Persistence burden and poor survival of pleural mesothelioma in central Italy, 2013–2022: a population-based study thirty years after asbestos ban
Anno: 2026
Rivista: BMC PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Bonifazi, Martina; Sarti, Donatella; Mei, Federico; Franchi, Matteo; Rossi, Marta; Pompili, Marco; Prospero, Emilia; Carle, Flavia; Gesuita, Rosaria; Skrami, Edlira
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357352
Citazioni:
Persistence burden and poor survival of pleural mesothelioma in central Italy, 2013–2022: a population-based study thirty years after asbestos ban / Iommi, M., Bonifazi, M., Sarti, D., Mei, F., Franchi, M., Rossi, M., Pompili, M., Prospero, E., Carle, F., Gesuita, R., Skrami, E.. - In: BMC PUBLIC HEALTH. - ISSN 1471-2458. - 26:(2026). [10.1186/s12889-026-26903-6]
Abstract:
Background: Pleural Mesothelioma (PM) is an asbestos-related cancer with poor prognosis. Despite the 1992 national asbestos ban, new cases continue to occur due to the long latency of the disease. The study aim was to evaluate incidence and survival trends of pleural mesothelioma in the Marche Regio...n, central Italy, between 2013 and 2022. Methods: This population-based incidence study included adult residents of the Marche Region between 2013 and 2022. Incident PM cases were identified from the Cancer Registry of Marche Region. Incidence rates per 100,000 person-years (py) were calculated and stratified by sex, age, and province of residence. Temporal trend and covariates effect were assessed with Poisson regression. Overall survival was estimated using the Kaplan-Meier method and compared across subgroups; adjusted hazard ratios (HR) were obtained from multiple Cox regression model. Results: Between 2013 and 2022, there were 322 incident PM cases (82% male; median age 77 years). The crude incidence rate was 2.1 per 100,000 py (95% CI: 1.9–2.4), with no temporal change over the study period. The highest rates were observed in men, in age-group 75–79 years, and in the province of Ancona. One- and five-year survival rates were 48.8% and 8.3%, respectively. Older age and non-epithelioid histology were independently associated with higher mortality. Conclusions: The incidence of pleural mesothelioma in the Marche Region remained stable between 2013 and 2022, with a peak in 2018 requiring further observation to confirm it. The persistently high burden among men, older adults, and those living in industrialized coastal areas reflects the legacy of historical asbestos exposure. Continued population-based surveillance, integrated with follow-up of previously exposed workers, remains essential to monitor disease trends and support timely diagnosis and appropriate care pathways.
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Efficacy of Dupilumab in Asthma: Focus on Early, Progressive, and Long-Lasting Effects on Small Airways
Anno: 2025
Rivista: ALLERGY
Autori/autrici: Martini, Matteo; Antonicelli, Leonardo; Garritani, Maria Stella; Braschi, Maria Chiara; Di Vincenzo, Angelica; Torresi, Giada; Gallifuoco, Marco; Claudi, Ilaria; Danieli, Maria Giovanna; Mei, Federico; Moroncini, Gianluca; Piga, Mario Andrea; Bilò, Maria Beatrice
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348783
Citazioni:
Efficacy of Dupilumab in Asthma: Focus on Early, Progressive, and Long-Lasting Effects on Small Airways / Martini, M., Antonicelli, L., Garritani, M.S., Braschi, M.C., Di Vincenzo, A., Torresi, G., Gallifuoco, M., Claudi, I., Danieli, M.G., Mei, F., Moroncini, G., Piga, M.A., Bilò, M.B.. - In: ALLERGY. - ISSN 0105-4538. - (2025). [10.1111/all.70097]

Pleural fluid biomarkers to predict response to pleurodesis or indwelling pleural catheter for malignant pleural effusion: still a long way to go
Anno: 2025
Rivista: RESPIRATORY RESEARCH
Autori/autrici: Fjaellegaard, Katrine; Ahmadzai, Sina; Porcel, José M; Mei, Federico; Shaw, Jane A; Bodtger, Uffe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348786
Citazioni:
Pleural fluid biomarkers to predict response to pleurodesis or indwelling pleural catheter for malignant pleural effusion: still a long way to go / Fjaellegaard, K., Ahmadzai, S., Porcel, J.M., Mei, F., Shaw, J.A., Bodtger, U.. - In: RESPIRATORY RESEARCH. - ISSN 1465-993X. - 26:1(2025). [10.1186/s12931-025-03288-5]
Abstract:
This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where th...e biomarkers prognostic value was not tested in separate validation cohorts. Although low pleural fluid LDH, high glucose, and high pH levels are associated with pleurodesis success, no clinically valuable biomarker has been identified. Hence, further research on the inflammatory processes of malignant pleural effusion and during definitive pleural procedures is needed, as well as proper testing of potential biomarkers in separate model derivation and validation cohorts.
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Use of Patient-Derived Organoids for Pleural Mesothelioma 3D modelling
Anno: 2025
Rivista: AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Autori/autrici: Volpini, Luca; Monaco, Federica; Casalone, Elisabetta; Herman, Elton Jalis; Filomena, Rebecca; Manzotti, Sandra; Strogovets, Olga; Moroncini, Gianluca; Mozzicafreddo, Matteo; Poloni, Antonella; Marinelli Busilacchi, Elena; Gonnelli, Francesca; Barbisan, Francesca; Goteri, Gaia; Zuccatosta, Lina; Bonifazi, Martina; Matullo, Giuseppe; Neuzil, Jiri; Santarelli, Lory; Rahman, Najib M; Blyth, Kevin; Tomasetti, Marco; Mei, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/349566
Citazioni:
Use of Patient-Derived Organoids for Pleural Mesothelioma 3D modelling / Volpini, L., Monaco, F., Casalone, E., Herman, E.J., Filomena, R., Manzotti, S., Strogovets, O., Moroncini, G., Mozzicafreddo, M., Poloni, A., Marinelli Busilacchi, E., Gonnelli, F., Barbisan, F., Goteri, G., Zuccatosta, L., Bonifazi, M., Matullo, G., Neuzil, J., Santarelli, L., Rahman, N.M., et al.. - In: AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. - ISSN 1040-0605. - 329:6(2025), pp. 756-769. [10.1152/ajplung.00078.2025]
Abstract:
Defining pre-clinical models is of utmost importance for pleural mesothelioma (PM) to improve prognosis and predict therapeutic response. Using cells isolated from pleural fluid (PF) and diagnostic pleural biopsy (PB), we generated PM patient-derived organoids (PM-PDOs) and reactive-mesothelial (RM)...-patient derived organoids (RM-PDO) aiming at assessing the proportion of successful cultures both from PF and PB. We also compared the architectural and immune-histochemical features of PM-PDOs to those of parental tissues and evaluated the PM-PDOs response to chemo-immunotherapy. We obtained 11 successful PM-PDOs from 15 PF/PB (73.3%). The rate of success was higher in epithelioid PM (88.8%) compared to biphasic PM (40.0%) (p=0.175), and when using PF (60.0%) compared to PB (20.0%) (p=0.001). We also obtained 3 RM effective cultures from 6 asbestos-exposed patients (50%) with non-specific pleuritis. Transcriptome analysis identified gene expression profile in PM-PDOs, which differentiate from RM-PDOs. PM-PDOs successfully maintained the histological architecture and molecular markers of their parental tumour tissues. The macrophagic component (CD68+ and CD163+) was an important component in RM-PDOs and was present in all three PM histotypes. Epithelioid PM-PDOs showed resistance to both Cis/PeMtx and pembrolizumab plus peripheral blood mononuclear cells (PBMCs), while both biphasic and sarcomatoid subtypes were sensitive to immunotherapy. Notably, immunotherapy induced an upregulation of PD-L1 expression and activated the STAT3/NF-κB signaling pathway, suggesting a mechanism of immune evasion. PF offers a valuable source of cancer and stromal cells to generate PDO, reinforcing its clinical utility for patients who cannot undergo invasive procedures.
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Understanding Patterns of Adherence to Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis: Insights from an Italian Prospective Cohort Study
Anno: 2024
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Iommi, Marica; Gonnelli, Francesca; Bonifazi, Martina; Faragalli, Andrea; Mei, Federico; Pompili, Marco; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348459
Citazioni:
Understanding Patterns of Adherence to Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis: Insights from an Italian Prospective Cohort Study / Iommi, M., Gonnelli, F., Bonifazi, M., Faragalli, A., Mei, F., Pompili, M., Carle, F., Gesuita, R.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 13:9(2024). [10.3390/jcm13092727]
Abstract:
Background: Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its association with clinical outcomes (i.e., acute exa...cerbation or death) during 2014–2021 in newly diagnosed IPF patients, using Healthcare Utilization Databases of the Marche Region, Italy. Methods: The first 12-month adherence to antifibrotic was estimated using the Proportion of Days Covered (PDC), defining adherence as PDC ≥ 75%. State Sequence Analysis over the initial 52 weeks of treatment was used to identify adherence patterns. The role of adherence patterns on acute exacerbations/death, adjusted by demographic, clinical features, and monthly adherence after the 52-week period (time-dependent variable), was assessed with Cox regression. Results: Among 667 new IPF cases, 296 received antifibrotic prescriptions, with 62.8% being adherent in the first year. Three antifibrotic utilization patterns emerged—high adherence (37.2%), medium adherence (42.5%), and low adherence (20.3%)—with median PDCs of 95.3%, 79.5%, and 18.6%, respectively. These patterns did not directly influence three-year mortality/exacerbation probability, but sustained adherence reduced risk over time. Conclusions: Good adherence was observed in in this population-based study, emphasizing the importance of continuous antifibrotics therapy over time to mitigate adverse outcomes.
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Malignant pleural effusion: current understanding and therapeutic approach
Anno: 2024
Rivista: RESPIRATORY RESEARCH
Autori/autrici: Gonnelli, Francesca; Hassan, Wafa; Bonifazi, Martina; Pinelli, Valentina; Bedawi, Eihab O; Porcel, José M; Rahman, Najib M; Mei, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/329912
Citazioni:
Malignant pleural effusion: current understanding and therapeutic approach / Gonnelli, F., Hassan, W., Bonifazi, M., Pinelli, V., Bedawi, E.O., Porcel, J.M., Rahman, N.M., Mei, F.. - In: RESPIRATORY RESEARCH. - ISSN 1465-993X. - 25:1(2024). [10.1186/s12931-024-02684-7]
Abstract:
Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality and elevated costs to healthcare systems. Over the last decades the understanding of pathophysiology mechanisms, diagnostic techniques and optimal treatment inte...rvention in MPE have been greatly advanced by recent high-quality research, leading to an ever less invasive diagnostic approach and more personalized management. Despite a number of management options, including talc pleurodesis, indwelling pleural catheters and combinations of the two, treatment for MPE remains symptom directed and centered around drainage strategy. In the next future, because of a better understanding of underlying tumor biology together with more sensitive molecular diagnostic techniques, it is likely that combined diagnostic and therapeutic procedures allowing near total outpatient management of MPE will become popular. This article provides a review of the current advances, new discoveries and future directions in the pathophysiology, diagnosis and management of MPE.
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Chest Tubes and Pleural Drainage: History and Current Status in Pleural Disease Management
Anno: 2024
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Sorino, Claudio; Feller-Kopman, David; Mei, Federico; Mondoni, Michele; Agati, Sergio; Marchetti, Giampietro; Rahman, Najib M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348785
Citazioni:
Chest Tubes and Pleural Drainage: History and Current Status in Pleural Disease Management / Sorino, C., Feller-Kopman, D., Mei, F., Mondoni, M., Agati, S., Marchetti, G., Rahman, N.M.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 13:21(2024). [10.3390/jcm13216331]
Abstract:
Thoracostomy and chest tube placement are key procedures in treating pleural diseases involving the accumulation of fluids (e.g., malignant effusions, serous fluid, pus, or blood) or air (pneumothorax) in the pleural cavity. Initially described by Hippocrates and refined through the centuries, chest... drainage achieved a historical milestone in the 19th century with the creation of closed drainage systems to prevent the entry of air into the pleural space and reduce infection risk. The introduction of plastic materials and the Heimlich valve further revolutionized chest tube design and function. Technological advancements led to the availability of various chest tube designs (straight, angled, and pig-tail) and drainage systems, including PVC and silicone tubes with radiopaque stripes for better radiological visualization. Modern chest drainage units can incorporate smart digital systems that monitor and graphically report pleural pressure and evacuated fluid/air, improving patient outcomes. Suction application via wall systems or portable digital devices enhances drainage efficacy, although careful regulation is needed to avoid complications such as re-expansion pulmonary edema or prolonged air leak. To prevent recurrent effusion, particularly due to malignancy, pleurodesis agents can be applied through the chest tube. In cases of non-expandable lung, maintaining a long-term chest drain may be the most appropriate approach and procedures such as the placement of an indwelling pleural catheter can significantly improve quality of life. Continued innovations and rigorous training ensure that chest tube insertion remains a cornerstone of effective pleural disease management. This review provides a comprehensive overview of the historical evolution and modern advancements in pleural drainage. By addressing both current technologies and procedural outcomes, it serves as a valuable resource for healthcare professionals aiming to optimize pleural disease management and patient care.
