Smooth blood pressure control obtained with extended-release felodipine in elderly patients with hypertension: evaluation by 24-hour ambulatory blood pressure monitoring
Anno: 2002
Rivista: DRUGS & AGING
Autori/autrici: Antonicelli, R; Omboni, S; Giovanni, Dc; Ansuini, R; Mori, A; Gesuita, Rosaria; Parati, G; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/39145
Citazioni:
Smooth blood pressure control obtained with extended-release felodipine in elderly patients with hypertension: evaluation by 24-hour ambulatory blood pressure monitoring / Antonicelli, R., Omboni, S., Giovanni, D.c., Ansuini, R., Mori, A., Gesuita, R., Parati, G., Paciaroni, E.. - In: DRUGS & AGING. - ISSN 1170-229X. - 19(7):(2002), pp. 541-551.

Cardiovascular phenotype of young adults and angiotensinogen alleles
Anno: 2001
Rivista: JOURNAL OF HYPERTENSION
Autori/autrici: Sarzani, Riccardo; DESSI' FULGHERI, Paolo Lorenzo; Mazzara, D; Catalini, R; Cola, G; Bersigotti, G; Siragusa, N; Salvi, Fabio; Ercolani, P; Spagnolo, D; Zingaretti, O; Serenelli, M; Pupita, M; Magni, Cm; Giantomassi, L; Pasquini, R; Gesuita, Rosaria; Carle, Flavia; Rappelli, Alessandro
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/51301
Citazioni:
Cardiovascular phenotype of young adults and angiotensinogen alleles / Sarzani, R., DESSI' FULGHERI, P.L., Mazzara, D., Catalini, R., Cola, G., Bersigotti, G., Siragusa, N., Salvi, F., Ercolani, P., Spagnolo, D., Zingaretti, O., Serenelli, M., Pupita, M., Magni, C.m., Giantomassi, L., Pasquini, R., Gesuita, R., Carle, F., Rappelli, A.. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 19(12):(2001), pp. 2171-2178.

Internal comparative audit in a thoracic surgery unit using the physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM).
Anno: 2001
Rivista: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Autori/autrici: Brunelli, A; Fianchini, A; AL REFAI, M; Gesuita, Rosaria; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/39850
Citazioni:
Internal comparative audit in a thoracic surgery unit using the physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) / Brunelli, A., Fianchini, A., AL REFAI, M., Gesuita, R., Carle, F.. - In: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. - ISSN 1010-7940. - 19(6):(2001), pp. 924-928.

Random fasting hyperglycemia as cardiovascular risk factor in the elderly: a 6-year longitudinal study.
Anno: 2000
Rivista: CLINICAL CARDIOLOGY
Autori/autrici: Antonicelli, R; Gesuita, Rosaria; Boemi, M; Paciaroni, E; CAMERANO STUDY, Group
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/39147
Citazioni:
Random fasting hyperglycemia as cardiovascular risk factor in the elderly: a 6-year longitudinal study / Antonicelli, R., Gesuita, R., Boemi, M., Paciaroni, E., CAMERANO STUDY, G.. - In: CLINICAL CARDIOLOGY. - ISSN 0160-9289. - 24(4):(2000), pp. 341-344.

Advanced non-small cell lung cancer in the elderly: effective and well tolerated weekly gemcitabine and cisplatin regimen. A pilot study.
Anno: 2000
Rivista: MINERVA MEDICA
Autori/autrici: Lippe, P; Silva, Rr; Giuliodori, L; Cancellieri, Ma; Battelli, N; Massacesi, C; Berardi, Rossana; Bisonni, R; Gesuita, Rosaria; Cellerino, Riccardo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76036
Citazioni:
Advanced non-small cell lung cancer in the elderly: effective and well tolerated weekly gemcitabine and cisplatin regimen. A pilot study / Lippe, P., Silva, R.r., Giuliodori, L., Cancellieri, M.a., Battelli, N., Massacesi, C., Berardi, R., Bisonni, R., Gesuita, R., Cellerino, R.. - In: MINERVA MEDICA. - ISSN 0026-4806. - STAMPA. - 91:3-4(2000), pp. 53-57.
