The MIGHTY project (P2022ASXKR): demographic and health status profiles among migrants and non-migrants in a region of central Italy between 2011-2023 using Healthcare Utilization Databases
Anno: 2026
Rivista: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Faragalli, Andrea; Pompili, Marco; Carle, Flavia; Skrami, Edlira; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357312
Citazioni:
The MIGHTY project (P2022ASXKR): demographic and health status profiles among migrants and non-migrants in a region of central Italy between 2011-2023 using Healthcare Utilization Databases / Iommi, M., Faragalli, A., Pompili, M., Carle, F., Skrami, E., Gesuita, R.. - In: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH. - ISSN 2282-0930. - 21:1(2026), pp. 67-75. [10.54103/2282-0930/30105]
Abstract:
Background Accurate identification of migrants using Healthcare Utilization Databases (HUDs) remains challenging, as citizenship and place of birth may classify residents differently. This study compared two migrant identification criteria and assessed their impact on demographic and health status ...estimates in an Italian region. Methods A population-based observational study was conducted in the Marche Region (Central Italy), including all residents between 2011 and 2023. The HUDs used were the Regional Beneficiaries Database (RBD), the Hospital Discharge Records, and the Drug Prescriptions Database. Migrants were classified using RBD’s country of birth (RBD birth criterion) and citizenship (RBD citizenship criterion), distinguishing Italians (Ita-Marche), migrants from High Migratory Pressure Countries (HMPC), and from Highly Developed Countries. Agreement between criteria was assessed using Cohen’s k. Health status was evaluated in residents aged ≥50 years using the Multisource Comorbidity Score (MCS). Results Using RBD birth criterion, 88.6% of residents were classified as Ita-Marche, 10.0% as HMPC, and 1.4% as HDC; using RBD citizenship criterion, these proportions shifted to 92.1%, 7.6%, and 0.3%, respectively. Agreement was moderate (k between 0.67-0.70). HMPC residents were notably younger and showed a more favourable health profile: 67% had MCS equal to 0 vs 45% among Ita-Marche, while multimorbidity (MCS ≥5) was lower (9% vs 21.5%). Similar patterns emerged using both criteria. Conclusion Different migrant identification criteria in HUDs lead to variations in population estimates and health indicators. The study provides updated and detailed overview of the demographic structure and comorbidity profiles of Marche’s residents, supporting health policy and service planning.
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Hospital Care Utilization Patterns Among Migrants and Natives in a Central Italian Region between 2011 and 2023: Findings from the MIGHTY Project (P2022ASXKR)
Anno: 2026
Rivista: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Skrami, Edlira; Faragalli, Andrea; Pompili, Marco; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357313
Citazioni:
Hospital Care Utilization Patterns Among Migrants and Natives in a Central Italian Region between 2011 and 2023: Findings from the MIGHTY Project (P2022ASXKR) / Iommi, M., Skrami, E., Faragalli, A., Pompili, M., Carle, F., Gesuita, R.. - In: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH. - ISSN 2282-0930. - 21:1(2026), pp. 91-99. [10.54103/2282-0930/30354]
Abstract:
Background: Migration has reshaped the demographic profile of Italian regions, yet evidence on differences in hospital care utilisation between migrant and native populations remains limited, particularly over long periods and across full population cohorts. This study evaluates hospital admissions... in the Marche Region from 2011 to 2023 according to citizenship. Methods A population-based longitudinal study was conducted using Healthcare Utilization Databases on residents of Marche Region, comparing Italian residents with migrants from High Migratory Pressure Countries (HMPC) and Highly Developed Countries (HDC). Age-standardised all-cause, avoidable, and cause-specific hospital admission rates were estimated. Temporal trends were assessed through Poisson regression models. Hospital care utilisation was evaluated using two-step models: logistic regression for the probability of being hospitalized and Poisson regression for the frequency of admissions among hospitalised individuals. Results Across 1.52 million person-years and 2.86 million admissions, HMPC and HDC residents consistently showed lower all-cause, avoidable, and cause-specific admission rates than Italians. Hospitalisations declined over time for all groups, with a marked drop in 2020. Avoidable hospitalisations decreased by 42% in the post-pandemic period. Migrants showed a dual pattern: lower probability of being hospitalised (Odds Ratio, 95% CI: HMPC 0.79, 0.75-0.76; HDC 0.53, 0.51-0.56), but higher admission frequency among those hospitalised (Rate Ratio, 95% CI: HMPC 1.10, 1.09-1.10; HDC 1.04, 1.01-1.07) than Italians. Conclusion Migrant populations in Marche show lower hospitalisation rates but higher utilisation once admitted, suggesting possible barriers to early or appropriate access. Monitoring hospital use through administrative databases is essential to identify potential inequities and guide targeted interventions.
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Epidemiology of coeliac disease in children and adolescents with type 1 diabetes: a 13-year population-based study using secondary data sources
Anno: 2026
Rivista: DIABETES RESEARCH AND CLINICAL PRACTICE
Autori/autrici: Fontanarosa, Alessandro; Iommi, Marica; Cesanelli, Federico; Pompei, Andrea; Pompili, Marco; Carle, Flavia; Skrami, Edlira; Cherubini, Valentino; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357333
Citazioni:
Epidemiology of coeliac disease in children and adolescents with type 1 diabetes: a 13-year population-based study using secondary data sources / Fontanarosa, A., Iommi, M., Cesanelli, F., Pompei, A., Pompili, M., Carle, F., Skrami, E., Cherubini, V., Gesuita, R.. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - 236:(2026). [10.1016/j.diabres.2026.113238]
Abstract:
Aims: To study the epidemiology of Coeliac Disease (CD) in the general paediatric population and among children with Type 1 Diabetes (T1D) in a population of Central Italy, and to assess the temporal trends of these two chronic conditions. Methods: A population-based longitudinal study on children a...ged < 15 was conducted using Healthcare Utilization Databases of the Marche Region, 2011–2023. Prevalent and incident cohorts of T1D and CD were identified using hospital discharges, drug prescriptions, and healthcare exemption databases. Prevalence ratios (PR), incidence rate ratios (IRR), temporal trends, and cumulative CD risk after T1D diagnosis were assessed with 95% confidence intervals (CI). Results: Overall 13-year period prevalences of T1D and CD were 1.65‰ and 5.28‰, respectively. CD prevalence among children with T1D was 97.7‰, 18-fold higher than in the general population (PR 18.6; 95%CI 14.3–24.0). CD incidence was 65 per 100,000 person-years in the general population and 2,410 per 100,000 person-years among children with newly diagnosed T1D (IRR 37.0; 95%CI 24.7–55.4). The six-year cumulative probability of developing CD in the T1D cohort was 10.3% (95%CI: 6.2%-14.3%). Conclusions: Children with T1D have a markedly increased risk of CD, particularly in the first years after diagnosis, supporting systematic CD screening in this high-risk population.
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Persistence burden and poor survival of pleural mesothelioma in central Italy, 2013–2022: a population-based study thirty years after asbestos ban
Anno: 2026
Rivista: BMC PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Bonifazi, Martina; Sarti, Donatella; Mei, Federico; Franchi, Matteo; Rossi, Marta; Pompili, Marco; Prospero, Emilia; Carle, Flavia; Gesuita, Rosaria; Skrami, Edlira
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/357352
Citazioni:
Persistence burden and poor survival of pleural mesothelioma in central Italy, 2013–2022: a population-based study thirty years after asbestos ban / Iommi, M., Bonifazi, M., Sarti, D., Mei, F., Franchi, M., Rossi, M., Pompili, M., Prospero, E., Carle, F., Gesuita, R., Skrami, E.. - In: BMC PUBLIC HEALTH. - ISSN 1471-2458. - 26:(2026). [10.1186/s12889-026-26903-6]
Abstract:
Background: Pleural Mesothelioma (PM) is an asbestos-related cancer with poor prognosis. Despite the 1992 national asbestos ban, new cases continue to occur due to the long latency of the disease. The study aim was to evaluate incidence and survival trends of pleural mesothelioma in the Marche Regio...n, central Italy, between 2013 and 2022. Methods: This population-based incidence study included adult residents of the Marche Region between 2013 and 2022. Incident PM cases were identified from the Cancer Registry of Marche Region. Incidence rates per 100,000 person-years (py) were calculated and stratified by sex, age, and province of residence. Temporal trend and covariates effect were assessed with Poisson regression. Overall survival was estimated using the Kaplan-Meier method and compared across subgroups; adjusted hazard ratios (HR) were obtained from multiple Cox regression model. Results: Between 2013 and 2022, there were 322 incident PM cases (82% male; median age 77 years). The crude incidence rate was 2.1 per 100,000 py (95% CI: 1.9–2.4), with no temporal change over the study period. The highest rates were observed in men, in age-group 75–79 years, and in the province of Ancona. One- and five-year survival rates were 48.8% and 8.3%, respectively. Older age and non-epithelioid histology were independently associated with higher mortality. Conclusions: The incidence of pleural mesothelioma in the Marche Region remained stable between 2013 and 2022, with a peak in 2018 requiring further observation to confirm it. The persistently high burden among men, older adults, and those living in industrialized coastal areas reflects the legacy of historical asbestos exposure. Continued population-based surveillance, integrated with follow-up of previously exposed workers, remains essential to monitor disease trends and support timely diagnosis and appropriate care pathways.
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Evaluating cross-country applicability of morbidity scores: validation of the Multisource Comorbidity Score in Catalonia
Anno: 2026
Rivista: EUROPEAN JOURNAL OF PUBLIC HEALTH
Autori/autrici: Fontanarosa, Alessandro; Carle, Flavia; Papa, Roberta; Pompili, Marco; Corrao, Giovanni; Valero-Bover, Damià; Roca, Josep; González-Colom, Rubèn; Skrami, Edlira
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/354652
Citazioni:
Evaluating cross-country applicability of morbidity scores: validation of the Multisource Comorbidity Score in Catalonia / Fontanarosa, A., Carle, F., Papa, R., Pompili, M., Corrao, G., Valero-Bover, D., Roca, J., González-Colom, R., Skrami, E.. - In: EUROPEAN JOURNAL OF PUBLIC HEALTH. - ISSN 1101-1262. - 36:2(2026). [10.1093/eurpub/ckag022]
Abstract:
Multimorbidity places increasing pressure on healthcare systems, requiring effective tools to assess clinical complexity. Existing comorbidity indices are often setting-specific and lack generalizability. The Multisource Comorbidity Score (MCS), developed in Italy, has shown strong predictive value.... This study aimed to externally validate MCS and to test recalibrated and context-adapted versions to enhance its performance in a different healthcare system. A longitudinal observational study included 198 753 residents aged >= 50 in the Barcelona-Esquerra health district, followed between 2016 and 2019. The original MCS was validated, and two adapted versions were tested: a recalibrated MCS with locally derived weights and an enhanced MCS incorporating primary care data. Predictive validity for 1-year mortality (primary outcome) and secondary outcomes (4-year mortality, hospitalizations, and healthcare use) was assessed using the Area Under the Receiver Operating Characteristic (AUROC) curve, survival analysis, and net reclassification improvement (NRI). All MCS versions showed good discrimination. AUROCs for 1-year mortality were 0.742 (original), 0.756 (recalibrated), and 0.771 (enhanced). Adapted versions achieved better risk reclassification and higher discrimination for long-term mortality. Higher MCS scores were associated with progressively lower survival probabilities and increased healthcare resource utilization. The MCS demonstrated satisfactory external validity in the validation context, with adapted versions offering modest improvements.
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2025: XIIIth SISMEC National Congress - Book of Abstracts - Vol. 20 Supplementary Issue 1
Anno: 2025
Rivista: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH
Autori/autrici: Fontanarosa, Alessandro; Carle, Flavia; Papa, Roberta; Pompili, Marco; Corrao, Giovanni; Valero-Bove, Damià; Roca, Josep; González-Colom, Rubèn; Skrami, Edlira
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/349074
Citazioni:
2025: XIIIth SISMEC National Congress - Book of Abstracts - Vol. 20 Supplementary Issue 1 / Fontanarosa, A., Carle, F., Papa, R., Pompili, M., Corrao, G., Valero-Bove, D., Roca, J., González-Colom, R., Skrami, E.. - In: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH. - ISSN 2282-0930. - (2025). [10.54103/2282-0930/sismec13]

Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection
Anno: 2025
Rivista: SCIENTIFIC REPORTS
Autori/autrici: Skrami, Edlira; Faragalli, Andrea; Iommi, Marica; Morbidoni, Marco; Mancini, Cristina; Guidi, Antonella; Cardone, Annalisa; Pompili, Marco; Serafini, Pietro; Appignanesi, Remo; Ferrante, Luigi; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/341733
Citazioni:
Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection / Skrami, E., Faragalli, A., Iommi, M., Morbidoni, M., Mancini, C., Guidi, A., Cardone, A., Pompili, M., Serafini, P., Appignanesi, R., Ferrante, L., Carle, F.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 15:1(2025). [10.1038/s41598-024-84100-0]
Abstract:
Healthcare Workers (HCWs) are at ongoing risk of SARS-CoV-2 infection, potentially contributing to its transmission. This study assessed full vaccination and vaccination timeliness impact on SARS-CoV-2 infections among HCWs in Italy’s Marche Region, using Healthcare Utilization Databases. We e...valuated vaccination coverage and its associated factors. The cohort comprised 21,118 HCWs aged 18–70 from the region’s five Local Health Authorities (LHA), enrolled between February 2020 - May 2021. Factors associated with full vaccination were assessed using multiple logistic regression. The impact of vaccination status, time to vaccination, occupational role, age, gender, and health status on infection risk was analysed with a multiple Cox regression model, adjusting for vaccination coverage velocity, swabbing probability, and monthly intensive care unit admissions rate in each LHA. Of the cohort, 81.2% were fully vaccinated. Factors associated with full vaccination included age, role, LHA, prior infection, and health status. Vaccination reduced infection risk by 77% (95% CI: 70–82). Infection risk was higher among healthcare assistants, nurses/physiotherapists/technicians compared to physicians, among male HCWs, and it decreased as vaccination timeliness increased. Vaccination timeliness is crucial for reducing SARS-CoV-2 infection risk among HCWs, regardless of their characteristics. This underscores the importance of efficiently organizing vaccination administration across different territories and for all HCW categories.
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Do machine learning methods solve the main pitfall of linear regression in dental age estimation?
Anno: 2025
Rivista: FORENSIC SCIENCE INTERNATIONAL
Autori/autrici: Faragalli, Andrea; Ferrante, Luigi; Angelakopoulos, Nikolaos; Cameriere, Roberto; Skrami, Edlira
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/341732
Citazioni:
Do machine learning methods solve the main pitfall of linear regression in dental age estimation? / Faragalli, A., Ferrante, L., Angelakopoulos, N., Cameriere, R., Skrami, E.. - In: FORENSIC SCIENCE INTERNATIONAL. - ISSN 0379-0738. - 367:(2025). [10.1016/j.forsciint.2024.112353]
Abstract:
Introduction: Age estimation is crucial in forensic and anthropological fields. Teeth, are valued for their resilience to environmental factors and their preservation over time, making them essential for age estimation when other skeletal remains deteriorate. Recently, Machine Learning algorithms ha...ve been used in age estimation, demonstrating high levels of accuracy. However, their precision with respect to the trend of age estimation error, typical in some traditional methods like linear regression, has not been thoroughly investigated. Aim: To evaluate and compare the performance of frequently used Machine Learning-assisted methods against two traditional age estimation methods, linear regression and the Segmented Normal Bayesian Calibration model. Methods: Overall, 1.949 orthopantomographs from black and white South African children aged 5–14 years, with 49 % males, were evaluated. The performance of Random Forest, Support Vector Regression, K-Nearest Neighbors and the Gradient Boosting Method were compared against traditional linear regression and the Segmented Normal Bayesian Calibration model. The comparison was based on accuracy measures, including Mean Absolute Error and Root Mean Squared Error, and precision measures, including the Inter-Quartile Range of the error distribution and the slope of the estimated age error relative to chronological age. Results: The Machine Learning methods outperformed linear regression and the Segmented Normal Bayesian Calibration models in terms of accuracy, although the differences were small. Gradient Boosting Method and Support Vector Regression achieved the highest levels of accuracy (Mean Absolute Error: 0.69 years, Root Mean Squared Error: 0.85 years). All Machine Learning methods and linear regression exhibited significant bias in residuals, whereas the Segmented Normal Bayesian Calibration model showed no significant bias. Gender-stratified analyses revealed similar results in terms of the accuracy and precision of all considered models. Conclusion: Although Machine Learning methods demonstrate high levels of accuracy, they may be prone to trends in error distribution when estimating dental age. Evaluating this error is crucial and should be an integral part of model performance evaluation. Future research should aim to improve accuracy while rigorously addressing systematic biases.
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Celichia nei bambini con diabete di tipo 1 nelle Marche: risultato di uno studio di popolazione basato sui flussi sanitari
Anno: 2024
Autori/autrici: Fontanarosa, Alessandro; Iommi, Marica; Cesanelli, Federico; Pompei, Andrea; Faragalli, Andrea; Pompili, Marco; Skrami, Edlira; Cherubini, Valentino; Carle, Flavia; Gesuita, Rosaria
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/331373
Citazioni:
Celichia nei bambini con diabete di tipo 1 nelle Marche: risultato di uno studio di popolazione basato sui flussi sanitari / Fontanarosa, A., Iommi, M., Cesanelli, F., Pompei, A., Faragalli, A., Pompili, M., Skrami, E., Cherubini, V., Carle, F., Gesuita, R.. - (2024).