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Beyond diagnosis: a narrative review of the evolving therapeutic role of medical thoracoscopy in the management of pleural diseases
Anno: 2024
Rivista: JOURNAL OF THORACIC DISEASE
Autori/autrici: Fantin, Alberto; Castaldo, Nadia; Palou, Michelangelo Schwartzbaum; Viterale, Giovanni; Crisafulli, Ernesto; Sartori, Giulia; Patrucco, Filippo; Vailati, Paolo; Morana, Giuseppe; Mei, Federico; Zuccatosta, Lina; Patruno, Vincenzo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348784
Citazioni:
Beyond diagnosis: a narrative review of the evolving therapeutic role of medical thoracoscopy in the management of pleural diseases / Fantin, A., Castaldo, N., Palou, M.S., Viterale, G., Crisafulli, E., Sartori, G., Patrucco, F., Vailati, P., Morana, G., Mei, F., Zuccatosta, L., Patruno, V.. - In: JOURNAL OF THORACIC DISEASE. - ISSN 2072-1439. - 16:3(2024), pp. 2177-2195. [10.21037/jtd-23-1745]
Abstract:
Background and Objective: Medical thoracoscopy (MT) is an endoscopic technique performed by interventional pulmonologists with a favorable safety profile and few contraindications, providing diagnostic and therapeutic intervention in a single sitting. This narrative review was designed to summarize ...the therapeutic role of MT based on the latest results from the available literature. Methods: Pertinent literature published in English, relative to human studies, between 2010–2022 was searched in Medline/PubMed and Cochrane databases. Publications regarded as relevant were considered for inclusion in this review; additional references were added based on the authors’ knowledge and judgment. The review considered population studies, meta-analyses, case series, and case reports. Key Content and Findings: MT has mostly been described and is currently used globally in the diagnostic approach to exudative pleural effusion of undetermined origin. Carefully evaluating the literature, it is clear that there is initial evidence to support the use of MT in the therapeutic approach of malignant pleural effusion, pneumothorax, empyema, and less frequently hemothorax and foreign body retrieval. Conclusions: MT is an effective procedure for treating the clinical entities presented in this document; it must be carried out in selected patients, managed in centers with high procedural expertise. Further evidence is needed to assess the optimal indications and appropriate patients’ profiles for therapeutic MT. The endpoints of length of hospital stay, surgical referral, complications and mortality will have to be considered in future studies to validate it as a therapeutic intervention to be applied globally.
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ERS statement on benign pleural effusions in adults
Anno: 2024
Rivista: EUROPEAN RESPIRATORY JOURNAL
Autori/autrici: Sundaralingam, Anand; Grabczak, Elzbieta M; Burra, Patrizia; Costa, M Inês; George, Vineeth; Harriss, Eli; Jankowska, Ewa A; Janssen, Julius P; Karpathiou, Georgia; Laursen, Christian B; Maceviciute, Kornelija; Maskell, Nick; Mei, Federico; Nagavci, Blin; Panou, Vasiliki; Pinelli, Valentina; Porcel, José M; Ricciardi, Sara; Shojaee, Samira; Welch, Hugh; Zanetto, Alberto; Udayaraj, Udaya Prabhakar; Cardillo, Giuseppe; Rahman, Najib M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/348782
Citazioni:
ERS statement on benign pleural effusions in adults / Sundaralingam, A., Grabczak, E.M., Burra, P., Costa, M.I., George, V., Harriss, E., Jankowska, E.A., Janssen, J.P., Karpathiou, G., Laursen, C.B., Maceviciute, K., Maskell, N., Mei, F., Nagavci, B., Panou, V., Pinelli, V., Porcel, J.M., Ricciardi, S., Shojaee, S., Welch, H., et al.. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 1399-3003. - 64:6(2024). [10.1183/13993003.02307-2023]
Abstract:
The incidence of non-malignant pleural effusions far outweighs that of malignant pleural effusions and is estimated to be at least 3-fold higher. These so-called benign effusions do not follow a “benign course” in many cases, with mortality rates matching and sometimes exceeding those of... malignant pleural effusions. In addition to the impact on patients, healthcare systems are also significantly affected, with recent US epidemiological data demonstrating that 75% of resource allocation for pleural effusion management is spent on non-malignant pleural effusions (excluding empyema). Despite this significant burden of disease, and by existing at the junction of multiple medical specialties, reflecting a heterogenous constellation of medical conditions, non-malignant pleural effusions are rarely the focus of research or the subject of management guidelines. With this European Respiratory Society Task Force, we assembled a multispecialty collaborative across 11 countries and three continents to provide a statement based on systematic searches of the medical literature to highlight evidence in the management of the following clinical areas: a diagnostic approach to transudative effusions, heart failure, hepatic hydrothorax, end-stage renal failure, benign asbestos-related pleural effusion, post-surgical effusion and nonspecific pleuritis.
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Diagnostic role of internal mammary lymph node involvement in tuberculous pleurisy: a multicenter study
Anno: 2024
Rivista: PULMONOLOGY
Autori/autrici: Levi, G.; Rocchetti, C.; Mei, F.; Stella, G. M.; Lettieri, S.; Lococo, F.; Taccari, F.; Seguiti, C.; Fantoni, M.; Natali, F.; Candoli, P.; Bortolotto, C.; Pinelli, V.; Mondoni, M.; Carlucci, P.; Fabbri, A.; Trezzi, M; Vannucchi, L.; Bonifazi, M.; Porcarelli, F.; Gasparini, S.; Sica, G.; Valente, T.; Biondini, D.; Damin, M.; Liani, V.; Tamburrini, M.; Sorino, C.; Mezzasalma, F.; Scaramozzino, M. U.; Pini, L.; Bezzi, M.; Marchetti, G. P.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/301743
Citazioni:
Diagnostic role of internal mammary lymph node involvement in tuberculous pleurisy: a multicenter study / Levi, G., Rocchetti, C., Mei, F., Stella, G.M., Lettieri, S., Lococo, F., Taccari, F., Seguiti, C., Fantoni, M., Natali, F., Candoli, P., Bortolotto, C., Pinelli, V., Mondoni, M., Carlucci, P., Fabbri, A., Trezzi, M., Vannucchi, L., Bonifazi, M., Porcarelli, F., et al.. - In: PULMONOLOGY. - ISSN 2531-0429. - 30:4(2024), pp. 330-336. [10.1016/j.pulmoe.2022.01.010]
Abstract:
Background and objectives: Diagnosis of tuberculous pleurisy (TP) may be challenging and it often requires pleural biopsy. A tool able to increase pre-test probability of TP may be helpful to guide diagnostic work-up and enlargement of internal mammary lymph node (IMLN) has been suggested to play a ...potential role. The aim of the present investigation was to assess role of IMLN involvement in TP in a multi-centric case-control study, by comparing its prevalence and test performance to those observed in patients with infectious, non-tuberculous pleurisy (NTIP), and in controls free from respiratory diseases (CP). Methods: A total of 419 patients, from 14 Pulmonology Units across Italy were enrolled (127 patients affected by TP, 163 affected by NTIP and 129 CP). Prevalence, accuracy and predictive values of ipsilateral IMLN involvement between cases and control groups were assessed, as well as concordance between chest computed tomography (CT scan) and thoracic ultrasound (TUS) measurements. Results: The prevalence of ipsilateral IMLN involvement in TP was significantly higher than that observed in NTIP and CP groups (respectively 77.2%, 39.3% and 14.7%). Results on test performance, stratified by age, revealed a high positive predictive value in patients aged ≤50 years, while a high negative predictive value in patients aged >50 years. The comparison between CT scan and ultrasound showed moderate agreement (Kappa=0.502). Conclusions: Evaluation of IMLN involvement plays a relevant role in assessing the pre-test probability of TP. Considering the increasing global prevalence of mycobacterial infections, a tool able to guide diagnostic work-up of suspected TP is crucial, especially where local sources are limited.
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Long-term effects of air pollutants on respiratory and cardiovascular mortality in a port city along the Adriatic sea
Anno: 2023
Rivista: BMC PULMONARY MEDICINE
Autori/autrici: Mei, Federico; Renzi, Matteo; Bonifazi, Martina; Bonifazi, Floriano; Pepe, Nicola; D'Allura, Alessio; Brusasca, Giuseppe; Viegi, Giovanni; Forastiere, Francesco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/324631
Citazioni:
Long-term effects of air pollutants on respiratory and cardiovascular mortality in a port city along the Adriatic sea / Mei, F., Renzi, M., Bonifazi, M., Bonifazi, F., Pepe, N., D'Allura, A., Brusasca, G., Viegi, G., Forastiere, F.. - In: BMC PULMONARY MEDICINE. - ISSN 1471-2466. - 23:(2023). [10.1186/s12890-023-02629-8]
Abstract:
Background: Shipping and port-related air pollution has a significant health impact on a global scale. The present study aimed to assess the mortality burden attributable to long-term exposure to ambient particulate matter (PM2.5, PM10) and nitrogen dioxide (NO2) in the city of Ancona (Italy), with ...one of the leading national commercial harbours. Methods Exposure to air pollutants was derived by dispersion models. The relationship between the long-term exposure of air pollution exposure and cause-specific mortality was evaluated by Poisson regression models, after adjustment for gender, age and socioeconomic status. Results are expressed as percent change of risk (and relative 95% confidence intervals) per 5 unit increases in the exposures. The health impact on the annual number of premature cause-specific deaths was also assessed. Results PM2.5 and NO2 annual concentrations were higher in the area close to the harbour than in the rest of the city. Positive associations between each pollutant and most of the mortality outcomes were observed, with estimates of up to 7.6% (95%CI 0.1, 15.6%) for 10 mu g/m(3) increase in NO2 and cardiovascular mortality and 15.3% (95%CI-1.1, 37.2%) for 10 mu g/m3 increase PM2.5 and lung cancer. In the subpopulation living close to the harbour, there were excess risks of up to 13.5%, 24.1% and 37.9% for natural, cardiovascular and respiratory mortality. The number of annual premature deaths due to the excess of PM2.5 and NO2 exposure (having as a reference the 2021 World Health Organization Air Quality Guidelines) was 82 and 25, respectively. Conclusions Our study confirms the long-term health effects of PM and NO2 on mortality and reveals a higher mortality burden in areas close to shipping and port-related emissions. Estimating the source-specific health burdens is key to achieve a deeper understanding of the role of different emission sources, as well as to support effective and targeted mitigation strategies.