Abstract:
BACKGROUND: The frequency of advanced non-small cell lung cancer (NSCLC) increases with age and more effective and less toxic chemotherapy schedules are needed in elderly patients. Cisplatin-based regimens are considered the best treatment for advanced NSCLC, although they produce only a modest adva...ntage in overall survival with considerable toxicity.METHODS: In the present study the activity and toxicity of a weekly gemcitabine and cisplatin schedule was evaluated in a small group of advanced NSCLC patients aged 68 years or more. Treatment consisted of gemcitabine 1000 mg/m2 i.v. and cisplatin 35 mg/m2 i.v., both given weekly on days 1, 8, 15 followed by 1 week of rest.RESULTS: Fifteen previously untreated patients entered the study; their median age was 72 years (range 68-76). One hundred and sixteen weekly administrations were delivered. The median dose-intensity was 614.5 mg/m2 per week for gemcitabine (82%) and 21 mg/m2 per week for cisplatin (80%). All the 15 patients were evaluable for response and toxicity. The overall response rate was 40% [95% CI = 16-68%]. The main toxicity was WHO grade III-IV thrombocytopenia that was recorded in 6 patients (40%). Other major toxicities were very low and no treatment-related deaths were reported.CONCLUSIONS: This schedule appears to be active, to have a favourable toxicity profile and can be considered in advanced NSCLC elderly patients. Of interest, the patients enrolled received high dose intensities of both drugs
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Sexual dimorphism in arterial hypertension: an age-related phenomenon.
Anno: 1999
Rivista: ARCHIVES OF GERONTOLOGY AND GERIATRICS
Autori/autrici: Antonicelli, R; Gesuita, Rosaria; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76042
Citazioni:
Sexual dimorphism in arterial hypertension: an age-related phenomenon / Antonicelli, R., Gesuita, R., Paciaroni, E.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 29:3(1999), pp. 283-289.
Abstract:
Epidemiological, clinical and experimental evidence is available indicating that male subjects develop hypertension with a higher probability than age-matched females. The sexual dimorphism of blood pressure (BP) has been observed both in normotensive and hypertensive subjects. In order to analyze t...he presence of sexual dimorphism of arterial hypertension (AH) and its relationship to the aging process - particularly to the menopause - the population screened in the Camerano Study has been examined. In addition, to evaluate sex-related differences in the AH, another sample of 3765 patients from our Hypertension Centre has also been considered. Our samples displayed a real cross-over in the prevalence of arterial hypertension, hypercolesterolemia, hyperglycemia and obesity in women versus men, after the menopausal period. In fact, in the adult group (20-54 years) the prevalence of arterial hypertension was significantly higher (P<0.005) in males (9.2%) than females (6.4%), whereas in the older group (>54 years), we observed a significantly higher prevalence (P<0.001) in females (46.6%) than in males (34.7%). These results suggest that the menopause and age can play a separate role in the sexual dimorphism of arterial hypertension. A significant gender-related difference in hypertensive patients was found only in hypercholesterolemia above the age of 50 years, namely, females have this disorder more frequently
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POSSUM scoring system as an instrument of audit in lung resection surgery. Physiological and operative severity score for the enumeration of mortality and morbidity.
