1001) and Enterococcus faecalis (2048), which were linezolid- and vancomycin-resistant due to the presence of optrA, c...
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2025

Antimicrobial Resistance Gene Patterns in Traditional Montenegrin Njeguški Cheese Revealed by qPCR
Anno: 2025
Rivista: GENES
Autori/autrici: Milanovic, V.; Rampanti, G.; Cantarini, A.; Cardinali, F.; Paderni, G.; Martinovic, A.; Brenciani, A.; Aquilanti, L.; Osimani, A.; Garofalo, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/349075
Citazioni:
Antimicrobial Resistance Gene Patterns in Traditional Montenegrin Njeguški Cheese Revealed by qPCR / Milanovic, V., Rampanti, G., Cantarini, A., Cardinali, F., Paderni, G., Martinovic, A., Brenciani, A., Aquilanti, L., Osimani, A., Garofalo, C.. - In: GENES. - ISSN 2073-4425. - ELETTRONICO. - 16:9(2025). [10.3390/genes16091089]
Abstract:
Background/Objectives: This study was aimed to investigate the safety profile of traditional Montenegrin Njegu & scaron;ki cheese by quantifying genes associated with resistance to clinically important antibiotics. Methods: Samples of Njegu & scaron;ki cheese were sourced from three ...
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2024

Persistence and evolution of linezolid- and methicillin-resistant Staphylococcus epidermidis ST2 and ST5 clones in an Italian hospital
Anno: 2024
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Pocognoli, Antonella; Zeni, Guido; Mazzariol, Annarita; Gregorio, Alessandra Di; Vignaroli, Carla; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326722
Citazioni:
Persistence and evolution of linezolid- and methicillin-resistant Staphylococcus epidermidis ST2 and ST5 clones in an Italian hospital / Cinthi, M., Coccitto, S.N., Pocognoli, A., Zeni, G., Mazzariol, A., Gregorio, A.D., Vignaroli, C., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - 36:(2024), pp. 358-364. [10.1016/j.jgar.2024.01.020]
Abstract:
Objectives: epidermidis is a member of the human skin microbiome. However, in recent decades multidrug-resistant and hospital-adapted S. epidermidis clones are increasingly involved in severe human infections associated to medical devices and in immunocompromisedpatients. In 2016, we reported that a...
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2024

Seafood as a source of antibiotic resistant Enterococcus spp
Anno: 2024
Rivista: APPLIED FOOD RESEARCH
Autori/autrici: Albini, Elisa; Leoni, Francesca; Massacci Francesca, Romana; Silvia, Pieralisi; Orsini, Serenella; Blasi, Francesca; DI GREGORIO, Alessandra; Coccitto, SONIA NINA; Cinthi, Marzia; D'Achille, Gloria; Morroni, Gianluca; Maresca, Carmen; Scoccia, Eleonora; Xiang-Dang, Du; Giovanetti, Eleonora; Brenciani, Andrea; Magistrali Chiara, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/337212
Citazioni:
Seafood as a source of antibiotic resistant Enterococcus spp / Albini, E., Leoni, F., Massacci Francesca, R., Silvia, P., Orsini, S., Blasi, F., DI GREGORIO, A., Coccitto, S.N., Cinthi, M., D'Achille, G., Morroni, G., Maresca, C., Scoccia, E., Xiang-Dang, D.u., Giovanetti, E., Brenciani, A., Magistrali Chiara, F.. - In: APPLIED FOOD RESEARCH. - ISSN 2772-5022. - 4:2(2024). [10.1016/j.afres.2024.100604]
Abstract:
Seafood is a crucial global food source, but its role as a reservoir for antibiotic-resistant pathogens is concerning. This study focuses on the prevalence of antibiotic resistance in retail seafood, using Enterococcus spp. as an indicator. Seven categories of raw seafood were collected from retail ...
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2024

Genomic analysis of enterococci carrying optrA, poxtA, and vanA resistance genes from wild boars, Italy
Anno: 2024
Rivista: JOURNAL OF APPLIED MICROBIOLOGY
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Massacci, Francesca Romana; Albini, Elisa; Binucci, Giorgia; Gobbi, Marco; Tentellini, Michele; D'Avino, Nicoletta; Ranucci, Alice; Papa, Paola; Magistrali, Chiara Francesca; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/333255
Citazioni:
Genomic analysis of enterococci carrying optrA, poxtA, and vanA resistance genes from wild boars, Italy / Cinthi, M., Coccitto, S.N., Massacci, F.R., Albini, E., Binucci, G., Gobbi, M., Tentellini, M., D'Avino, N., Ranucci, A., Papa, P., Magistrali, C.F., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF APPLIED MICROBIOLOGY. - ISSN 1365-2672. - 135:8(2024). [10.1093/jambio/lxae193]
Abstract:
Aims: To investigate enterococci carrying linezolid and vancomycin resistance genes from fecal samples recovered from wild boars. Methods and results: Florfenicol- and vancomycin-resistant enterococci, isolated on selective agar plates, were screened by PCR for the presence of linezolid and vancomyc...
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2024

Molecular Characterization of Enterococcus faecium Clinical Isolates Harbouring erm (T) from an Italian Hospital
Anno: 2024
Rivista: CURRENT MICROBIOLOGY
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia N; Simoni, Serena; D'Achille, Gloria; Zeni, Guido; Mazzariol, Annarita; Pocognoli, Antonella; Di Lodovico, Silvia; Di Giulio, Mara; Morroni, Gianluca; Mingoia, Marina; Vignaroli, Carla; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/336772
Citazioni:
Molecular Characterization of Enterococcus faecium Clinical Isolates Harbouring erm (T) from an Italian Hospital / Cinthi, M., Coccitto, S.N., Simoni, S., D'Achille, G., Zeni, G., Mazzariol, A., Pocognoli, A., Di Lodovico, S., Di Giulio, M., Morroni, G., Mingoia, M., Vignaroli, C., Brenciani, A., Giovanetti, E.. - In: CURRENT MICROBIOLOGY. - ISSN 0343-8651. - 81:(2024). [10.1007/s00284-024-03968-3]
Abstract:
The presence of erm(T) gene conferring resistance to macrolides, lincosamides and streptogramin B (MLSB), was screened in 296 enterococci collected from clinical samples in a central Italy hospital and seven Enterococcus faecium isolates resulted positive to erm(T) by PCR. All isolates were resistan...
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2024

Global spread of the linezolid-resistant Enterococcus faecalis ST476 clonal lineage carrying optrA
Anno: 2024
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Cinthi, Marzia; Coccitto, Sonia Nina; Massacci, Francesca Romana; Albini, Elisa; Cucco, Lucilla; Paniccià, Marta; Freitas, Ana R; Schwarz, Stefan; Giovanetti, Eleonora; Magistrali, Chiara Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326953
Citazioni:
Global spread of the linezolid-resistant Enterococcus faecalis ST476 clonal lineage carrying optrA / Brenciani, A., Cinthi, M., Coccitto, S.N., Massacci, F.R., Albini, E., Cucco, L., Paniccià, M., Freitas, A.R., Schwarz, S., Giovanetti, E., Magistrali, C.F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 79:4(2024), pp. 846-850. [10.1093/jac/dkae039]
Abstract:
Objectives: To investigate the global distribution of an optrA-harbouring linezolid-resistant Enterococcus faecalis ST476 clonal lineage. Methods: Comprehensive searches of the NCBI database were performed to identify published peer-reviewed articles and genomes of E. faecalis ST476. Each genome was...
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2024

Clonal dissemination of Klebsiella pneumoniae carrying blaOXA-48 gene in a central Italy hospital
Anno: 2024
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: D'Achille, Gloria; Nunzi, Ilaria; Fioriti, Simona; Cirioni, Oscar; Brescini, Lucia; Giacometti, Andrea; Teodori, Lucia; Brenciani, Andrea; Giovanetti, Eleonora; Mingoia, Marina; Morroni, Gianluca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/337554
Citazioni:
Clonal dissemination of Klebsiella pneumoniae carrying blaOXA-48 gene in a central Italy hospital / D'Achille, G., Nunzi, I., Fioriti, S., Cirioni, O., Brescini, L., Giacometti, A., Teodori, L., Brenciani, A., Giovanetti, E., Mingoia, M., Morroni, G.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7173. - 38:(2024), pp. 339-340. [10.1016/j.jgar.2024.07.004]

2024

poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis
Anno: 2024
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Shan, Xinxin; Li, Chenglong; Zhang, Likuan; Zou, Chenhui; Yu, Runhao; Schwarz, Stefan; Shang, Yanhong; Li, Dexi; Brenciani, Andrea; Du, Xiang-Dang
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/335132
Citazioni:
poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis / Shan, X., Li, C., Zhang, L., Zou, C., Yu, R., Schwarz, S., Shang, Y., Li, D., Brenciani, A., Du, X.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 79:12(2024), pp. 3199-3203. [10.1093/jac/dkae342]
Abstract:
Objectives: This study aimed to explore the evolutionary patterns and resistance mechanisms of an Enterococcus faecalis strain harbouring poxtA under linezolid exposure. Methods: A poxtA-carrying E. faecalis electrotransformant DJH702 with a linezolid minimum inhibitory concentration of 4 mg/L was...
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2024

Novel optrA-carrying integrative and conjugative element in a porcine Streptococcus suis, Italy
Anno: 2024
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Coccitto, Sonia Nina; Massacci, Francesca Romana; Cinthi, Marzia; Albini, Elisa; Cucco, Lucilla; Paniccià, Marta; Pezzotti, Giovanni; Di Lodovico, Silvia; Di Giulio, Mara; Du, Xiang-Dang; Magistrali, Chiara Francesca; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/335273
Citazioni:
Novel optrA-carrying integrative and conjugative element in a porcine Streptococcus suis, Italy / Coccitto, S.N., Massacci, F.R., Cinthi, M., Albini, E., Cucco, L., Paniccià, M., Pezzotti, G., Di Lodovico, S., Di Giulio, M., Du, X., Magistrali, C.F., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 79:12(2024), pp. 3356-3358. [10.1093/jac/dkae354]

2024

Genetic elements harbouring oxazolidinone resistance genes detected in swine enterococci circulate in clinical isolates, Italy
Anno: 2024
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Coccitto, Sonia Nina; Cinthi, Marzia; Massacci, Francesca Romana; Albini, Elisa; Magistrali, Chiara Francesca; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/332778
Citazioni:
Genetic elements harbouring oxazolidinone resistance genes detected in swine enterococci circulate in clinical isolates, Italy / Coccitto, S.N., Cinthi, M., Massacci, F.R., Albini, E., Magistrali, C.F., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - 38:(2024), pp. 245-246. [10.1016/j.jgar.2024.06.016]

2024

Emerging resistance to florfenicol in Actinobacillus pleuropneumoniae isolates on two Italian pig farms
Anno: 2024
Rivista: VETERINARY MICROBIOLOGY
Autori/autrici: Brenciani, A; Coccitto, S N; Cucco, L; Ustulin, M; Albini, E; Paniccià, M; Vio, D; Cinthi, M; Giovanetti, E; Massacci, F R; Magistrali, C F
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/333174
Citazioni:
Emerging resistance to florfenicol in Actinobacillus pleuropneumoniae isolates on two Italian pig farms / Brenciani, A., Coccitto, S.N., Cucco, L., Ustulin, M., Albini, E., Paniccià, M., Vio, D., Cinthi, M., Giovanetti, E., Massacci, F.R., Magistrali, C.F.. - In: VETERINARY MICROBIOLOGY. - ISSN 0378-1135. - 296:(2024). [10.1016/j.vetmic.2024.110186]
Abstract:
: Actinobacillus pleuropneumoniae is responsible for porcine pleuropneumonia, a highly contagious lung infection. The control of this respiratory disease remains heavily reliant on antibiotics, with phenicols being one of the primary classes of antibiotics used in pig farming. In the present study, ...
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2024

Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy
Anno: 2024
Rivista: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Autori/autrici: Coccitto, Sonia Nina; Cinthi, Marzia; Simoni, Serena; Pocognoli, Antonella; Zeni, Guido; Mazzariol, Annarita; Morroni, Gianluca; Mingoia, Marina; Giovanetti, Eleonora; Brenciani, Andrea; Vignaroli, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326571
Citazioni:
Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy / Coccitto, S.N., Cinthi, M., Simoni, S., Pocognoli, A., Zeni, G., Mazzariol, A., Morroni, G., Mingoia, M., Giovanetti, E., Brenciani, A., Vignaroli, C.. - In: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. - ISSN 0934-9723. - 43:4(2024), pp. 673-682. [10.1007/s10096-024-04768-0]
Abstract:
Purpose: To investigate the occurrence of vancomycin-variable enterococci (VVE) in a hospital in central Italy. Methods: vanA positive but vancomycin-susceptible Enterococcus faecium isolates (VVE-S) were characterized by antibiotic susceptibility tests, molecular typing (PFGE and MLST), and WGS app...
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2024

Search for carbapenem-resistant bacteria and carbapenem resistance genes along swine food chains in Central Italy
Anno: 2024
Rivista: PLOS ONE
Autori/autrici: Garofalo, Cristiana; Cesaro, Cristiana; Milanovic, Vesna; Belleggia, Luca; Matricardi, Tullia; Osimani, Andrea; Aquilanti, Lucia; Cardinali, Federica; Rampanti, Giorgia; Simoni, Serena; Vignaroli, Carla; Brenciani, Andrea; Pasquini, Marina; Trombetta, Maria Federica
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/324996
Citazioni:
Search for carbapenem-resistant bacteria and carbapenem resistance genes along swine food chains in Central Italy / Garofalo, C., Cesaro, C., Milanovic, V., Belleggia, L., Matricardi, T., Osimani, A., Aquilanti, L., Cardinali, F., Rampanti, G., Simoni, S., Vignaroli, C., Brenciani, A., Pasquini, M., Trombetta, M.F.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 19:1(2024), pp. e0296098.1-e0296098.13. [10.1371/journal.pone.0296098]
Abstract:
The presence of carbapenem–resistant bacteria and carbapenem resistance genes (CRGs) in livestock is increasing. To evaluate the presence of carbapenemase-producing Enterobacteriaceae (CPE) and the main CRGs along swine food chains of the Marche Region (Central Italy), samples of faeces, fe...
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2023

Letter to the Editor: A Porcine Enterococcus hirae Shares a poxtA-Carrying Plasmid with a Human Enterococcus faecium Isolate
Anno: 2023
Rivista: MICROBIAL DRUG RESISTANCE
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Simoni, Serena; Garofalo, Cristiana; Cesaro, Cristiana; Vignaroli, Carla; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/311708
Citazioni:
Letter to the Editor: A Porcine Enterococcus hirae Shares a poxtA-Carrying Plasmid with a Human Enterococcus faecium Isolate / Cinthi, M., Coccitto, S.N., Simoni, S., Garofalo, C., Cesaro, C., Vignaroli, C., Brenciani, A., Giovanetti, E.. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - 29:6(2023), pp. 271-272. [10.1089/mdr.2022.0201]

2023

Characterization of a non-functional erm(T) gene in a clinical Enterococcus faecium strain
Anno: 2023
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Simoni, Serena; Zeni, Guido; Mazzariol, Annarita; Pocognoli, Antonella; Du, Xiang-Dang; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323011
Citazioni:
Characterization of a non-functional erm(T) gene in a clinical Enterococcus faecium strain / Cinthi, M., Coccitto, S.N., Simoni, S., Zeni, G., Mazzariol, A., Pocognoli, A., Du, X., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 78:(2023), pp. 3006-3008. [10.1093/jac/dkad321]

2023

optrA-mediated linezolid resistance in an Enterococcus faecalis isolate recovered from a wild raptor (Falco peregrinus peregrinus), central Italy
Anno: 2023
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Albini, E; Coccitto, S N; Cinthi, M; Giovanetti, E; Gobbi, M; Massacci, F R; Pavone, S; Magistrali, C F; Brenciani, A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/309599
Citazioni:
optrA-mediated linezolid resistance in an Enterococcus faecalis isolate recovered from a wild raptor (Falco peregrinus peregrinus), central Italy / Albini, E., Coccitto, S.N., Cinthi, M., Giovanetti, E., Gobbi, M., Massacci, F.R., Pavone, S., Magistrali, C.F., Brenciani, A.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - 32:(2023), pp. 48-49. [10.1016/j.jgar.2022.12.006]

2023

Identification of plasmids co-carrying cfr(D)/optrA and cfr(D2)/poxtA linezolid resistance genes in two Enterococcus avium isolates from swine brain
Anno: 2023
Rivista: VETERINARY MICROBIOLOGY
Autori/autrici: Coccitto, Sonia Nina; Cinthi, Marzia; Simoni, Serena; Vignaroli, Carla; Massacci, Francesca Romana; Albini, Elisa; Garofalo, Cristiana; Aquilanti, Lucia; Magistrali, Chiara Francesca; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314228
Citazioni:
Identification of plasmids co-carrying cfr(D)/optrA and cfr(D2)/poxtA linezolid resistance genes in two Enterococcus avium isolates from swine brain / Coccitto, S.N., Cinthi, M., Simoni, S., Vignaroli, C., Massacci, F.R., Albini, E., Garofalo, C., Aquilanti, L., Magistrali, C.F., Brenciani, A., Giovanetti, E.. - In: VETERINARY MICROBIOLOGY. - ISSN 0378-1135. - 282:(2023). [10.1016/j.vetmic.2023.109749]
Abstract:
Oxazolidinones are critically important antibiotics to treat human infections caused by multidrug-resistant bacteria, therefore the occurrence of linezolid-resistant enterococci from food-producing animals poses a serious risk to human health. In this study, Enterococcus avium 38157 and 44917 strain...
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2023

Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy
Anno: 2023
Rivista: MICROBIAL DRUG RESISTANCE
Autori/autrici: Brescini, Lucia; Fioriti, Simona; Coccitto, Sonia N; Cinthi, Marzia; Mingoia, Marina; Cirioni, Oscar; Giacometti, Andrea; Giovanetti, Eleonora; Morroni, Gianluca; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/316655
Citazioni:
Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy / Brescini, L., Fioriti, S., Coccitto, S.N., Cinthi, M., Mingoia, M., Cirioni, O., Giacometti, A., Giovanetti, E., Morroni, G., Brenciani, A.. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - (2023). [10.1089/mdr.2022.0330]
Abstract:
Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with...
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2023

An Enterococcus faecium Isolated from Bovine Feces in Italy Shares optrA- and poxtA-Carrying Plasmids with Enterococci from Switzerland
Anno: 2023
Rivista: MICROBIAL DRUG RESISTANCE
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Simoni, Serena; Vignaroli, Carla; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/320011
Citazioni:
An Enterococcus faecium Isolated from Bovine Feces in Italy Shares optrA- and poxtA-Carrying Plasmids with Enterococci from Switzerland / Cinthi, M., Coccitto, S.N., Simoni, S., Vignaroli, C., Brenciani, A., Giovanetti, E.. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - (2023). [10.1089/mdr.2023.0055]
Abstract:
Abstract: To investigate the occurrence of oxazolidinone resistance genes, 18 florfenicol-resistant enterococci were isolated from 66 fecal samples collected from several cattle farms in central Italy. The PCR screening indicated that only a bovine florfenicol-resistant isolate, Enterococcus faecium...
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2023

The Emerging Nosocomial Pathogen Klebsiella michiganensis: Genetic Analysis of a KPC-3 Producing Strain Isolated from Venus Clam
Anno: 2023
Rivista: MICROBIOLOGY SPECTRUM
Autori/autrici: Simoni, Serena; Leoni, Francesca; Veschetti, Laura; Malerba, Giovanni; Carelli, Maria; Lleò, Maria M; Brenciani, Andrea; Morroni, Gianluca; Giovanetti, Eleonora; Rocchegiani, Elena; Barchiesi, Francesca; Vignaroli, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/309600
Citazioni:
The Emerging Nosocomial Pathogen Klebsiella michiganensis: Genetic Analysis of a KPC-3 Producing Strain Isolated from Venus Clam / Simoni, S., Leoni, F., Veschetti, L., Malerba, G., Carelli, M., Lleò, M.M., Brenciani, A., Morroni, G., Giovanetti, E., Rocchegiani, E., Barchiesi, F., Vignaroli, C.. - In: MICROBIOLOGY SPECTRUM. - ISSN 2165-0497. - 11:1(2023). [10.1128/spectrum.04235-22]
Abstract:
The recovery and characterization of a multidrug-resistant, KPC-3-producing Klebsiella michiganensis that was obtained from Venus clam samples is reported in this study. A whole-genome sequencing (WGS) analysis using Illumina and Nanopore technologies of the K. michiganensis 23999A2 isolate revealed... that the strain belonged to the new sequence type 382 (ST382) and carried seven plasmid replicon sequences, including four IncF type plasmids (FII, FIIY, FIIk, and FIB), one IncHI1 plasmid, and two Col plasmids. The FIB and FIIk plasmids showed high homology to each other and to multireplicon pKpQIL-like plasmids that are found in epidemic KPC-K. pneumoniae clones worldwide. The strain carried multiple β-lactamase genes on the IncF plasmids: blaOXA-9 and blaTEM-1A on FIB, blaKPC-3 inserted in a Tn4401a on FIIK, and blaSHV-12 on FIIY. The IncHI1-ST11 harbored no resistance gene. The curing of the strain caused the loss of all of the bla genes and a rearrangement of the IncF plasmids. Conjugal transfer of the blaOXA-9, blaTEM-1A and blaKPC-3 genes occurred at a frequency of 5 × 10-7, using K. quasipneumoniae as a recipient, and all of the bla genes were transferred through a pKpQIL that originated from the recombination of the FIB and FIIk plasmids of the donor. A comparison with 31 K. michiganensis genomes that are available in the NCBI database showed that the closest phylogenetic relatives of K. michiganensis 23999A2 are an environmental isolate from soil in South Korea and a clinical isolate from human sputum in Japan. Finally, a pan-genome analysis showed a large accessory genome of the strain as well as the great genomic plasticity of the K. michiganensis species. IMPORTANCE Klebsiella michiganensis is an emerging nosocomial pathogen, and, so far, few studies describe isolates of clinical origin in the environment. This study contributes to the understanding of how the dissemination of carbapenem-resistance outside the hospital setting may be related to the circulation of pKpQIL-like plasmids that are derived from epidemic Klebsiella pneumoniae strains. The recovery of a carbapenem-resistant isolate in clams is of great concern, as bivalves could represent vehicles of transmission of pathogens and resistance genes to humans via the food chain. The study demonstrates the plasticity of K. michiganensis genome, which is probably useful to multiple environment adaptation and to the evolution of the species.
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2023