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Efficacy of Small versus Large-Bore Chest Drain in Pleural Infection: A Systematic Review and Meta-Analysis
Anno: 2023
Rivista: RESPIRATION
Autori/autrici: Mei, Federico; Rota, Matteo; Bonifazi, Martina; Zuccatosta, Lina; Porcarelli, Francesco M.; Sediari, Michele; Bedawi, Eihab O.; Sundaralingam, Anand; Addala, Dinesh; Gasparini, Stefano; Rahman, Najib M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315029
Citazioni:
Efficacy of Small versus Large-Bore Chest Drain in Pleural Infection: A Systematic Review and Meta-Analysis / Mei, F., Rota, M., Bonifazi, M., Zuccatosta, L., Porcarelli, F.M., Sediari, M., Bedawi, E.O., Sundaralingam, A., Addala, D., Gasparini, S., Rahman, N.M.. - In: RESPIRATION. - ISSN 0025-7931. - 102:3(2023), pp. 247-256. [10.1159/000529027]
Abstract:
Background: Pleural infection represents a significant clinical challenge worldwide. Although prompt drainage of pleural fluid is thought to play a key role in pleural infection management, the optimal size of intrapleural catheter has yet to be defined. Objectives: The aim of this systematic review... and meta-analysis was to summarize data on efficacy and complications of small-bore drain (SBD), defined as <= 14F, in comparison to large-bore drain (LBD) in patients with pleural infection. Method: We searched MEDLINE and Embase for all studies reporting outcomes of interest published up to October 2021. Two authors reviewed selected full text to identify studies according to predefined eligibility criteria. Summary estimates were derived using the random-effects model. Results: Twelve original studies were included for qualitative analysis and 7 of these for quantitative analysis. The surgical referral rate of SBD and LBD were, respectively, 0.16 (95% confidence interval [CI], 0.12-0.21) and 0.20 (95% CI, 0.10-0.32), the pooled mortality were 0.12 (95% CI, 0.05-0.21) and 0.20 (95% CI, 0.10-0.32), and the length of hospital stay was 24 days in both groups. Data on complications suggest similar proportions of tube dislodgement. Intensity of pain was evaluated in one study only, reporting higher scores for LBD. Conclusions: This systematic review and meta-analysis provide the first synthesis of data on performance of SBD and LBD in management of pleural infection, and, overall, clinical outcomes and complications did not substantially differ, although the limited number of studies and the absence of dedicated randomized trials does limit the reliability of results.(c) 2023 S.
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Clinical characteristics of chylothorax: results from the International Collaborative Effusion database
Anno: 2023
Rivista: ERJ OPEN RESEARCH
Autori/autrici: Porcel, José M.; Bielsa, Silvia; Civit, Carmen; Aujayeb, Avinash; Janssen, Julius; Bodtger, Uffe; Fjaellegaard, Katrine; Petersen, Jesper Koefod; Welch, Hugh; Symonds, Jenny; Mitchell, Michael A.; Grabczak, Elżbieta Magdalena; Ellayeh, Mohamed; Addala, Dinesh; Wrightson, John M.; Rahman, Najib M.; Munavvar, Mohammed; Koegelenberg, Coenraad F. N.; Labarca, Gonzalo; Mei, Federico; Maskell, Nick; Bhatnagar, Rahul
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/329245
Citazioni:
Clinical characteristics of chylothorax: results from the International Collaborative Effusion database / Porcel, J.M., Bielsa, S., Civit, C., Aujayeb, A., Janssen, J., Bodtger, U., Fjaellegaard, K., Petersen, J.K., Welch, H., Symonds, J., Mitchell, M.A., Grabczak, E.M., Ellayeh, M., Addala, D., Wrightson, J.M., Rahman, N.M., Munavvar, M., Koegelenberg, C.F.N., Labarca, G., Mei, F., et al.. - In: ERJ OPEN RESEARCH. - ISSN 2312-0541. - 9:5(2023). [10.1183/23120541.00091-2023]
Abstract:
Background Chylothorax is an uncommon medical condition for which limited data are available regarding the contemporary aetiology, management and outcomes. The goal of this study was to better define these poorly characterised features.Methods The medical records of adult patients diagnosed with chy...lothorax at 12 centres across Europe, America and South Africa from 2009-2021 were retrospectively reviewed. Descriptive and inferential statistics were performed.Results 77 patients (median age 69 years, male to female ratio 1.5) were included. Subacute dyspnoea was the most typical presenting symptom (66%). The commonest cause of chylothorax was malignancy (68.8%), with lymphoma accounting for 62% of these cases. Other aetiologies were trauma (13%), inflammatory/miscellaneous conditions (11.7%) and idiopathic cases (6.5%). At the initial thoracentesis, the pleural fluid appeared milky in 73%, was exudative in 89% and exhibited triglyceride concentrations >100 mg.dL(-1) in 88%. Lymphangiography/lymphoscintigraphy were rarely ordered (3%), and demonstration of chylomicrons in pleural fluid was never ascertained. 67% of patients required interventional pleural procedures. Dietary measures were infrequently followed (36%). No patient underwent thoracic duct ligation or embolisation. Morbidity included infections (18%), and thrombosis in malignant aetiologies (16%). The 1-year mortality was 47%. Pleural fluid protein >3.5 mg.dL(-1) (subdistribution hazard ratio (SHR) 4.346) or lactate dehydrogenase <500 U.L-1 (SHR 10.21) increased the likelihood of effusion resolution. Pleural fluid protein >= 3.5 mg.dL(-1) (HR 4.047), bilateral effusions (HR 2.749) and a history of respiratory disease (HR 2.428) negatively influenced survival.Conclusion Chylothoraces have a poor prognosis and most require pleural interventions. Despite the standard recommendations, lymphatic imaging is seldom used, nor are dietary restrictions followed.
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Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer
Anno: 2023
Rivista: ADVANCES IN RESPIRATORY MEDICINE
Autori/autrici: Zuccatosta, Lina; Mei, Federico; Sediari, Michele; Di Marco Berardino, Alessandro; Bonifazi, Martina; Barbisan, Francesca; Goteri, Gaia; Gasparini, Stefano; Gonnelli, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/312792
Citazioni:
Diagnostic Accuracy of Slow-Capillary Endobronchial Ultrasound Needle Aspiration in Determining PD-L1 Expression in Non-Small Cell Lung Cancer / Zuccatosta, L., Mei, F., Sediari, M., Di Marco Berardino, A., Bonifazi, M., Barbisan, F., Goteri, G., Gasparini, S., Gonnelli, F.. - In: ADVANCES IN RESPIRATORY MEDICINE. - ISSN 2451-4934. - 91:1(2023), pp. 1-8. [10.3390/arm91010001]
Abstract:
Introduction: The role of EBUS-TBNA in the diagnosis and staging of lung cancer is well established. EBUS-TBNA can be performed using different aspiration techniques. The most common aspiration technique is known as "suction". One alternative to the suction technique is the slow-pull capil...lary aspiration. To the best of our knowledge, no studies have assessed the diagnostic yield of slow-pull capillary EBUS-TBNA in PD-L1 amplification assessment in NSCLC. Herein, we conducted a single-centre retrospective study to establish the diagnostic yield of slow-pull capillary EBUS-TBNA in terms of PD-L1 in patients with NSCLC and hilar/mediastinal lymphadenopathies subsequent to NSCLC. Materials and Methods: Patients with hilar and/or mediastinal lymph node (LN) NSCLC metastasis, diagnosed by EBUS-TBNA between January 2021 and April 2022 at Pulmonology Unit of "Ospedali Riuniti di Ancona" (Ancona, Italy) were enrolled. We evaluated patient characteristics, including demographic information, CT scan/ FDG-PET features and final histological diagnoses, including PD-L1 assessment. Results: A total of 174 patients underwent EBUS-TBNA for diagnosis of hilar/mediastinal lymphadenopathies between January 2021 and April 2022 in the Interventional Pulmonology Unit of the "Ospedali Riuniti di Ancona". Slow-pull capillary aspiration was adopted in 60 patients (34.5%), and in 30/60 patients (50.0%) NSCLC was diagnosed. EBUS-TBNA with slow-pull capillary aspiration provided adequate sampling for molecular biology and PD-L1 testing in 96.7% of patients (29/30); in 15/29 (51.7%) samples with more than 1000 viable cells/HPF were identified, whereas in 14/29 (48.3%) samples contained 101-1000 viable cells/HPF. Conclusion: These retrospective study shows that slow-pull capillary aspiration carries an excellent diagnostic accuracy, almost equal to that one reported in literature, supporting its use in EBUS-TBNA for PD-L1 testing in NSCLC.
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Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database
Anno: 2023
Rivista: ERJ OPEN RESEARCH
Autori/autrici: Sundaralingam, Anand; Aujayeb, Avinash; Jackson, Karl A; Pellas, Emilia I; Khan, Irfan I; Chohan, Muhammad T; Joosten, Roos; Boersma, Anton; Kerkhoff, Jordy; Bielsa, Silvia; Porcel, Jose M; Rozman, Ales; Marc-Malovrh, Mateja; Welch, Hugh; Symonds, Jenny; Anevlavis, Stavros; Froudrakis, Marios; Mei, Federico; Zuccatosta, Lina; Gasparini, Stefano; Gonnelli, Francesca; Dhaliwal, Inderdeep; Mitchell, Michael A; Fjaellegaard, Katrine; Petersen, Jesper K; Ellayeh, Mohamed; Rahman, Najib M; Burden, Tom; Bodtger, Uffe; Koegelenberg, Coenraad F N; Maskell, Nick A; Janssen, Julius; Bhatnagar, Rahul
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/329913
Citazioni:
Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database / Sundaralingam, A., Aujayeb, A., Jackson, K.A., Pellas, E.I., Khan, I.I., Chohan, M.T., Joosten, R., Boersma, A., Kerkhoff, J., Bielsa, S., Porcel, J.M., Rozman, A., Marc-Malovrh, M., Welch, H., Symonds, J., Anevlavis, S., Froudrakis, M., Mei, F., Zuccatosta, L., Gasparini, S., et al.. - In: ERJ OPEN RESEARCH. - ISSN 2312-0541. - 9:2(2023). [10.1183/23120541.00599-2022]
Abstract:
Introduction We present findings from the International Collaborative Effusion database, a European Respiratory Society clinical research collaboration. Nonspecific pleuritis (NSP) is a broad term that describes chronic pleural inflammation. Various aetiologies lead to NSP, which poses a diagnostic ...challenge for clinicians. A significant proportion of patients with this finding eventually develop a malignant diagnosis. Methods 12 sites across nine countries contributed anonymised data on 187 patients. 175 records were suitable for analysis. Results The commonest aetiology for NSP was recorded as idiopathic (80 out of 175, 44%). This was followed by pleural infection (15%), benign asbestos disease (12%), malignancy (6%) and cardiac failure (6%). The malignant diagnoses were predominantly mesothelioma (six out of 175, 3.4%) and lung adenocarcinoma (four out of 175, 2.3%). The median time to malignant diagnosis was 12.2 months (range 0.8-32 months). There was a signal towards greater asbestos exposure in the malignant NSP group compared to the benign group (0.63 versus 0.27, p=0.07). Neither recurrence of effusion requiring further therapeutic intervention nor initial biopsy approach were associated with a false-negative biopsy. A computed tomography finding of a mass lesion was the only imaging feature to demonstrate a significant association (0.18 versus 0.01, p=0.02), although sonographic pleural thickening also suggested an association (0.27 versus 0.09, p=0.09). Discussion This is the first multicentre study of NSP and its associated outcomes. While some of our findings are reflected by the established body of literature, other findings have highlighted important areas for future research, not previously studied in NSP.
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Effectiveness and economic impact of Dupilumab in asthma: a population-based cohort study
Anno: 2023
Rivista: RESPIRATORY RESEARCH
Autori/autrici: Faverio, Paola; Ronco, Raffaella; Monzio Compagnoni, Matteo; Franchi, Matteo; Franco, Giovanni; Bonaiti, Giulia; Bonifazi, Martina; Mei, Federico; Luppi, Fabrizio; Pesci, Alberto; Corrao, Giovanni
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315028
Citazioni:
Effectiveness and economic impact of Dupilumab in asthma: a population-based cohort study / Faverio, P., Ronco, R., Monzio Compagnoni, M., Franchi, M., Franco, G., Bonaiti, G., Bonifazi, M., Mei, F., Luppi, F., Pesci, A., Corrao, G.. - In: RESPIRATORY RESEARCH. - ISSN 1465-993X. - 24:(2023). [10.1186/s12931-023-02372-y]
Abstract:
Rationale: Severe asthma is burdened by relevant socio-economic and clinical impact. Randomized controlled trials on Dupilumab showed efficacy and a good safety profile, but post-market studies are needed.ObjectivesTo evaluate the impact of Dupilumab on (i) the use of anti-asthmatic drugs, including... oral corticosteroids (OCS), (ii) the rates of asthma exacerbation-related hospital admissions, and (iii) the healthcare costs in patients with asthma.MethodsData were retrieved from Healthcare Utilization database of Lombardy region (Italy). We compared healthcare resources use between the 6 months after Dupilumab initiation ("post-intervention period") and (i) the 6 months before Dupilumab initiation ("wash-out period") and (ii) the corresponding 6 months of the prior year ("pre-intervention period").Main resultsIn a cohort of 176 patients, Dupilumab significantly reduced anti-asthmatic drugs use (including OCS and short-acting beta 2-agonists, inhaled corticosteroids (ICS)/long-acting beta 2-agonists and ICS alone) when comparing the "pre-intervention" to the "post-intervention" period. When considering hospital admissions, we observed a not statistically or marginally significant reduction between both periods before Dupilumab and the post-intervention period. Six-months discontinuation rate was 8%. Overall healthcare costs had a tenfold increase between the "pre-intervention" and "post-intervention" period, which was mainly led by the biologic drug cost. Conversely, expenditures connected to hospital admissions did not change.ConclusionsOur real-world investigation suggests that Dupilumab reduced anti-asthmatic drugs use, including OCS, in comparison to a corresponding period in the prior year. However, long-term healthcare sustainability remains an open issue.