Anno: 1999
Rivista: ANNALS OF THORACIC SURGERY
Autori/autrici: Brunelli, A.; Fianchini, A.; Gesuita, Rosaria; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76055
Citazioni:
POSSUM scoring system as an instrument of audit in lung resection surgery. Physiological and operative severity score for the enumeration of mortality and morbidity / Brunelli, A., Fianchini, A., Gesuita, R., Carle, F.. - In: ANNALS OF THORACIC SURGERY. - ISSN 0003-4975. - STAMPA. - 67:2(1999), pp. 329-331. [10.1016/S0003-4975(98)00822-4]
Abstract:
BACKGROUND: The physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) is a scoring system that was validated in general surgery with the aim of being used as an instrument to evaluate surgical outcome. We applied POSSUM to a population of lung resection c...andidates to assess its capability to predict postoperative complications. METHODS: Two hundred fifty lung resection candidates were prospectively evaluated from 1993 through 1996. The POSSUM value was entered along with other variables (sex, smoking history, type of resection, pulmonary function tests, arterial carbon dioxide, serum albumin level, total lymphocyte count, neoadjuvant chemotherapy and radiotherapy, and diabetes) in a multivariate analysis to identify independent predictors of postoperative morbidity. RESULTS: Logistic regression analysis showed POSSUM was predictive of postoperative complications, showing no significant difference between predicted and observed morbidity (chi2 test, p > 0.05). CONCLUSIONS: We think POSSUM can be appropriately used as a tool of surgical audit in lung resection operations.
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E’ ancora utile la determinazione del 2,5-esandione urinario per la tutela della salute dei calzaturieri?
Anno: 1999
Rivista: LAVORO E MEDICINA
Autori/autrici: Rapisarda, VENERANDO ANTONIO; Amati, Monica; Pieragostini, Ernesta; Gesuita, Rosaria
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83281
Citazioni:
E’ ancora utile la determinazione del 2,5-esandione urinario per la tutela della salute dei calzaturieri? / Rapisarda, V.A., Amati, M., Pieragostini, E., Gesuita, R.. - In: LAVORO E MEDICINA. - ISSN 0391-3147. - STAMPA. - Atti del 62° Congresso Nazionale della Società Italiana di Medicina del Lavoro e Igiene Industriale:(1999), pp. 677-679.

Large incidence variation of type 1 diabetes in central-southern Italy 1990-1995: lower risk in rural areas
Anno: 1999
Rivista: DIABETES, NUTRITION & METABOLISM
Autori/autrici: Cherubini, V.; Carle, Flavia; Gesuita, Rosaria; Iannilli, A.; Tuomilehto, J.; Prisco, F.; Iafusco, D.; Altobelli, E.; Chiarelli, F.; DE GIORGI, G.; Falorni, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/26411
Citazioni:
Large incidence variation of type 1 diabetes in central-southern Italy 1990-1995: lower risk in rural areas / Cherubini, V., Carle, F., Gesuita, R., Iannilli, A., Tuomilehto, J., Prisco, F., Iafusco, D., Altobelli, E., Chiarelli, F., DE GIORGI, G., Falorni, A.. - In: DIABETES, NUTRITION & METABOLISM. - ISSN 0394-3402. - STAMPA. - 42:7(1999), pp. 789-792.
Abstract:
AIMS/HYPOTHESIS: To evaluate the relation between the incidence of childhood Type I (insulin-dependent) diabetes mellitus and the degree of urbanization in the central-southern part of Italy. METHODS: The incidence was determined in two areas: area A encompasses 3 regions of central-eastern Italy... (Marche, Abruzzo, Umbria), whereas area B encompasses one southern region (Campania). During 1990-1995, 706 children aged 14 or under with insulin-dependent diabetes mellitus of recent onset were registered. The completeness of the case ascertainment in the registries analysed separately for each region was high, ranging from 96.3 % to 99%. RESULTS: The age-standardized incidence was higher in area A (9.6 per 100000 person per year; 95 % confidence interval: 8.5-10.8) than in area B (5.4 per 100000 person per year; 95% confidence interval: 4.9-6.0). In both areas the standardized incidence ratios increased with the degree of urbanization (chi-squared for trend: area A= 140, p < 0.0001; area B = 79, p < 0.0001). The highest standardized incidence ratios were in the most urban communities. CONCLUSION/INTERPRETATION: This study showed a statistically significant difference in incidence of childhood insulin-dependent diabetes mellitus among different areas of the continental peninsula of Italy. People living in the rural communities appear to have a lower risk.