IMPATTO DELLA PANDEMIA DA SARS-COV2 SUGLI ACCESSI AL PRONTO SOCCORSO DELL'AZIENDA OSPEDALIERO UNIVERSITARIA DELLE MARCHE: UN MODELLO DI SERIE STORICA INTERROTTA
Anno: 2023
Autori/autrici: Fontanarosa, Alessandro; Skrami, Edlira; Salvi, Aldo; Contucci, Susanna; Ferrante, Luigi; Carle, Flavia
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/331469
Citazioni:
IMPATTO DELLA PANDEMIA DA SARS-COV2 SUGLI ACCESSI AL PRONTO SOCCORSO DELL'AZIENDA OSPEDALIERO UNIVERSITARIA DELLE MARCHE: UN MODELLO DI SERIE STORICA INTERROTTA / Fontanarosa, A., Skrami, E., Salvi, A., Contucci, S., Ferrante, L., Carle, F.. - (2023).

Combining Bayesian Calibration and Copula Models for Age Estimation
Anno: 2023
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Faragalli, Andrea; Skrami, Edlira; Bucci, Andrea; Gesuita, Rosaria; Cameriere, Roberto; Carle, Flavia; Ferrante, Luigi
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315448
Citazioni:
Combining Bayesian Calibration and Copula Models for Age Estimation / Faragalli, A., Skrami, E., Bucci, A., Gesuita, R., Cameriere, R., Carle, F., Ferrante, L.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 20:2(2023). [10.3390/ijerph20021201]
Abstract:
Accurately estimating and predicting chronological age from some anthropometric characteristics of an individual without an identity document can be crucial in the context of a growing number of forced migrants. In the related literature, the prediction of chronological age mostly relies upon the us...e of a single predictor, which is usually represented by a dental/skeletal maturity index, or multiple independent ordinal predictor (stage of maturation). This paper is the first attempt to combine a robust method to predict chronological age, such as Bayesian calibration, and the use of multiple continuous indices as predictors. The combination of these two aspects becomes possible due to the implementation of a complex statistical tool as the copula. Comparing the forecasts from our copula-based method with predictions from an independent model and two single predictor models, we showed that the accuracy increased.
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Identification of multinucleated cells in human kidney cortex: A way for tissue repairing?
Anno: 2022
Rivista: JOURNAL OF ANATOMY
Autori/autrici: Fantone, Sonia; Tossetta, Giovanni; Graciotti, Laura; Galosi, Andrea Benedetto; Skrami, Edlira; Marzioni, Daniela; Morroni, Manrico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/296887
Citazioni:
Identification of multinucleated cells in human kidney cortex: A way for tissue repairing? / Fantone, S., Tossetta, G., Graciotti, L., Galosi, A.B., Skrami, E., Marzioni, D., Morroni, M.. - In: JOURNAL OF ANATOMY. - ISSN 0021-8782. - ELETTRONICO. - 240:5(2022), pp. 985-990. [10.1111/joa.13595]
Abstract:
The presence of multinucleated cells has never been demonstrated in renal tissue, although, polyploid cells were recently observed in the tubules of normal and pathological human kidney. Therefore, the aim of the present study is to identify and quantify, by electron microscopy, multinucleated cells... in the cortical tissue of normal human kidney i.e., in the three compartments of renal tubule: the proximal tubule (PT), the distal tubule (DT), and the collecting duct (CD), as well as, in the glomerulus (podocytes). The percentage of the multinucleated cells observed was 5% (95%CI: 3.6%–6.7%) in renal cortical tubules with distribution in each tubular compartment of 6% in PT, 4% in DT and 3% in CD with no statistically significant difference in the distribution of multinucleated cells according to tubular compartments. Four percent of analysed podocytes (in total 149 podocytes) were multinucleated (95%CI: 1.5%−8.6%). In conclusion, multinucleated cells were identified and quantified in functionally normal kidneys, as previously demonstrated in other organs such as the liver.
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Validity of age estimation methods and reproducibility of bone/dental maturity indices for chronological age estimation: a systematic review and meta-analysis of validation studies
Anno: 2022
Rivista: SCIENTIFIC REPORTS
Autori/autrici: Marconi, V; Iommi, M; Monachesi, C; Faragalli, A; Skrami, E; Gesuita, R; Ferrante, L; Carle, F
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/329470
Citazioni:
Validity of age estimation methods and reproducibility of bone/dental maturity indices for chronological age estimation: a systematic review and meta-analysis of validation studies / Marconi, V., Iommi, M., Monachesi, C., Faragalli, A., Skrami, E., Gesuita, R., Ferrante, L., Carle, F.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 12:1(2022). [10.1038/s41598-022-19944-5]
Abstract:
Several approaches have been developed to estimate age, an important aspect of forensics and orthodontics, using different measures and radiological examinations. Here, through meta-analysis, we determined the validity of age estimation methods and reproducibility of bone/dental maturity indices use...d for age estimation. The PubMed and Google Scholar databases were searched to December 31, 2021 for human cross-sectional studies meeting pre-defined PICOS criteria that simultaneously assessed the reproducibility and validity. Meta-estimates of validity (mean error: estimated age-chronological age) and intra- and inter-observer reproducibility (Cohen's kappa, intraclass correlation coefficient) and their predictive intervals (PI) were calculated using mixed-effect models when heterogeneity was high (I-2 > 50%). The literature search identified 433 studies, and 23 met the inclusion criteria. The mean error meta-estimate (mixed effects model) was 0.08 years (95% CI - 0.12; 0.29) in males and 0.09 (95% CI - 0.12; 0.30) in females. The PI of each method spanned zero; of nine reported estimation methods, Cameriere's had the smallest (- 0.82; 0.47) and Haavikko's the largest (- 7.24; 4.57) PI. The reproducibility meta-estimate (fixed effects model) was 0.98 (95% CI 0.97; 1.00) for intra- and 0.99 (95% CI 0.98; 1.00) for inter-observer agreement. All methods were valid but with different levels of precision. The intra- and inter-observer reproducibility was high and homogeneous across studies.
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Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Iommi, Marica; Bonifazi, Martina; Faragalli, Andrea; Latini, Lara Letizia; Mei, Federico; Spazzafumo, Liana; Skrami, Edlira; Ferrante, Luigi; Carle, Flavia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/296112
Citazioni:
Occurrence of Idiopathic Pulmonary Fibrosis in Italy: Latest Evidence from Real-World Data / Iommi, M., Bonifazi, M., Faragalli, A., Latini, L.L., Mei, F., Spazzafumo, L., Skrami, E., Ferrante, L., Carle, F., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:5(2022). [10.3390/ijerph19052510]
Abstract:
The aim of the study was to evaluate the trend in the incidence of idiopathic pulmonary fibrosis (IPF) in a real-world setting of the Marche region, a region of Central Italy, between 2014 and 2019. This observational prospective study was based on administrative databases of hospital discharges and... drug prescriptions. All adult residents in the Marche Region with a first prescription of antifibrotic drugs, or a first hospitalization with a diagnosis of IPF during the study period, were identified as incident cases of IPF. A multiple Poisson regression analysis was used to estimate the IPF incidence trend, adjusted for age, sex, and health conditions. The mean incidence rate was 9.8 cases per 100,000 person-years. A significant increasing trend of 6% per year was observed. The incidence rates were significantly higher in males than females, older subjects, and those with poorer health conditions. To our knowledge, this is the first study evaluating incidences of IPF over a 6-year period in Italy, combining hospital discharge and drug prescription databases. The study highlights that the combined use of two secondary sources is a reliable strategy to accurately identify new cases of IPF when the appropriate disease registry is lacking.
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The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies
Anno: 2022
Rivista: ANDROLOGY
Autori/autrici: Giulioni, Carlo; Maurizi, Valentina; Castellani, Daniele; Scarcella, Simone; Skrami, Edlira; Balercia, Giancarlo; Galosi, Andrea Benedetto
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305364
Citazioni:
The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies / Giulioni, C., Maurizi, V., Castellani, D., Scarcella, S., Skrami, E., Balercia, G., Galosi, A.B.. - In: ANDROLOGY. - ISSN 2047-2927. - 10:7(2022), pp. 1250-1271. [10.1111/andr.13228]
Abstract:
Background: The environment plays a key role in male infertility, changing the incidence in various populations, and pesticides are one of the most studied hazards. The use of the latter has never decreased, jeopardizing the safety of workers and the general population. Objective: Our purpose was to... summarize the results of studies discussing the association between pesticides and male fertility. Methods: A comprehensive literature search was performed through MEDLINE via PubMed, Scopus, and Web of Science. Only human studies were considered. Semen parameters and DNA integrity were considered to evaluate the effect of pesticides on men. Results: A total of 64 studies that investigated their impact in terms of semen parameters (51 studies) and chromatin and DNA integrity (25 studies) were included. The most frequently affected parameters were total sperm count, sperm motility, and sperm morphology, although a reduction in ejaculate volume and concentration occur in several cases. A tangible worsening of semen quality was associated with organochlorines and organophosphates. Furthermore, pesticide exposure, especially pyrethroids, was related to a higher DNA fragmentation index and chromosome aneuploidy in most articles. Conclusion: The epidemiological evidence supports the association between pesticides and male fertility for workers and the exposed population in terms of semen quality, DNA fragmentation, and chromosome aneuploidy.
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Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)
Anno: 2021
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Bonifazi, Martina; Mei, Federico; Skrami, Edlira; Latini, Lara Letizia; Amico, Donatella; Balestro, Elisabetta; Bini, Francesco; Bonifazi, Floriano; Caminati, Antonella; Candoli, Piero; Cinti, Saverio; Contucci, Susanna; Di Marco Berardino, Alessandro; Harari, Sergio; Levi, Guido; Lococo, Sara; Menditto, Vincenzo; Marchetti, Giampietro; Piciucchi, Sara; Poletti, Venerino; Ravaglia, Claudia; Saetta, Marina; Svegliati-Baroni, Gianluca; Tomassetti, Sara; Tamburrini, Mario; Zanforlin, Alessandro; Zuccon, Umberto; Zuccatosta, Lina; Gasparini, Stefano; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290062
Citazioni:
Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50) / Bonifazi, M., Mei, F., Skrami, E., Latini, L.L., Amico, D., Balestro, E., Bini, F., Bonifazi, F., Caminati, A., Candoli, P., Cinti, S., Contucci, S., Di Marco Berardino, A., Harari, S., Levi, G., Lococo, S., Menditto, V., Marchetti, G., Piciucchi, S., Poletti, V., et al.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - ELETTRONICO. - 10:6(2021). [10.3390/jcm10061218]
Abstract:
Obesity as well as metabolic and cardiovascular comorbidities are established, significant predictors of worse prognosis in the overall COVID-19 population, but limited information is available on their roles in young and middle-aged adults (aged ≤ 50 years). The main objectives of the present It...alian multi-center study were to describe clinical characteristics and role of selected prognostic predictors in a large cohort of young and middle-aged hospitalized patients. Nine pulmonology units, across north and center of Italy, were involved in this retrospective study. Comorbidities were classified according to their known or potential association with COVID-19. A total of 263 subjects were included. The prevalence of obesity was 25.9%, mechanical ventilation (MV) was needed in 27.7%, and 28 in-hospital deaths occurred (10.6%). Obesity and older age were the only independent, significant predictors for MV. Comorbidities, such as hypertension, diabetes, asthma, and increased D-dimer levels were significantly associated with higher mortality risk, regardless of age, body mass index, and MV. Obesity in young and middle-aged adults is a strong predictor of a more complicated COVID-19, without, however, evidence of a significant effect on in-hospital mortality. Selected comorbidities, including hypertension, diabetes and asthma, significantly impact survival even in a younger population, suggesting the need for prompt recognition of these conditions.
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Laparoscopic transperitoneal adrenalectomy: a comparative study of different techniques for vessel sealing
Anno: 2021
Rivista: SURGICAL ENDOSCOPY
Autori/autrici: Cardinali, Luca; Skrami, Edlira; Catani, Elisa; Carle, Flavia; Ortenzi, Monica; Balla, Andrea; Guerrieri, Mario
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/274964
Citazioni:
Laparoscopic transperitoneal adrenalectomy: a comparative study of different techniques for vessel sealing / Cardinali, L., Skrami, E., Catani, E., Carle, F., Ortenzi, M., Balla, A., Guerrieri, M.. - In: SURGICAL ENDOSCOPY. - ISSN 0930-2794. - 35:2(2021), pp. 673-683. [10.1007/s00464-020-07432-8]
Abstract:
Background Laparoscopic adrenalectomy is the standard surgical approach to adrenal lesions. Adrenal vessel sealing is the critical surgical phase of laparoscopic adrenalectomy. This study aimed at comparing perioperative outcomes of laparoscopic transperitoneal adrenalectomy by means of radiofrequen...cy energy-based device (LARFD) to those performed with traditional clipping device (LACD), while focusing on the diferent adrenal vessel control techniques. Methods Patients who underwent adrenalectomy for adrenal disease between January 1994 and April 2019 at the Surgical Clinic, Polytechnic University of Marche were included in the study. Overall, 414 patients met inclusion criteria for study eligibility: 211 and 203 patients underwent LARFD and LACD, respectively. Multiple models of quantile regression, logistic regression and Poisson fnite mixture regression were used to assess the relationship between operative time, conversion to open procedure, length of stay (LoS), surgical procedure and patient characteristics, respectively. Results LARFD reduced operative time of about 12 min compared to LACD. Additional operative time-related factors were surgery side, surgery approach, conversion to open procedure and trocar number. The probability of conversion to open procedure decreased by about 76% for each added trocar, whereas it increased by about 49% for each added centimeter of adrenal lesion and by about 25% for each added year of surgery. Two patient clusters were identifed based on the LoS: longstay and short-stay. In the long-stay cluster, LoS decreased of about 30% in LARFD group and it was signifcantly associated with conversion to open procedure and postoperative complications, whereas in short-stay cluster only postoperative complications had a signifcant efect on LoS. Conclusion Laparoscopic transperitoneal adrenalectomy performed by means of radiofrequency energy-based device for the sealing of adrenal vessels is an efective procedure reducing operative time with potentially improved postoperative outcomes.
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Stratification of the risk of developing severe or lethal Covid-19 using a new score from a large Italian population: A population-based cohort study
Anno: 2021
Rivista: BMJ OPEN
Autori/autrici: Corrao, G.; Rea, F.; Carle, F.; Scondotto, S.; Allotta, A.; Lepore, V.; D'Ettorre, A.; Tanzarella, C.; Vittori, P.; Abena, S.; Iommi, M.; Spazzafumo, L.; Ercolanoni, M.; Blaco, R.; Carbone, S.; Giordani, C.; Manfellotto, D.; Galli, M.; Mancia, G.; Bellentani, D.; Ceccolini, C.; De Feo, A.; Mariniello, R.; Visca, M.; Magliocchetti, N.; Romano, G.; Lora, A.; Pisanti, P.; Zanini, R; Skrami, E.; Cantarutti, A.; Monzio Compagnoni, M.; Pugni, P.; Davoli, M.; Di Martino, M.; Lallo, A.; Vuillermin, G.; Bernardo, A.; Frusciante, A.; Belotti, L.; De Palma, R.; Di Lenarda, A.; Prezza, M.; Fusco, D.; Marinacci, C.; Leoni, O.; Pizzi, S.; Gallo, L.; Attolini, E.; De Luca, G.; Francesconi, P.; Rizzuti, C.; Avossa, F.; Vigna, S.; Dondi, L.; Martini, N.; Pedrini, A.; Piccinni, C.; Cosentino, M.; Marvulli, M.; Maggioni, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/294689
Citazioni:
Stratification of the risk of developing severe or lethal Covid-19 using a new score from a large Italian population: A population-based cohort study / Corrao, G., Rea, F., Carle, F., Scondotto, S., Allotta, A., Lepore, V., D'Ettorre, A., Tanzarella, C., Vittori, P., Abena, S., Iommi, M., Spazzafumo, L., Ercolanoni, M., Blaco, R., Carbone, S., Giordani, C., Manfellotto, D., Galli, M., Mancia, G., Bellentani, D., et al.. - In: BMJ OPEN. - ISSN 2044-6055. - ELETTRONICO. - 11:11(2021). [10.1136/bmjopen-2021-053281]
Abstract:
Objectives To develop a population-based risk stratification model (COVID-19 Vulnerability Score) for predicting severe/fatal clinical manifestations of SARS-CoV-2 infection, using the multiple source information provided by the healthcare utilisation databases of the Italian National Health Service.... Design Retrospective observational cohort study. Setting Population-based study using the healthcare utilisation database from five Italian regions. Participants Beneficiaries of the National Health Service, aged 18-79 years, who had the residentship in the five participating regions. Residents in a nursing home were not included. The model was built from the 7 655 502 residents of Lombardy region. Main outcome measure The score included gender, age and 29 conditions/diseases selected from a list of 61 conditions which independently predicted the primary outcome, that is, severe (intensive care unit admission) or fatal manifestation of COVID-19 experienced during the first epidemic wave (until June 2020). The score performance was validated by applying the model to several validation sets, that is, Lombardy population (second epidemic wave), and the other four Italian regions (entire 2020) for a total of about 15.4 million individuals and 7031 outcomes. Predictive performance was assessed by discrimination (areas under the receiver operating characteristic curve) and calibration (plot of observed vs predicted outcomes). Results We observed a clear positive trend towards increasing outcome incidence as the score increased. The areas under the receiver operating characteristic curve of the COVID-19 Vulnerability Score ranged from 0.85 to 0.88, which compared favourably with the areas of generic scores such as the Charlson Comorbidity Score (0.60). A remarkable performance of the score on the calibration of observed and predicted outcome probability was also observed. Conclusions A score based on data used for public health management accurately predicted the occurrence of severe/fatal manifestations of COVID-19. Use of this score may help health decision-makers to more accurately identify high-risk citizens who need early preventive or treatment interventions.
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Methods in childhood health: Chronic disease epidemiology and age estimation
Anno: 2020
Autori/autrici: Gesuita, R.; Ferrante, L.; Skrami, E.; Carle, F.
Lingua: ENG
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290255
Citazioni:
Methods in childhood health: Chronic disease epidemiology and age estimation / Gesuita, R., Ferrante, L., Skrami, E., Carle, F.. - (2020), pp. 389-403. [10.1007/978-3-030-33832-9_26]
Abstract:
This review reports the main results concerning two of the principal research topics of the Centre of Epidemiology, Biostatics and medical Information technology: epidemiology of type 1 diabetes, and statistical methods of age estimation. Our studies investigated the disease incidence, the time tren...d, the geographical patterns, the role of environmental factors, contributing to increase the knowledge of type 1 diabetes occurrence. Studying the determinants of disease management, the use of new technologies, patients’ quality of life and disease awareness, have provided useful information improving disease management. Statistical methods of age estimation were studied evaluating the performance of regression-based models assessing age in children. To overcome bias in age estimation of these models, a full Bayesian calibration method was developed. On-going research is developing aspects related to dietary intake, glycaemic variability, evaluation of therapeutic diagnostic paths and appropriateness of care in type 1 diabetes. Future studies will assess ethnic and racial differences in skeletal growth pattern and incorporation of multiple age predictors in the Bayesian calibration method to improve accuracy.
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Availability of Real-World Data in Italy: A Tool to Navigate Regional Healthcare Utilization Databases
Anno: 2020
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Skrami, E.; Carle, F.; Villani, S.; Borrelli, P.; Zambon, A.; Corrao, G.; Trerotoli, P.; Guardabasso, V.; Gesuita, R.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/272874