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Management of malignant pleural effusion in Italian clinical practice: a nationwide survey
Anno: 2023
Rivista: BMC PULMONARY MEDICINE
Autori/autrici: Mei, Federico; Tamburrini, Mario; Gonnelli, Francesca; Morandi, Luca; Bonifazi, Martina; Sediari, Michele; Berardino, Alessandro Di Marco; Barisione, Emanuela; Failla, Giuseppe; Zuccatosta, Lina; Papi, Alberto; Gasparini, Stefano; Marchetti, Giampietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/324632
Citazioni:
Management of malignant pleural effusion in Italian clinical practice: a nationwide survey / Mei, F., Tamburrini, M., Gonnelli, F., Morandi, L., Bonifazi, M., Sediari, M., Berardino, A.D.M., Barisione, E., Failla, G., Zuccatosta, L., Papi, A., Gasparini, S., Marchetti, G.. - In: BMC PULMONARY MEDICINE. - ISSN 1471-2466. - 23:1(2023). [10.1186/s12890-023-02530-4]
Abstract:
Background: Pleural disease (PD), particularly malignant pleural effusion (MPE), is a common cause of hospital admission and its prevalence is rising worldwide. Recent advances in diagnostic and therapeutic options, such as Indwelling Pleural Catheters (IPCs), have simplified PD treatment, allowing ...an effective outpatients management. Therefore, dedicated pleural services can improve PD care, guaranteeing specialized management and optimizing time and cost. We aimed to provide an overview on MPE management in Italy, mainly focused on distribution and characteristics of pleural services and IPCs use.MethodsA nationwide survey, endorsed by the Italian Thoracic Society, was distributed by email to members of selected subgroups in 2021.ResultsNinety (23%) members replied, most of whom being pulmonologists (91%). MPE resulted the most common cause of pleural effusion and was managed with heterogenous approaches, including talc pleurodesis via slurry (43%), talc poudrage (31%), repeated thoracentesis (22%) and IPCs insertion (2%). The setting of IPC insertion was inpatient care in 48% of cases, with a predominance of draining frequency every other day. IPC management mainly relied on caregivers (42%). The presence of a pleural service was reported by 37% of respondents.ConclusionsThe present study provides an extensive overview of MPE management in Italy, showing a highly heterogeneous approach, a scarce prevalence of out-patient pleural services, and a still limited adoption of IPCs, mainly due to lack of dedicated community care systems. This survey emphasizes the need of promoting a higher spreading of pleural services and an innovative healthcare delivery with more favourable cost-benefit ratio.
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Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Bonifazi, Martina; Faragalli, Andrea; Latini, Lara Letizia; Mei, Federico; Spazzafumo, Liana; Skrami, Edlira; Ferrante, Luigi; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/296112
Citazioni:
Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data / Iommi, M., Bonifazi, M., Faragalli, A., Latini, L.L., Mei, F., Spazzafumo, L., Skrami, E., Ferrante, L., Carle, F., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:5(2022). [10.3390/ijerph19052510]
Abstract:
The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and... drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.
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Chronic obstructive pulmonary disease (COPD) mortality trends worldwide: An update to 2019
Anno: 2022
Rivista: RESPIROLOGY
Autori/autrici: Mei, Federico; Dalmartello, Michela; Bonifazi, Martina; Bertuccio, Paola; Levi, Fabio; Boffetta, Paolo; Negri, Eva; La Vecchia, Carlo; Malvezzi, Matteo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305320
Citazioni:
Chronic obstructive pulmonary disease (COPD) mortality trends worldwide: An update to 2019 / Mei, F., Dalmartello, M., Bonifazi, M., Bertuccio, P., Levi, F., Boffetta, P., Negri, E., La Vecchia, C., Malvezzi, M.. - In: RESPIROLOGY. - ISSN 1440-1843. - 27:11(2022), pp. 941-950. [10.1111/resp.14328]
Abstract:
Background and objective: Chronic obstructive pulmonary disease (COPD) incidence, prevalence, mortality and socioeconomic burden are considerable and vary across countries. The aim of the present study was to update the analysis of COPD mortality worldwide using data from the World Health Organizati...on (WHO) up to 2019. Methods: We obtained COPD mortality and population data for 22 European countries and the European Union (EU) as a whole, 10 American countries and six other countries from the WHO mortality database. We calculated age-standardized mortality rates in both sexes and examined trends by country with joinpoint analysis between 1994 and 2019. Results: Between 2005–2007 and 2015–2017, overall COPD mortality decreased in EU men (−16.3%) but increased in women (12.7%) to reach rates of 14.0/100,000 in men and of 6.4/100,000 in women. In the United States, mortality declined in men to 21.3/100,000 but rose in women to 18.3/100,000. Mortality declined in most Latin American countries and all Asian countries, while an increase in Australian women was observed. Conclusion: A steady decrease in COPD mortality was observed in most of countries for men, whilst a different trend was observed in women in several countries. These trends are largely explained by changes in smoking habits, with an additional contribution of air pollution and occupational exposures. Despite past and ongoing tobacco control initiatives, this condition still remains a leading cause of death, in particular in countries with lower socio-demographic indices.
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Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Faragalli, Andrea; Bonifazi, Martina; Mei, Federico; Latini, Lara Letizia; Pompili, Marco; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/329463
Citazioni:
Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases / Iommi, M., Faragalli, A., Bonifazi, M., Mei, F., Latini, L.L., Pompili, M., Carle, F., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:24(2022). [10.3390/ijerph192416689]
Abstract:
The aim was to evaluate the determinants of acute exacerbation (AE) and death in new cases of idiopathic pulmonary fibrosis (IPF) using administrative databases in the Marche Region. Adults at their first prescription of antifibrotics or hospitalization with a diagnosis of IPF occurring in 2014-2019... were considered as new cases. Multiple Cox regression was used to estimate the risk of AE and of all-cause mortality adjusted by demographic and clinical characteristics, stratifying patients according to antifibrotic treatment. Overall, 676 new cases of IPF were identified and 276 deaths and 248 AE events occurred. In never-treated patients, the risk of AE was higher in patients with poor health conditions at diagnosis; the risk of death was higher in males, in patients aged >= 75 and in those with poor health conditions at baseline. The increasing number of AEs increased the risk of death in treated and never-treated patients. Within the limits of an observational study based on secondary data, the combined use of healthcare administrative databases allows the accurate analysis of progression and survival of IPF from the beginning of the antifibrotic therapy era, suggesting that timely and early diagnosis is critical to prescribing the most suitable treatment to increase survival and maintain a healthy life expectancy.
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A lymph node mediastinal foreign body reaction mimicking nodal metastasis: A case series
Anno: 2022
Rivista: FRONTIERS IN MEDICINE
Autori/autrici: Zuccatosta, Lina; Latini, Maria Agnese; Mei, Federico; Bonifazi, Martina; Barisione, Emanuela; Salio, Mario; Gasparini, Stefano; Gonnelli, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/306167
Citazioni:
A lymph node mediastinal foreign body reaction mimicking nodal metastasis: A case series / Zuccatosta, L., Latini, M.A., Mei, F., Bonifazi, M., Barisione, E., Salio, M., Gasparini, S., Gonnelli, F.. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - 9:(2022). [10.3389/fmed.2022.1014617]
Abstract:
Introduction: In the last decades, many haemostatic substances included oxidized cellulose topically applied have been used during surgery and their use have become a common practice. Oxidized cellulose (OC) is one of the most used haemostatic substances. However, different studies have shown the pe...rsistence of OC deposits after surgical procedures that may simulate recurrent malignancies and abscesses. We present a case series of patients with enlarged on CT and PET-FDG positive lymphadenopathies due to foreign body inflammatory reaction to OC after lung surgery for pulmonary malignancies. Methods: Retrospective chart review of patients from 2021 to 2022 who underwent EBUS-TBNA for the characterization of hilar and/or mediastinal lymphadenopathies and a histopathological diagnosis of foreign body inflammatory reaction to OC. Results: Eight patients were referred to “Ospedali Riuniti di Ancona” (n = 7) and “Ospedale San Martino” (Genoa) (n = 1) Interventional Pulmonology Units for the characterization of hilar and/or mediastinal lymphadenopathies. All the evaluated patients underwent surgical procedures for lung cancers within the previous 12 months. EBUS-TBNA was performed in all the patients to rule out nodal metastasis. The cyto-pathological evaluation revealed amorphous acellular eosinofilic material surrounded by inflammatory reaction. As no other apparent causes might explain this finding and considering the temporal relationship between the lymphadenopathy and the lung surgery, foreign body inflammatory reaction to OC is the most likely cause of the phenomenon. Conclusion: In patients who underwent surgery for lung cancer, especially within few months, the development of lymph node foreign body reaction due to surgical material retention should always be considered.
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Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study
Anno: 2022
Rivista: RESPIRATION
Autori/autrici: Mondoni, Michele; Gasparini, Stefano; Varone, Francesco; Trisolini, Rocco; Mancino, Laura; Rossi, Giulio; Carlucci, Paolo; Bonifazi, Martina; Mei, Federico; Zuccatosta, Lina; Michieletto, Lucio; Pitari, Federica; Saderi, Laura; Richeldi, Luca; Centanni, Stefano; Sotgiu, Giovanni
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/301742
Citazioni:
Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study / Mondoni, M., Gasparini, S., Varone, F., Trisolini, R., Mancino, L., Rossi, G., Carlucci, P., Bonifazi, M., Mei, F., Zuccatosta, L., Michieletto, L., Pitari, F., Saderi, L., Richeldi, L., Centanni, S., Sotgiu, G.. - In: RESPIRATION. - ISSN 0025-7931. - ELETTRONICO. - (2022), p. 1-9. [10.1159/000524398]
Abstract:
Background: The role of endoscopic ultrasound with bronchoscope fine-needle aspiration (EUS-B-FNA) in the diagnosis of suspected malignant pulmonary lesions adjacent to the esophagus has been poorly investigated. The aim of the present study was to assess the accuracy of EUS-B-FNA for the diagnosis ...and molecular profiling of paraesophageal pulmonary lesions, as well as its predictors of success. Materials and Methods: Patients who underwent EUS-B-FNA for the diagnosis of paraesophageal lesions were consecutively enrolled in four Italian centers. Demographic, clinical, procedural, pathological, and molecular characteristics of the malignant samples were collected. The primary outcome was the diagnostic accuracy for pulmonary malignancies. Secondary outcomes were diagnostic yield and predictors of success for diagnosis and molecular profiling. Results: 107 adult patients (60 [56.1%] males; median (interquartile range) age: 69 [60-70] years) were enrolled. The diagnostic accuracy of EUS-B-FNA was 95.3% in the overall cohort and 95.2% in the 99 patients with a final diagnosis of malignancy. Neither clinical nor procedural variables significantly affected the diagnostic accuracy, whereas rapid on-site evaluation (ROSE), performed by pathologists or trained pulmonologists, was a strong predictor for a complete molecular profiling (OR [95% CI]: 12.9 [1.2-137.4]; p value: 0.03). Conclusion: EUS-B-FNA is a safe and accurate method for the diagnosis of paraesophageal pulmonary lesions. The presence of ROSE is relevant for a complete molecular profiling in this selected cohort of patients with advanced lung cancer.