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Therapeutic organizer (TH.OR.): a new tool in critical patient management.
Anno: 1999
Rivista: CARDIOVASCULAR DRUGS AND THERAPY
Autori/autrici: Antonicelli, R; Cecconi, M; Ciampani, N; Valente, M; Penna, A; Marri, C; Gesuita, Rosaria; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76051
Citazioni:
Therapeutic organizer (TH.OR.): a new tool in critical patient management / Antonicelli, R., Cecconi, M., Ciampani, N., Valente, M., Penna, A., Marri, C., Gesuita, R., Paciaroni, E.. - In: CARDIOVASCULAR DRUGS AND THERAPY. - ISSN 0920-3206. - STAMPA. - 13:2(1999), pp. 173-176. [10.1023/A:1007712915615]

Posttraumatic epilepsy risk factors: one-year prospective study after head injury.
Anno: 1999
Rivista: EPILEPSIA
Autori/autrici: Angeleri, F; Majkowski, J; Cacchiò, G; Sobieszek, A; D'Acunto, S; Gesuita, Rosaria; Bachleda, A; Polonara, Gabriele; Królicki, L; Signorino, M; Salvolini, U.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76045
Citazioni:
Posttraumatic epilepsy risk factors: one-year prospective study after head injury / Angeleri, F., Majkowski, J., Cacchiò, G., Sobieszek, A., D'Acunto, S., Gesuita, R., Bachleda, A., Polonara, G., Królicki, L., Signorino, M., Salvolini, U.. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 40:9(1999), pp. 1222-1230. [10.1111/j.1528-1157.1999.tb00850.x]
Abstract:
Abstract: Purpose: Prospective evaluation of risk factors for posttraumatic epilepsy (PTE) by using clinical, EEG, and brain computed tomography (CT) data in four assessments from the head injury (HI) acute phase to 1 year later; and evaluation of the possible epileptogenic role of hemosiderin as sh...own by brain magnetic resonance imaging (MRI). Methods: Risk factors for PTE were evaluated by using Kaplan-Meier curves, log-rank test, and the Cox model in 137 consecutively enrolled adult inpatients. Percentage differences of patients with brain hyperintense and/or hemosiderin areas shown by MRI 1 year after HI were statistically evaluated by univariate tests considering two subgroups [e.g., patients with (PTE) and without (WLS) late seizures]. Results: The PTE subgroup included 18 patients with at least two seizures between the second and twelfth months. Kaplan-Meier curves demonstrated that Glasgow Coma Scale low score, early seizures, and single brain CT lesions are PTE risk factors, as is the development of an EEG focus 1 month after HI. No significant percentage difference was found between PTE and WLS patients with hemosiderin spots shown by MRI 1 year after HI. Conclusions: the Cox model indicates that, for HI patients with early seizures and brain CT single temporal or frontal lesions in the acute phase, the PTE risk is 8.58 and 3.43 times higher, respectively, than for those without. An EEG focus 1 month after HI is a risk factor 3.49 times higher than for patients without such EEG changes. One year after HI, a higher percentage of PTE than WLS patients had cortical MRI hyperintense areas including hemosiderin
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Sensory nerves affect the recruitment and differentiation of rat periovarian brown adipocytes during cold acclimation
Anno: 1998
Rivista: JOURNAL OF CELL SCIENCE
Autori/autrici: Giordano, Antonio; Morroni, Manrico; Carle, Flavia; Gesuita, Rosaria; Marchesi, Gf; Cinti, Saverio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76173
Citazioni:
Sensory nerves affect the recruitment and differentiation of rat periovarian brown adipocytes during cold acclimation / Giordano, A., Morroni, M., Carle, F., Gesuita, R., Marchesi, G.f., Cinti, S.. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 111:17(1998), pp. 2587-2594.

Evaluation of the POSSUM scoring system in lung surgery. Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity.