Citazioni:
Availability of Real-World Data in Italy: A Tool to Navigate Regional Healthcare Utilization Databases / Skrami, E., Carle, F., Villani, S., Borrelli, P., Zambon, A., Corrao, G., Trerotoli, P., Guardabasso, V., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - ELETTRONICO. - 17:1(2020), pp. 8-19. [10.3390/ijerph17010008]
Abstract:
The purpose of the study was to map and describe the healthcare utilization databases (HUDs) available in Italy's 19 regions and two autonomous provinces and develop a tool to navigate through them. A census of the HUDs covering the population of a single region/province and recording local-lev...el data was conducted between January 2014 and October 2016. The characteristics of each HUD regarding the start year, data type and completeness, data management system (DMS), data protection procedures, and data quality control adopted were collected through interviews with the database managers using a standard questionnaire or directly from the website of the regional body managing them. Overall, 352 HUDs met the study criteria. The DMSs, anonymization procedures of personal identification data, and frequency of data quality control were fairly homogeneous within regions, whereas the number of HUDs, data availability, type of identification code, and anonymization procedures were considerably heterogeneous across regions. The study provides an updated inventory of the available regional HUDs in Italy and highlights the need for greater homogeneity across regions to improve comparability of health data from secondary sources. It could represent a reference model for other countries to provide information on the available HUDs and their features, enhancing epidemiological studies across countries.
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Italian response to coronavirus pandemic in dental care access: The DeCADE study
Anno: 2020
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Aquilanti, L.; Gallegati, S.; Temperini, V.; Ferrante, L.; Skrami, E.; Procaccini, M.; Rappelli, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286213
Citazioni:
Italian response to coronavirus pandemic in dental care access: The DeCADE study / Aquilanti, L., Gallegati, S., Temperini, V., Ferrante, L., Skrami, E., Procaccini, M., Rappelli, G.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - ELETTRONICO. - 17:19(2020), pp. 6977.1-6977.12. [10.3390/ijerph17196977]
Abstract:
The aim of the study was to evaluate the impact of the coronavirus pandemic on the willingness, anxiety and concerns of Italian people on undergoing dental appointments. An anonymous survey was posted online on social media on 11 May 2020 and was completed by 1003 respondents in one week. Multiple c...orrespondence analysis and multiple logistic regression were used to evaluate the association between socio-demographic characteristics, dental care access, contagion fear of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), trust in dentists regarding sanitization procedures and perception of the impact of the risk of contagion on dental care. Subjects with a high level of education, attending public dental offices and that are used to go to dental offices for urgent care would not feel comfortable in undergoing a dental appointment and would prefer to postpone or cancel dental visits, waiting for a decrease in the number of the contagions. Moreover, the risk of canceling or postponing the appointment at the dentist was 1.59 times greater in those who claimed to be strongly influenced by SARS-CoV-2. Fear of coronavirus disease (COVID-19), new cases decrease and the not urgent nature of dental visits influenced more than the lowered income household on upcoming or resuming dental appointments. In the next months, despite the forecasted economic crisis caused by coronavirus pandemic, fear and anxiety generated by the spread of the virus will impact more than the lowered familiar income with regards to access to dental care.
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Effect of national and local lockdowns on the control of COVID-19 pandemic: a rapid review
Anno: 2020
Rivista: EPIDEMIOLOGIA E PREVENZIONE
Autori/autrici: Caristia, Silvia; Ferranti, Margherita; Skrami, Edlira; Raffetti, Elena; Pierannunzio, Daniela; Palladino, Raffeele; Carle, Flavia; Saracci, Rodolfo; Badaloni, Chiara; Barone-Adesi, Francesco; Belleudi, Valeria; Ancona, Carla
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286937
Citazioni:
Effect of national and local lockdowns on the control of COVID-19 pandemic: a rapid review / Caristia, S., Ferranti, M., Skrami, E., Raffetti, E., Pierannunzio, D., Palladino, R., Carle, F., Saracci, R., Badaloni, C., Barone-Adesi, F., Belleudi, V., Ancona, C.. - In: EPIDEMIOLOGIA E PREVENZIONE. - ISSN 1120-9763. - ELETTRONICO. - 44:5-6 Suppl 2(2020), pp. 60-68. [10.19191/EP20.5-6.S2.104]
Abstract:
Objectives: to describe and compare the effectiveness of national and local lockdowns in controlling the spread of COVID-19. Methods: a rapid review of published and grey literature on COVID-19 pandemic was conducted following predefined eligibility criteria by searching electronic databases, rep...ositories of pre-print articles, websites and databases of international health, and research related institutions and organisations. Results: of 584 initially identified records up to 5 July 2020, 19 articles met the inclusion criteria and were included in the review. Most of the studies (No. 11) used the reproduction number (Rt) as a measure of effect and in all of them areduction of the estimated value at post-intervention period was found. The implementation of lockdown in 11 European countries was associated with an average 82% reduction of Rt, ranging from a posterior Rt of 0.44 (95%CI 0.26-0.61) for Norway to a posterior Rt of 0.82 (95%CI 0.73- 0.93) for Belgium. Changes in infection rates and transmission rates were estimated in 8 studies. Daily changes in infection rates ranged from -0.6% (Sweden) to -11.3% (Hubei and Guangdong provinces). Additionally, other studies reported a change in the trend of hospitalizations (Italy, Spain) and positive effects on the doubling time of cases (Hubei, China) after lockdown. Conclusions: results of this rapid review suggest a positive effect of the containment measures on the spread of COVID-19 pandemic, with a major effect in countries where lockdown started early and was more restrictive. Rigorous research is warranted to evaluate which approach is the most effective in each stage of the epidemic and in specific social contexts, in particular addressing if these approaches should be implemented on the whole population or target specific risk groups.
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Prospective evaluation of lung function in children with parapneumonic empyema
Anno: 2019
Rivista: PEDIATRIC PULMONOLOGY. SUPPLEMENT
Autori/autrici: de Benedictis FM1 Carloni, I; Osimani, P; Cobellis, G; Martino, A; Lanza, C; Niccoli, Aa; Azzari, C; Skrami, E; Gesuita, R
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/262714
Citazioni:
Prospective evaluation of lung function in children with parapneumonic empyema / de Benedictis FM1 Carloni, I., Osimani, P., Cobellis, G., Martino, A., Lanza, C., Niccoli, A.a., Azzari, C., Skrami, E., Gesuita, R.. - In: PEDIATRIC PULMONOLOGY. SUPPLEMENT. - ISSN 1054-187X. - STAMPA. - 54:4(2019), pp. 421-427. [10.1002/ppul.24204]
Abstract:
RATIONALE: Prospective studies that evaluated the outcome of childhood empyema are limited. OBJECTIVE: To compare the outcome of pulmonary function in children with empyema. PATIENTS AND METHODS: Children discharged with a diagnosis of empyema underwent a longitudinal study includi...ng measurement of pulmonary function and radiographic imaging. RESULTS: The population consisted of 39 patients, 24 males, and 15 females; with a median age of 4.6 years. Etiology was defined in 20/39 patients, and predominant microorganism was Streptococcus pneumoniae (19/20 isolates). Chest tube drainage with or without fibrinolytic agents was the primary intervention in 25 children. Video-assisted thoracoscopic surgery was performed in 14 and 5 children as primary and secondary intervention, respectively. Thirty-five children completed the lung function follow-up. At first follow-up visit, 5 out of 17 children able to perform spirometry (initially collaborating children) had normal tests, and 12 had mild-to-moderate defects of lung function that returned to normal over 2-57 months. Eighteen children unable to perform spirometry at first follow-up visit (initially non-collaborating children) had normal tests when they were evaluated 5-78 months postdischarge. At the end of the follow-up, all patients had normal lung function. Time to normalize did not differ between groups receiving different treatments (initially collaborating children, P = 0.064; initially non-collaborating children P = 0.223). Three previously healthy children had recurrent cough, and all children had normal chest radiographs aside from pleural thickening. CONCLUSIONS: The respiratory outcome in children with empyema is generally good and is not influenced by the type of intervention.
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Segmented Bayesian calibration approach for estimating age in forensic science
Anno: 2019
Rivista: BIOMETRICAL JOURNAL
Autori/autrici: Bucci, A.; Skrami, E.; Faragalli, A.; Gesuita, R.; Cameriere, R.; Carle, F.; Ferrante, L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/270311
Citazioni:
Segmented Bayesian calibration approach for estimating age in forensic science / Bucci, A., Skrami, E., Faragalli, A., Gesuita, R., Cameriere, R., Carle, F., Ferrante, L.. - In: BIOMETRICAL JOURNAL. - ISSN 0323-3847. - (2019). [10.1002/bimj.201900016]
Abstract:
Forensic age estimation is receiving growing attention from researchers in the last few years. Accurate estimates of age are needed both for identifying real age in individuals without any identity document and assessing it for human remains. The methods applied in such context are mostly based on r...adiological analysis of some anatomical districts and entail the use of a regression model. However, estimating chronological age by regression models leads to overestimated ages in younger subjects and underestimated ages in older ones. We introduced a full Bayesian calibration method combined with a segmented function for age estimation that relied on a Normal distribution as a density model to mitigate this bias. In this way, we were also able to model the decreasing growth rate in juveniles. We compared our new Bayesian-segmented model with other existing approaches. The proposed method helped producing more robust and precise forecasts of age than compared models while exhibited comparable accuracy in terms of forecasting measures. Our method seemed to overcome the estimation bias also when applied to a real data set of South-African juvenile subjects.
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Carpals and epiphyses of radius and ulna as age indicators using longitudinal data: a Bayesian approach
Anno: 2019
Rivista: INTERNATIONAL JOURNAL OF LEGAL MEDICINE
Autori/autrici: Cameriere, Roberto; Bestetti, Fiorella; Velandia Palacio, Luz Andrea; Riccomi, Giulia; Skrami, Edlira; Parente, Valentina; Ferrante, Luigi
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256363
Citazioni:
Carpals and epiphyses of radius and ulna as age indicators using longitudinal data: a Bayesian approach / Cameriere, R., Bestetti, F., Velandia Palacio, L.A., Riccomi, G., Skrami, E., Parente, V., Ferrante, L.. - In: INTERNATIONAL JOURNAL OF LEGAL MEDICINE. - ISSN 0937-9827. - ELETTRONICO. - (2019), pp. 1-8. [10.1007/s00414-018-1807-7]
Abstract:
The aim of this study is to develop a new formula for age estimation in a longitudinal study of a sample from the radiological collection of wrist bones of growing infants, children, and adolescents recorded at the Burlington Growth Centre. A sample of 82 individuals (43 boys and 39 girls), aged bet...ween 3 and 16 years, were analyzed with a total of 623 X-rays of left hand-wrist bones by measuring the area of carpal bones and epiphyses of the ulna and radius (Bo) and carpal area (Ca). The intra-class correlation coefficient (ICC) and its 95% confidence interval were used to evaluate intra-observer agreement. Hierarchical Bayesian calibration has been adopted to exceed the bias deriving from the classical regression approach used for age estimation in forensic disciplines, since it tends to overestimate or underestimate the age of the individuals. Calibration distributions of the dataset obtained by the evaluation of BoCa (the ratio of Bo and Ca) suggested mean absolute errors (MAE) of 1.07 and 1.34 years in boys and girls, respectively. The mean interquartile range (MIQR) was 1.7 and 2.42 years in boys and girls, respectively. The respective bias of the estimates was βERR = - 0.025 and - 0.074. Furthermore, a correspondence between different BoCa values and estimated age with its standard deviation (SD) was calculated for boys and girls, respectively. In conclusion, the Bayesian calibration method appears to be suitable for assessing both age and its distribution in subadults, according to hand-wrist maturity. Furthermore, it can easily incorporate other age predictors, obtaining a distribution of the subjects with multivariate predictors.
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Effectiveness of adherence to recommended clinical examinations of diabetic patients in preventing diabetes-related hospitalizations
Anno: 2019
Rivista: INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
Autori/autrici: Corrao, Giovanni; Rea, Federico; DI Martino, Mirko; Lallo, Adele; Davoli, Marina; DE Palma, Rossana; Belotti, Laura; Merlino, Luca; Pisanti, Paola; Lispi, Lucia; Skrami, Edlira; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264134
Citazioni:
Effectiveness of adherence to recommended clinical examinations of diabetic patients in preventing diabetes-related hospitalizations / Corrao, G., Rea, F., DI Martino, M., Lallo, A., Davoli, M., DE Palma, R., Belotti, L., Merlino, L., Pisanti, P., Lispi, L., Skrami, E., Carle, F.. - In: INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE. - ISSN 1353-4505. - ELETTRONICO. - 31:(2019), pp. 464-472. [10.1093/intqhc/mzy186]
Abstract:
Objective: To validate a set of indicators for quality of diabetes care through their relationship with measurable clinical outcomes. Design: A retrospective cohort study was carried out from 2010 to 2015. Setting: Population-based study. Data were retrieved from healthcare utilization databases of ...three Italian regions (Lombardy, Emilia Romagna and Lazio) on the whole covering 20 million citizens. Participants: The 77 285 individuals who were newly taken in care for diabetes during 2010 entered into the cohort. Interventions: Exposure to selected clinical recommendations (i.e. periodic controls for glycated hemoglobin, lipid profile, urine albumin excretion, serum creatinine and dilated eye exams) was recorded. Main outcomes measures: A composite outcome was employed taking into account hospitalizations for brief-term diabetes complications, uncontrolled diabetes, long-term vascular outcomes and no traumatic lower limb amputation. A multivariable proportional hazards model was fitted to estimate hazard ratio, and 95% confidence intervals (CI), for the exposure-outcome association. Results: Among the newly taken in care patients with diabetes, those who adhered to almost none (0 or 1), just some (2 or 3) or almost all (4 or 5) recommendations during the first year after diagnosis were 44%, 36% and 20%, respectively. Compared patients who adhered to almost none recommendation, significant risk reductions of 16% (95% CI, 6-24%) and 20% (7-28%) were observed for those who adhered to just some and almost all recommendations, respectively. Conclusions: Tight control of patients with diabetes through regular clinical examinations must to be considered the cornerstone of national guidance, national audits and quality improvement incentives schemes.
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Managing Pathologic Scars by Injecting Auto-Cross-linked Hyaluronic Acid: A Preliminary Prospective Clinical Study
Anno: 2019
Rivista: AESTHETIC PLASTIC SURGERY
Autori/autrici: Riccio, Michele; Marchesini, Andrea; Senesi, Letizia; Skrami, Edlira; Gesuita, Rosaria; De Francesco, Francesco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264141
Citazioni:
Managing Pathologic Scars by Injecting Auto-Cross-linked Hyaluronic Acid: A Preliminary Prospective Clinical Study / Riccio, M., Marchesini, A., Senesi, L., Skrami, E., Gesuita, R., De Francesco, F.. - In: AESTHETIC PLASTIC SURGERY. - ISSN 0364-216X. - ELETTRONICO. - (2019). [10.1007/s00266-018-01303-3]
Abstract:
BACKGROUND: Pathological scars are unattractive and may significantly impair the patient's quality of life. Current treatments provide inconsistent results, and none may be regarded as definitive. Recently, an auto-cross-linked hyaluronic acid (HA) formulation, IAL-SYSTEM ACP, featuring a lon...g residence time and an enhanced safety profile, has been successfully used to prevent surgical adhesions, treat tendon lesions and rejuvenate the face and the décolletage. This study aims to preliminarily investigate whether IAL-SYSTEM ACP may also be effective in treating pathological scars resulting from burns, trauma or iatrogenic causes. METHODS: Patients presenting one pathological scar were prospectively recruited and treated with two IAL-SYSTEM ACP injections carried out two weeks apart. Scar improvement was measured comparing the patient and observer scar assessment scale (POSAS) scores collected before treatment (T0) and 90 days after the second injection (T90) using nonparametric tests. The effect of age and scar type over score variation was investigated through quantile regression analysis. RESULTS: Forty-one patients, 10 women and 31 men (median age, 34 years) were recruited. No patient dropped out, and no significant adverse event was observed. At T90, the median observer total score decreased by 11 units (- 77.5%) and the median patient total score decreased by 15 units (- 73.7%). The difference was significant (p < 0.001) in both cases. Traumatic injuries and young patient's age were the most significant predictors of a positive treatment outcome. CONCLUSIONS: Treatment of pathological scars by two IAL-SYSTEM ACP injections, carried out two weeks apart, may provide significant clinical benefits. These findings should be the subject of further investigations. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
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Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study
Anno: 2019
Rivista: EUROPEAN RADIOLOGY
Autori/autrici: Castaldo, Pasqualina; Frasca', GIOVANNI MARIA; Brigante, Fabiana; Ferrante, Luigi; Magi, Simona; Pavani, Marianna; Skrami, Edlira; Giuseppetti, Gian Marco; Polonara, Gabriele; Amoroso, Salvatore
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/265725
Citazioni:
Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study / Castaldo, P., Frasca', G.M., Brigante, F., Ferrante, L., Magi, S., Pavani, M., Skrami, E., Giuseppetti, G.M., Polonara, G., Amoroso, S.. - In: EUROPEAN RADIOLOGY. - ISSN 0938-7994. - STAMPA. - 29:7(2019), pp. 3927-3934. [10.1007/s00330-019-06147-2]
Abstract:
Objectives To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure. Methods This prospective cohort study included all consecutive patients who underwent radiological investigations using lowosmolar iopamidol 370... mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2–10 days) and after (24–36 h) radiological investigations. CI-AKI was defined as a ≥ 25% decrease in eGFR from baseline. CI-AKI incidence was estimated using a binomial distribution. The association between CI-AKI and demographic and clinical characteristics was modeled using logistic regression. Results The study included 1541 patients with a median age of 68 (1st–3rd quartiles 58–76) years with various comorbidities, 30% of whom had pre-existing CKD. Patients affected by stage III or IV chronic kidney disease (CKD) received an infusion of 0.9% normal saline (1.0–1.5 ml/kg/h) before and after iso-osmolar iodixanol administration. CI-AKI was observed in 33 patients (2.1%, 95% CI 1.5–3.0). The logistic regression analysis showed that antibiotic and statin therapies were significantly associated with CI-AKI. The probability of developing CI-AKI decreased by 80% in patients taking statins (OR = 0.20, 95% CI 0.03; 0.68) and increased approximately three times in patients with antibiotic therapy compared with those who did not take statins and antibiotics (OR = 2.92, 95% CI 1.21; 6.36). Conclusions Our data suggest that low-osmolar iopamidol carries a low incidence of nephrotoxicity, even in subjects with various comorbid conditions or reduced renal function.
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Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy
Anno: 2019
Rivista: SURGICAL ENDOSCOPY
Autori/autrici: Ghiselli, Roberto; Ortenzi, Monica; Cardinali, Luca; Skrami, Edlira; Gesuita, Rosaria; Guerrieri, Mario
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/300873
Citazioni:
Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy / Ghiselli, R., Ortenzi, M., Cardinali, L., Skrami, E., Gesuita, R., Guerrieri, M.. - In: SURGICAL ENDOSCOPY. - ISSN 0930-2794. - (2019).