Characterization of a prophage and a defective integrative conjugative element carrying the optrA gene in linezolid-resistant Streptococcus dysgalactiae subsp. equisimilis isolates from pigs, Italy
Anno: 2023
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Cinthi, Marzia; Massacci, Francesca Romana; Coccitto, Sonia Nina; Albini, Elisa; Cucco, Lucilla; Orsini, Massimiliano; Simoni, Serena; Giovanetti, Eleonora; Brenciani, Andrea; Magistrali, Chiara Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/316654
Citazioni:
Characterization of a prophage and a defective integrative conjugative element carrying the optrA gene in linezolid-resistant Streptococcus dysgalactiae subsp. equisimilis isolates from pigs, Italy / Cinthi, M., Massacci, F.R., Coccitto, S.N., Albini, E., Cucco, L., Orsini, M., Simoni, S., Giovanetti, E., Brenciani, A., Magistrali, C.F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 78:7(2023). [10.1093/jac/dkad164]
Abstract:
Objectives: To investigate the optrA-carrying genetic elements and their transferability in two linezolid-resistant Streptococcus dysgalactiae subsp. equisimilis (SDSE) strains of swine origin. Methods: SDSE strains (V220 and V1524) were phenotypically and genotypically characterized. Transferabilit...
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2023

Co-location of the oxazolidinone resistance poxtA2 and cfr(D) genes on a multiresistance plasmid from a porcine Streptococcus dysgalactiae subsp. equisimilis, Italy
Anno: 2023
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Coccitto, Sonia Nina; Massacci, Francesca Romana; Cinthi, Marzia; Albini, Elisa; Cucco, Lucilla; D'Achille, Gloria; Morroni, Gianluca; Mingoia, Marina; Orsini, Massimiliano; Giovanetti, Eleonora; Brenciani, Andrea; Magistrali, Chiara Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/316651
Citazioni:
Co-location of the oxazolidinone resistance poxtA2 and cfr(D) genes on a multiresistance plasmid from a porcine Streptococcus dysgalactiae subsp. equisimilis, Italy / Coccitto, S.N., Massacci, F.R., Cinthi, M., Albini, E., Cucco, L., D'Achille, G., Morroni, G., Mingoia, M., Orsini, M., Giovanetti, E., Brenciani, A., Magistrali, C.F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 78:8(2023), pp. 2099-2102. [10.1093/jac/dkad169]

2022

Clinical and microbiological features of ceftolozane/tazobactam-resistant Pseudomonas aeruginosa isolates in a university hospital in central Italy
Anno: 2022
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Morroni, Gianluca; Brescini, Lucia; Antonelli, Alberto; Di Pilato, Vincenzo; Castelletti, Sefora; Brenciani, Andrea; D'Achille, Gloria; Mingoia, Marina; Giovanetti, Eleonora; Fioriti, Simona; Masucci, Annamaria; Giani, Tommaso; Giacometti, Andrea; Rossolini, GIAN MARIA; Cirioni, Oscar
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305721
Citazioni:
Clinical and microbiological features of ceftolozane/tazobactam-resistant Pseudomonas aeruginosa isolates in a university hospital in central Italy / Morroni, G., Brescini, L., Antonelli, A., Di Pilato, V., Castelletti, S., Brenciani, A., D'Achille, G., Mingoia, M., Giovanetti, E., Fioriti, S., Masucci, A., Giani, T., Giacometti, A., Rossolini, G.M., Cirioni, O.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - (2022).
Abstract:
Objectives: Ceftolozane/tazobactam (C/T) is a novel cephalosporin and β-lactamase inhibitor combination with great activity against Pseudomonas aeruginosa. To assess P. aeruginosa susceptibility to C/T, a surveil- lance study was conducted from October 2018 to March 2019 at the University Hos...
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2022

Detection of an Enterococcus faecium Carrying a Double Copy of the PoxtA Gene from Freshwater River, Italy
Anno: 2022
Rivista: ANTIBIOTICS
Autori/autrici: Cinthi, Marzia; Coccitto, SONIA NINA; Morroni, Gianluca; D’Achille, Gloria; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/307923
Citazioni:
Detection of an Enterococcus faecium Carrying a Double Copy of the PoxtA Gene from Freshwater River, Italy / Cinthi, M., Coccitto, S.N., Morroni, G., D’Achille, G., Brenciani, A., Giovanetti, E.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 11:11(2022). [10.3390/antibiotics11111618]
Abstract:
Oxazolidinones are valuable antimicrobials that are used to treat severe infections due to multidrug-resistant (MDR) Gram-positive bacteria. However, in recent years, a significant spread of clinically relevant linezolid-resistant human bacteria that is also present in animal and environmental setti...
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2022

Characterization of a novel cfr(D)/poxtA-carrying plasmid in an oxazolidinone-resistant Enterococcus casseliflavus isolate from swine manure, Italy
Anno: 2022
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; D'Achille, Gloria; Morroni, Gianluca; Simoni, Serena; Fioriti, Simona; Magistrali, Chiara Francesca; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305723
Citazioni:
Characterization of a novel cfr(D)/poxtA-carrying plasmid in an oxazolidinone-resistant Enterococcus casseliflavus isolate from swine manure, Italy / Cinthi, M., Coccitto, S.N., D'Achille, G., Morroni, G., Simoni, S., Fioriti, S., Magistrali, C.F., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7173. - 30:(2022), pp. 308-310. [10.1016/j.jgar.2022.07.007]

2022

Linezolid-resistant Enterococcus gallinarum isolate of swine origin carrying cfr, optrA and poxtA genes
Anno: 2022
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Coccitto, SONIA NINA; Cinthi, Marzia; Fioriti, Simona; Morroni, Gianluca; Simoni, Serena; Vignaroli, Carla; Garofalo, Cristiana; Mingoia, Marina; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293308
Citazioni:
Linezolid-resistant Enterococcus gallinarum isolate of swine origin carrying cfr, optrA and poxtA genes / Coccitto, S.N., Cinthi, M., Fioriti, S., Morroni, G., Simoni, S., Vignaroli, C., Garofalo, C., Mingoia, M., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 77:2(2022), pp. 331-337. [10.1093/jac/dkab408]
Abstract:
Objectives To characterize a linezolid-resistant Enterococcus gallinarum isolate of porcine origin co-carrying cfr, optrA and poxtA genes. Methods The genome was sequenced using the Illumina and Nanopore platforms. The presence of circular intermediates was examined by inverse PCR. Transferabil...
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2022

Occurrence of a plasmid co-carrying cfr(D) and poxtA2 linezolid resistance genes in Enterococcus faecalis and Enterococcus casseliflavus from porcine manure, Italy
Anno: 2022
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Cinthi, Marzia; Coccitto, Sonia Nina; Fioriti, Simona; Morroni, Gianluca; Simoni, Serena; Vignaroli, Carla; Magistrali, Chiara Francesca; Albini, Elisa; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/295047
Citazioni:
Occurrence of a plasmid co-carrying cfr(D) and poxtA2 linezolid resistance genes in Enterococcus faecalis and Enterococcus casseliflavus from porcine manure, Italy / Cinthi, M., Coccitto, S.N., Fioriti, S., Morroni, G., Simoni, S., Vignaroli, C., Magistrali, C.F., Albini, E., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 77:3(2022), pp. 598-603. [10.1093/jac/dkab456]
Abstract:
Objectives: To investigate the genetic elements and the transferability of linezolid resistance genes in three enterococci co-carrying cfr(D) and poxtA2 isolates from manure of a swine farm in central Italy. Methods: Two Enterococcus faecalis isolates and one Enterococcus casseliflavus isolate carry...
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2022

Oxazolidinones: mechanisms of resistance and mobile genetic elements involved
Anno: 2022
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Morroni, Gianluca; Schwarz, Stefan; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305724
Citazioni:
Oxazolidinones: mechanisms of resistance and mobile genetic elements involved / Brenciani, A., Morroni, G., Schwarz, S., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 77:10(2022), pp. 2596-2621. [10.1093/jac/dkac263]
Abstract:
The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome inhibiting protein synthesis. Even if the majority of G...
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2022

Co-existence of cfr and fosB genes in an MDR Staphylococcus hominis blood isolate from an Italian hospital
Anno: 2022
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Coccitto, Sonia Nina; Cinthi, Marzia; Morroni, Gianluca; Pocognoli, Antonella; Simoni, Serena; D'Achille, Gloria; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/308182
Citazioni:
Co-existence of cfr and fosB genes in an MDR Staphylococcus hominis blood isolate from an Italian hospital / Coccitto, S.N., Cinthi, M., Morroni, G., Pocognoli, A., Simoni, S., D'Achille, G., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - 31:(2022), pp. 391-393. [10.1016/j.jgar.2022.11.009]

2021

Detection of a chromosomal truncated cfr gene in a linezolid-susceptible LA-MRSA ST398 of porcine origin, Italy
Anno: 2021
Rivista: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
Autori/autrici: Fioriti, Simona; Coccitto, Sonia Nina; Morroni, Gianluca; Simoni, Serena; Cinthi, Marzia; Magi, Gloria; Sante, Laura Di; Jm, Alvarez-Suarez; Mingoia, Marina; Giovanetti, Eleonora; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290970
Citazioni:
Detection of a chromosomal truncated cfr gene in a linezolid-susceptible LA-MRSA ST398 of porcine origin, Italy / Fioriti, S., Coccitto, S.N., Morroni, G., Simoni, S., Cinthi, M., Magi, G., Sante, L.D., Jm, A., Mingoia, M., Giovanetti, E., Brenciani, A.. - In: JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. - ISSN 2213-7165. - (2021). [10.1016/j.jgar.2021.06.008]

2021

The Osmotic Action of Sugar Combined with Hydrogen Peroxide and Bee-Derived Antibacterial Peptide Defensin-1 is Crucial for the Antibiofilm Activity of Eucalyptus Honey
Anno: 2021
Rivista: LEBENSMITTEL-WISSENSCHAFT + TECHNOLOGIE
Autori/autrici: Proaño, Adrián; Coello, Dayana; Villacrés-Granda, Irina; Ballesteros, Isabel; Debut, Alexis; Vizuete, Karla; Brenciani, Andrea; Álvarez-Suarez, José M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/284343
Citazioni:
The Osmotic Action of Sugar Combined with Hydrogen Peroxide and Bee-Derived Antibacterial Peptide Defensin-1 is Crucial for the Antibiofilm Activity of Eucalyptus Honey / Proaño, A., Coello, D., Villacrés-Granda, I., Ballesteros, I., Debut, A., Vizuete, K., Brenciani, A., Álvarez-Suarez, J.M.. - In: LEBENSMITTEL-WISSENSCHAFT + TECHNOLOGIE. - ISSN 0023-6438. - 136:(2021), p. 110379.110379. [10.1016/j.lwt.2020.110379]
Abstract:
Honey is known for its important antimicrobial activity, which is considered one of its main biological properties. This property has been associated with different factors, among which floral origin stands out and can directlyaffect this biological activity. The aim of this study was to evaluate th...
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2021