Anno: 1998
Rivista: THORACIC AND CARDIOVASCULAR SURGEON
Autori/autrici: Brunelli, A; Fianchini, A; Xiume, F; Gesuita, Rosaria; Mattei, A; Carle, Flavia
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76077
Citazioni:
Evaluation of the POSSUM scoring system in lung surgery. Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity / Brunelli, A., Fianchini, A., Xiume, F., Gesuita, R., Mattei, A., Carle, F.. - In: THORACIC AND CARDIOVASCULAR SURGEON. - ISSN 0171-6425. - STAMPA. - 46:3(1998), pp. 141-146. [10.1055/s-2007-1010211]
Abstract:
The current study was designed to test the POSSUM (Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity) in a population of lung resection candidates, and to propose its use as an instrument of evaluation of surgical outcome and quality in thoracic surgery. 250 c...onsecutive patients submitted to lung resection from 1993 through 1996 at our institution were prospectively evaluated. Two significant predictive models were than yielded by logistic regression analysis (model I: POSSUM alone; model II: Combining POSSUM Physiological Score with predicted postoperative FEV1 ) and compared with each other by means of ROC curves analysis. The study of the areas under the ROC curves showed that these models were equally predictive of postoperative complications (area of model I=0.66; area of model II=0.67). Both models showed no significant differences between predicted and observed morbidity (chi-square test p > 0.05). In particular, in model II there was perfect agreement between observed and predicted morbidity in the group of patients with a predicted morbidity above 60%. These results suggest that POSSUM may be appropriately used as a tool of surgical audit even in lung surgery.
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A randomized, controlled, clinical study of laparoscopic vs open tension-free inguinal hernia repair.
Anno: 1998
Rivista: SURGICAL ENDOSCOPY
Autori/autrici: Paganini, Am; Lezoche, E; Carle, Flavia; Carlei, F; Favretti, F; Feliciotti, F; Gesuita, Rosaria; Guerrieri, M; Lomanto, D; Nardovino, M; Panti, M; Ribichini, P; Sarli, L; Sottili, M; Tamburini, A; Taschieri, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76067
Citazioni:
A randomized, controlled, clinical study of laparoscopic vs open tension-free inguinal hernia repair / Paganini, A.m., Lezoche, E., Carle, F., Carlei, F., Favretti, F., Feliciotti, F., Gesuita, R., Guerrieri, M., Lomanto, D., Nardovino, M., Panti, M., Ribichini, P., Sarli, L., Sottili, M., Tamburini, A., Taschieri, A.. - In: SURGICAL ENDOSCOPY. - ISSN 0930-2794. - STAMPA. - 12:7(1998), pp. 979-986.
Abstract:
BACKGROUND: The aim of this prospective, randomized, controlled clinical study was to compare laparoscopic transabdominal preperitoneal (TAPP) hernia repair with a standard tension-free open mesh repair (open). METHODS: A total of 108 low-risk patients with unilateral (primary or recurrent) or bi...lateral hernias were randomized to TAPP (group 1 = 52 cases) or open (group 2 = 56 cases). The outcome measures included operating time, complications, postoperative pain, return to normal activity, operating theater costs, and recurrences. RESULTS: The mean operative time was longer for the TAPP than for the open group only in unilateral primary hernias. At rest, the median Visual Analog Scale (VAS) score was higher for group 1 than group 2 at 48 h postoperatively. Mild to discomforting pain in the inguinal region after 7 days, night pain after 30 days, and inguinal hardening after 3 months were more frequent in group 2 than group 1. No significant differences were observed in return to normal activities between the groups. One hernia recurrence was observed after 1 month in group 1. TAPP was significantly more expensive than open. CONCLUSIONS: TAPP was associated with less postoperative pain than open. The increase in operating theater costs, however, was dramatic and was not compensated by shorter time away from work. TAPP should not be adopted routinely unless its costs can be drastically reduced.
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Congestive heart failure in the elderly requiring hospital admission.