Estimating segmented regression in gretl
Anno: 2019
Autori/autrici: Bucci, A.; Faragalli, A.; Skrami, E.; Dajko, Marianxhela; Carle, F.
Lingua: ENG
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/271166
Citazioni:
Estimating segmented regression in gretl / Bucci, A., Faragalli, A., Skrami, E., Dajko, M., Carle, F.. - ELETTRONICO. - (2019), pp. 17-22. [10.6093/978-88-6887-057-7]

Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes
Anno: 2019
Rivista: PEDIATRIC DIABETES
Autori/autrici: Cherubini, Valentino; Gesuita, Rosaria; Skrami, Edlira; Rabbone, Ivana; Bonfanti, Riccardo; Arnaldi, Claudia; D'Annunzio, Giuseppe; Frongia, Annapaola; Lombardo, Fortunato; Piccinno, Elvira; Schiaffini, Riccardo; Toni, Sonia; Tumini, Stefano; Tinti, Davide; Cipriano, Paola; Minuto, Nicola; Lenzi, Lorenzo; Ferrito, Lucia; Ventrici, Claudia; Ortolani, Federica; Cohen, Ohad; Scaramuzza, Andrea
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264140
Citazioni:
Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes / Cherubini, V., Gesuita, R., Skrami, E., Rabbone, I., Bonfanti, R., Arnaldi, C., D'Annunzio, G., Frongia, A., Lombardo, F., Piccinno, E., Schiaffini, R., Toni, S., Tumini, S., Tinti, D., Cipriano, P., Minuto, N., Lenzi, L., Ferrito, L., Ventrici, C., Ortolani, F., et al.. - In: PEDIATRIC DIABETES. - ISSN 1399-543X. - ELETTRONICO. - 20:1(2019), pp. 107-112. [10.1111/pedi.12792]
Abstract:
OBJECTIVES: To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise-induced hypoglycemia in adolescents with type 1 diabetes. METHODS: Thirty-four adolescents, 15 to 20 years, wearing PLGM system, were followed during 3 days exercis...e during a diabetes camp. PLGM threshold was set at 70 mg/dL between 8 am and 10 pm and 90 mg/dL during 10 pm and 8 am Adolescents were divided into group A and B, with PLGM threshold at 90 and 70 mg/dL, respectively, during exercise. Time spent in hypoglycemia and AUC for time slots 8 am to 1 pm, 1 to 4 pm, 4 to 11 pm, 11 pm to 3 am, 3 to 8 am, in 3 days were compared between groups by Wilcoxon rank sum test. RESULTS: We analyzed 31 patients (median age 15.0 years, 58.1% males, median diabetes duration 7.0 years, hemoglobin A1c [HbA1c] 7.1%). No significant difference has been observed in time spent in hypoglycemia between groups using threshold 70 or 90. Time spent in target was similar in both groups, as well as time spent in hypo or hyperglycemia. The trends of blood glucose over the 3 days in the 2 groups over-lapped without significant differences. CONCLUSIONS: A PLGM threshold of 90 mg/dL during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dL seems to be safe in the duration of the physical exercise. PLGM system in adolescents with type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used.
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Socio-economic disparities in the appropriateness of diabetes care in an Italian region: Findings of AEQUITAS study
Anno: 2018
Rivista: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH
Autori/autrici: Gesuita, Rosaria; Piraccini, Francesca; Skrami, Edlira; Paolini, Italo; Sebastianelli, Giuliano; Stramenga, Carlo; Bartolucci, Dario; Marcobelli, Alberico; Romagnoli, Fabio; Silvestrini, Giulia; Ricciardi, Walter; Damiani, Gianfranco; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264142
Citazioni:
Socio-economic disparities in the appropriateness of diabetes care in an Italian region: Findings of AEQUITAS study / Gesuita, R., Piraccini, F., Skrami, E., Paolini, I., Sebastianelli, G., Stramenga, C., Bartolucci, D., Marcobelli, A., Romagnoli, F., Silvestrini, G., Ricciardi, W., Damiani, G., Carle, F.. - In: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH. - ISSN 2282-0930. - STAMPA. - 15:4(2018), pp. e12951-e12951-8. [10.2427/12951]
Abstract:
Background: To evaluate socio-economic disparities in diabetes prevalence and care in Marches (a region of central Italy) in 2003-2010 through a cross-sectional study. Methods: The databases of 52 general practitioners were mined for people with diabetes (age ≥20 years). These data were linked wi...th records from other regional administrative databases. Healthcare disparities, specifically potentially preventable hospitalizations (PPH) related to diabetes and its complications, were analysed using participants’ gender, age, and education data and the Italian Deprivation Index. Crude, age-specific and gender-specific diabetes prevalence was estimated for each year of observation. A time-trend analysis was performed. Admissions that might have been prevented according to Agency for Healthcare Research and Quality criteria were used to calculate the PPH rate for each level of social condition indicators. Rate ratios and 95% confidence intervals were estimated with a multiple Poisson regression model. Results: The search found 6,494 participants with diabetes mellitus aged ≥20 years. Disease prevalence ranged from 5.4% (2003) to 7.8% (2010), with a significant 0.31% positive trend. Those aged ≤44 years were at significantly higher risk of PPH than older people. A significant PPH excess was found among people living in socio-economically disadvantaged areas. Education and gender did not significantly affect PPH. Conclusions: People with diabetes seem to use primary care services appropriately irrespective of socio-economic status. Outpatient services are not equally distributed on the regional territory; this may increase disease severity and/ or the risk of diabetes complications and affect appropriateness of diabetes care.
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Disordered eating behaviors in adolescents with type 1 diabetes: A cross-sectional population-based study in Italy
Anno: 2018
Rivista: INTERNATIONAL JOURNAL OF EATING DISORDERS
Autori/autrici: Cherubini, Valentino; Skrami, Edlira; Iannilli, Antonio; Cesaretti, Alessandra; Paparusso, Anna Maria; Alessandrelli, Maria Cristina; Carle, Flavia; Ferrito, Lucia; Gesuita, Rosaria
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264131
Citazioni:
Disordered eating behaviors in adolescents with type 1 diabetes: A cross-sectional population-based study in Italy / Cherubini, V., Skrami, E., Iannilli, A., Cesaretti, A., Paparusso, A.M., Alessandrelli, M.C., Carle, F., Ferrito, L., Gesuita, R.. - In: INTERNATIONAL JOURNAL OF EATING DISORDERS. - ISSN 0276-3478. - ELETTRONICO. - 51:8(2018), pp. 890-898. [10.1002/eat.22889]
Abstract:
OBJECTIVE: To evaluate the association of clinical, metabolic and socioeconomic factors with disordered eating behaviors (DEB) among adolescents with type 1 diabetes screened using the Diabetes Eating Problem Survey-Revised (DEPS-R). METHODS: A cross-sectional, population-based study involved 163 a...dolescents with type 1 diabetes, aged 11-20 years, recruited from the registry for type 1 diabetes of Marche Region, Italy, who completed the DEPS-R (response rate 74.4%). Clinical characteristics, lipid profile, HbA1c , family profile of education and occupation were evaluated. The Italian version of DEPS-R was validated, and the prevalence of DEB estimated. The association of demographic, socioeconomic, and clinical factors with DEB was evaluated by multiple correspondence analysis and multiple logistic regression. RESULTS: The prevalence of DEPS-R-positive (score ≥20) was 27% (95% CI 17-38) in boys and 42% (95% CI 31-53) in girls. A clinical profile of DEPS-R-positive was identified: overweight, little time spent in physical activity, low socioeconomic status, poor metabolic control, skipping insulin injections. Furthermore, the probability of DEPS-R-positive increased 63% for every added unit of HbA1c , 36% for every added number of insulin injections skipped in a week and decreased about 20% for every added hour/week spent in physical activity. Overweight youth were six times more likely to be DEPS-R-positive. DISCUSSION: A specific clinical profile of DEPS-R-positive was identified. A multidisciplinary clinical approach aimed to normalize eating behaviors and enhance self-esteem should be used to prevent the onset of these behaviors, and continuous educational programs are needed to promote healthy behaviors and lifestyles.
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Sclerostin and Antisclerostin Antibody Serum Levels Predict the Presence of Axial Spondyloarthritis in Patients with Inflammatory Bowel Disease
Anno: 2018
Rivista: THE JOURNAL OF RHEUMATOLOGY
Autori/autrici: Luchetti, Michele Maria; Ciccia, Francesco; Avellini, Chiara; Benfaremo, Devis; Guggino, Giuliana; Farinelli, Alessia; Ciferri, Monia; Rossini, Matteo; Svegliati, Silvia; Spadoni, Tatiana; Bolognini, Laura; Fava, Giammarco; Mosca, Piergiorgio; Gesuita, Rosaria; Skrami, Edlira; Triolo, Giovanni; Gabrielli, Armando
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/253827
Citazioni:
Sclerostin and Antisclerostin Antibody Serum Levels Predict the Presence of Axial Spondyloarthritis in Patients with Inflammatory Bowel Disease / Luchetti, M.M., Ciccia, F., Avellini, C., Benfaremo, D., Guggino, G., Farinelli, A., Ciferri, M., Rossini, M., Svegliati, S., Spadoni, T., Bolognini, L., Fava, G., Mosca, P., Gesuita, R., Skrami, E., Triolo, G., Gabrielli, A.. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - STAMPA. - 00:00(2018), p. jrheum.170833. [10.3899/jrheum.170833]
Abstract:
The early diagnosis of inflammatory bowel disease (IBD)-associated spondyloarthritis (SpA/IBD) in patients affected by IBD represents a major topic in clinical practice; in particular, to date there are no available serum biomarkers revealing the presence of joint inflammation in these patients. Scl...erostin (SOST), an antagonist of the Wnt/β-catenin pathway, and antisclerostin-immunoglobulin G (anti-SOST-IgG) have been recently studied in patients with ankylosing spondylitis (AS) as a putative marker of disease activity.
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Swallowing impairments in Amyotrophic Lateral Sclerosis and Myotonic Dystrophy type 1: Looking for the portrait of dysphagic patient in neuromuscular diseases
Anno: 2018
Rivista: NEUROREHABILITATION
Autori/autrici: Andrenelli, Elisa; Galli, FEDERICA LUCIA; Gesuita, Rosaria; Skrami, Edlira; Logullo, Francesco Ottavio; Provinciali, Leandro; Capecci, Marianna; Ceravolo, Maria Gabriella; Coccia, Michela
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/253077
Citazioni:
Swallowing impairments in Amyotrophic Lateral Sclerosis and Myotonic Dystrophy type 1: Looking for the portrait of dysphagic patient in neuromuscular diseases / Andrenelli, E., Galli, F.L., Gesuita, R., Skrami, E., Logullo, F.O., Provinciali, L., Capecci, M., Ceravolo, M.G., Coccia, M.. - In: NEUROREHABILITATION. - ISSN 1053-8135. - ELETTRONICO. - 42:1(2018), pp. 93-102-102. [10.3233/NRE-172272]
Abstract:
Abstract. BACKGROUND: Dysphagia is a critical symptom of Neuromuscular Diseases and is often associated with considerable morbidity and mortality. OBJECTIVE: This study is designed to investigate the prevalence of dysphagia and to identify different clinical profiles of swallowing disorders in Myot...onic Dystrophy type 1 (DM1) and Amyotrophic Lateral Sclerosis (ALS), the most common Neuromuscular Diseases in the adult age. METHODS: Consecutive DM1 and ALS patients from 2013 to 2015 referred to a Centre for Neuromuscular Disease were enrolled. A comprehensive assessment of swallowing function with a Clinical Swallowing Examination and Fluid and Food Trials was performed. RESULTS: 157 patients were included: 86 ALS, 71 DM1. The dysphagic patients affected by ALS and DM1 (79% and 86% of the respective samples) showed two different profiles. ALS patients with dysphagia were older and underweight. They experienced a global dysfunction of the oral and pharyngeal phases with more difficulty in swallowing thin liquids. Conversely, DM1 patients with dysphagia were younger and tended to obesity. Most of them showed impairment of oral phase and had more frequently difficulty in swallowing solid bolus. CONCLUSION: The recognition of specific clinical profiles supports and guides the detection of swallowing disorders in patients with neuromuscular diseases.
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Un modello dinamico per la valutazione dell’andamento della glicemia in adolescenti con diabete di tipo 1 in terapia con un sistema integrato
Anno: 2017
Autori/autrici: Skrami, E; Gesuita, R; Cherubini, V; Ferrito, L; Carle, F; Ferrante, L
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256365
Citazioni:
Un modello dinamico per la valutazione dell’andamento della glicemia in adolescenti con diabete di tipo 1 in terapia con un sistema integrato / Skrami, E., Gesuita, R., Cherubini, V., Ferrito, L., Carle, F., Ferrante, L.. - ELETTRONICO. - (2017), pp. 119-122. (La statistica a supporto della salute: dalla prevenzione alla continuità delle cure Gargnano (BS) 13-16 settembre 2017).