Detection of phenicol-oxazolidinone resistance gene optrA in Aerococcus viridans from bovine faeces, Italy
Anno: 2021
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Coccitto, Sonia Nina; Fioriti, Simona; Cinthi, Marzia; Morroni, Gianluca; Di Giannatale, Elisabetta; Mingoia, Marina; Brenciani, Andrea; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290597
Citazioni:
Detection of phenicol-oxazolidinone resistance gene optrA in Aerococcus viridans from bovine faeces, Italy / Coccitto, S.N., Fioriti, S., Cinthi, M., Morroni, G., Di Giannatale, E., Mingoia, M., Brenciani, A., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 76:9(2021), pp. 2479-2481. [10.1093/jac/dkab162]

2021

High prevalence of carbapenem-resistant Klebsiella pneumoniae ST307 recovered from faecal samples in an Italian hospital
Anno: 2021
Rivista: FUTURE MICROBIOLOGY
Autori/autrici: Magi, Gloria; Tontarelli, Federica; Caucci, Sara; Di Sante, Laura; Brenciani, Andrea; Morroni, Gianluca; Giovanetti, Eleonora; Menzo, Stefano; Mingoia, Marina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/291006
Citazioni:
High prevalence of carbapenem-resistant Klebsiella pneumoniae ST307 recovered from faecal samples in an Italian hospital / Magi, G., Tontarelli, F., Caucci, S., Di Sante, L., Brenciani, A., Morroni, G., Giovanetti, E., Menzo, S., Mingoia, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - STAMPA. - 16:10(2021), pp. 703-711. [10.2217/fmb-2020-0246]
Abstract:
Aim: This study reports the characterization of carbapenem-resistant colonizing strains of K. pneumoniae.Methods: 650 stool samples were screened for carbapenem-resistant K. pneumoniae (CR-Kp). All strains were characterized for antibiotic susceptibility, typing features, main carbapenemases and ext...
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2021

Synergistic effect of antimicrobial peptide LL-37 and colistin combination against multidrug-resistant Escherichia coli isolates
Anno: 2021
Rivista: FUTURE MICROBIOLOGY
Autori/autrici: Morroni, Gianluca; Sante, Laura Di; Simonetti, Oriana; Brescini, Lucia; Kamysz, Wojciech; Kamysz, Elzbieta; Mingoia, Marina; Brenciani, Andrea; Giovanetti, Eleonora; Bagnarelli, Patrizia; Giacometti, Andrea; Cirioni, Oscar
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/288297
Citazioni:
Synergistic effect of antimicrobial peptide LL-37 and colistin combination against multidrug-resistant Escherichia coli isolates / Morroni, G., Sante, L.D., Simonetti, O., Brescini, L., Kamysz, W., Kamysz, E., Mingoia, M., Brenciani, A., Giovanetti, E., Bagnarelli, P., Giacometti, A., Cirioni, O.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - (2021). [10.2217/fmb-2020-0204]
Abstract:
Overview: The global spread of antibiotic resistance represents a serious threat for public health. Aim: We evaluated the efficacy of the antimicrobial peptide LL-37 as antimicrobial agent against multidrug-resistant Escherichia coli. Results: LL-37 showed good activity against mcr-1 carrying, exten...
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2021

First IncHI2 Plasmid Carrying mcr-9.1, blaVIM-1, and Double Copies of blaKPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate
Anno: 2021
Rivista: MSPHERE
Autori/autrici: Simoni, Serena; Mingoia, Marina; Brenciani, Andrea; Carelli, Maria; Lleò, Maria M; Malerba, Giovanni; Vignaroli, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290599
Citazioni:
First IncHI2 Plasmid Carrying mcr-9.1, blaVIM-1, and Double Copies of blaKPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate / Simoni, S., Mingoia, M., Brenciani, A., Carelli, M., Lleò, M.M., Malerba, G., Vignaroli, C.. - In: MSPHERE. - ISSN 2379-5042. - ELETTRONICO. - 6:3(2021), pp. 1-5. [10.1128/mSphere.00302-21]
Abstract:
We report a novel IncHI2 plasmid coharboring blaVIM-1, two copies of blaKPC-3, and mcr-9.1 resistance genes in a human Escherichia coli isolate of the new serogroup O188. The blaVIM-1 gene was included in a class 1 integron, mcr-9.1 in a cassette bracketed by IS903 and ΔIS1R, and blaKPC-3 in t...
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2021

Characterization and clonal diffusion of ceftaroline non-susceptible mrsa in two hospitals in central Italy
Anno: 2021
Rivista: ANTIBIOTICS
Autori/autrici: Morroni, G.; Fioriti, S.; Salari, F.; Brenciani, A.; Brescini, L.; Mingoia, M.; Giovanetti, E.; Pocognoli, A.; Giacometti, A.; Molinelli, E.; Offidani, A.; Simonetti, O.; Cirioni, O.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293309
Citazioni:
Characterization and clonal diffusion of ceftaroline non-susceptible mrsa in two hospitals in central Italy / Morroni, G., Fioriti, S., Salari, F., Brenciani, A., Brescini, L., Mingoia, M., Giovanetti, E., Pocognoli, A., Giacometti, A., Molinelli, E., Offidani, A., Simonetti, O., Cirioni, O.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 10:8(2021). [10.3390/antibiotics10081026]
Abstract:
Background: Ceftaroline represents a novel fifth-generation cephalosporin to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Ceftaroline susceptibility of 239 MRSA isolates was assessed by disk diffusion and a MIC test strip following both EUCAST and CLSI guid...
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2021

Linezolid resistance genes in enterococci isolated from sediment and zooplankton in two Italian coastal areas
Anno: 2021
Rivista: APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Autori/autrici: Fioriti, Simona; Coccitto, Sonia Nina; Cedraro, Nicholas; Simoni, Serena; Morroni, Gianluca; Brenciani, Andrea; Mangiaterra, Gianmarco; Vignaroli, Carla; Vezzulli, Luigi; Biavasco, Francesca; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/287993
Citazioni:
Linezolid resistance genes in enterococci isolated from sediment and zooplankton in two Italian coastal areas / Fioriti, S., Coccitto, S.N., Cedraro, N., Simoni, S., Morroni, G., Brenciani, A., Mangiaterra, G., Vignaroli, C., Vezzulli, L., Biavasco, F., Giovanetti, E.. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 0099-2240. - 87:9(2021), pp. e02958-20.1-e02958-20.10. [10.1128/AEM.02958-20]
Abstract:
Linezolid is a last resort antibiotic for the treatment of severe infections caused by multi-resistant Gram-positives; although linezolid resistance remains uncommon, the number of linezolid-resistant enterococci has increased during recent years due to worldwide spread of acquired resistance genes ...(cfr, optrA and poxtA) in clinical, animal and environmental setting. In this study we investigated the occurrence of linezolid-resistant enterococci in marine samples from two coastal areas in Italy. Isolates grown on florfenicol-supplemented Slanetz-Bartley were investigated for their carriage of optrA, poxtA and cfr genes: optrA was found in one E. faecalis, poxtA in three E. faecium and two E. hirae and cfr was not found. Two of the three poxtA-carrying E. faecium and the two E. hirae showed related PFGE profiles. Two E. faecium belonged to the new ST1710, which clustered in the clonal complex CC94, encompassing nosocomial strains. S1-PFGE/hybridization assays showed a double (chromosome and plasmid) location of poxtA and plasmid location of optrA WGS revealed that poxtA was contained in a Tn6657-like element carried by two plasmids (pEfm-EF3 and pEh-GE2) of similar size, found in different species, and that poxtA were flanked by two copies of IS1216 in both plasmids. In mating experiments all but one (E. faecalis EN3) strains were able to transfer the poxtA gene to E. faecium 64/3. The occurrence of linezolid resistance genes in enterococci from marine samples is of great concern and highlights the need to improve practices aimed at limiting the transmission of linezolid resistant strains to humans from the environmental reservoirs.Importance Linezolid is one of the few antimicrobials available to treat severe infections due to drug-resistant Gram-positive bacteria, thus the emergence of linezolid-resistant enterococci carrying transferable resistance determinants is of great concern for public health. Linezolid resistance genes (cfr, optrA and poxtA), often plasmid located, can be transmitted via horizontal gene transfer and have the potential to spread globally. This study highlights the first detection of enterococci carrying linezolid resistance genes from sediment and zooplankton samples in two coastal urban areas in Italy. The presence of clinically relevant resistant bacteria, such as linezolid-resistant enterococci, in marine environment could reflect their spillover from human and/or animal reservoirs and could indicate that also coastal seawaters could represent a source of these resistance genes.
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2020

Human leptospirosis in Marche region: over 10 years of surveillance
Anno: 2020
Rivista: MICROBIOLOGY AND IMMUNOLOGY
Autori/autrici: Magi, Gloria; Mingoia, Marina; Morroni, Gianluca; Fioriti, Simona; Coccitto, Sonia Nina; Di Sante, Laura; Giovanetti, Eleonora; Brenciani, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/284147
Citazioni:
Human leptospirosis in Marche region: over 10 years of surveillance / Magi, G., Mingoia, M., Morroni, G., Fioriti, S., Coccitto, S.N., Di Sante, L., Giovanetti, E., Brenciani, A.. - In: MICROBIOLOGY AND IMMUNOLOGY. - ISSN 0385-5600. - (2020). [10.1111/1348-0421.12853]
Abstract:
We conducted a ten-years retrospective study in 347 symptomatic individuals to assess the regional distribution of leptospirosis. 173 were diagnosed positive (49.8%): 11.5% were MAT-positive, while 38.3% were found positive to Leptospira by microscopy analysis. The maximum peak of leptospirosis was ...
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2020

Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds
Anno: 2020
Rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Autori/autrici: Amabili, P.; Biavasco, F.; Brenciani, A.; Citterio, B.; Corbisiero, D.; Ferrazzano, L.; Fioriti, S.; Guerra, G.; Orena, M.; Rinaldi, S.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/273415
Citazioni:
Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds / Amabili, P., Biavasco, F., Brenciani, A., Citterio, B., Corbisiero, D., Ferrazzano, L., Fioriti, S., Guerra, G., Orena, M., Rinaldi, S.. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 1768-3254. - 189:(2020). [10.1016/j.ejmech.2020.112072]
Abstract:
Pursuing the search for a new class of structurally simple mimics of antimicrobial peptides, we optimized a short, cheap and high-yielding synthesis of mono-charged amphiphilic α-hydrazido acid derivatives. The most active derivatives furnished MICs that are among the best values reported in l...
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2020

Trend of clinical vancomycin-resistant enterococci isolated in a regional Italian hospital from 2001 to 2018
Anno: 2020
Rivista: BRAZILIAN JOURNAL OF MICROBIOLOGY
Autori/autrici: Fioriti, S.; Simoni, S.; Caucci, S.; Morroni, G.; Ponzio, E.; Coccitto, S. N.; Brescini, L.; Cirioni, O.; Menzo, S.; Biavasco, F.; Giovanetti, E.; Brenciani, A.; Vignaroli, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/283629
Citazioni:
Trend of clinical vancomycin-resistant enterococci isolated in a regional Italian hospital from 2001 to 2018 / Fioriti, S., Simoni, S., Caucci, S., Morroni, G., Ponzio, E., Coccitto, S.N., Brescini, L., Cirioni, O., Menzo, S., Biavasco, F., Giovanetti, E., Brenciani, A., Vignaroli, C.. - In: BRAZILIAN JOURNAL OF MICROBIOLOGY. - ISSN 1517-8382. - (2020). [10.1007/s42770-020-00360-8]
Abstract:
A retrospective study of the epidemiology of vancomycin-resistant enterococci (VRE) in a regional hospital of central Italy in 2001–2018 demonstrated an increased VRE prevalence since 2016. A total of 113 VRE isolates, 89 E. faecium (VREfm) and 24 E. faecalis (VREfs), were collected in the stu...
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2020