Anno: 1996
Rivista: ARCHIVES OF GERONTOLOGY AND GERIATRICS
Autori/autrici: Fraticelli, A; Gesuita, Rosaria; Vespa, A; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76054
Citazioni:
Congestive heart failure in the elderly requiring hospital admission / Fraticelli, A., Gesuita, R., Vespa, A., Paciaroni, E.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 23:3(1996), pp. 225-238. [10.1016/S0167-4943(96)00731-5]
Abstract:
Fifty consecutive elderly (> 60 years) patients admitted to our department with congestive heart failure (CHF) entered a prospective database, to define their main clinical, instrumental and cognitive characteristics. In addition we evaluated the patterns of drug therapy in this aged population. ...Eighty percent of this sample had been previously hospitalized for CHF. Two or more associated diseases were present in 92%. Heart disease was ischemic or hypertensive in etiology in 80% of patients. Acute dyspnea was the most common presenting symptom. Atrial fibrillation or flutter were found in 38% of patients. Ultrasound evaluation evidenced left ventricular dysfunction of a systolic type in 49% and of a diastolic type in 28.6% of subjects. Diuretics and cardiac glycosides were the most widely administered drugs, followed by ACE-inhibitors, nitrates and dobutamine. Older (>75 years) patients were treated with more agents, with a trend to a lesser use of dobutamine. Moderate to severe mental deficit was present in 20.8% of our sample, while significant depression was more common (54.2%). The main implications of the clinical profile of the elderly patient hospitalized for CHF are discussed.
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[Defecography in the diagnosis of fecal incontinence: an analysis of the receiver operating characteristic (ROC)].
Anno: 1996
Rivista: LA RADIOLOGIA MEDICA
Autori/autrici: Piloni, V; Gesuita, Rosaria; Fioravanti, P; Spazzafumo, L.
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76062
Citazioni:
[Defecography in the diagnosis of fecal incontinence: an analysis of the receiver operating characteristic (ROC)] / Piloni, V., Gesuita, R., Fioravanti, P., Spazzafumo, L.. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - STAMPA. - 91:1-2(1996), pp. 73-80.
Abstract:
Two groups of patients with altered bowel habit and pelvic floor dysfunction, but comparable epidemiologic characteristics (i.e. n = 105 each; mean age and SD 47.3 +/- 15.8 yrs vs. 54.9 +/- 16.7 yrs; range 15-80 yrs vs. 9-88 yrs; F/M ratio 28:1 vs. 2.6:1) with the exception of the absence (or presen...ce) of fecal incontinence, were examined with defecography, taking into account criteria other than anorectal angle values and anorectal junction mobility. At the Receiver Operating Characteristic (ROC) analysis a "barium leak sign", occurring either at rest or on straining was found to be a highly reliable index of fecal incontinence (specificity: 100% and 92-93%, respectively, intraobserver agreement K value = 0.82, Z = 21.58, p < 0.001). A false negative rate of 14.2% was limited to "minor" incontinence only, i.e., incontinence to gas and/or occasional staining episodes. In the search for an etiologic diagnosis, useful adjunctive criteria included (a) anal diameter > 10 mm at rest; (b) poor stop test (inability to interrupt the barium stream); (c) rectal diameter > 6.5 cm and < 4 cm (abnormally increased and reduced compliance, respectively). Defecography is a useful diagnostic tool in fecal incontinence and should precede anal endosonography, manometry and electromyography for proper therapeutic decision-making and in risk conditions, e.g., in the patients about to undergo elective pelvic surgery.
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MRI in characterization of focal liver lesions: comparison of T2 weighting by conventional spin-echo and turbo spin-echo sequences.