Analisi del profilo clinico e socio-economico degli adolescenti con disturbi del comportamento alimentare e diabete di tipo 1
Anno: 2017
Autori/autrici: Skrami, E; Carle, F; Ferrito, L; Iannilli, A; Cherubini, V; Gesuita, R
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256366
Citazioni:
Analisi del profilo clinico e socio-economico degli adolescenti con disturbi del comportamento alimentare e diabete di tipo 1 / Skrami, E., Carle, F., Ferrito, L., Iannilli, A., Cherubini, V., Gesuita, R.. - ELETTRONICO. - (2017), pp. 6-9. (La statistica a supporto della salute: dalla prevenzione alla continuità delle cure Gargnano (BS) 13-16 settembre 2017).

Is there an Association between Clinical, Metabolic, Socio-economic Features and Eating Disorders in Adolescents with Type 1 Diabetes?
Anno: 2017
Rivista: DIABETES
Autori/autrici: Cherubini, V; Ferrito, L; Iannilli, A; Skrami, E; Gesuita, R
Lingua: ENG
Classificazione IRIS: 1.5 Abstract in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256525
Citazioni:
Is there an Association between Clinical, Metabolic, Socio-economic Features and Eating Disorders in Adolescents with Type 1 Diabetes? / Cherubini, V., Ferrito, L., Iannilli, A., Skrami, E., Gesuita, R.. - In: DIABETES. - ISSN 0012-1797. - ELETTRONICO. - 66:(2017), pp. A378-A378.

Quality assessment of healthcare databases
Anno: 2017
Rivista: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH
Autori/autrici: Carle, Flavia; Di Minco, Lidia; Skrami, Edlira; Gesuita, Rosaria; Palmieri, Luigi; Giampaoli, Simona; Corrao, Giovanni
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/264143
Citazioni:
Quality assessment of healthcare databases / Carle, F., Di Minco, L., Skrami, E., Gesuita, R., Palmieri, L., Giampaoli, S., Corrao, G.. - In: EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH. - ISSN 2282-0930. - ELETTRONICO. - 14:3(2017), pp. e12901-1-e12901-11.
Abstract:
The assessment of data quality and suitability plays an important role in improving the validity and generalisability of the results of studies based on secondary use of health databases. The availability of more and more updated and valid information on data quality and suitability provides data us...ers and researchers an useful tool to optimize their activities. In this paper, we have summarized and synthesized the main aspects of Data Quality Assessment (DQA) applied in the field of secondary use of healthcare databases, with the aim of drawing attention to the critical aspects having to be considered and developed for improving the correct and effective use of secondary sources. Four developing features are identified: standardizing DQA methods, reporting DQA methods and results, synergy between data managers and data users, role of Institutions. Interdisciplinarity, multi-professionality and connection between government institutions, regulatory bodies, universities and the scientific community will provide the "toolbox" for i) developing standardized and shared DQA methods for health databases, ii) defining the best strategies for disseminating DQA information and results.
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Influence of personal meaning organization and 5-HTTLPR genotype on cortisol stress reactivity in healthy women
Anno: 2017
Rivista: EUROPEAN PSYCHIATRY
Autori/autrici: Marini, A; Turchi, C; Skrami, E; Gesuita, R; Giordani, M; Nardi, B
Lingua: ENG
Classificazione IRIS: 1.5 Abstract in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256526
Citazioni:
Influence of personal meaning organization and 5-HTTLPR genotype on cortisol stress reactivity in healthy women / Marini, A., Turchi, C., Skrami, E., Gesuita, R., Giordani, M., Nardi, B.. - In: EUROPEAN PSYCHIATRY. - ISSN 0924-9338. - ELETTRONICO. - 41:(2017), pp. S165-S166. [10.1016/j.eurpsy.2017.01.2049]

Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial
Anno: 2017
Rivista: METABOLISM, CLINICAL AND EXPERIMENTAL
Autori/autrici: Soare, Andreea; Khazrai, Yeganeh Manon; Fontana, Lucia; Del Toro, Rossella; Lazzaro, Maria Concetta; Di Rosa, Claudia; Buldo, Antonia; Fioriti, Elvira; Maddaloni, Ernesto; Angeletti, Silvia; Di Mauro, Antonio; Gesuita, Rosaria; Skrami, Edlira; Tuccinardi, Dario; Fallucca, Sara; Pianesi, Mario; Pozzilli, Paolo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/249048
Citazioni:
Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial / Soare, A., Khazrai, Y.M., Fontana, L., Del Toro, R., Lazzaro, M.C., Di Rosa, C., Buldo, A., Fioriti, E., Maddaloni, E., Angeletti, S., Di Mauro, A., Gesuita, R., Skrami, E., Tuccinardi, D., Fallucca, S., Pianesi, M., Pozzilli, P.. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - ELETTRONICO. - 69:(2017), pp. 148-156. [10.1016/j.metabol.2017.01.023]
Abstract:
Background and Aims. Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by hypoglycemia that occurs within four hours after a meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type 2 diabetes.We explored the effect o...f this diet on outcomes in non-diabetic individuals with RH. Materials and Methods. Twelve subjects with RH were randomized to the Ma-Pi 2 diet for three days and a control diet for three days in a randomized crossover design. Subjects received snacks on two days out of each three-day period only, and were monitored using continuous glucose monitoring. The 24-h period was divided into daytime (08:00–22:30 h [subdivided into ‘daytime without snacks’ and ‘daytime with snacks’]) and night-time (22:31–07:59 h). The effects of the two diets on the number of RH events (blood glucose <70 mg/dL [3.9 mmol/L]) and the percentage distribution of glucose readings within each of 16 glycemic intervals from <40 mg/dL (2.2 mmol/L) to >180 mg/dL (4.4 mmol/L) were determined. Results. There were significantly fewer RH events on the Ma-Pi 2 diet than the control diet during daytime without snacks (−2.5 events; 95% CI: -7.5, 0.0; P = 0.022) and daytime with snacks (−4.25 events; 95% CI: -7.5; −2.0; P = 0.013) but no difference at night. The percentage of glucose readings in the interval 71–80 mg/dL (3.9–4.4 mmol/L) was significantly higher on the control diet during daytime with and without snacks (P = 0.03 for both), while the percentage of glucose readings in the interval 91–100 mg/dL (5.1–5.6 mmol/L) was significantly higher on the Ma-Pi 2 diet during daytime without snacks (P = 0.02). Conclusions. The macrobiotic Ma-Pi 2 diet reduced blood glucose excursions during the day, thereby facilitating glycemic control in subjects with RH. The Ma-Pi 2 diet represents an effective nutritional tool for management of RH
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The role of socio-economic and clinical factors on HbA1c in children and adolescents with type 1 diabetes: An Italian multicentre survey
Anno: 2017
Rivista: PEDIATRIC DIABETES
Autori/autrici: Gesuita, Rosaria; Skrami, Edlira; Bonfanti, Riccardo; Cipriano, Paola; Ferrito, Lucia; Frongia, Paola; Iafusco, Dario; Iannilli, Antonio; Lombardo, Fortunato; Mozzillo, Enza; Paleari, Renata; Rabbone, Ivana; Sabbion, Alberto; Salvatoni, Alessandro; Scaramuzza, Andrea; Schiaffini, Riccardo; Sulli, Nicoletta; Toni, Sonia; Carle, Flavia; Cherubini, Valentino
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/236870
Citazioni:
The role of socio-economic and clinical factors on HbA1c in children and adolescents with type 1 diabetes: An Italian multicentre survey / Gesuita, R., Skrami, E., Bonfanti, R., Cipriano, P., Ferrito, L., Frongia, P., Iafusco, D., Iannilli, A., Lombardo, F., Mozzillo, E., Paleari, R., Rabbone, I., Sabbion, A., Salvatoni, A., Scaramuzza, A., Schiaffini, R., Sulli, N., Toni, S., Carle, F., Cherubini, V.. - In: PEDIATRIC DIABETES. - ISSN 1399-543X. - 18:3(2017), pp. 241-248. [10.1111/pedi.12378]
Abstract:
OBJECTIVE: To identify the role of the family's socio-economic and clinical characteristics on metabolic control in children and adolescents with type 1 diabetes. METHODS: In this cross-sectional, multicentre study, 768 subjects with type 1 diabetes under 18 years of age were consecu...tively recruited from January 2008 to February 2009. Target condition was considered for HbA1c values <7.5% (<58 mmol/mol). A multiple correspondence analysis (MCA) was performed to analyze the association between the socio-economic and clinical characteristics of the participants. A logistic regression analysis was performed to identify factors associated with the subjects metabolic control. In both analyses, the family's socio-economic status was represented, measured by the Hollingshead Four-Factor Index of Social Status (SES) or by parental years of education. RESULTS: A total of 28.1% of subjects reached target HbA1c values. The MCA identified a strong association between at-target condition and several factors: high levels of SES or high levels of parental education, the use of the carbohydrate counting system, the use of insulin pumps, the use of the insulin delivery system over a short period of time, a normal body mass index. The logistic regression analysis showed that SES and the mother's years of education were significantly associated with the target condition [odds ratio (OR): 1.01, 95% confidence interval (CI): 1.01-1.03, p = 0.029; OR: 1.05, 95% CI: 1.01-1.10, p = 0.027, respectively). CONCLUSIONS: Personal, clinical, and family characteristics were found to be associated with HbA1c target. Their identification can be crucial in addressing strategies to optimize metabolic control and improve diabetes management
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Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy
Anno: 2017
Rivista: SURGICAL ENDOSCOPY
Autori/autrici: Ghiselli, Roberto; Ortenzi, Monica; Cardinali, Luca; Skrami, Edlira; Gesuita, Rosaria; Guerrieri, Mario
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/249096
Citazioni:
Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy / Ghiselli, R., Ortenzi, M., Cardinali, L., Skrami, E., Gesuita, R., Guerrieri, M.. - In: SURGICAL ENDOSCOPY. - ISSN 0930-2794. - ELETTRONICO. - 31:7(2017), pp. 2997-3003. [10.1007/s00464-016-5321-z]
Abstract:
Background In patients who exhibit a complete clinical response after radio-chemotherapy for rectal cancer, the standard surgical approach might constitute overtreatment. The aim of this study is to analyse the outcomes of anorectal function and quality of life after transanal endoscopic microsurge...ry (TEM) in irradiated patients with complete clinical response. Patients and methods Between 2007 and 2014, 84 patients who were diagnosed with stage T2–T3–T4 N0 rectal cancer before chemoradiotherapy showed a complete clinical response to neoadjuvant therapy and underwent TEM. All patients were evaluated before and 1 year after TEM using the Cleveland Clinic Florida Fecal Incontinence Score (CCF-FIS) questionnaire to determine the impact of this surgical technique on the degree of faecal continence. To assess the quality of life of patients after surgery, we administered the Fecal Incontinence Quality of Life Scale. Results Twenty-three patients exhibited a worse incontinence status after surgical intervention (27.4; 95% CI 18.2–38.2). These patients experienced a median positive absolute variation in the CCF-FIS of four points (95% CI 3.5–4.5; p.001). Female sex and age showed a significant correlation with the worsening of continence status. Scores on the Fecal Incontinence Quality of Life Index Scale did not show a significant difference efore and after TEM. Conclusions TEM may be an alternative treatment for patients with rectal cancer who exhibit a complete clinical response to neoadjuvant chemoradiotherapy because it offers the possibility to achieve a full hickness excision of the rectal wall. TEM also allows the identification of any residual disease and provides optimal quality of life and functional results.
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Le amputazioni non traumatiche degli arti inferiori associate alla patologia diabetica in Italia durante il 2005-2014: studio dell’andamento temporale e della variabilità geografica basato sull’utilizzo dei database amministrativi sanitari.
Anno: 2016
Autori/autrici: Skrami, E; Romagnoli, F; Carle, F; Gesuita, R
Lingua: ITA
Classificazione IRIS: 4.3 Poster
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256435
Citazioni:
Le amputazioni non traumatiche degli arti inferiori associate alla patologia diabetica in Italia durante il 2005-2014: studio dell’andamento temporale e della variabilità geografica basato sull’utilizzo dei database amministrativi sanitari / Skrami, E., Romagnoli, F., Carle, F., Gesuita, R.. - (2016). (L'evoluzione della ricerca epidemiologica basata sugli archivi sanitari: uno sguardo al futuro Pavia 24 - 25 novembre 2016).