Detection of Oxazolidinone Resistance Genes and Characterization of Genetic Environments in Enterococci of Swine Origin, Italy
Anno: 2020
Rivista: MICROORGANISMS
Autori/autrici: Fioriti, Simona; Morroni, Gianluca; Coccitto, Sonia Nina; Brenciani, Andrea; Antonelli, Alberto; Di Pilato, Vincenzo; Baccani, Ilaria; Pollini, Simona; Cucco, Lucilla; Morelli, Alessandra; Paniccià, Marta; Magistrali, Chiara Francesca; Rossolini, Gian Maria; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/285992
Citazioni:
Detection of Oxazolidinone Resistance Genes and Characterization of Genetic Environments in Enterococci of Swine Origin, Italy / Fioriti, S., Morroni, G., Coccitto, S.N., Brenciani, A., Antonelli, A., Di Pilato, V., Baccani, I., Pollini, S., Cucco, L., Morelli, A., Paniccià, M., Magistrali, C.F., Rossolini, G.M., Giovanetti, E.. - In: MICROORGANISMS. - ISSN 2076-2607. - 8:12(2020). [10.3390/microorganisms8122021]
Abstract:
One hundred forty-five florfenicol-resistant enterococci, isolated from swine fecal samples collected from 76 pig farms, were investigated for the presence of optrA, cfr, and poxtA genes by PCR. Thirty florfenicol-resistant Enterococcus isolates had at least one linezolid resistance gene. optrA was ...
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2020

Antimicrobial Resistance: A Challenge for the Future
Anno: 2020
Autori/autrici: Varaldo, Pietro Emanuele; Facinelli, Bruna; Bagnarelli, Patrizia; Menzo, Stefano; Mingoia, Marina; Brenciani, Andrea; Giacometti, Andrea; Barchiesi, Francesco; Brescini, Lucia; Cirioni, Oscar; Scalise, Giorgio; Barbadoro, Pamela; Di Stanislao, Francesco; Prospero, Emilia; D'Errico, Marcello Mario
Lingua: ENG
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/351592
Citazioni:
Antimicrobial Resistance: A Challenge for the Future / Varaldo, P.E., Facinelli, B., Bagnarelli, P., Menzo, S., Mingoia, M., Brenciani, A., Giacometti, A., Barchiesi, F., Brescini, L., Cirioni, O., Scalise, G., Barbadoro, P., Di Stanislao, F., Prospero, E., D'Errico, M.M.. - STAMPA. - (2020), pp. 13-29. [10.1007/978-3-030-33832-9_2]
Abstract:
The global emergence of antibiotic-resistance, together with the lack of/reduced development of new antibiotic molecules, currently represents a serious public health problem as it can mean the return to a pre-antibiotic era in which infections caused by multiple-resistant pathogens are intractable....
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2019

Validation of a universal DNA extraction method for human and microbiAL DNA analysis
Anno: 2019
Rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES
Autori/autrici: Alessandrini, Federica; Brenciani, Andrea; Fioriti, Simona; Melchionda, Filomena; Mingoia, Marina; Morroni, Gianluca; Tagliabracci, Adriano
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/270724
Citazioni:
Validation of a universal DNA extraction method for human and microbiAL DNA analysis / Alessandrini, F., Brenciani, A., Fioriti, S., Melchionda, F., Mingoia, M., Morroni, G., Tagliabracci, A.. - In: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES. - ISSN 1875-1768. - ELETTRONICO. - (2019), pp. 256-258. [10.1016/j.fsigss.2019.09.098]
Abstract:
The study of microbiomes has enormous potential for forensic science because microorganisms are ubiquitous and particular communities of microbes are often associated with specific processes or environments. With recent advances in microbiome science, new opportunities exist for microbiome technolog...
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2019

Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium
Anno: 2019
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Morroni, Gianluca; Brenciani, Andrea; Litta-Mulondo, Alice; Vignaroli, Carla; Mangiaterra, Gianmarco; Fioriti, Simona; Citterio, Barbara; Cirioni, Oscar; Giovanetti, Eleonora; Biavasco, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/262816
Citazioni:
Characterization of a new transferable MDR plasmid carrying the pbp5 gene from a clade B commensal Enterococcus faecium / Morroni, G., Brenciani, A., Litta-Mulondo, A., Vignaroli, C., Mangiaterra, G., Fioriti, S., Citterio, B., Cirioni, O., Giovanetti, E., Biavasco, F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 74:4(2019), pp. 843-850. [10.1093/jac/dky549]
Abstract:
OBJECTIVES: To evaluate the transferability of antibiotic resistance from an MDR clade B Enterococcus faecium and to characterize the genetic elements involved. METHODS: The erm(B)-positive strain E. faecium 37BA (donor) and strains E. faecium 64/3 and Listeria welshimeri 11857RF (recipients) w...
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2019

Characterization of Tn6349, a novel mosaic transposon carrying poxtA, cfr and other resistance determinants, inserted in the chromosome of an ST5-MRSA-II strain of clinical origin
Anno: 2019
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: D’Andrea, Marco Maria; Antonelli, Alberto; Brenciani, Andrea; Di Pilato, Vincenzo; Morroni, Gianluca; Pollini, Simona; Fioriti, Simona; Giovanetti, Eleonora; Rossolini, Gian Maria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/268686
Citazioni:
Characterization of Tn6349, a novel mosaic transposon carrying poxtA, cfr and other resistance determinants, inserted in the chromosome of an ST5-MRSA-II strain of clinical origin / D’Andrea, M.M., Antonelli, A., Brenciani, A., Di Pilato, V., Morroni, G., Pollini, S., Fioriti, S., Giovanetti, E., Rossolini, G.M.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 74:10(2019), pp. 2870-2875. [10.1093/jac/dkz278]
Abstract:
Objectives: To characterize the genetic element carrying the poxtA oxazolidinone resistance gene found in the poxtA index strain Staphylococcus aureus AOUC-0915 isolated from a cystic fibrosis patient. Methods: The genetic context of poxtA was investigated by bioinformatics analysis of WGS data of...
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2019

Increase and diversity of carbapenemase-producing Escherichia coli isolates, Italy
Anno: 2019
Rivista: FUTURE MICROBIOLOGY
Autori/autrici: Simoni, S; Caucci, Sara; Brenciani, A; Morroni, G; Giovanetti, E; Menzo, S; Facinelli, B; Mingoia, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/269541
Citazioni:
Increase and diversity of carbapenemase-producing Escherichia coli isolates, Italy / Simoni, S., Caucci, S., Brenciani, A., Morroni, G., Giovanetti, E., Menzo, S., Facinelli, B., Mingoia, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - STAMPA. - 14:2(2019), pp. 1035-1042. [10.2217/fmb-2019-0069]
Abstract:
Aim: This study reports on a surveillance in an Italian hospital focused on carbapenemase-producing Escherichia coli (CP-Ec). Materials & methods: Eighteen isolates (nine from clinical specimens and nine from rectal swab) were characterized for antibiotic susceptibilities, typing features, main ...
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2019

In vitro activity of Protegrin-1, alone and in combination with clinically useful antibiotics, against Acinetobacter baumannii strains isolated from surgical wounds
Anno: 2019
Rivista: MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Autori/autrici: Morroni, Gianluca; Simonetti, Oriana; Brenciani, Andrea; Brescini, Lucia; Kamysz, Wojciech; Kamysz, Elzbieta; Neubauer, Damian; Caffarini, Miriam; Orciani, Monia; Giovanetti, Eleonora; Offidani, Annamaria; Giacometti, Andrea; Cirioni, Oscar
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/267244
Citazioni:
In vitro activity of Protegrin-1, alone and in combination with clinically useful antibiotics, against Acinetobacter baumannii strains isolated from surgical wounds / Morroni, G., Simonetti, O., Brenciani, A., Brescini, L., Kamysz, W., Kamysz, E., Neubauer, D., Caffarini, M., Orciani, M., Giovanetti, E., Offidani, A., Giacometti, A., Cirioni, O.. - In: MEDICAL MICROBIOLOGY AND IMMUNOLOGY. - ISSN 0300-8584. - ELETTRONICO. - 208:6(2019), pp. 877-883. [10.1007/s00430-019-00624-7]
Abstract:
In the past few years the increasing incidence of hospital infections with Acinetobacter baumannii, especially in immunocompromised patients, and its proneness to develop multidrug resistance have been raising considerable concern. This study examines the antimicrobial and antibiofilm activity of pr...
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2019

Detection in Italy of a porcine Enterococcus faecium isolate carrying the novel phenicol-oxazolidinone-tetracycline resistance gene poxtA
Anno: 2019
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Fioriti, Simona; Morroni, Gianluca; Cucco, Lucilla; Morelli, Alessandra; Pezzotti, Giovanni; Paniccià, Marta; Antonelli, Alberto; Magistrali, Chiara Francesca; Rossolini, Gian Maria; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/262815
Citazioni:
Detection in Italy of a porcine Enterococcus faecium isolate carrying the novel phenicol-oxazolidinone-tetracycline resistance gene poxtA / Brenciani, A., Fioriti, S., Morroni, G., Cucco, L., Morelli, A., Pezzotti, G., Paniccià, M., Antonelli, A., Magistrali, C.F., Rossolini, G.M., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 74:3(2019), pp. 817-818. [10.1093/jac/dky505]

2018

Comparison of the Antimicrobial Activities of Four Honeys From Three Countries (New Zealand, Cuba, and Kenya)
Anno: 2018
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Morroni, Gianluca; Alvarez-Suarez, José M.; Brenciani, Andrea; Simoni, Serena; Fioriti, Simona; Pugnaloni, Armanda; Giampieri, Francesca; Mazzoni, Luca; Gasparrini, Massimiliano; Marini, Emanuela; Mingoia, Marina; Battino, Maurizio; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/259566
Citazioni:
Comparison of the Antimicrobial Activities of Four Honeys From Three Countries (New Zealand, Cuba, and Kenya) / Morroni, G., Alvarez-Suarez, J.M., Brenciani, A., Simoni, S., Fioriti, S., Pugnaloni, A., Giampieri, F., Mazzoni, L., Gasparrini, M., Marini, E., Mingoia, M., Battino, M., Giovanetti, E.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - ELETTRONICO. - 9:1378(2018). [10.3389/fmicb.2018.01378]
Abstract:
Skin and chronic wound infections are an increasing and urgent health problem worldwide. Their management is difficult and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative treatments. The purpose of this study was to comp...
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2018