Anno: 1996
Rivista: JOURNAL OF MAGNETIC RESONANCE IMAGING
Autori/autrici: Giovagnoni, A; Paci, E; Valeri, G; Ercolani, P; Gesuita, Rosaria; Carle, Flavia; Piga, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76082
Citazioni:
MRI in characterization of focal liver lesions: comparison of T2 weighting by conventional spin-echo and turbo spin-echo sequences / Giovagnoni, A., Paci, E., Valeri, G., Ercolani, P., Gesuita, R., Carle, F., Piga, A.. - In: JOURNAL OF MAGNETIC RESONANCE IMAGING. - ISSN 1053-1807. - STAMPA. - 6:4(1996), pp. 589-595. [10.1002/jmri.1880060406]
Abstract:
Forty-one patients with 61 proved focal liver lesions underwent MRI of the liver at 1.0 T, with the aim of evaluating the usefulness of turbo spin-echo (TSE) sequences in characterizing focal liver lesions, by comparing them with conventional spin-echo (CSE) sequences. Two different TSE protocols we...re employed. with constant echo time and varying repetition time: TSE-S (3000 msec) and TSE-L (5100 msec). All images were evaluated quantitatively (signal-to-noise ration 'SNR') and qualitatively: because benign lesions were all liquid (12 cysts and 10 hemangiomas), they were well characterized morphologically on the basis of signal intensity. Mean SNR was significantly different between metastases and benign lesions (P < .0001) with all T2 sequences. Among the single T2 sequences tested, logistic regression analysis showed TSE-L to have the best predictive ability of the nature of focal lesions, with a G value of 42.02, compared to 29.87 of TSE-S and 25.55 of CSE second echo (SE II). The combination of TSE-L with TSE-S did not modify these results, whereas the combination of TSE-L with CSE only resulted in slight improvement (G = 46.95). Comparison of the receiver operating characteristic (ROC) curves showed only SE II (area under the ROC curve of .8312) to be significantly inferior to the best single sequence, or TSE-L (area under the ROC curve of .9176; P = .027). All sequences were equivalent in qualitative evaluation with good reproducibility, sensitivity ranging from .94 to 1.0 and specificity ranging from .86 to .93. This study confirms the value of TSE sequences in characterization of focal liver lesions. Time of acquisition is strongly reduced with these sequences, whereas results are fairly similar to those obtained with CSE. TSE sequences could therefore replace CSE for the study of focal liver lesions.
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Neuronal plasticity in aging: a quantitative immunohistochemical study of GAP-43 distribution in discrete regions of the rat brain.
Anno: 1996
Rivista: BRAIN RESEARCH
Autori/autrici: Casoli, T; Spagna, C; Fattoretti, P; Gesuita, Rosaria; Bertoni Freddari, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76058
Citazioni:
Neuronal plasticity in aging: a quantitative immunohistochemical study of GAP-43 distribution in discrete regions of the rat brain / Casoli, T., Spagna, C., Fattoretti, P., Gesuita, R., Bertoni Freddari, C.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 714:1-2(1996), pp. 111-117. [10.1016/0006-8993(95)01504-3]
Abstract:
Age-related changes in neuroplasticity have been investigated considering the neuronal growth-associated protein GAP-43 as a marker of nerve cell structural adaptive capabilities. We carried out a quantitative immunohistochemical study on the distribution of GAP-43 in the molecular layer of the cere...bellar cortex, in the inner molecular layer of the hippocampal dentate gyrus, in the stratum radiatum of the CA1 region, in layer 1 of the cingulate cortex and in the nerve fiber layer of the main olfactory bulb of 3-, 18- and 31-month-old Wistar rats. A decrease of GAP-43 immunoreactivity was observed in the old rats in comparison with the adult animals in all the 5 areas analyzed, although these variations were only statistically significant in the dentate gyrus, cingulate cortex and olfactory bulb. In these latter zones, GAP-43 immunolabeling is reduced by 54, 42 and 38%, respectively, in the old versus the adult group. Comparing these data with the age-dependent decrease of neuron density innervating the areas investigated, we support the hypothesis that the decline of GAP-43 observed in old animals documents a consistent reduction of axon plasticity in the inner molecular layer of the dentate gyrus and in layer 1 of the cingulate cortex. These results suggest an important role of GAP-43 as a marker of age-dependent deterioration of synaptic plasticity, especially in those areas of the brain involved in memory and emotional behavior.
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Epidemiological aspects of isolated systolic hypertension in the elderly population as cerebrovascular risk factor.