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Validation of a Cytological Classification System for the Rapid On-Site Evaluation (Rose) of Pulmonary and Mediastinal Needle Aspirates
Anno: 2022
Rivista: DIAGNOSTICS
Autori/autrici: Zuccatosta, Lina; Rossi, Giulio; Gasparini, Stefano; Ferretti, Maurizio; Mei, Federico; Sediari, Michele; Barbisan, Francesca; Goteri, Gaia; Corbo, Giuseppe Maria; Di Marco Berardino, Alessandro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315017
Citazioni:
Validation of a Cytological Classification System for the Rapid On-Site Evaluation (Rose) of Pulmonary and Mediastinal Needle Aspirates / Zuccatosta, L., Rossi, G., Gasparini, S., Ferretti, M., Mei, F., Sediari, M., Barbisan, F., Goteri, G., Corbo, G.M., Di Marco Berardino, A.. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:11(2022). [10.3390/diagnostics12112777]
Abstract:
Rapid on-site evaluation (ROSE) is a procedure that allows immediate assessment of adequacy of cytological specimens obtained by fine needle aspiration (FNA). The application of ROSE diagnostic categories has been applied in various organs, but not in thoracic pathology. We aimed to retrospectively ...assess the concordance with the final diagnosis of a categorization from C1 (inadequate) to C5 (neoplastic) during ROSE performed with bronchoscopic or percutaneous sampling procedures of thoracic lesions in a large series of consecutive cases. This retrospective single-center study evaluated 2282 consecutive ROSEs performed on 1827 patients from January 2016 to December 2020 in 994 cases of transbronchial needle aspiration (TBNA) in peripheral pulmonary lesions, in 898 transthoracic FNAs, in 318 ultrasound-guided TBNAs, in 50 conventional TBNAs and in 22 endobronchial TBNAs. False positive and false negative cases of ROSE were 43 (1.88%) and 73 (3.2%), respectively, when compared with the definitive diagnosis. The sensitivity, specificity and the positive and negative prognostic values of ROSE were 94.84%, 95.05%, 96.89% and 91.87%, respectively. Overall concordance between ROSE and the final diagnosis was 0.8960 (Cohen's kappa). No significant differences were observed in terms of sampling procedures and type and location of the lesions. A tiered classification scheme of ROSE from C1 to C5 during bronchoscopic and percutaneous sampling procedures is helpful in effectively guiding clinical management of patients with thoracic lesions.
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Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Faragalli, Andrea; Bonifazi, Martina; Mei, Federico; Latini, Lara Letizia; Pompili, Marco; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314979
Citazioni:
Prognosis and Survival in Idiopathic Pulmonary Fibrosis in the Era of Antifibrotic Therapy in Italy: Evidence from a Longitudinal Population Study Based on Healthcare Utilization Databases / Iommi, M., Faragalli, A., Bonifazi, M., Mei, F., Latini, L.L., Pompili, M., Carle, F., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:24(2022), p. 16689. [10.3390/ijerph192416689]
Abstract:
The aim was to evaluate the determinants of acute exacerbation (AE) and death in new cases of idiopathic pulmonary fibrosis (IPF) using administrative databases in the Marche Region. Adults at their first prescription of antifibrotics or hospitalization with a diagnosis of IPF occurring in 2014-2019... were considered as new cases. Multiple Cox regression was used to estimate the risk of AE and of all-cause mortality adjusted by demographic and clinical characteristics, stratifying patients according to antifibrotic treatment. Overall, 676 new cases of IPF were identified and 276 deaths and 248 AE events occurred. In never-treated patients, the risk of AE was higher in patients with poor health conditions at diagnosis; the risk of death was higher in males, in patients aged >= 75 and in those with poor health conditions at baseline. The increasing number of AEs increased the risk of death in treated and never-treated patients. Within the limits of an observational study based on secondary data, the combined use of healthcare administrative databases allows the accurate analysis of progression and survival of IPF from the beginning of the antifibrotic therapy era, suggesting that timely and early diagnosis is critical to prescribing the most suitable treatment to increase survival and maintain a healthy life expectancy.
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Economic impact of anti-IL-5 agents in patients with severe eosinophilic asthma: a population-based cohort study
Anno: 2022
Rivista: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE
Autori/autrici: Faverio, Paola; Monzio Compagnoni, Matteo; Ronco, Raffaella; Franchi, Matteo; Della Zoppa, Matteo; Bonaiti, Giulia; Bonifazi, Martina; Mei, Federico; Luppi, Fabrizio; Pesci, Alberto; Corrao, Giovanni
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305321
Citazioni:
Economic impact of anti-IL-5 agents in patients with severe eosinophilic asthma: a population-based cohort study / Faverio, P., Monzio Compagnoni, M., Ronco, R., Franchi, M., Della Zoppa, M., Bonaiti, G., Bonifazi, M., Mei, F., Luppi, F., Pesci, A., Corrao, G.. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE. - ISSN 2213-2198. - (2022). [10.1016/j.jaip.2022.07.029]

Diagnostic Role of Bronchoalveolar Lavage in Patients with Suspected SARS-CoV-2 Pneumonia and Negative Upper Respiratory Tract Swab: A Systematic Review and Meta-Analysis
Anno: 2022
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Mei, Federico; Rota, Matteo; Bonifazi, Martina; Zuccatosta, Lina; Porcarelli, Francesco; Sediari, Michele; Gonnelli, Francesca; Di Marco Berardino, Alessandro; Gasparini, Stefano
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305323
Citazioni:
Diagnostic Role of Bronchoalveolar Lavage in Patients with Suspected SARS-CoV-2 Pneumonia and Negative Upper Respiratory Tract Swab: A Systematic Review and Meta-Analysis / Mei, F., Rota, M., Bonifazi, M., Zuccatosta, L., Porcarelli, F., Sediari, M., Gonnelli, F., Di Marco Berardino, A., Gasparini, S.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:16(2022). [10.3390/jcm11164656]
Abstract:
The added role of bronchoalveolar lavage (BAL) in SARS-CoV-2 detection in hospitalized patients with suspected COVID-19 pneumonia and at least one negative nasopharyngeal swab (NPS) has yet to be definitively established. We aimed to provide a systematic review and meta-analysis to summarize data fr...om the literature on the diagnostic yield of BAL in this context. We searched Medline and Embase for all studies reporting outcomes of interest published up to October 2021. Two authors reviewed all titles/abstracts and retrieved the selected full texts according to predefined selection criteria. The summary estimate was derived using the random-effects model. Thirteen original studies, involving 868 patients, were included. The summary estimate of proportions of SARS-CoV-2 positivity in BAL fluid in patients with at least one previous negative NPS was 20% (95% confidence interval [CI]; 11–30%). Moreover, microbiological tests of BAL fluid led to the identification of other pathogens, mainly bacteria, in up to two-thirds of cases. BAL plays a crucial role in the diagnostic work-up of patients with clinical suspicion of COVID-19 and previous negative NPS, as it allowed to detect the infection in a significant proportion of subjects, who would have been otherwise misclassified, with relevant implications in the prevention of disease spread, especially in hospital settings.
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Broncoscopia diagnosis of peripheral lung lesions
Anno: 2021
Rivista: CURRENT OPINION IN PULMONARY MEDICINE
Autori/autrici: Gasparini, Stefano; Mei, Federico; Bonifazi, Martina; Lina Zuccatosta, And
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293350
Citazioni:
Broncoscopia diagnosis of peripheral lung lesions / Gasparini, S., Mei, F., Bonifazi, M., Lina Zuccatosta, A.. - In: CURRENT OPINION IN PULMONARY MEDICINE. - ISSN 1070-5287. - STAMPA. - 27:(2021), pp. 1-6. [10.1097/MCP.0000000000000842]

Pleural involvement in IgG4-related disease: Case report and review of the literature
Anno: 2021
Rivista: DIAGNOSTICS
Autori/autrici: Mei, F.; Mancini, M.; Maurizi, G.; Vecchione, A.; Zuccatosta, L.; Rendina, E. A.; Gasparini, S.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/301741
Citazioni:
Pleural involvement in IgG4-related disease: Case report and review of the literature / Mei, F., Mancini, M., Maurizi, G., Vecchione, A., Zuccatosta, L., Rendina, E.A., Gasparini, S.. - In: DIAGNOSTICS. - ISSN 2075-4418. - 11:12(2021), p. 2177. [10.3390/diagnostics11122177]
Abstract:
Diagnostic work-up of IgG4-related disease (IgG4-RD) pleural involvement is a complex task, as there is a broad spectrum of differential diagnoses to consider. We report the case of a patient presenting with relapsing pleural effusion, discussing the main challenges for achievement of a def-inite di...agnosis. A 63-year-old man was admitted for pleural effusion prevalent on the ride side, initially labeled as idiopathic non-specific pleuritis, based on tissue evaluation after a medical tho-racoscopy. He was started on steroids with initial improvement, but a later CT scan showed a re-lapse of pleural effusion associated with diffuse pleural thickening; a subsequent surgical pleural biopsy revealed features suggestive for IgG4-RD, with a marked increase of IgG4 positive plasma cells. High IgG4 serum levels were also found. The present case underlines the importance of increasing awareness of this potential condition among physicians in order to properly guide the diagnostic work-up, as it is likely that IgG4-RD accounts for a proportion of patients with pleural effusions, labeled as idiopathic. In particular, in patients with unexplained pleural effusion, IgG4- RD should be included among differential diagnoses when lymphoplasmacytic infiltration is ob-served, and a multidisciplinary interaction between clinicians and pathologists appears crucial for an accurate diagnosis and an appropriate management.
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Tocilizumab in COVID-19 interstitial pneumonia
Anno: 2021
Rivista: JOURNAL OF INTERNAL MEDICINE
Autori/autrici: Pomponio, G; Ferrarini, A; Bonifazi, M; Moretti, M; Salvi, A; Giacometti, A; Tavio, M; Titolo, G; Morbidoni, L; Frausini, G; Onesta, M; Amico, D; B Rocchi, M L; Menzo, S; Zuccatosta, L; Mei, F; Menditto, V; Svegliati, S; Donati, A; M D'Errico, M; Pavani, M; Gabrielli, A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290128
Citazioni:
Tocilizumab in COVID-19 interstitial pneumonia / Pomponio, G., Ferrarini, A., Bonifazi, M., Moretti, M., Salvi, A., Giacometti, A., Tavio, M., Titolo, G., Morbidoni, L., Frausini, G., Onesta, M., Amico, D., B Rocchi, M.L., Menzo, S., Zuccatosta, L., Mei, F., Menditto, V., Svegliati, S., Donati, A., M D'Errico, M., et al.. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - ELETTRONICO. - 289:5(2021), pp. 738-746. [10.1111/joim.13231]
Abstract:
Background: Published reports on tocilizumab in COVID-19 pneumonitis show conflicting results due to weak designs or heterogeneity in critical methodological issues. Methods: This open-label trial, structured according to Simon's optimal design, aims to identify factors predicting which patient...s could benefit from anti-IL6 strategies and to enhance the design of unequivocal and reliable future randomized trials. A total of 46 patients with COVID-19 pneumonia needing of oxygen therapy to maintain SO2 &gt; 93% and with recent worsening of lung function received a single infusion of tocilizumab. Clinical and biological markers were measured to test their predictive values. Primary end point was early and sustained clinical response. Results: Twenty-one patients fulfilled pre-defined response criteria. Lower levels of IL-6 at 24 h after tocilizumab infusion (P = 0.049) and higher baseline values of PaO2/FiO2 (P = 0.008) predicted a favourable response. Conclusions: Objective clinical response rate overcame the pre-defined threshold of 30%. Efficacy of tocilizumab to improve respiratory function in patients selected according to our inclusion criteria warrants investigations in randomized trials.