Ricoveri per complicanze acute
Anno: 2016
Autori/autrici: Carle, Flavia; Galadini, Marco; Skrami, Edlira; Lispi, Lucia
Lingua: ITA
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256369
Citazioni:
Ricoveri per complicanze acute / Carle, F., Galadini, M., Skrami, E., Lispi, L.. - ELETTRONICO. - (2016), pp. 333-338.

Time trend and geographical pattern of diabetic lower-extremity amputations incidence in Italy during 2005-2014
Anno: 2016
Autori/autrici: Skrami, E; Romagnoli, F; Fabbietti, P; Carle, F; Gesuita, R
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256529
Citazioni:
Time trend and geographical pattern of diabetic lower-extremity amputations incidence in Italy during 2005-2014 / Skrami, E., Romagnoli, F., Fabbietti, P., Carle, F., Gesuita, R.. - (2016). (51th Annual meeting of the European Diabetes Epidemiology Group Dublino, Irlanda 16 - 19 Aprile 2016).

Andamento temporale e distribuzione geografica delle amputazioni non traumatiche degli arti inferiori nei soggetti con diabete in Italia durante il 2005-2014
Anno: 2016
Autori/autrici: Skrami, E; Romagnoli, F; Carle, F; Gesuita, R.
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256528
Citazioni:
Andamento temporale e distribuzione geografica delle amputazioni non traumatiche degli arti inferiori nei soggetti con diabete in Italia durante il 2005-2014 / Skrami, E., Romagnoli, F., Carle, F., Gesuita, R.. - (2016). (40° Congresso dell’Associazione Italiana di Epidemiologia “Le evidenze in epidemiologia: una storia lunga 40 anni” Torino 19 - 21 ottobre 2016).

Epidemiology, clinical characteristics, and outcome of candidemia in a tertiary referral center in Italy from 2010 to 2014
Anno: 2016
Rivista: INFECTION
Autori/autrici: Barchiesi, Francesco; Orsetti, Elena; Gesuita, Rosaria; Skrami, Edlira; Manso, Esther
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/230456
Citazioni:
Epidemiology, clinical characteristics, and outcome of candidemia in a tertiary referral center in Italy from 2010 to 2014 / Barchiesi, F., Orsetti, E., Gesuita, R., Skrami, E., Manso, E.. - In: INFECTION. - ISSN 0300-8126. - ELETTRONICO. - 44:2(2016), pp. 205-213. [10.1007/s15010-015-0845-z]
Abstract:
PURPOSE: We evaluated the epidemiology, clinical characteristics and outcome of candidemia in a single institution from 2010 to 2014. METHODS: A retrospective observational study of all cases of candidemia was carried out at a University Hospital in Central Italy including five intensive care... units (ICUs), 11 medical and 11 surgical wards. Data regarding demographic characteristics and clinical risk factors were collected from the patient's medical records. Antifungal susceptibility testing was performed and MIC results were interpreted according to species-specific clinical breakpoints. RESULTS: A total of 270 episodes of candidemia were identified. Overall incidence rate was 1.5 episodes/1000 hospital admissions. Although Candida albicans represented the most commonly isolated species, its percentage significantly decreased from 68 to 48 % (p = 0.040). The overall 30-day mortality was 35 %. The variables independently associated with a significant higher risk of mortality were: older age; being hospitalized in ICU or in medical wards vs surgical wards; being infected with C. albicans vs other species; the occurrence of septic shock, pneumonia and acute renal failure; the presence of a solid organ tumor or a chronic pulmonary disease. Conversely, an appropriate treatment was confirmed to be significantly associated with a lower risk of mortality. The overall resistance was low and it was noted only among triazoles. CONCLUSIONS: Our study shows that candidemia is a significant source of morbidity and mortality. The identification of risk factors associated with mortality along with the knowledge of local susceptibility may lead to a better management in terms of preventive and therapeutic measures.
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Effect of nerve growth factor on cultured human chondrocytes
Anno: 2016
Rivista: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Autori/autrici: Gigante, A; Senesi, Letizia; Manzotti, S; Palmieri, A; Skrami, E; Sollazzo, V
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256364
Citazioni:
Effect of nerve growth factor on cultured human chondrocytes / Gigante, A., Senesi, L., Manzotti, S., Palmieri, A., Skrami, E., Sollazzo, V.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - STAMPA. - 30:4 Suppl 1(2016), pp. 1-6.
Abstract:
Nerve growth factor (NGF) is involved in several joint diseases. It participates in nociception and neurogenic inflammation and its concentrations increase in synovial fluid and tissue from arthritis. However, data about its role in articular cartilage are scant and conflicting. This study analysed ...effects of different NGF concentrations on cultured human chondrocytes by evaluating cell proliferation, cell phenotype, and gene expression. The MTT test excluded an influence on cell viability. Alcian blue and S100 staining demonstrated that NGF may induce de-differentiation of the chondrocyte phenotype. Real-time PCR showed that NGF did not influence gene expression of type I, II and XI collagen, TGF-β, IGF-1 and metalloproteinase (MMP)-13, while it reduced the expression of MMP-3. These findings show that NGF may have uncertain effects in human chondrocytes. Further investigations by wider gene expression and protein synthesis analyses are required to determine how chondrocytes may be influenced by NGF.
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STANDARD CUT RATE 25-GAUGE VITRECTOMY VERSUS ULTRAHIGH-SPEED 25-GAUGE SYSTEM IN CORE VITRECTOMY: A Randomized Clinical Trial
Anno: 2016
Rivista: RETINA
Autori/autrici: Mariotti, Cesare; Nicolai, Michele; Saitta A, Andrea; Orsini, Emanuele; Viti, Francesca; Skrami, Edlira; Gesuita, Rosaria; Reibaldi, Michele; Giovannini, Alfonso
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/234036
Citazioni:
STANDARD CUT RATE 25-GAUGE VITRECTOMY VERSUS ULTRAHIGH-SPEED 25-GAUGE SYSTEM IN CORE VITRECTOMY: A Randomized Clinical Trial / Mariotti, C., Nicolai, M., Saitta A, A., Orsini, E., Viti, F., Skrami, E., Gesuita, R., Reibaldi, M., Giovannini, A.. - In: RETINA. - ISSN 0275-004X. - 36:7(2016), pp. 1271-1274. [10.1097/IAE.0000000000000924]
Abstract:
Purpose: The aim of this study was to compare the efficiency and safety of ultrahigh-speed cut rate 25-gauge system and standard cut rate 25-gauge vitrectomy system. Methods: In this single-center, prospective randomized study, all consecutive eyes that underwent 25-gauge vitrectomy at the Eye Cl...inic of the University of Ancona from September 2014 to November 2014 were randomized to receive 25-gauge vitrectomy with 7,500 cuts per minute (cpm) probes (7,500 Group) or 25-gauge vitrectomy with 5,000 cpm probes (Standard Group). Exclusion criteria were previously vitrectomized eye, trauma cases, retinal detachment with proliferative vitreoretinopathy, and endophthalmitis. Main outcome measure was core vitrectomy duration. Secondary outcome was the incidence of iatrogenic retinal breaks and other complications related to surgery. Results: Overall, 62 eyes were enrolled; 31 eyes received 25-gauge 7,500 cpm vitrectomy and 31 eyes received 25-gauge 5,000 cpm vitrectomy. The duration of core vitrectomy was significantly lower in the 7,500 Group (P = 0.030, t-test for independent samples). Mean ± standard deviation core vitrectomy time was 161.32 ± 39.10 seconds in the 7,500 Group and 184.10 ± 41.69 seconds in the Standard Group. The observed difference in mean core vitrectomy duration between subjects treated with 7,500 cpm probes and those in the Standard Group was equal −22 seconds (95% confidence interval: −43.3 to −2.2). There was no difference in the incidence of iatrogenic breaks between the 2 groups, and there were no other complications over a 3-month follow-up period. Conclusion: The 25-gauge 7,500 cpm vitrectomy is an effective and safe surgical procedure, and it can significantly reduce core vitrectomy time in eyes undergoing vitreoretinal surgery.
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A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes
Anno: 2016
Rivista: NUTRITION & DIABETES
Autori/autrici: Soare, A.; Del Toro, R.; Khazrai, Y. M.; Di Mauro, A.; Fallucca, S.; Angeletti, S.; Skrami, Edlira; Gesuita, Rosaria; Tuccinardi, D.; Manfrini, S.; Fallucca, F.; Pianesi, M.; Pozzilli, P.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/249091
Citazioni:
A 6-month follow-up study of the randomized controlled Ma-Pi macrobiotic dietary intervention (MADIAB trial) in type 2 diabetes / Soare, A., Del Toro, R., Khazrai, Y.M., Di Mauro, A., Fallucca, S., Angeletti, S., Skrami, E., Gesuita, R., Tuccinardi, D., Manfrini, S., Fallucca, F., Pianesi, M., Pozzilli, P.. - In: NUTRITION & DIABETES. - ISSN 2044-4052. - ELETTRONICO. - 6:8(2016), p. e222. [10.1038/nutd.2016.29]
Abstract:
BACKGROUND: In the MADIAB trial (a 21-day randomized, controlled trial in patients with type 2 diabetes (T2D)), intervention with the Ma-Pi 2 macrobiotic diet resulted in significantly greater improvements in metabolic control compared with a standard recommended diet for patients with T2D. We repor...t on a 6-month follow-up study, which investigated, whether these benefits extended beyond the 21-day intensive dietary intervention, in real-world conditions. SUBJECTS: At the end of the MADIAB trial (baseline of this follow-up study), all participants continued their assigned diet (Ma-Pi or control) for 6 months. The Ma-Pi 2 group followed the Ma-Pi 4 diet during this follow-up study. Forty of the original 51 subjects (78.4%) participated in the follow-up (body mass index, 27-45 kg m(-2); age, 40-75 years). Primary outcome was percentage change from baseline in HbA1c; secondary outcomes were anthropometric data and lipid panel. RESULTS: A significantly greater median percentage reduction was observed for HbA1c in the Ma-Pi group (-11.27% (95% confidence interval (CI): -10.17; -12.36)) compared with the control group (-5.88% (95% CI: -3.79; -7.98)) (P < 0.001). Total and low-density lipoprotein (LDL) cholesterol increased in both groups with no differences between groups (P=0.331 and P=0.082, respectively). After correcting for age and gender, the Ma-Pi diet was associated with a higher percentage reduction in HbA1c (95% CI: 2.56; 7.61) and body weight (95% CI: 0.40; 3.99), and a higher percentage increase in LDL cholesterol (95% CI: -1.52; -33.16). However, all participants' total and LDL cholesterol levels remained within recommended ranges (<200 mg dl(-1) and <100 mg dl(-1), respectively). The Ma-Pi diet group achieved the target median HbA1c value (<5.7% (39 mmol mol(-1))) at 6 months. CONCLUSIONS: Both the Ma-Pi and control diets maintained their benefits beyond the 21-day intensive monitored intervention over a 6-month follow-up in real-world conditions. The Ma-Pi diet resulted in greater improvement in glycemic control.
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High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: A nationwide longitudinal study, 2004-2013
Anno: 2016
Rivista: SCIENTIFIC REPORTS
Autori/autrici: Cherubini, Valentino; Skrami, Edlira; Ferrito, Lucia; Zucchini, Stefano; Scaramuzza, Andrea; Bonfanti, Riccardo; Buono, Pietro; Cardella, Francesca; Cauvin, Vittoria; Chiari, Giovanni; D'Annunzio, Giuseppe; Frongia, Anna Paola; Iafusco, Dario; Patera, Ippolita Patrizia; Toni, Sonia; Tumini, Stefano; Rabbone, Ivana; Lombardo, Fortunato; Carle, Flavia; Gesuita, Rosaria; Lera, Riccardo; De Luna, Livia; Gualtieri, Antonella; Zecchino, Clara; Piccinno, Elvira; Reinstadler, Petra; Prandi, Elena; Gallo, Francesco; Morganti, Gianfranco; Ripoli, Carlo; La Loggia, Alfonso; Scanu, Piera; Cardinale, Giuliana; Tomaselli, Letizia Grazia; Citriniti, Felice; Lazzaro, Nicola; De Donno, Valeria; Mainetti, Benedetta; Coccioli, Maria Susanna; Maccioni, Rosella; Marongiu, Ugo; Bruzzese, Mariella; Iannilli, Antonio; Pardi, Daniela; Confetto, Santino; Zanfardino, Angela; Iughetti, Lorenzo; Franzese, Adriana; Cadario, Francesco; Milia, Anna Franca; Piredda, Gavina; Soro, Miriam; Correddu, Antonella; Galderisi, Alfonso; De Berardinis, Fiorella; Federico, Giovanni; Zanette, Giorgio; Suprani, Tosca; Pedini, Annalisa; Bitti, Maria Luisa Manca; Delvecchio, Maurizio; Trada, Michela; Meloni, Gianfranco; Gaiero, Alberto; Bulciolu, Pasquale; Guerraggio, Lucia; Faleschini, Elena; Zanatta, Manuela; Salvatoni, Alessandro; Maffeis, Claudio; Arnaldi, Claudia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/249093
Citazioni:
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: A nationwide longitudinal study, 2004-2013 / Cherubini, V., Skrami, E., Ferrito, L., Zucchini, S., Scaramuzza, A., Bonfanti, R., Buono, P., Cardella, F., Cauvin, V., Chiari, G., D'Annunzio, G., Frongia, A.P., Iafusco, D., Patera, I.P., Toni, S., Tumini, S., Rabbone, I., Lombardo, F., Carle, F., Gesuita, R., et al.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 6:1(2016), p. 38844. [10.1038/srep38844]
Abstract:
This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004–2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Tw...o multiple logistic regression models were used to evaluate the time trend of DKA frequency considered as present versus absent and severe versus absent, adjusted for gender, age group and geographical area of residence at diagnosis. Overall, 9,040 cases were ascertained. DKA frequency was 40.3% (95%CI: 39.3–41.4%), with 29.1% and 11.2% for mild/moderate and severe DKA, respectively. Severe DKA increased significantly during the period (OR = 1.03, 95%CI: 1.003–1.05). Younger-age children and children living in Southern Italy compared to Central Italy were at significantly higher risk of DKA and severe DKA. Family history of type 1 diabetes and residence in Sardinia compared to Central Italy were significantly associated with a lower probability of DKA and severe DKA. The high frequency of ketoacidosis in Italy over time and high variability among age groups and geographical area of residence, strongly suggests a continuing need for nationwide healthcare strategies to increase awareness of early detection of diabetes.
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Real-time sonoelastography as novel follow-up method in Achilles tendon surgery
Anno: 2016
Rivista: KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
Autori/autrici: Busilacchi, Alberto; Olivieri, M.; Ulisse, S.; Gesuita, Rosaria; Skrami, Edlira; Lording, T.; Fusini, F.; Gigante, ANTONIO POMPILIO
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/234032
Citazioni:
Real-time sonoelastography as novel follow-up method in Achilles tendon surgery / Busilacchi, A., Olivieri, M., Ulisse, S., Gesuita, R., Skrami, E., Lording, T., Fusini, F., Gigante, A.P.. - In: KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY. - ISSN 0942-2056. - 24:7(2016), pp. 2124-2132. [10.1007/s00167-014-3484-5]