Characterization of poxtA, a novel phenicol-oxazolidinone-tetracycline resistance gene from an MRSA of clinical origin
Anno: 2018
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Antonelli, Alberto; D'Andrea, Marco Maria; Brenciani, Andrea; Galeotti, Cesira L; Morroni, Gianluca; Pollini, Simona; Varaldo, Pietro Emanuele; Rossolini, Gian Maria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/257432
Citazioni:
Characterization of poxtA, a novel phenicol-oxazolidinone-tetracycline resistance gene from an MRSA of clinical origin / Antonelli, A., D'Andrea, M.M., Brenciani, A., Galeotti, C.L., Morroni, G., Pollini, S., Varaldo, P.E., Rossolini, G.M.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 73:7(2018), pp. 1763-1769. [10.1093/jac/dky088]
Abstract:
Abstract OBJECTIVES: To characterize a novel phenicol-oxazolidinone-tetracycline resistance gene, named poxtA, identified in a previously described MRSA strain that was highly resistant to linezolid and also carried the cfr gene. METHODS: The poxtA gene was identified by bioinformatic analysis...
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2018

Characterization of a Multiresistance Plasmid Carrying the optrA and cfr Resistance Genes From an Enterococcus faecium Clinical Isolate
Anno: 2018
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Morroni, Gianluca; Brenciani, Andrea; Antonelli, Alberto; Maria D’Andrea, Marco; Di Pilato, Vincenzo; Fioriti, Simona; Mingoia, Marina; Vignaroli, Carla; Cirioni, Oscar; Biavasco, Francesca; Varaldo, Pietro E.; Rossolini, Gian Maria; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/260150
Citazioni:
Characterization of a Multiresistance Plasmid Carrying the optrA and cfr Resistance Genes From an Enterococcus faecium Clinical Isolate / Morroni, G., Brenciani, A., Antonelli, A., Maria D’Andrea, M., Di Pilato, V., Fioriti, S., Mingoia, M., Vignaroli, C., Cirioni, O., Biavasco, F., Varaldo, P.E., Rossolini, G.M., Giovanetti, E.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - ELETTRONICO. - 9:2189(2018). [10.3389/fmicb.2018.02189]
Abstract:
Enterococcus faecium E35048, a bloodstream isolate from Italy, was the first strain where the oxazolidinone resistance gene optrA was detected outside China. The strain was also positive for the oxazolidinone resistance gene cfr. WGS analysis revealed that the two genes were linked (23.1 kb apart), ...
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2018

Apis mellifera vs Melipona beecheii Cuban polifloral honeys: A comparison based on their physicochemical parameters, chemical composition and biological properties
Anno: 2018
Rivista: LEBENSMITTEL-WISSENSCHAFT + TECHNOLOGIE
Autori/autrici: Alvarez-Suarez, José M.; Giampieri, Francesca; Brenciani, Andrea; Mazzoni, Luca; Gasparrini, Massimiliano; González-Paramás, Ana M.; Santos-Buelga, Celestino; Morroni, Gianluca; Simoni, Serena; Forbes-Hernández, Tamara Y.; Afrin, Sadia; Giovanetti, Eleonora; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/253753
Citazioni:
Apis mellifera vs Melipona beecheii Cuban polifloral honeys: A comparison based on their physicochemical parameters, chemical composition and biological properties / Alvarez-Suarez, J.M., Giampieri, F., Brenciani, A., Mazzoni, L., Gasparrini, M., González-Paramás, A.M., Santos-Buelga, C., Morroni, G., Simoni, S., Forbes-Hernández, T.Y., Afrin, S., Giovanetti, E., Battino, M.. - In: LEBENSMITTEL-WISSENSCHAFT + TECHNOLOGIE. - ISSN 0023-6438. - 87:(2018), pp. 272-279. [10.1016/j.lwt.2017.08.079]
Abstract:
Several polifloral honeys from the Apis mellifera and Melipona beecheii bee were analyzed to evaluate their pollen profile, physicochemical parameters, chemical composition and their antioxidant and antimicrobial activity. Flavonoids and other phenolic derivatives, 16 compounds in Apis mellifera h...
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2018

Molecular Characterization of Italian Isolates of Fluoroquinolone-Resistant Streptococcus agalactiae and Relationships with Chloramphenicol Resistance
Anno: 2018
Rivista: MICROBIAL DRUG RESISTANCE
Autori/autrici: Simoni, Serena; Vincenzi, Chiara; Brenciani, Andrea; Morroni, Gianluca; Bagnarelli, Patrizia; Giovanetti, Eleonora; Varaldo, Pietro; Mingoia, Marina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/250559
Citazioni:
Molecular Characterization of Italian Isolates of Fluoroquinolone-Resistant Streptococcus agalactiae and Relationships with Chloramphenicol Resistance / Simoni, S., Vincenzi, C., Brenciani, A., Morroni, G., Bagnarelli, P., Giovanetti, E., Varaldo, P., Mingoia, M.. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - STAMPA. - 24:3(2018), pp. 225-231. [10.1089/mdr.2017.0139]
Abstract:
A total number of 368 clinical isolates of Streptococcus agalactiae (group B Streptococcus, GBS) were collected in 2010–2016 from three hospitals in a region of central Italy. Fluoroquinolone (FQ)-resistant isolates were selected using levofloxacin. Levofloxacin-resistant (LR) strains (11/36...
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2018

Spread of colistin resistance gene mcr-1 in Italy: characterization of the mcr-1.2 allelic variant in a colistin-resistant blood isolate of Escherichia coli
Anno: 2018
Rivista: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Autori/autrici: Simoni, Serena; Morroni, Gianluca; Brenciani, Andrea; Vincenzi, Chiara; Cirioni, Oscar; Castelletti, Sefora; Varaldo, Pietro E.; Giovanetti, Eleonora; Mingoia, Marina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/252571
Citazioni:
Spread of colistin resistance gene mcr-1 in Italy: characterization of the mcr-1.2 allelic variant in a colistin-resistant blood isolate of Escherichia coli / Simoni, S., Morroni, G., Brenciani, A., Vincenzi, C., Cirioni, O., Castelletti, S., Varaldo, P.E., Giovanetti, E., Mingoia, M.. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 91:1(2018), pp. 66-68. [10.1016/j.diagmicrobio.2017.12.015]
Abstract:
mcr-1.2, an allelic variant of the transferable colistin resistance gene mcr-1, was characterized in a colistin-resistant blood isolate of Escherichia coli. It was harbored by an IncX4-type plasmid (33,293 bp). Despite its low prevalence, the potentially worrying spread of the mcr-1 gene, particular...
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2018

Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus
Anno: 2018
Rivista: PHYTOTHERAPY RESEARCH
Autori/autrici: Marini, Emanuela; Di Giulio, Mara; Magi, Gloria; Di Lodovico, Silvia; Cimarelli, Maria Enrica; Brenciani, Andrea; Nostro, Antonia; Cellini, Luigina; Facinelli, Bruna
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/252469
Citazioni:
Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus / Marini, E., Di Giulio, M., Magi, G., Di Lodovico, S., Cimarelli, M.E., Brenciani, A., Nostro, A., Cellini, L., Facinelli, B.. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - ELETTRONICO. - 32:3(2018), pp. 488-495. [10.1002/ptr.5994]
Abstract:
Curcumin, a phenolic compound extracted from Curcuma longa, exerts multiple pharmacological effects, including an antimicrobial action. Mycobacterium abscessus, an environmental, nontuberculous, rapidly growing mycobacterium, is an emerging human pathogen causing serious lung infections and one of t...
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2018

High rate of ceftobiprole resistance among clinical methicillin-resistant Staphylococcus aureus isolates from a hospital in central Italy
Anno: 2018
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Morroni, Gianluca; Brenciani, Andrea; Brescini, Lucia; Fioriti, Simona; Simoni, Serena; Pocognoli, Antonella; Mingoia, Marina; Giovanetti, Eleonora; Barchiesi, Francesco; Giacometti, Andrea; Cirioni, Oscar
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264133
Citazioni:
High rate of ceftobiprole resistance among clinical methicillin-resistant Staphylococcus aureus isolates from a hospital in central Italy / Morroni, G., Brenciani, A., Brescini, L., Fioriti, S., Simoni, S., Pocognoli, A., Mingoia, M., Giovanetti, E., Barchiesi, F., Giacometti, A., Cirioni, O.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 62:12(2018). [10.1128/AAC.01663-18]
Abstract:
Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter). Epidemiological char...
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2018

In vitro and in vivo activity of fosfomycin alone and in combination with rifampin and tigecycline against Grampositive cocci isolated from surgical wound infections
Anno: 2018
Rivista: JOURNAL OF MEDICAL MICROBIOLOGY
Autori/autrici: Simonetti, Oriana; Morroni, Gianluca; Ghiselli, Roberto; Orlando, Fiorenza; Brenciani, Andrea; Xhuvelaj, Ledia; Provinciali, Mauro; Offidani, Annamaria; Guerrieri, Mario; Giacometti, Andrea; Cirioni, Oscar
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/252528
Citazioni:
In vitro and in vivo activity of fosfomycin alone and in combination with rifampin and tigecycline against Grampositive cocci isolated from surgical wound infections / Simonetti, O., Morroni, G., Ghiselli, R., Orlando, F., Brenciani, A., Xhuvelaj, L., Provinciali, M., Offidani, A., Guerrieri, M., Giacometti, A., Cirioni, O.. - In: JOURNAL OF MEDICAL MICROBIOLOGY. - ISSN 0022-2615. - ELETTRONICO. - 67:1(2018), pp. 139-143. [10.1099/jmm.0.000649]
Abstract:
Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal activities of antimicrobial combinations of fosfomyci...
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2018

Chemical composition of Pistacia vera L. oleoresin and its antibacterial, anti-virulence and anti-biofilm activities against oral streptococci, including Streptococcus mutans.
Anno: 2018
Rivista: ARCHIVES OF ORAL BIOLOGY
Autori/autrici: Magi, G; Marini, E; Brenciani, A; Di Lodovico, S; Gentile, D; Ruberto, G; Cellini, L; Nostro, A; Facinelli, B; Napoli, E
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/260748
Citazioni:
Chemical composition of Pistacia vera L. oleoresin and its antibacterial, anti-virulence and anti-biofilm activities against oral streptococci, including Streptococcus mutans / Magi, G., Marini, E., Brenciani, A., Di Lodovico, S., Gentile, D., Ruberto, G., Cellini, L., Nostro, A., Facinelli, B., Napoli, E.. - In: ARCHIVES OF ORAL BIOLOGY. - ISSN 0003-9969. - ELETTRONICO. - 96:(2018), pp. 208-215. [10.1016/j.archoralbio.2018.09.013]
Abstract:
OBJECTIVE: The aim of this study was to characterize the chemical composition of oleoresin of Pistacia vera L. and to determine its antimicrobial and anti-virulence activity versus selected oral streptococci. DESIGN: A gaschromatografic analysis of the oleoresin was performed. The antimicrobial...
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2017

Antibiofilm effect of curcumin against a multiresistant clinical isolate of Mycobacterium abscessus
Anno: 2017
Autori/autrici: Marini, Emanuela; Di Giulio, Mara; Magi, Gloria; Di Lodovico, Silvia; Enrica Cimarelli, Maria; Brenciani, Andrea; Nostro, Antonia; Cellini, Luigina; Facinelli, Bruna
Lingua: ITA
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256212
Citazioni:
Antibiofilm effect of curcumin against a multiresistant clinical isolate of Mycobacterium abscessus / Marini, E., Di Giulio, M., Magi, G., Di Lodovico, S., Enrica Cimarelli, M., Brenciani, A., Nostro, A., Cellini, L., Facinelli, B.. - (2017), pp. 146-146. (45° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI MICROBIOLOGIA Genova, Palazzo Ducale 27 - 30 settembre 2017).