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Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
Anno: 2021
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Bonifazi, Martina; Mei, Federico; Skrami, Edlira; Latini, Lara Letizia; Amico, Donatella; Balestro, Elisabetta; Bini, Francesco; Bonifazi, Floriano; Caminati, Antonella; Candoli, Piero; Cinti, Saverio; Contucci, Susanna; Di Marco Berardino, Alessandro; Harari, Sergio; Levi, Guido; Lococo, Sara; Menditto, Vincenzo; Marchetti, Giampietro; Piciucchi, Sara; Poletti, Venerino; Ravaglia, Claudia; Saetta, Marina; Svegliati-Baroni, Gianluca; Tomassetti, Sara; Tamburrini, Mario; Zanforlin, Alessandro; Zuccon, Umberto; Zuccatosta, Lina; Gasparini, Stefano; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290062
Citazioni:
Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) / Bonifazi, M., Mei, F., Skrami, E., Latini, L.L., Amico, D., Balestro, E., Bini, F., Bonifazi, F., Caminati, A., Candoli, P., Cinti, S., Contucci, S., Di Marco Berardino, A., Harari, S., Levi, G., Lococo, S., Menditto, V., Marchetti, G., Piciucchi, S., Poletti, V., et al.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - ELETTRONICO. - 10:6(2021). [10.3390/jcm10061218]
Abstract:
Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present It...alian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
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Predictors of readmission requiring hospitalization after discharge from emergency departments in patients with COVID-19
Anno: 2021
Rivista: THE AMERICAN JOURNAL OF EMERGENCY MEDICINE
Autori/autrici: Menditto, Vincenzo G; Fulgenzi, Francesca; Bonifazi, Martina; Gnudi, Umberto; Gennarini, Silvia; Mei, Federico; Salvi, Aldo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290063
Citazioni:
Predictors of readmission requiring hospitalization after discharge from emergency departments in patients with COVID-19 / Menditto, V.G., Fulgenzi, F., Bonifazi, M., Gnudi, U., Gennarini, S., Mei, F., Salvi, A.. - In: THE AMERICAN JOURNAL OF EMERGENCY MEDICINE. - ISSN 0735-6757. - 46:(2021), pp. 146-149-149. [10.1016/j.ajem.2021.04.055]
Abstract:
Little is known on prevalence of early return hospital admission of subjects with COVID-19 previously evaluated and discharged from emergency departments (EDs). This study aims to describe readmission rate within 14 days of patients with COVID-19 discharged from ED and to identify predictors of retu...rn hospital admission.
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Validation of remote dielectric sensing (Reds) in monitoring adult patients affected by covid-19 pneumonia
Anno: 2021
Rivista: DIAGNOSTICS
Autori/autrici: Mei, F.; Berardino, A. D. M.; Bonifazi, M.; Latini, L. L.; Zuccatosta, L.; Gasparini, S.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/294423
Citazioni:
Validation of remote dielectric sensing (Reds) in monitoring adult patients affected by covid-19 pneumonia / Mei, F., Berardino, A.D.M., Bonifazi, M., Latini, L.L., Zuccatosta, L., Gasparini, S.. - In: DIAGNOSTICS. - ISSN 2075-4418. - 11:6(2021), p. NA. [10.3390/diagnostics11061003]
Abstract:
Remote dielectric sensing (ReDS) is a non-invasive electromagnetic wave technology which provides an accurate reading of lung fluid content, and it has been reported as a valid tool in monitoring heart failure patients. Considering that morphological alterations in COVID-19 include pulmonary edema, ...the purpose of the present study was to evaluate the reliability of ReDS technology in assessing the excess of lung fluid status in COVID-19 pneumonia, as compared to CT scans. In this pilot single center study, confirmed COVID-19 patients were enrolled on admission to an intermediate care unit. Measurements with the ReDS system and CT scans were performed on admission and at weeks 1 and 2. Eleven patients were recruited. The average change in ReDS was −3.1 ± 1.7 after one week (p = 0.001) and −4.6 ± 2.9 after two weeks (p = 0.006). A similar trend was seen in total CT score (−3.3 ± 2.1, p = 0.001). The level of agreement between ReDS and CT changes yielded a perfect result. Statistically significant changes were observed in lactate dehydrogenase, lymphocytes, and c-reactive protein over 2 weeks. This pilot study shows that ReDS can track changes in lung involvement according to the severity of COVID-19. Further studies to detect early clinical deterioration are needed.
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Role of bronchoscopy in critically ill patients managed in intermediate care units - indications and complications: A narrative review
Anno: 2021
Rivista: WORLD JOURNAL OF CRITICAL CARE MEDICINE
Autori/autrici: Menditto, Vincenzo G; Mei, Federico; Fabrizzi, Benedetta; Bonifazi, Martina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/294364
Citazioni:
Role of bronchoscopy in critically ill patients managed in intermediate care units - indications and complications: A narrative review / Menditto, V.G., Mei, F., Fabrizzi, B., Bonifazi, M.. - In: WORLD JOURNAL OF CRITICAL CARE MEDICINE. - ISSN 2220-3141. - 10:6(2021), pp. 334-344-344. [10.5492/wjccm.v10.i6.334]
Abstract:
: Flexible bronchoscopy (FB) has become a standard of care for the triad of inspection, sampling, and treatment in critical care patients. It is an invaluable tool for diagnostic and therapeutic purposes in critically ill patients in intensive care unit (ICU). Less is known about its role outside th...e ICU, particularly in the intermediate care unit (IMCU), a specialized environment, where an intermediate grade of intensive care and monitoring between standard care unit and ICU is provided. In the IMCU, the leading indications for a diagnostic work-up are: To visualize airway system/obstructions, perform investigations to detect respiratory infections, and identify potential sources of hemoptysis. The main procedures for therapeutic purposes are secretion aspiration, mucus plug removal to solve atelectasis (total or lobar), and blood aspiration during hemoptysis. The decision to perform FB might depend on the balance between potential benefits and risks due to frailty of critically ill patients. Serious adverse events related to FB are relatively uncommon, but they may be due to lack of expertise or appropriate precautions. Finally, nowadays, during dramatic recent coronavirus disease 2019 (COVID-19) pandemic, the exact role of FB in COVID-19 patients admitted to IMCU has yet to be clearly defined. Hence, we provide a concise review on the role of FB in an IMCU setting, focusing on its indications, technical aspects and complications.
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Diagnostic Yield and Safety of Image-Guided Pleural Biopsy: A Systematic Review and Meta-Analysis
Anno: 2021
Rivista: RESPIRATION
Autori/autrici: Mei, F.; Bonifazi, M.; Rota, M.; Cirilli, L.; Grilli, M.; Duranti, C.; Zuccatosta, L.; Bedawi, E. O.; Mccracken, D.; Gasparini, S.; Rahman, N. M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290064
Citazioni:
Diagnostic Yield and Safety of Image-Guided Pleural Biopsy: A Systematic Review and Meta-Analysis / Mei, F., Bonifazi, M., Rota, M., Cirilli, L., Grilli, M., Duranti, C., Zuccatosta, L., Bedawi, E.O., Mccracken, D., Gasparini, S., Rahman, N.M.. - In: RESPIRATION. - ISSN 0025-7931. - 100:1(2021), pp. 77-87. [10.1159/000511626]
Abstract:
Background: Diagnostic yield (DY) and safety of computed tomography (CT)- and thoracic ultrasound (TUS)-guided biopsies in the diagnosis of pleural lesions have been investigated in a number of studies, but no synthesis of data from the literature has ever been performed. Objectives: We aimed to pro...vide the first systematic review and meta-analysis on the DY and safety of CT- versus TUS-guided biopsy in the diagnosis of pleural lesions. Method: We searched MEDLINE and EMBASE for all studies reporting outcomes of interest published up to April 2018. Two authors reviewed all titles/abstracts and retrieved selected full text to identify studies according to predefined selection criteria. Summary estimates were derived using the random-effects model. Cumulative meta-analysis assessed the influence of increasing adoption of the procedures over time. Results: Thirty original studies were included in the present review; the number of studies on TUS-guided biopsy was almost three-fold higher than those on CT-guided biopsy. The pooled DYs of the 2 procedures were overall excellent and differed &lt;10%, being 84% for TUS-guided biopsy and 93% for CT-guided biopsy. Safety profiles were reassuring for both the techniques, being 7 and 3% for CT- and TUS-guided biopsy, respectively. DY of ultrasound technique significantly improved over time, while no time effect was observed for CT-guided biopsy. Conclusions: Data show that CT- and TUS-guided biopsies in the diagnosis of pleural lesions are both excellent procedures, without meaningful differences in DYs and safety. Considering that TUS is non-ionizing and easily performed at the bedside, it should be the preferred approach in presence of adequate skills.
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Pleuroparenchymal fibroelastosis in systemic sclerosis: prevalence and prognostic impact
Anno: 2020
Rivista: EUROPEAN RESPIRATORY JOURNAL
Autori/autrici: Bonifazi, Martina; Sverzellati, Nicola; Negri, Eva; Jacob, Joseph; Egashira, Ryoko; Moser, Joanna; Piciucchi, Sara; Mei, Federico; De Lauretis, Angelo; Visca, Dina; Goh, Nicole; Bonini, Matteo; Cirilli, Laura; La Vecchia, Carlo; Chua, Felix; Kouranos, Vasileios; Margaritopoulos, George; Kokosi, Maria; Maher, Toby M; Gasparini, Stefano; Gabrielli, Armando; Wells, Athol U; Renzoni, Elisabetta A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/277333
Citazioni:
Pleuroparenchymal fibroelastosis in systemic sclerosis: prevalence and prognostic impact / Bonifazi, M., Sverzellati, N., Negri, E., Jacob, J., Egashira, R., Moser, J., Piciucchi, S., Mei, F., De Lauretis, A., Visca, D., Goh, N., Bonini, M., Cirilli, L., La Vecchia, C., Chua, F., Kouranos, V., Margaritopoulos, G., Kokosi, M., Maher, T.M., Gasparini, S., et al.. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - ELETTRONICO. - 56:1(2020). [10.1183/13993003.02135-2019]
Abstract:
Interstitial lung disease (ILD) in systemic sclerosis (SSc) is a major cause of morbidity and mortality, mostly presenting as nonspecific interstitial pneumonia. Little is known about the prevalence of pleuroparenchymal fibroelastosis (PPFE), a specific entity affecting the visceral pleura and subpl...eural parenchyma. We set out to estimate PPFE prevalence in two large cohorts of SSc patients and to assess its impact on survival and functional decline.A total of 359 SSc patients, derived from two referral centers in two different countries (UK and Italy), were included. The first available high-resolution computed tomography scan was independently evaluated by two radiologists blind to clinical information, to quantify ILD extent, freestanding bronchial abnormalities, and lobar percentage involvement of PPFE on a 4-point categorical scale. Discordant scores were adjudicated by a third scorer. PPFE extent was further classified as limited (≤2/18) or extensive (&gt;2/18). Results were evaluated against functional decline and mortality.The overall prevalence of PPFE in the combined SSc population was 18% (11% with extensive PPFE), with no substantial difference between the two cohorts. PPFE was significantly linked to free-standing bronchial abnormalities (61% versus 25% in PPFE versus no PPFE; p&lt;0.0001) and to worse survival, independently of ILD severity or short-term lung function changes (HR 1.89, 95% CI 1.10-3.25; p=0.005).In the current study, we provide an exhaustive description of PPFE prevalence and clinical impact in the largest cohort of SSc subjects published so far. PPFE presence should be carefully considered, due to its significant prognostic implications.
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First Detection of SARS-CoV-2 by Real-Time Reverse Transcriptase-Polymerase Chain Reaction Assay in Pleural Fluid
Anno: 2020
Rivista: CHEST
Autori/autrici: Mei, Federico; Bonifazi, Martina; Menzo, Stefano; Di Marco Berardino, Alessandro; Sediari, Michele; Paolini, Luca; Re, Antonina; Gonnelli, Francesca; Duranti, Claudia; Grilli, Martina; Spurio Vennarucci, Giacomo; Agnese Latini, Maria; Zuccatosta, Lina; Gasparini, Stefano
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286389
Citazioni:
First Detection of SARS-CoV-2 by Real-Time Reverse Transcriptase-Polymerase Chain Reaction Assay in Pleural Fluid / Mei, F., Bonifazi, M., Menzo, S., Di Marco Berardino, A., Sediari, M., Paolini, L., Re, A., Gonnelli, F., Duranti, C., Grilli, M., Spurio Vennarucci, G., Agnese Latini, M., Zuccatosta, L., Gasparini, S.. - In: CHEST. - ISSN 1931-3543. - ELETTRONICO. - 158:4(2020), pp. 143-146. [10.1016/j.chest.2020.05.583]
Abstract:
Coronavirus disease 2019 (COVID-19) is a pandemic infection due to the spread of a novel coronavirus (severe acute respiratory syndrome coronavirus 2), resulting in a wide range of clinical features, from asymptomatic carriers to ARDS. The gold standard for diagnosis is nucleic acid detection by rea...l-time reverse transcriptase-polymerase chain reaction in nasopharyngeal swabs. However, due to limitations in this technique’s sensitivity, thoracic imaging plays a crucial, complementary role in diagnostic evaluation and also allows for detection of atypical findings and potential alternative targets for sampling (eg, pleural effusion). Although less common, pleural involvement has been described in a minority of patients. This report describes the first case of reverse transcriptase-polymerase chain reaction detection of severe acute respiratory syndrome coronavirus 2 in pleural fluid obtained by means of ultrasoundguided thoracentesis, and its main characteristics are detailed. Pleural effusion is not a common finding in COVID-19 infection, but a prompt recognition of this potential localization may be useful to optimize diagnostic evaluation as well as the management of these patients.