Utilizzo degli archivi elettronici sanitari nell’epidemiologia analitica: aspetti metodologici del disegno dello studio e dell’analisi statistica dei dati applicati alla stima del rischio di un evento clinico raro
Anno: 2015
Autori/autrici: Skrami, Edlira
Lingua: IT
Classificazione IRIS: 8.2 Tesi di dottorato (EX-A3)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/243049
Citazioni:
Utilizzo degli archivi elettronici sanitari nell’epidemiologia analitica: aspetti metodologici del disegno dello studio e dell’analisi statistica dei dati applicati alla stima del rischio di un evento clinico raro / Skrami, Edlira. - (2015 Mar 17).
Abstract:
La crescente disponibilità di banche dati informatizzate sanitarie ha reso gli studi osservazionali uno strumento potente a fornire evidenze scientifiche. Limiti connessi ai database e distorsioni da cui possono essere affetti questi studi, possono compromettere i risultati. Questa tesi anal...izza i metodi di correzione da utilizzare in fase di disegno e di analisi statistica. Alcune di essi sono stati applicati ad uno studio volto a valutare il rischio di sviluppare un evento raro, danno renale acuto (DRA) da somministrazione di mezzo di contrasto iodato (MCI). A tal fine sono stati applicati il disegno di coorte e di caso-controllo innestato nella coorte, utilizzando le schede di dimissioni ospedaliere della regione Marche. La coorte comprendeva 29925 soggetti a cui era stata somministrato il MCI durante il 2008-2011; sono stati individuati 324 casi di DRA in totale, per 129 di questi il tempo trascorso dalla data di somministrazione di MCI era <7 giorni, perciò associati al DRA. Il rischio di sviluppare DRA da MCI risultava 0.43%. Soggetti di età superiore a 65 anni, che soffrivano di una malattia del sistema genitourinario sono risultati a maggior rischio. Nello studio caso-controllo innestato, i 324 casi sono stati appaiati a 1258 controlli. L’esposizione al MCI e le malattie del sistema genitourinario erano significativamente associate ad un maggior rischio di DRA. L’effetto dell’esposizione sullo sviluppo del DRA riduceva il rischio nei soggetti con età superiore a 65 anni e in quelli con più di una somministrazione, mentre aumentava in quelli con una patologia diversa dalle malattie genitourinarie e del sistema circolatorio. Lo studio ha permesso di stimare il rischio di un evento raro e l’effetto dei fattori ad esso associati; rappresenta, altresì, una concreta applicazione della metodologia epidemiologica attuale, particolarmente attenta alle problematiche connesse all’utilizzo di una fonte di dati potente ma che al contempo richiede cautela e cognizione di causa nella sua applicazione.
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Type 1 Diabetes Mellitus incidence in Italy. Results from a population based registry study
Anno: 2015
Autori/autrici: Gesuita, R; Skrami, E; Carle, F; Cherubini, V; and RIDI study, Group
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256915
Citazioni:
Type 1 Diabetes Mellitus incidence in Italy. Results from a population based registry study / Gesuita, R., Skrami, E., Carle, F., Cherubini, V., and RIDI study, G.. - (2015). (50th annual EDEG meeting Francia 25-28 Aprile 2015).

Utilizzo degli archivi elettronici sanitari nella stima dell’associazione tra danno renale acuto e mezzo di contrasto iodato
Anno: 2015
Autori/autrici: Skrami, E; Ferrante, L; Carle, F; Gesuita, R
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256913
Citazioni:
Utilizzo degli archivi elettronici sanitari nella stima dell’associazione tra danno renale acuto e mezzo di contrasto iodato / Skrami, E., Ferrante, L., Carle, F., Gesuita, R.. - (2015). (Orizzonti 2020 per la Biostatistica e l’Epidemiologia Clinica: sfide e opportunità nel area dei big data Toriino 16-19 settembre 2015).

I database elettronici amministrativi di natura sanitaria in Italia: risultati preliminari del censimento SISMEC
Anno: 2015
Autori/autrici: Gesuita, R; Skrami, E; Guardabasso, V; Trerotoli, P; Villani, S; Zambon, A; Gruppo di Lavoro “Studi, Osservazionali”
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256914
Citazioni:
I database elettronici amministrativi di natura sanitaria in Italia: risultati preliminari del censimento SISMEC / Gesuita, R., Skrami, E., Guardabasso, V., Trerotoli, P., Villani, S., Zambon, A., Gruppo di Lavoro “Studi, O.. - (2015). (VIII Congresso Nazionale SISMEC. Orizzonti 2020 per la Biostatistica e l’Epidemiologia Clinica: sfide e opportunità nel area dei big data Torino 16-19 settembre 2015).

Epidemiology and clinical outcome of Healthcare-Associated Infections: a 4-year experience of an Italian ICU
Anno: 2015
Rivista: MINERVA ANESTESIOLOGICA
Autori/autrici: Boncagni, Federico; Francolini, Rossana; Nataloni, S; Skrami, Edlira; Gesuita, Rosaria; Donati, Abele; Pelaia, Paolo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/227416
Citazioni:
Epidemiology and clinical outcome of Healthcare-Associated Infections: a 4-year experience of an Italian ICU / Boncagni, F., Francolini, R., Nataloni, S., Skrami, E., Gesuita, R., Donati, A., Pelaia, P.. - In: MINERVA ANESTESIOLOGICA. - ISSN 1827-1596. - STAMPA. - 81:7(2015), pp. 765-775.
Abstract:
Due to their impact on the outcome, hospital-acquired infections (HAIs) in ICUs represent a critical issue of patients' assistance. This study describes microbiological and clinical findings of a surveillance program covering 4 years in an Italian ICU.

Invasive Aspergillosis in liver transplant recipients: Epidemiology, clinical characteristics, treatment, and outcomes in 116 cases
Anno: 2015
Rivista: LIVER TRANSPLANTATION
Autori/autrici: Barchiesi, Francesco; Mazzocato, Susanna; Mazzanti, Sara; Gesuita, Rosaria; Skrami, Edlira; Fiorentini, Alessro; Singh, Nina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/230446
Citazioni:
Invasive Aspergillosis in liver transplant recipients: Epidemiology, clinical characteristics, treatment, and outcomes in 116 cases / Barchiesi, F., Mazzocato, S., Mazzanti, S., Gesuita, R., Skrami, E., Fiorentini, A., Singh, N.. - In: LIVER TRANSPLANTATION. - ISSN 1527-6465. - ELETTRONICO. - 21:2(2015), pp. 204-212. [10.1002/lt.24032]
Abstract:
nvasive aspergillosis (IA) in liver transplant recipients is associated with grave outcomes. We reviewed 116 individual cases reported in the literature from 1985 to 2013. IA was diagnosed after a median of 25 days after transplantation and involved a single organ in 51% of the cases, whereas in the... remaining cases, multiple sites were involved. The most common infecting Aspergillus species were Aspergillus fumigatus (73%), Aspergillus flavus (14%), and Aspergillus terreus (8%). Amphotericin B was the drug most frequently used, and it was followed by voriconazole and itraconazole. Combination regimens were used in 51% of the cases. The overall 1-year cumulative survival probability was 35% [95% confidence interval (CI) = 24.6%-49.6%]. Survival was significantly higher for patients reported from the year 2000 and thereafter (P < 0.001), for those diagnosed with IA more than 30 days after transplantation versus those diagnosed earlier (P = 0.019), and for patients without renal failure (P = 0.020). Additionally, the use of voriconazole was significantly associated with a higher probability of survival (P < 0.001). Cox regression analysis showed that subjects with the involvement of multiple sites had a 2.52 times higher risk of a negative outcome (95% CI = 1.08-5.87) than those with the involvement of a single site. Thus, IA causes life-threatening infections in liver transplant recipients. Predictors associated with poor outcomes may help clinicians to optimize the management of this infection.
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Effect of a barley-vegetable soup on plasma carotenoids and biomarkers of cardiovascular disease
Anno: 2015
Rivista: JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Autori/autrici: Bacchetti, Tiziana; Tullii, Domenico; Masciangelo, Simona; Gesuita, Rosaria; Skrami, Edlira; Bruge', Francesca; Silvestri, Sonia; Orlando, Patrick; Tiano, Luca; Ferretti, Gianna
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/228069
Citazioni:
Effect of a barley-vegetable soup on plasma carotenoids and biomarkers of cardiovascular disease / Bacchetti, T., Tullii, D., Masciangelo, S., Gesuita, R., Skrami, E., Bruge', F., Silvestri, S., Orlando, P., Tiano, L., Ferretti, G.. - In: JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION. - ISSN 0912-0009. - STAMPA. - 57:1(2015), pp. 66-73. [10.3164/jcbn.15-11]
Abstract:
Functional foods that provide benefits beyond their traditional nutritional value have attracted much interest. Aim of the study was to evaluate the nutritional and the functional properties of a frozen ready-to-eat soup containing barley and pigmented vegetables. Both glycaemic index and the glycea...mic load of ready-to-eat soup were evaluated in vivo. Moreover the bioavailability of carotenoids (lutein and beta-carotene) and the effect on lipid profile and lipid peroxidation were studied in 38 volunteers whose diet was supplemented for two weeks with a daily portion (250 g) of the ready-to-eat soup. Plasma levels of carotenoids (lutein and beta-carotene) and plasma total antioxidant capacity significantly increased after 2 weeks of treatment. Furthermore, we observed a decrease in the levels of lipids (total cholesterol and low density lipoprotein-cholesterol) and of markers of lipid peroxidation (oxidized low density lipoprotein and lipid hydroperoxides) in plasma of all subjects. The glyceamic index of the product was 36, therefore it could be considered a low glyceamic index food. An accurate selection of vegetable foods results in a palatable and healthy product that provides benefits on plasma lipids and lipid peroxidation (Protocol number 211525).
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Bayesian calibration for forensic age estimation.
Anno: 2015
Rivista: STATISTICS IN MEDICINE
Autori/autrici: Ferrante, Luigi; Skrami, Edlira; Gesuita, Rosaria; Cameriere, R.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/223732
Citazioni:
Bayesian calibration for forensic age estimation / Ferrante, L., Skrami, E., Gesuita, R., Cameriere, R.. - In: STATISTICS IN MEDICINE. - ISSN 0277-6715. - STAMPA. - 34:(2015), pp. 1779-1790. [10.1002/sim.6448]
Abstract:
Forensic medicine is increasingly called upon to assess the age of individuals. Forensic age estimation is mostly required in relation to illegal immigration and identification of bodies or skeletal remains. A variety of age estimation methods are based on dental samples and use of regression models..., where the age of an individual is predicted by morphological tooth changes that take place over time. From the medico-legal point of view, regression models, with age as the dependent random variable entail that age tends to be overestimated in the young and underestimated in the old. To overcome this bias, we describe a new full Bayesian calibration method (asymmetric Laplace Bayesian calibration) for forensic age estimation that uses asymmetric Laplace distribution as the probability model. The method was compared with three existing approaches (two Bayesian and a classical method) using simulated data. Although its accuracy was comparable with that of the other methods, the asymmetric Laplace Bayesian calibration appears to be significantly more reliable and robust in case of misspecification of the probability model. The proposed method was also applied to a real dataset of values of the pulp chamber of the right lower premolar measured on x-ray scans of individuals of known age.
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Incidence of childhood type 1 diabetes in Italy during 2004-2013
Anno: 2015
Rivista: DIABETES
Autori/autrici: Cherubini, V; Gesuita, R; Bruzzese, M; D'Annunzio, G; Ferrito, Lucia; Frongia, A; Iafusco, D; Iannilli, A; Iughetti, L; Lombardo, F; Piffer, S; Toni, S; Tumini, S; Skrami, E; Carle, F; Ridi Study, Group
Lingua: ENG
Classificazione IRIS: 1.5 Abstract in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256912
Citazioni:
Incidence of childhood type 1 diabetes in Italy during 2004-2013 / Cherubini, V., Gesuita, R., Bruzzese, M., D'Annunzio, G., Ferrito, L., Frongia, A., Iafusco, D., Iannilli, A., Iughetti, L., Lombardo, F., Piffer, S., Toni, S., Tumini, S., Skrami, E., Carle, F., Ridi Study, G.. - In: DIABETES. - ISSN 0012-1797. - 64:(2015), pp. A405-A405.
Abstract:
Childhood type 1 diabetes has been shown an increase in Italy of 3.0% during 1990-2003. Aim of this study was to describe the incidence for type 1 diabetes in children 0-14 years in the same geographical area, during 2004-2013, according to gender, age and area of residence. Registry for type 1 dia...betes mellitus in Italy (RIDI) is a coordination of local registries established in 1997. Eleven registries, distributed throughout the country, contributed to this analysis, covering more than 25% of the total Italian population. Cases were grouped into four macro-area of residence at diagnosis: North, Centre, South, and Sardinia. The incidence rates were age-standardized on the World Standard Population. 95% Confidence intervals (95%CI) were estimated assuming the Poisson distribution of cases. Rates were expressed per 100,000 person-years. Trend analysis of incidence was performed using a Poisson regression model. Ascertainment exceeded 90% in all registers. During the 10-year period 3643 subjects under 15 years of age developed type 1 diabetes. The highest incidence occurred in Sardinia for both males and females [41.8 (95%CI: 36.3-48.0) and 42.1 (95%CI: 36.4-48.7), respectively]. In the Peninsular Italy, the overall incidence was 14.5 (95%CI: 13.6-15.4) for males, and 13.1 (95%CI: 12.3-14.0) for females. No significant differences were found between the three geographical macro-areas and gender. A significant positive time trend was found in Sardinia and in South Italy, with an average increase of 2.6% (95%CI 0.6%-4.7%) and 3.9% (95%CI: 2.2%-5.6%) of new cases per year, respectively. During 2004-2013 the incidence rates of childhood diabetes were stable in North and Central Italy, whereas South Italy and Sardinia showed significantly increased rates. This pattern of change suggests that important risk exposures differed over time in different geographical area. Further time trend analysis and comparison of the patterns in defined regions is warranted
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Epidemiology and outcome of systemic infections due to saprochaete capitata: case report and review of the literature
Anno: 2015
Rivista: INFECTION
Autori/autrici: Mazzocato, Susanna; Marchionni, E.; Fothergill, A. W.; Sutton, D. A.; Staffolani, S.; Gesuita, Rosaria; Skrami, Edlira; Fiorentini, A.; Manso, E.; Barchiesi, Francesco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/230469
Citazioni:
Epidemiology and outcome of systemic infections due to saprochaete capitata: case report and review of the literature / Mazzocato, S., Marchionni, E., Fothergill, A.W., Sutton, D.A., Staffolani, S., Gesuita, R., Skrami, E., Fiorentini, A., Manso, E., Barchiesi, F.. - In: INFECTION. - ISSN 0300-8126. - ELETTRONICO. - 43:2(2015), pp. 211-215. [10.1007/s15010-014-0668-3]
Abstract:
A case of systemic infection due to Saprochaete capitata in a patient with chronic lymphocytic leukemia is described. A review of the literature was conducted to identify all reported cases of this infection described between 1977 and August 2013. One hundred and four cases (included the present one...) were identified. The median age of the patients was 56 years and 56% were males. Comorbidities included acute myeloid leukemia (52%), acute lymphoid leukemia (22%), other hematological malignancies (13%) and non-hematological diseases (9%). At the time of the infection, 82% of the patients were neutropenic. In 75% of the cases, the yeast was isolated from blood culture, in 25% from other sterile sites. Empirical treatment was done in 36% of the cases. Fifty-eight percent of the individual cases were treated with a combination or a sequential antifungal therapy. Amphotericin B was the antifungal drug most commonly used, followed by voriconazole and itraconazole. The overall crude mortality was 60%. Saprochaete capitata causes life-threatening infections in neutropenic patients. This comprehensive literature review may help the clinician to optimize the management of this rare infection.
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Dysfunctional breathing and association with asthma in the age of adolescence
Anno: 2014
Autori/autrici: Skrami, E; Ferrante, L; D’Alba, I; Carloni, I; Carle, F; De Benedictis, Fm; Gesuita, R
Lingua: ITA
Classificazione IRIS: 4.3 Poster
Scheda completa IRIS: https://iris.univpm.it/handle/11566/256916
Citazioni:
Dysfunctional breathing and association with asthma in the age of adolescence / Skrami, E., Ferrante, L., D’Alba, I., Carloni, I., Carle, F., De Benedictis, F.m., Gesuita, R.. - (2014). (Congresso Intermedio SISMEC 2014 “Large scale population-based surveys on respiratory health in Italy and Europe Verona 23 – 24 ottobre 2014).