2017

Commentary: Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014
Anno: 2017
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Morroni, Gianluca; Brenciani, Andrea; Simoni, Serena; Vignaroli, Carla; Mingoia, Marina; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/250554
Citazioni:
Commentary: Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014 / Morroni, G., Brenciani, A., Simoni, S., Vignaroli, C., Mingoia, M., Giovanetti, E.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - ELETTRONICO. - 8:(2017), pp. 1-5. [10.3389/fmicb.2017.01631]

2017

pHTβ-promoted mobilization of non-conjugative resistance plasmids from Enterococcus faecium to Enterococcus faecalis
Anno: 2017
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Di Sante, Laura; Morroni, Gianluca; Brenciani, Andrea; Vignaroli, Carla; Antonelli, Alberto; D'Andrea, Marco Maria; Di Cesare, Andrea; Giovanetti, Eleonora; Varaldo, Pietro E; Rossolini, Gian Maria; Biavasco, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/249883
Citazioni:
pHTβ-promoted mobilization of non-conjugative resistance plasmids from Enterococcus faecium to Enterococcus faecalis / Di Sante, L., Morroni, G., Brenciani, A., Vignaroli, C., Antonelli, A., D'Andrea, M.M., Di Cesare, A., Giovanetti, E., Varaldo, P.E., Rossolini, G.M., Biavasco, F.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 72:9(2017), pp. 2447-2453. [10.1093/jac/dkx197]
Abstract:
OBJECTIVES: To analyse the recombination events associated with conjugal mobilization of two multiresistance plasmids, pRUM17i48 and pLAG (formerly named pDO1-like), from Enterococcus faecium 17i48 to Enterococcus faecalis JH2-2. METHODS: The plasmids from two E. faecalis transconjugants (JH-4T...
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2017

A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]
Anno: 2017
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Morici, Eleonora; Simoni, Serena; Brenciani, Andrea; Giovanetti, Eleonora; Varaldo, Pietro; Mingoia, Marina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/237853
Citazioni:
A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)] / Morici, E., Simoni, S., Brenciani, A., Giovanetti, E., Varaldo, P., Mingoia, M.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - STAMPA. - 72:1(2017), pp. 64-67. [10.1093/jac/dkw367]
Abstract:
Objectives: To investigate the genetic basis of catQ-mediated chloramphenicol resistance in Streptococcus agalactiae. Methods: Two clinical strains of catQ-positive chloramphenicol-resistant S. agalactiae (Sag236 and Sag403) were recently isolated, typed (MLST, PFGE pulsotypes, capsular types) an...
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2016

A clone of linezolid-resistant Staphylococcus epidermidis bearing the G2576T mutation is endemic in an Italian hospital
Anno: 2016
Rivista: THE JOURNAL OF HOSPITAL INFECTION
Autori/autrici: Morroni, Gianluca; Brenciani, Andrea; Vincenzi, Chiara; Barocci, Simone; Tili, Emily; Manso, E; Mingoia, Marina; Menzo, Stefano; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/236693
Citazioni:
A clone of linezolid-resistant Staphylococcus epidermidis bearing the G2576T mutation is endemic in an Italian hospital / Morroni, G., Brenciani, A., Vincenzi, C., Barocci, S., Tili, E., Manso, E., Mingoia, M., Menzo, S., Varaldo, P., Giovanetti, E.. - In: THE JOURNAL OF HOSPITAL INFECTION. - ISSN 0195-6701. - ELETTRONICO. - 94:(2016), pp. 203-206. [10.1016/j.jhin.2016.07.012]

2016

Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907
Anno: 2016
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Mingoia, Marina; Morici, E; Marini, Emanuela; Brenciani, Andrea; Giovanetti, Eleonora; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/230534
Citazioni:
Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907 / Mingoia, M., Morici, E., Marini, E., Brenciani, A., Giovanetti, E., Varaldo, P.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - STAMPA. - 71:3(2016), pp. 593-600. [doi: 10.1093/jac/dkv408]
Abstract:
Objectives: The objective of this study was to investigate macrolide-resistant Streptococcus agalactiae isolates harbouring erm(TR), an erm(A) gene subclass, with emphasis on their erm(TR)-carrying genetic elements. Four erm(TR)-carrying elements have been described to date: three closely related ...
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2016

Characterization of novel conjugative multiresistance plasmids carrying cfr from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy
Anno: 2016
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Morroni, Gianluca; Pollini, Simona; Tiberi, Erika; Mingoia, Marina; Varaldo, Pietro; Rossolini, Gian Maria; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/228053
Citazioni:
Characterization of novel conjugative multiresistance plasmids carrying cfr from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy / Brenciani, A., Morroni, G., Pollini, S., Tiberi, E., Mingoia, M., Varaldo, P., Rossolini, G.M., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - ELETTRONICO. - 71:(2016), pp. 307-313. [10.1093/jac/dkv341]
Abstract:
Objectives: The objective of this study was to investigate the genetic environment of the cfr gene from two linezolid-resistant clinical isolates of Staphylococcus epidermidis from Italy. Methods: The two strains (SP1 and SP2) were phenotypically and genotypically characterized. Transferability of...
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2016

Stability of the cargo regions of the cfr-carrying, multiresistance plasmid pSP01 from Staphylococcus epidermidis
Anno: 2016
Rivista: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Autori/autrici: Brenciani, Andrea; Morroni, Gianluca; Mingoia, Marina; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/236691
Citazioni:
Stability of the cargo regions of the cfr-carrying, multiresistance plasmid pSP01 from Staphylococcus epidermidis / Brenciani, A., Morroni, G., Mingoia, M., Varaldo, P., Giovanetti, E.. - In: INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. - ISSN 1438-4221. - ELETTRONICO. - 306:(2016), pp. 717-721. [10.1016/j.ijmm.2016.08.002]
Abstract:
This study investigated the stability or instability — i.e. the ability or inability to undergo excision in circular form — of the four cargo regions (cr1 to cr4) of the novel cfr-carrying, multiresistance plasmid pSP01, arboured by a clinical Staphylococcus epidermidis isolate. Only c...
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2016

Linezolid-resistant cfr-positive MRSA, Italy
Anno: 2016
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Antonelli, A; D'Andrea, Mm; Galano, A; Borchi, B; Brenciani, Andrea; Vaggelli, G; Cavallo, A; Bartoloni, A; Giovanetti, Eleonora; Rossolini, Gm
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/236694
Citazioni:
Linezolid-resistant cfr-positive MRSA, Italy / Antonelli, A., D'Andrea, M.m., Galano, A., Borchi, B., Brenciani, A., Vaggelli, G., Cavallo, A., Bartoloni, A., Giovanetti, E., Rossolini, G.m.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - ELETTRONICO. - 71:(2016), pp. 2349-2351. [10.1093/jac/dkw108]

2016

Detection in Italy of two clinical Enterococcus faecium isolates carrying both the oxazolidinone and phenicol resistance gene optrA and a silent multiresistance gene cfr.
Anno: 2016
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Morroni, Gianluca; Vincenzi, C; Manso, E; Mingoia, Marina; Giovanetti, Eleonora; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/234551
Citazioni:
Detection in Italy of two clinical Enterococcus faecium isolates carrying both the oxazolidinone and phenicol resistance gene optrA and a silent multiresistance gene cfr / Brenciani, A., Morroni, G., Vincenzi, C., Manso, E., Mingoia, M., Giovanetti, E., Varaldo, P.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - ELETTRONICO. - 71:4(2016), pp. 1118-1119. [10.1093/jac/dkv438]

2016

Enterococcus faecium ST17 from Coastal Marine Sediment Carrying Transferable Multidrug Resistance Plasmids
Anno: 2016
Rivista: MICROBIAL DRUG RESISTANCE
Autori/autrici: Morroni, Gianluca; Di Cesare, Andrea; DI SANTE, Laura; Brenciani, Andrea; Vignaroli, Carla; Pasquaroli, Sonia; Giovanetti, Eleonora; Sabatino, Raffaella; Rossi, Luigia; Magnani, Mauro; Biavasco, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/236169
Citazioni:
Enterococcus faecium ST17 from Coastal Marine Sediment Carrying Transferable Multidrug Resistance Plasmids / Morroni, G., Di Cesare, A., DI SANTE, L., Brenciani, A., Vignaroli, C., Pasquaroli, S., Giovanetti, E., Sabatino, R., Rossi, L., Magnani, M., Biavasco, F.. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - ELETTRONICO. - 22:7(2016), pp. 523-530. [10.1089/mdr.2015.0222]
Abstract:
The multidrug-resistant Enterococcus faecium 17i48, sequence type 17, from marine sediment, carrying erm(B), tet(M), and tet(L) genes, was analyzed for the presence of antibiotic resistance plasmids and for the ability to transfer resistance genes. The strain was found to harbor the replicon type (r...
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2015

Transduction of the Streptococcus pyogenes bacteriophage Φm46.1, carrying resistance genes mef(A)and tet(O), to other Streptococcus species
Anno: 2015
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Giovanetti, Eleonora; Brenciani, Andrea; Morroni, Gianluca; Tiberi, Erika; Pasquaroli, Sonia; Mingoia, Marina; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/222715
Citazioni:
Transduction of the Streptococcus pyogenes bacteriophage Φm46.1, carrying resistance genes mef(A)and tet(O), to other Streptococcus species / Giovanetti, E., Brenciani, A., Morroni, G., Tiberi, E., Pasquaroli, S., Mingoia, M., Varaldo, P.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - ELETTRONICO. - 5:746(2015). [10.3389/fmicb.2014.00746]
Abstract:
Φm46.1 - Streptococcus pyogenes bacteriophage carrying mef(A) and tet(O), respectively, encoding resistance to macrolides (M phenotype) and tetracycline - is widespread in S. pyogenes but has not been reported outside this species. Φm46.1 is transferable in vitro among S. pyogenes isolates, ...
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2015

Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci
Anno: 2015
Rivista: FRONTIERS IN MICROBIOLOGY
Autori/autrici: Mingoia, Marina; Morici, Eleonora; Brenciani, Andrea; Giovanetti, Eleonora; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/217513
Citazioni:
Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci / Mingoia, M., Morici, E., Brenciani, A., Giovanetti, E., Varaldo, P.. - In: FRONTIERS IN MICROBIOLOGY. - ISSN 1664-302X. - ELETTRONICO. - 5:747(2015). [10.3389/fmicb.2014.00747]
Abstract:
In streptococci mef(I) and catQ, two relatively uncommon macrolide and chloramphenicol resistance genes, respectively, are typically linked in a genetic module designated IQ module. Though variable, the module consistently encompasses, and is sometimes reduced to, a conserved ∼5.8-kb mef(I)-catQ...
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2014

ICESp1116, the genetic element responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, belongs to the TnGBS family of integrative and conjugative elements
Anno: 2014
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Tiberi, Erika; Morroni, Gianluca; Mingoia, Marina; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/157715
Citazioni:
ICESp1116, the genetic element responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, belongs to the TnGBS family of integrative and conjugative elements / Brenciani, A., Tiberi, E., Morroni, G., Mingoia, M., Varaldo, P., Giovanetti, E.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 58:4(2014), pp. 2479-2481. [10.1128/AAC.00048-14]