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How the pathological microenvironment affects the behavior of mesenchymal stem cells in the idiopathic pulmonary fibrosis
Anno: 2020
Rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Autori/autrici: Bonifazi, M.; Vincenzo, M. D.; Caffarini, M.; Mei, F.; Salati, M.; Zuccatosta, L.; Refai, M.; Mattioli-Belmonte, M.; Gasparini, S.; Orciani, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/291372
Citazioni:
How the pathological microenvironment affects the behavior of mesenchymal stem cells in the idiopathic pulmonary fibrosis / Bonifazi, M., Vincenzo, M.D., Caffarini, M., Mei, F., Salati, M., Zuccatosta, L., Refai, M., Mattioli-Belmonte, M., Gasparini, S., Orciani, M.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 21:21(2020). [10.3390/ijms21218140]
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by fibroblasts activation, ECM accumulation, and diffused alveolar inflammation. The role of inflammation in IPF is still controversial and its involvement may follow nontraditional mechanisms. It is seen that a pathological micr...oenvironment may affect cells, in particular mesenchymal stem cells (MSCs) that may be able to sustain the inflamed microenvironment and influence the surrounding cells. Here MSCs have been isolated from fibrotic (IPF-MSCs) and control (C-MSCs) lung tissue; first cells were characterized and compared by the expression of molecules related to ECM, inflammation, and other interdependent pathways such as hypoxia and oxidative stress. Subsequently, MSCs were co-cultured between them and with NHLF to test the effects of the cellular crosstalk. Results showed that pathological microenvironment modified the features of MSCs: IPF-MSCs, compared to C-MSCs, express higher level of molecules related to ECM, inflammation, oxidative stress, and hypoxia; notably, when co-cultured with C-MSCs and NHLF, IPF-MSCs are able to induce a pathological phenotype on the surrounding cell types. In conclusion, in IPF the pathological microenvironment affects MSCs that in turn can modulate the behavior of other cell types favoring the progression of IPF.
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Pulmonary embolism: a retrospective comparative study between patients with atypical vs typical clinical presentation
Anno: 2019
Rivista: RECENTI PROGRESSI IN MEDICINA
Autori/autrici: Menditto, Vincenzo G; Mei, Federico; Postacchini, Laura; Manfredi, Lucia; Tedesco, Silvia; Pomponio, Giovanni; Gabrielli, Armando; Salvi, Aldo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/306165
Citazioni:
Pulmonary embolism: a retrospective comparative study between patients with atypical vs typical clinical presentation / Menditto, V.G., Mei, F., Postacchini, L., Manfredi, L., Tedesco, S., Pomponio, G., Gabrielli, A., Salvi, A.. - In: RECENTI PROGRESSI IN MEDICINA. - ISSN 2038-1840. - 110:2(2019), pp. 93-97. [10.1701/3112.31005]
Abstract:
Natural history and outcomes of patients with pulmonary embolism (PE) without typical symptoms (atypical PE) remain unclear. The aim of the study is to compare the clinical characteristics and the prognosis between typical PE and atypical PE.

SINGLE-CENTER PROSPECTIVE STUDY ON CLINICAL EVOLUTION OF NON-SPECIFIC PLEURITIS
Anno: 2018
Rivista: EUROPEAN RESPIRATORY JOURNAL
Autori/autrici: Mei, F; Bonifazi, M; Zuccatosta, L; Barbisan, F; Sediari, M; Gasparini, S
Lingua: ENG
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/263311
Citazioni:
SINGLE-CENTER PROSPECTIVE STUDY ON CLINICAL EVOLUTION OF NON-SPECIFIC PLEURITIS / Mei, F., Bonifazi, M., Zuccatosta, L., Barbisan, F., Sediari, M., Gasparini, S.. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 1399-3003. - STAMPA. - 52 (suppl.62):(2018), pp. 2877-2877. (ERS International Congress Parigi 15-19/09/2018) [10.1183/13993003.congress-2018.PA2877].

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study
Anno: 2017
Rivista: EUROPEAN RESPIRATORY JOURNAL
Autori/autrici: Walsh, S. L. F.; Maher, Tm; Kolb, M; Poletti, V; Nusser, R; Richeldi, L; Vancheri, C; Wilsher, Ml; Antoniou, Kmj; Behr, J; Bendstrup, E; Brown, K; Calandriello, L; Corte, Tj; Cottin, V; Crestani, B; Flaherty, K; Glaspole, I; Grutters, J; Inoue, Y; Kokosi, M; Kondoh, Y; Kouranos, V; Kreuter, M; Johannson, K; Judge, E; Ley, B; Margaritopoulos, G; Martinez, Fj; Molina-Molina, M; Morais, A; Nunes, H; Raghu, G; Ryerson, Cj; Selman, M; Spagnolo, P; Taniguchi, H; Tomassetti, S; Valeyre, D; Wijsenbeek, M; Wuyts, W; Hansell, D; Wells, A; Zhu, Ps; Yuan, Y; Yoshito Fukuda, C; Yoshimatsu, Y; Xaubet, A; Wong, Am; White, P; Westney, G; West, A; Wessendorf, T; Waseda, Y; Wang, C; Vienna, Jm; Videnovic Ivanov, J; Vicens Zygmunt, V; Venero Caceres, Mc; Velásquez Pinto, G; Veitch, E; Vasakova, M; Varone, F; Varela, Be; Van Hal, P; Van De Ven, M; Van Der Lee, I; Van Den Toorn, L; Urrutia Gajate, A; Urban, J; Ugarte Fornell, Lg; Tzouvelekis, A; Twohig, K; Turner, A; Trujillo, S; Triani, A; Traila, D; Torres, V; Tomioka, H; Tomii, K; Tomic, R; Toma, C; Tokgoz Akyil, F; Tobino, K; Tobar, R; Tiwari, A; Tibana, R; Tian, X; Thillai, M; Tham, W; Teo, F; Tekavec Trkanjec, J; Teixeira, P; Tarpey, D; Tapias, L; Tanizawa, K; Tanino, Y; Takada, T; Tabaj, G; Szolnoki, E; Swarnakar, R; Strambu, I; Sterclova, M; Spinks, K; Soo, Ci; Soltani, A; Solanki, S; Sobh, E; Soares, Mr; Smith, J; Smith, B; Slocum, P; Slabbynck, H; Sivokozov, I; Shifren, A; Shen, Sm; Sharp, C; Shanmuganathan, A; Sebastiani, A; Scarlata, S; Savas, R; Sasaki, S; Santeliz, J; Santana, Anc; Sanchez, R; Salinas, M; Saito, S; Ryan, F; Royo Prats, Ja; Rosi, E; Rokadia, H; Robles Perez, A; Rivera Ortega, P; Rio Ramirez, M; Righetti, S; Reichner, C; Ravaglia, C; Ratanawatkul, P; Ramalingam, V; Rajasekaran, A; Radzikowska, E; Ra, Sw; Quadrelli, S; Precerutti, J; Prasad, J; Popa, D; Pizzalato, S; Piotrowski, W; Pineiro, A; Piloni, D; Peros Golubicic, T; Perez, R; Pereira, C; Pereira, B; Perch, M; Patel, N; Patel, D; Papanikolaou, I; Papakosta, D; Panselinas, E; Pang, Yk; Pandya, P; Padrão, E; Ozdemir Kumbasar, O; Overbeek, Mj; Otto Minasian, A; O'Riordan, D; Ora, J; Oldham, J; Okutan, O; Ohshimo, S; Oguzulgen, Ik; Ogura, T; O'Donnell, T; O'Dochartaigh, C; O'Beirne, S; Novikova, L; Novelli, L; Noth, I; Nogueira Mendes Neto, N; Niroumand, M; Nieto, A; Neves, A; Nambiar, A; Nair, S; Nadama, R; Murtagh, E; Mura, M; Müller Quernheim, J; Mukhopadhyay, A; Mukherjee, S; Morisset, J; Moran, O; Mooney, J; Møller, J; Mogulkoc, N; Miyamoto, A; Milenkovic, B; Mette, S; Mejia, M; Mei, F; Mazzei, M; Matsuda, T; Mason, C; Martínez Francés, M; Mannarino, S; Mancuzo, E; Malli, F; Malhotra, P; Maillo, M; Maia, J; Mahdavian, M; Madsen, F; Luckhardt, T; Lucht, W; Low, Sy; Lopez Miguel, Cp; Lipchik, R; Levy, S; Levin, K; Lee, Kl; Lederer, D; Lammi, Mr; Kwan, Hy; Kukreja, S; Kruavit, A; Kotecki, M; Kolilekas, L; Knoop, H; Kiyan, E; Kishaba, T; King Biggs, M; Khor, Yh; Khan, A; Khalil, N; Kedia, R; Kebba, N; Kawano Dourado, L; Kapitan, K; Kan, Cd; Kalyoncu, Af; Kalluri, M; Kabasakal, Y; Jyothula, S; Juretschke, Ma; Jovanovic, D; Jonkers, R; Jo, H; Izumi, S; Ishii, H; Ikeda, S; Ibrahim, A; Hyldgaard, C; Hunninghake, G; Huie, T; Hufton, A; Hu, X; Hseih, Wc; Hoyos, R; Hoyles, R; Holguin Rodriguez, O; Hogan, Mp; Hodgson, U; Hilkin Sogoloff, H; Herrera, E; Henry, Bm; Hellemons, M; Hecimovic, A; Hayashi, R; Hart, S; Harari, S; Haney, S; Hambly, N; Hakkim, R; Gutiérrez, M; Gripaldo, R; Gomez, A; Goh, N; Godoy, R; Gilbert, C; Giannarakis, I; Gasparini, S; Garcha, P; Furtado, S; Fois, A; Flood Page, P; Fletcher, S; Fiss, E; Figueroa Casas, J; Figueroa Casas, M; Fiddler, Ca; Ferrara, G; Fernandez Casares, M; Felton, C; Faverio, P; Fabro, At; Estrada, A; Errhalt, P; Enomoto, N; Enghelmayer, Ji; El Kersh, K; Eiger, G; Dubaniewicz, A; Drakopanagiotakis, F; Disayabutr, S; Dijkstra, A; Diaz Patiño, Jc; Diaz Castañon, Jj; Dhooria, S; Dhasmana, Dj; De Rosa, M; De Luca, S; Delobbe, A; Delgado, D; Delgado, C; De La Fuente, I; De Kruif, M; De Gier, M; De Andrade, J; Davidsen, Jr; Daoud, B; Dalhoff, K; Cotera Solano, Jv; Costa, An; Coronel, S; Confalonieri, M; Conemans, L; Comellas, A; Colella, S; Clemente, S; Clark, J; Ciuffreda, M; Chung, Cl; Chong, Sg; Chirita, D; Chen, Pl; Chaudhuri, N; Chambers, D; Chalmers, G; Chairman, D; Chai, Gt; Chacon Chaves, R; Çetinsu, V; Ceruti, M; Ceballos Zuñiga, Co; Castillo, D; Carbone, Rg; Caminati, A; Callejas González, Fj; Butler, M; Bustos, C; Bukowczan, M; Buendia, I; Brunetti, G; Brockway, B; Bresser, P; Breseghello, J; Bouros, D; Botero Zaccour, Ja; Borzone, G; Borie, R; Blum, Hc; Blank, J; Biswas, A; Bennett, D; Benjamin, M; Belaconi, In; Beirne, P; Beckert, L; Bastiampillai, S; Bascom, R; Bartholmai, B; Barros, M; Ban, Ayl; Balestro, E; Baldi, B; Baddini Martinez, J; Baburao, A; Babu, S; Averyanov, A; Avdeev, S; Athanazio, R; Atahan, E; Asuquo, B; Assayag, D; Antuni, J; Antillon, S; Anderson, Kc; Anderson, A; Alwani, F; Altinisik, G; Alsouofi, N; Allam, Js; Al Jahdali, H; Al Farttoosi, A; Alfaro, T; Al Busaidi, N; Alavi Foumani, A; Agreda Vedia, Mg; Agarwal, A; Afridi, F; Adeyeye, Oo; Adegunsoye, A; Adamali, H; Abedini, A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/278823
Citazioni:
Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study / Walsh, S.L.F., Maher, T.m., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M.l., Antoniou, K., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T.j., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., Inoue, Y., et al.. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 1399-3003. - STAMPA. - 50:2(2017), pp. 1700936-1700946. [10.1183/13993003.00936-2017]

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study
Anno: 2017
Rivista: EUROPEAN RESPIRATORY JOURNAL
Autori/autrici: Walsh, Simon L F; Maher, Toby M; Kolb, Martin; Poletti, Venerino; Nusser, Richard; Richeldi, Luca; Vancheri, Carlo; Wilsher, Margaret L; Antoniou, Katerina M; Behr, Jüergen; Bendstrup, Elisabeth; Brown, Kevin; Calandriello, Lucio; Corte, Tamera J; Cottin, Vincent; Crestani, Bruno; Flaherty, Kevin; Glaspole, Ian; Grutters, Jan; Inoue, Yoshikazu; Kokosi, Maria; Kondoh, Yasuhiro; Kouranos, Vasileios; Kreuter, Michael; Johannson, Kerri; Judge, Eoin; Ley, Brett; Margaritopoulos, George; Martinez, Fernando J; Molina-Molina, Maria; Morais, António; Nunes, Hilario; Raghu, Ganesh; Ryerson, Christopher J; Selman, Moises; Spagnolo, Paolo; Taniguchi, Hiroyuki; Tomassetti, Sara; Valeyre, Dominique; Wijsenbeek, Marlies; Wuyts, Wim; Hansell, David; Wells, Athol; Mei, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/306221
Citazioni:
Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study / Walsh, S.L.F., Maher, T.M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M.L., Antoniou, K.M., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T.J., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., Inoue, Y., et al.. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 50:2(2017), p. 1700936. [10.1183/13993003.00936-2017]
Abstract:
We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of inters...titial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (kappa w). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (kappa w= 0.65, IQR 0.53-0.72, p&lt;0.0001) than academic physicians (kappa w= 0.56, IQR 0.45-0.65, p&lt;0.0001) or physicians with access to multidisciplinary team (MDT) meetings (kappa w=0.54, IQR 0.45-0.64, p&lt;0.0001). The prognostic accuracy of academic physicians with &gt;20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index= 0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index= 0.74 IQR 0.72-0.75).Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.