Ketoacidosis at diabetes diagnosis: An Italian national – wide study, 2005 – 2012.
Anno: 2014
Autori/autrici: Skrami, Edlira; Gesuita, Rosaria; Iannili, A.; Sternardi, S.; Carle, Flavia; Cherubini, V.
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179322
Citazioni:
Ketoacidosis at diabetes diagnosis: An Italian national – wide study, 2005 – 2012 / Skrami, E., Gesuita, R., Iannili, A., Sternardi, S., Carle, F., Cherubini, V.. - STAMPA. - (2014), pp. 23-24. (49th Annual meeting of the European Diabetes Epidemiology Group Cagliari 29 marzo - 1 aprile 2014).

Epidemiologia della chetoacidosi diabetica in Italia
Anno: 2014
Rivista: GIDM. GIORNALE ITALIANO DI DIABETOLOGIA E METABOLISMO
Autori/autrici: Cherubini, V.; Gesuita, R.; Sternardi, Sara; Ferrito, L.; Lenzi, L.; Iannilli, A.; Piccini, B.; Skrami, E.; Nicolucci, A.; Pintaudi, B.; Toni, S.; Lera, R.; De Luna, L.; Kienberger, Beatrice; Ferrito, L.; Gualtieri, A.; Zecchino, C.; Piccino, E.; Ortolani, F.; Zucchini, S.; Maltoni, G.; Pasquino, B.; Reinstadler, P.; Prandi, E.; Zattoni, V.; Gallo, Francesco; Morganti, G.; Guerraggio, L.; Ripoli, C.; Frongia, M.; Pusceddu, P.; La Loggia, A.; Scanu, BATTISTA PASQUALE; Cardinale, G.; Ponzi, G.; Tomaselli, L. G.; Rapisarda, V.; Citriniti, F.; Soprani, T.; Tumini, S.; Lazzaro, N.; De Donno, V.; Banin, P.; Toni, S.; Lenzi, L.; Mainetti, B.; Coccioli, M. S.; D'Annunzio, Gianluca; Minuto, N.; Montani, E.; Maccioni, R.; Marongiu, U.; Beccaria, L.; Bruzzese, M.; Mammì, F.; Pardi, D.; Lombardo, F.; Ventrici, C.; Scaramazza, A.; Ferrari, M.; Bonfanti, R.; Rigamonti, A.; Iughetti, L.; Predieri, B.; Iafusco, D.; Confetto, S.; Zanfardino, A.; Prisco, F.; Franzese, A.; De Nitto, E.; Cadario, F.; Milia, A.; Piredda, G.; Mereu, L.; Soro, M.; Correddu, A.; Pipia, A.; Monciotti, C.; Cardella, F.; DE BERARDINIS, Fabiana; Santoro, G.; Chiari, G.; Berioli, M. G.; DI FEDERICO, Giulio; Zanette, G.; Marsciani, A.; Pedini, A.; Patera, I. P.; Schiaffini, R.; Bitti, M.; Lidano, R.; Pietrosanti, S.; Delvecchio, M.; Trada, M.; Marinaro, A.; Meloni, G.; Galero, A.; Fichera, G.; Bulciolu, P.; Rabbone, I.; Ignaccolo, G.; Cauvin, V.; Franceschi, R.; Faleschini, E.; Tornese, G.; Salvatoni, A.; Cardani, R.; Maffeis, Claudio; Marigliano, M.; Sabbion, A.; Arnaldi, C.
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179902
Citazioni:
Epidemiologia della chetoacidosi diabetica in Italia / Cherubini, V., Gesuita, R., Sternardi, S., Ferrito, L., Lenzi, L., Iannilli, A., Piccini, B., Skrami, E., Nicolucci, A., Pintaudi, B., Toni, S., Lera, R., De Luna, L., Kienberger, B., Ferrito, L., Gualtieri, A., Zecchino, C., Piccino, E., Ortolani, F., Zucchini, S., et al.. - In: GIDM. GIORNALE ITALIANO DI DIABETOLOGIA E METABOLISMO. - ISSN 1593-6104. - STAMPA. - 34:(2014), pp. 109-115.

The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial
Anno: 2014
Rivista: NUTRITION & METABOLISM
Autori/autrici: Soare, Andreea; Khazrai, Yeganeh M; Del Toro, Rossella; Roncella, Elena; Fontana, Lucia; Fallucca, Sara; Angeletti, Silvia; Formisano, Valeria; Capata, Francesca; Ruiz, Vladimir; Porrata, Carmen; Skrami, Edlira; Gesuita, Rosaria; Manfrini, Silvia; Fallucca, Francesco; Pianesi, Mario; Pozzilli, Paolo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/225337
Citazioni:
The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial / Soare, A., Khazrai, Y.M., Del Toro, R., Roncella, E., Fontana, L., Fallucca, S., Angeletti, S., Formisano, V., Capata, F., Ruiz, V., Porrata, C., Skrami, E., Gesuita, R., Manfrini, S., Fallucca, F., Pianesi, M., Pozzilli, P.. - In: NUTRITION & METABOLISM. - ISSN 1743-7075. - STAMPA. - 11:1(2014). [10.1186/1743-7075-11-39]
Abstract:
Background: Diet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different dietary approach, the macrobiotic Ma-Pi 2 diet, and compared it with standard di...ets recommended for patients with type 2 diabetes. Methods: A randomized, controlled, open-label, 21-day trial was undertaken in patients with type 2 diabetes comparing the Ma-Pi 2 diet with standard (control) diet recommended by professional societies for treatment of type 2 diabetes. Changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) were primary outcomes. HbA1c, insulin resistance (IR), lipid panel and anthropometrics were secondary outcomes. Results: After correcting for age, gender, BMI at baseline, and physical activity, there was a significantly greater reduction in the primary outcomes FBG (95% CI: 1.79; 13.46) and PPBG (95% CI: 5.39; 31.44) in those patients receiving the Ma-Pi 2 diet compared with those receiving the control diet. Statistically significantly greater reductions in the secondary outcomes, HbA1c (95% CI: 1.28; 5.46), insulin resistance, total cholesterol, LDL cholesterol and LDL/HDL ratio, BMI, body weight, waist and hip circumference were also found in the Ma-Pi 2 diet group compared with the control diet group. The latter group had a significantly greater reduction of triglycerides compared with the Ma-Pi 2 diet group. Conclusions: Intervention with a short-term Ma-Pi 2 diet resulted in significantly greater improvements in metabolic control in patients with type 2 diabetes compared with intervention with standard diets recommended for these patients
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A BAYESIAN APPROACH TO FORENSIC AGE ESTIMATION
Anno: 2014
Autori/autrici: Ferrante, Luigi; Gesuita, Rosaria; Skrami, Edlira; Cameriere, R.
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179110
Citazioni:
A BAYESIAN APPROACH TO FORENSIC AGE ESTIMATION / Ferrante, L., Gesuita, R., Skrami, E., Cameriere, R.. - (2014). (XXVII International Biometric Conference 2014 Florence, Italy july, 6-11 2014).

Ketoacidosis at diagnosis of type 1 diabetes: an Italian Survey 2005-2012
Anno: 2014
Rivista: DIABETES
Autori/autrici: Cherubini, V.; Skrami, E.; Sternardi, S.; Iannilli, A.; Carle, F.; Gesuita, R.; Grp DKA Italy, Study
Lingua: ENG
Classificazione IRIS: 1.5 Abstract in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179721
Citazioni:
Ketoacidosis at diagnosis of type 1 diabetes: an Italian Survey 2005-2012 / Cherubini, V., Skrami, E., Sternardi, S., Iannilli, A., Carle, F., Gesuita, R., Grp DKA Italy, S.. - In: DIABETES. - ISSN 0012-1797. - STAMPA. - 63:(2014), pp. A408-A408. [10.2337/db14-1317-1629]

Effect of black and red cabbage on plasma carotenoid levels, lipid profile and oxidized low density lipoprotein
Anno: 2014
Rivista: JOURNAL OF FUNCTIONAL FOODS
Autori/autrici: Bacchetti, Tiziana; Domenico, Tullii; Masciangelo, Simona; Gesuita, Rosaria; Skrami, Edlira; Bruge', Francesca; Silvestri, Sonia; Orlando, Patrick; Tiano, Luca; Ferretti, Gianna
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/157718
Citazioni:
Effect of black and red cabbage on plasma carotenoid levels, lipid profile and oxidized low density lipoprotein / Bacchetti, T., Domenico, T., Masciangelo, S., Gesuita, R., Skrami, E., Bruge', F., Silvestri, S., Orlando, P., Tiano, L., Ferretti, G.. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 8:(2014), pp. 129-138. [10.1016/j.jff.2014.02.020]
Abstract:
The bioavailability of carotenoids and the protective effect exerted by Brassica vegetables against lipoprotein peroxidation has not previously been investigated in humans. The aim of this study was to evaluate the bioavailability of carotenoids in black (Brassica oleracea L. var. acephala subvar. L...aciniata L) and red cabbage (Brassica oleracea L. var. capitata L.f. rubra) and their protective effect against LDL oxidation. Moreover, we studied the effect on plasma lipid profile. Thirty-eight healthy volunteers (23 females and 15 males) participated in the 2-week intervention study which included a daily portion (300 g) of black and red cabbage. Plasma lutein and β-carotene levels and total antioxidant capacity after dietary intervention were significantly increased. The results obtained demonstrated that Brassica supplementation favourably influenced serum lipid profile with a significant decrease in total cholesterol, LDL-cholesterol and oxidized LDL. Moreover, our results strengthen the hypothesis that the effect of dietary intervention could be modulated by baseline conditions of the subjects
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THE EFFECT OF MISSING DATA IMPUTATION METHODS IN EPIDEMIOLOGICAL STUDIES BASED ON HEALTH ELECTRONIC DATABASES: AN APPLICATION TO THE EVALUATION OF INEQUALITY IN DIABETES
Anno: 2013
Autori/autrici: Gesuita, Rosaria; Paolini, I.; Skrami, Edlira; Piraccini, F.; Damiani, G.; Carle, Flavia; Ferrante, Luigi; AEQUITAS Study, Group
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179112
Citazioni:
THE EFFECT OF MISSING DATA IMPUTATION METHODS IN EPIDEMIOLOGICAL STUDIES BASED ON HEALTH ELECTRONIC DATABASES: AN APPLICATION TO THE EVALUATION OF INEQUALITY IN DIABETES / Gesuita, R., Paolini, I., Skrami, E., Piraccini, F., Damiani, G., Carle, F., Ferrante, L., AEQUITAS Study, G.. - STAMPA. - (2013), pp. 77-78. (48th annual meeting of the European Diabetes Epidemiology Group Potsdam, Germany 13th – 16th April 2013).

Parents, physicians and adolescents’ perspectives in the management of type 1 diabetes
Anno: 2013
Autori/autrici: Skrami, Edlira; Cherubini, V.; Ferrante, Luigi; Giorgetti, C.; Alessandrelli, M. C.; Carle, Flavia; Gesuita, Rosaria; VIPKIDS Study, Group
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179109
Citazioni:
Parents, physicians and adolescents’ perspectives in the management of type 1 diabetes / Skrami, E., Cherubini, V., Ferrante, L., Giorgetti, C., Alessandrelli, M.C., Carle, F., Gesuita, R., VIPKIDS Study, G.. - STAMPA. - (2013), pp. 78-78. (48th annual meeting of the European Diabetes Epidemiology Group Potsdam, Germany 13th – 16th April 2013).

Stima del rischio di danno renale acuto da mezzo di contrasto mediante l’utilizzo di banche di dati amministrativi
Anno: 2013
Autori/autrici: Skrami, Edlira; Gesuita, Rosaria; Marcobelli, A.; Carle, Flavia; Ferrante, Luigi
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179111
Citazioni:
Stima del rischio di danno renale acuto da mezzo di contrasto mediante l’utilizzo di banche di dati amministrativi / Skrami, E., Gesuita, R., Marcobelli, A., Carle, F., Ferrante, L.. - ELETTRONICO. - (2013). (VII Congresso Nazionale SISMEC - Scoperte scientifiche, Evidenze cliniche. Misure e metodi Roma, Italia 25-28 settembre 2013).

The role of subject’s clinical characteristics and family’s socio – economic status on glycemic control in children and adolescents with type 1 diabetes.
Anno: 2012
Autori/autrici: Skrami, Edlira; Gesuita, Rosaria; Francesca, Rosati; Antonio, Iannilli; Martina, Biagioni; Valentino, Cherubini; Andrea, Mosca; Carle, Flavia; VIPKIDS Study, Group
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179324
Citazioni:
The role of subject’s clinical characteristics and family’s socio – economic status on glycemic control in children and adolescents with type 1 diabetes / Skrami, E., Gesuita, R., Francesca, R., Antonio, I., Martina, B., Valentino, C., Andrea, M., Carle, F., VIPKIDS Study, G.. - STAMPA. - (2012), pp. 28-30. (7th World Congress on Prevention of Diabetes and its Complications Madrid 11-14 novembre).

Social, demographic, clinic characteristics and metabolic control of youth affected from type 1 diabetes in Italy
Anno: 2012
Autori/autrici: Skrami, Edlira; Gesuita, Rosaria; Antonio, Iannilli; Martina, Biagioni; Carle, Flavia; Valentino, Cherubini; VIPKIDS Study, Group
Lingua: ENG
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179325
Citazioni:
Social, demographic, clinic characteristics and metabolic control of youth affected from type 1 diabetes in Italy / Skrami, E., Gesuita, R., Antonio, I., Martina, B., Carle, F., Valentino, C., VIPKIDS Study, G.. - STAMPA. - (2012), pp. 57-57. (46th annual meeting of the European Diabetes Epidemiology Group Swansea, Wales 12-15 maggio 2012).

Confronto tra metodi calibrativi per la stima dell’età.
Anno: 2011
Autori/autrici: Skrami, Edlira; Gesuita, Rosaria; Carle, Flavia; Cameriere, R.; Ferrante, Luigi
Lingua: ITA
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/179113
Citazioni:
Confronto tra metodi calibrativi per la stima dell’età / Skrami, E., Gesuita, R., Carle, F., Cameriere, R., Ferrante, L.. - STAMPA. - (2011), pp. 212-213. (VI Congresso Nazionale SISMEC “Misurare per migliorare” Ancona, Italia 28 settembre 1 ottobre 2011).