2014

Genetic determinants and elements associated with antibiotic resistance in viridans group streptococci
Anno: 2014
Rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Tiberi, Erika; Tili, E.; Mingoia, Marina; Palmieri, Claudio; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/160903
Citazioni:
Genetic determinants and elements associated with antibiotic resistance in viridans group streptococci / Brenciani, A., Tiberi, E., Tili, E., Mingoia, M., Palmieri, C., Varaldo, P., Giovanetti, E.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 1460-2091. - STAMPA. - 69:5(2014), pp. 1197-1204. [10.1093/jac/dkt495]

2013

Pitfalls encountered while investigating genetic elements by PCR
Anno: 2013
Rivista: MOBILE GENETIC ELEMENTS
Autori/autrici: Palmieri, Claudio; Brenciani, Andrea; Mingoia, Marina; Giovanetti, Eleonora; Facinelli, Bruna; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/112684
Citazioni:
Pitfalls encountered while investigating genetic elements by PCR / Palmieri, C., Brenciani, A., Mingoia, M., Giovanetti, E., Facinelli, B., Varaldo, P.. - In: MOBILE GENETIC ELEMENTS. - ISSN 2159-256X. - 1;3(3):(2013), pp. e25255-1-e25255-3. [10.4161/mge.25255]

2012

ICESp1116, the genetic element responsible for erm(B)-mediated, inducible resistance to erythromycin in Streptococcus pyogenes
Anno: 2012
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Tiberi, Erika; Morici, Eleonora; Oryasın, E.; Giovanetti, Eleonora; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/82900
Citazioni:
ICESp1116, the genetic element responsible for erm(B)-mediated, inducible resistance to erythromycin in Streptococcus pyogenes / Brenciani, A., Tiberi, E., Morici, E., Oryasın, E., Giovanetti, E., Varaldo, P.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 56:(2012), pp. 6425-6429. [10.1128/AAC.01494-12]
Abstract:
ICESp1116, responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, was comprehensively characterized, and its chromosomal integration site was determined. It displayed a unique mosaic organization consisting of a scaffold, related to TnGallo1 from Streptococcus ...
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2012

ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements.
Anno: 2012
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Giovanetti, Eleonora; Brenciani, Andrea; Tiberi, Erika; Bacciaglia, Alessandro; Varaldo, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/63685
Citazioni:
ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements / Giovanetti, E., Brenciani, A., Tiberi, E., Bacciaglia, A., Varaldo, P.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 56:(2012), pp. 591-594.

2011

Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis.
Anno: 2011
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Palmieri, Claudio; Princivalli, MARIA STELLA; Brenciani, Andrea; Varaldo, Pietro; Facinelli, Bruna
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/54516
Citazioni:
Different genetic elements carrying the tet(W) gene in two human clinical isolates of Streptococcus suis / Palmieri, C., Princivalli, M.S., Brenciani, A., Varaldo, P., Facinelli, B.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 55:(2011), pp. 631-636. [10.1128/AAC.00965-10]
Abstract:
The genetic support for tet(W), an emerging tetracycline resistance determinant, was studied in two strains of Streptococcus suis, SsCA and SsUD, both isolated in Italy from patients with meningitis. Two completely different tet(W)-carrying genetic elements, sharing only a tet(W)-containing segment ...
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2011

Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes
Anno: 2011
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Tiberi, Erika; Bacciaglia, Alessandro; Petrelli, D.; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/54820
Citazioni:
Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes / Brenciani, A., Tiberi, E., Bacciaglia, A., Petrelli, D., Varaldo, P., Giovanetti, E.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 55:(2011), pp. 2106-2112.

2010

Caratterizzazione di ΦSSUD.1, un nuovo elemento che veicola geni di resistenza ad antibiotici [tet(W), erm(B), aadE, sat4, aphA] ed a sali di metalli pesanti [cadc/cada] in Streptococcus suis
Anno: 2010
Autori/autrici: Palmieri, Claudio; Princivalli, MARIA STELLA; Brenciani, Andrea; Varaldo, Pietro; Facinelli, Bruna
Lingua: ITA
Classificazione IRIS: 5.12 Altro
Scheda completa IRIS: https://iris.univpm.it/handle/11566/55242
Citazioni:
Caratterizzazione di ΦSSUD.1, un nuovo elemento che veicola geni di resistenza ad antibiotici [tet(W), erm(B), aadE, sat4, aphA] ed a sali di metalli pesanti [cadc/cada] in Streptococcus suis / Palmieri, C., Princivalli, M.S., Brenciani, A., Varaldo, P., Facinelli, B.. - (2010).
Abstract:
38° Congresso Nazionale di Microbiologia SIM

2010

ICESp2905: un nuovo elemento composito che veicola i determinanti di resistenza erm(TR) e tet(O) in Streptococcus pyogenes.
Anno: 2010
Autori/autrici: Brenciani, Andrea; Tiberi, Erika; Bacciaglia, Alessandro; Vitali, L. A.; Ripa, S.; Varaldo, P. E.; Giovanetti, Eleonora
Lingua: ITA
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/82950
Citazioni:
ICESp2905: un nuovo elemento composito che veicola i determinanti di resistenza erm(TR) e tet(O) in Streptococcus pyogenes / Brenciani, A., Tiberi, E., Bacciaglia, A., Vitali, L.A., Ripa, S., Varaldo, P.E., Giovanetti, E.. - (2010).

2010

ΦSsUD.1, a new element carrying antibiotic [tet(W), erm(B), aadE, sat4, and aphA] and heavy metal [cadC/cadA] resistance genes detected in a human isolate of Streptococcus suis
Anno: 2010
Autori/autrici: Palmieri, Claudio; Princivalli, MARIA STELLA; Brenciani, Andrea; Varaldo, Pietro; Facinelli, Bruna
Lingua: ENG
Classificazione IRIS: 5.12 Altro
Scheda completa IRIS: https://iris.univpm.it/handle/11566/55244
Citazioni:
ΦSsUD.1, a new element carrying antibiotic [tet(W), erm(B), aadE, sat4, and aphA] and heavy metal [cadC/cadA] resistance genes detected in a human isolate of Streptococcus suis / Palmieri, C., Princivalli, M.S., Brenciani, A., Varaldo, P., Facinelli, B.. - (2010).
Abstract:
International Conference on Antimicrobial Research, Valladolid, Spagna

2010

Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes.
Anno: 2010
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Bacciaglia, Alessandro; Vignaroli, Carla; Pugnaloni, Armanda; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/51407
Citazioni:
Phim46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes / Brenciani, A., Bacciaglia, A., Vignaroli, C., Pugnaloni, A., Varaldo, P., Giovanetti, E.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 54:(2010), pp. 221-229.
Abstract:
Phi-m46.1, the recognized representative of the most common variant of mobile, prophage-associated genetic elements carrying resistance genes mef(A) (which confers efflux-mediated erythromycin resistance) and tet(O) (which confers tetracycline resistance) in Streptococcus pyogenes, was fully chara...
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2008

Caratterizzazione di фm46.1, un elemento genetico che veicola tet(O) e mef(A) in Streptococcus pyogenes.
Anno: 2008
Autori/autrici: Brenciani, Andrea; Bacciaglia, Alessandro; Varaldo, P. E.; Giovanetti, Eleonora
Lingua: ITA
Classificazione IRIS: 4.3 Poster
Scheda completa IRIS: https://iris.univpm.it/handle/11566/82951
Citazioni:
Caratterizzazione di фm46.1, un elemento genetico che veicola tet(O) e mef(A) in Streptococcus pyogenes / Brenciani, A., Bacciaglia, A., Varaldo, P.E., Giovanetti, E.. - (2008).

2007

Expressed and unexpressed tet(M) genes and the erm(B)-carrying Tn1116 transposon in Streptococcus pyogenes and Streptococcus pneumoniae.
Anno: 2007
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Giovanetti, Eleonora; Brenciani, Andrea; Bacciaglia, A.; Montanari, MARIA PIA; Varaldo, Pietro
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/50112
Citazioni:
Expressed and unexpressed tet(M) genes and the erm(B)-carrying Tn1116 transposon in Streptococcus pyogenes and Streptococcus pneumoniae / Giovanetti, E., Brenciani, A., Bacciaglia, A., Montanari, M.P., Varaldo, P.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 51:(2007), pp. 4535-4536.

2007

Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene.
Anno: 2007
Rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Autori/autrici: Brenciani, Andrea; Bacciaglia, Alessandro; Vecchi, M.; Vitali, L. A.; Varaldo, Pietro; Giovanetti, Eleonora
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/52601
Citazioni:
Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene / Brenciani, A., Bacciaglia, A., Vecchi, M., Vitali, L.A., Varaldo, P., Giovanetti, E.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 51:(2007), pp. 1209-1216. [10.1128/AAC.01484-06]
Abstract:
This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance... in constitutively resistant isolates (cMLS phenotype) and in a subset (iMLS-A) of inducibly resistant isolates. A total of 125 erm(B)-positive strains were investigated, 81 iMLS-A (uniformly tetracycline susceptible) and 44 cMLS (29 tetracycline resistant and 15 tetracycline susceptible). Whereas all tetracycline-resistant isolates carried the tet(M) gene, tet(M) sequences were also detected in most tetracycline-susceptible isolates (81/81 iMLS-A and 7/15 cMLS). In 2 of the 8 tet(M)-negative cMLS isolates, erm(B) was carried by a plasmid-located Tn917-like transposon. erm(B)- and tet(M)-positive isolates were tested by PCR for the presence of genes int (integrase), xis (excisase), and tndX (resolvase), associated with conjugative transposons of the Tn916 family. In mating experiments using representatives of different combinations of phenotypic and genotypic characteristics as donors, erm(B) and tet(M) were consistently cotransferred, suggesting their linkage in individual genetic elements. The linkage was confirmed by pulsed-field gel electrophoresis and hybridization studies, and different elements, variably associated with the different phenotypes/genotypes, were detected and characterized by amplification and sequencing experiments. A previously unreported genetic organization, observed in all iMLS-A and some cMLS isolates, featured an erm(B)-containing DNA insertion into the tet(M) gene of a defective Tn5397, a Tn916-related transposon. This new element was designated Tn1116. Genetic elements not previously described in S. pyogenes also included Tn6002, an unpublished transposon whose complete sequence is available in GenBank, and Tn3872, a composite element resulting from the insertion of the Tn917 transposon into Tn916 [associated with a tet(M) gene expressed in some cMLS isolates and silent in others]. The high frequency of association between a tetracycline-susceptible phenotype and tet(M) genes suggests that transposons of the Tn916 family, so far typically associated solely with a tetracycline-resistant phenotype, may be more widespread in S. pyogenes than currently believed.
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ANDREA BRENCIANI

Pubblicazioni

ANDREA BRENCIANI

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Andrea BRENCIANI

AREA MIN. 06 - Scienze mediche
Dipartimento Scienze Biomediche e Sanita' Pubblica
Facolta' di MEDICINA e CHIRURGIA

111 pubblicazioni

ANDREA BRENCIANI

Pubblicazioni

ANDREA BRENCIANI

Pubblicazioni

Andrea BRENCIANI

AREA MIN. 06 - Scienze mediche Dipartimento Scienze Biomediche e Sanita' Pubblica Facolta' di MEDICINA e CHIRURGIA

111 pubblicazioni

AREA MIN. 06 - Scienze mediche
Dipartimento Scienze Biomediche e Sanita' Pubblica
Facolta' di MEDICINA e CHIRURGIA