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Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial
Anno: 2017
Rivista: RESPIRATION
Autori/autrici: Bonifazi, Martina; Tramacere, I; Zuccatosta, L; Mei, Federico; Sediari, Michele; Paonessa, Mc; Gasparini, Stefano
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/250125
Citazioni:
Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial / Bonifazi, M., Tramacere, I., Zuccatosta, L., Mei, F., Sediari, M., Paonessa, M.c., Gasparini, S.. - In: RESPIRATION. - ISSN 0025-7931. - ELETTRONICO. - (2017). [10.1159/000475843]
Abstract:
BACKGROUND: Conventional transbronchial needle aspiration (c-TBNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are both valuable diagnostic techniques for the diagnosis of hilar/mediastinal lesions. Although a superiority of EBUS-TBNA over c-TBNA may be expected..., evidence-based data on a direct comparison between these 2 procedures are still lacking. OBJECTIVES: We aimed to test the superiority of EBUS-TBNA over c-TBNA in a randomized trial and to evaluate the cost-effectiveness profile of a staged strategy, including c-TBNA as initial test followed by EBUS-TBNA, in case of inconclusive results at rapid on-site evaluation. METHODS: Eligible patients were randomized 1:1 to either the EBUS-TBNA or c-TBNA group. The primary endpoint was to test the superiority of EBUS-TBNA sensitivity over c-TBNA. The secondary endpoints included the sensitivity of the staged strategy, as well as costs and safety related to each procedure and to their sequential combination. RESULTS: A total of 253 patients were randomized to either EBUS-TBNA (n = 127) or c-TBNA (n = 126), and 31 patients of the c-TBNA group subsequently underwent EBUS-TBNA. The sensitivity of EBUS-TBNA was higher, but not significantly superior to that of c-TBNA (respectively. 92% [95% CI 87-97] and 82% [95% CI 75-90], p > 0.05). The sensitivity of the staged strategy was 94% (95% CI 89-98). No major adverse events occurred. CONCLUSIONS: EBUS-TBNA was the single best diagnostic tool, although not significantly superior to c-TBNA. Due to the favorable cost-effectiveness profile of their sequential combination, in selected scenarios with a high probability of success from the standard procedure, these should not be necessarily intended as competitive and the staged strategy could be considered in clinical practice.
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Fibroelastosi pleuroparenchimale familiare diagnosticata mediante criobiopsia polmonare
Anno: 2015
Rivista: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO
Autori/autrici: Mei, Federico; Bonifazi, Martina; Barbisan, Francesca; Rossi, Giulio; Zuccatosta, Lina; Lacedonia, Donato; Barbaro, Maria Pia Foschino; Gasparini, Stefano
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/229763
Citazioni:
Fibroelastosi pleuroparenchimale familiare diagnosticata mediante criobiopsia polmonare / Mei, F., Bonifazi, M., Barbisan, F., Rossi, G., Zuccatosta, L., Lacedonia, D., Barbaro, M.P.F., Gasparini, S.. - In: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO. - ISSN 0033-9563. - STAMPA. - 30:5(2015), pp. 289-293.

The role of the Pulmonologist in rapid on-site cytological evaluation of transbronchial needle aspiration: a prospective study.
Anno: 2014
Rivista: CHEST
Autori/autrici: Bonifazi, Martina; Sediari, M; Ferretti, M; Poidomani, G; Tramacere, I; Mei, F; Zuccatosta, L; Gasparini, Stefano
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/164120
Citazioni:
The role of the Pulmonologist in rapid on-site cytological evaluation of transbronchial needle aspiration: a prospective study / Bonifazi, M., Sediari, M., Ferretti, M., Poidomani, G., Tramacere, I., Mei, F., Zuccatosta, L., Gasparini, S.. - In: CHEST. - ISSN 0012-3692. - STAMPA. - 145:1(2014), pp. 60-65. [10.1378/chest.13-0756]

Gastrointestinal motility disorder assessment in systemic sclerosis
Anno: 2013
Rivista: RHEUMATOLOGY
Autori/autrici: Savarino, Edoardo; Mei, Federico; Parodi, Andrea; Ghio, Massimo; Furnari, Manuele; Gentile, Adelina; Berdini, Michela; Di Sario, Antonio; Bendia, Emanuele; Bonazzi, Patrizia; Scarpellini, Emidio; Laterza, Lucrezia; Savarino, Vincenzo; Gasbarrini, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305322
Citazioni:
Gastrointestinal motility disorder assessment in systemic sclerosis / Savarino, E., Mei, F., Parodi, A., Ghio, M., Furnari, M., Gentile, A., Berdini, M., Di Sario, A., Bendia, E., Bonazzi, P., Scarpellini, E., Laterza, L., Savarino, V., Gasbarrini, A.. - In: RHEUMATOLOGY. - ISSN 1462-0332. - 52:6(2013), pp. 1095-1100. [10.1093/rheumatology/kes429]
Abstract:
SSc is a clinically heterogeneous and generalized disease, characterized by thickness of the connective tissue of the skin and internal organs, such as the digestive tract, impairing gastrointestinal (GI) motility. Our aim is to evaluate retrospectively abnormalities of oesophageal motility, gastric... emptying, oro-cecal transit time (OCTT) and small intestine bacterial overgrowth (SIBO) in a large cohort of SSc patients.
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Successful diagnosis of bilateral pulmonary nodules using electromagnetic navigation bronchoscopy.
Anno: 2012
Rivista: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO
Autori/autrici: Zuccatosta, L; Bonifazi, Martina; Sediari, M; Mei, F; Gasparini, Stefano
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83682
Citazioni:
Successful diagnosis of bilateral pulmonary nodules using electromagnetic navigation bronchoscopy / Zuccatosta, L., Bonifazi, M., Sediari, M., Mei, F., Gasparini, S.. - In: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO. - ISSN 0033-9563. - 27:1(2012), pp. 52-54.

Il trattamento broncoscopico dell'enfisema. Stato dell'arte.
Anno: 2010
Rivista: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO
Autori/autrici: Gasparini, Stefano; Mei, F; Zuccatosta, L; Sediari, M.
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83692
Citazioni:
Il trattamento broncoscopico dell'enfisema. Stato dell'arte / Gasparini, S., Mei, F., Zuccatosta, L., Sediari, M.. - In: RASSEGNA DI PATOLOGIA DELL’APPARATO RESPIRATORIO. - ISSN 0033-9563. - 25:5(2010), pp. 280-292.

Stenting right main bronchus with montgomery T tube for upper lobe ventilation
Anno: 2010
Rivista: JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
Autori/autrici: Deshmukh, Vikrant; Zuccatosta, Lina; Sediari, Michele; Mei, Federico; Gasparini, Stefano; Salvolini, Luca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/306166
Citazioni:
Stenting right main bronchus with montgomery T tube for upper lobe ventilation / Deshmukh, V., Zuccatosta, L., Sediari, M., Mei, F., Gasparini, S., Salvolini, L.. - In: JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY. - ISSN 1944-6586. - 17:1(2010), pp. 90-92. [10.1097/LBR.0b013e3181cd361a]
Abstract:
The involvement of the right main bronchus (RMB) along with the upper lobe bronchus and bronchus intermedius by malignant tumor is frequently encountered. However, the use of a stent for palliation of airway stenosis of the RMB might obstruct upper lobe orifice and pose complications such as atelect...asis or recurrent pneumonia. We report the use of modified Montgomery T tube in a 78-year-old man with neoplasm of the RMB by placing the tracheostomy arm of the T tube in the upper lobe bronchus to maintain its patency.
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Pilot feasibility study of transbronchial needle forceps: a new tool for obtaining histology samples from mediastinal subcarinal lymph nodes
Anno: 2009
Rivista: JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
Autori/autrici: Gasparini, Stefano; Zuccatosta, Lina; Sediari, Michele; Mei, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/306220
Citazioni:
Pilot feasibility study of transbronchial needle forceps: a new tool for obtaining histology samples from mediastinal subcarinal lymph nodes / Gasparini, S., Zuccatosta, L., Sediari, M., Mei, F.. - In: JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY. - ISSN 1944-6586. - 16:3(2009), pp. 183-187. [10.1097/LBR.0b013e3181afde66]
Abstract:
BACKGROUND: Cutting transbronchial histology needles to obtain tissue cores from hilar/mediastinal lymph nodes or masses adjacent to the tracheobronchial tree are able to provide adequate histology tissue samples in only 38% to 78% of cases. The aim of this pilot study was to evaluate the efficacy a...nd safety of a new instrument developed to obtain a fragment of a tissue for histologic diagnosis of enlarged subcarinal lymph nodes.METHODS: The transbronchial needle forceps (TBNF) is a sampling instrument that combines the characteristics of a needle (beveled tip for penetrating through the bronchial wall) with that of a forceps (2 serrated jaws for grasping the biopsy). The external diameter of the needle forceps is 1.5mm.RESULTS: Fourteen patients (11 male, 3 female; mean age: 51y) with subcarinal lymph node enlargement greater than 2cm in short axis were included in this pilot study. TBNF provided tissue for histologic diagnosis in 8 patients (57.1%). In 4 patients (28.5%) TBNF could not be inserted through the bronchial wall. For patients in whom it was possible to insert the TBNF, a tissue core adequate for histologic examination was obtained in 9 (90%) and a diagnosis in 8 (80%) (non-small-cell lung cancer in 3, sarcoidosis in 2, small cell lung cancer in 1, tuberculosis in 1, and Hodgkin lymphoma in 1). No clinically significant procedure-related complications were encountered.CONCLUSIONS: This study demonstrates that, when insertion through the bronchial wall is possible, TBNF safely provides diagnostic histologic specimens of subcarinal lymphadenopathy in a large percentage of cases.
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