Anno: 1995
Rivista: ARCHIVES OF GERONTOLOGY AND GERIATRICS
Autori/autrici: Antonicelli, R; Gesuita, Rosaria; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76066
Citazioni:
Epidemiological aspects of isolated systolic hypertension in the elderly population as cerebrovascular risk factor / Antonicelli, R., Gesuita, R., Paciaroni, E.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 20:1(1995), pp. 87-91.
Abstract:
A large number of studies indicate that isolated systolic hypertension (ISH) is an important cerebrovascular risk factor. This clinical state is very common in elderly people who are the most exposed to stroke risk. Therefore, it is important to know the real prevalence of ISH, in order to predict t...he possible incidence of cerebrovascular disease in the elderly population. In the Camerano study on hypertension, we have verified the prevalence of ISH in the elderly. ISH has been considered clinically when the systolic arterial pressure (SAP) was higher than 160 mmHg, and the diastolic arterial pressure (DAP) was lower than 90 mmHg. In our study population, an ISH prevalence of 11.9% was found in the elderly (above 60 years of age); whereas in the adult population (between 30 and 60 years), it amounted only to 4.5%.
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Camerano study on hypertension: association between arterial hypertension and cardiovascular risk factors.
Anno: 1993
Rivista: CLINICAL AND EXPERIMENTAL HYPERTENSION
Autori/autrici: Antonicelli, R; Gesuita, Rosaria; Amadio, L; Ursini, T; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76068
Citazioni:
Camerano study on hypertension: association between arterial hypertension and cardiovascular risk factors / Antonicelli, R., Gesuita, R., Amadio, L., Ursini, T., Paciaroni, E.. - In: CLINICAL AND EXPERIMENTAL HYPERTENSION. - ISSN 1064-1963. - STAMPA. - 15 Suppl 1:(1993), pp. 91-101.
Abstract:
The Camerano study on Arterial Hypertension (AH), was a cross-sectional study carried out on a population living in a small town in central Italy. Its aim was to show the prevalence of certain characteristics of AH. We studied the association between AH and other well-known cardiovascular risk facto...rs (CRF) such as: hypercholesterolemia, hypertriglyceridemia, cigarette smoking, hyperglycemia, obesity and in particular the hereditary factor, evaluated as the degree of association between the AH of the subject and that of his parents. The results reveal a significantly high association between AH and all the CRF examined. Subjects suffering from AH had double the chance of concomitant another CRF compared to the normotensives. If three CRF are present at the same time, then the hypertensive subjects are three times as many. When hereditary factors are evaluated, then subjects with two hypertensive parents have twice as much probability of developing AH compared to subjects from a normotensive family.
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CAMERANO STUDY ON HYPERTENSION - THE PROBLEM OF BLOOD-PRESSURE VARIABILITY DURING MEDICAL VISIT
Anno: 1993
Rivista: CLINICAL AND EXPERIMENTAL HYPERTENSION
Autori/autrici: Antonicelli, R.; Gesuita, Rosaria; Zingaretti, Primo; Amadio, L.; Pagelli, P.; Cusi, D.; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/66250
Citazioni:
CAMERANO STUDY ON HYPERTENSION - THE PROBLEM OF BLOOD-PRESSURE VARIABILITY DURING MEDICAL VISIT / Antonicelli, R., Gesuita, R., Zingaretti, P., Amadio, L., Pagelli, P., Cusi, D., Paciaroni, E.. - In: CLINICAL AND EXPERIMENTAL HYPERTENSION. - ISSN 1064-1963. - STAMPA. - 15(1):(1993), pp. 125-138.
Abstract:
The Camerano Study on Arterial Hypertension (AH) is a cross-sectional study, carried out on a wide population sample in a small town in Central Italy, and aimed at revealing the prevalence of certain characteristics of AH in the population examined. In particular, we studied some aspects of blood pr...essure (BP) levels during the medical visits. To evaluate the effects of the medical visit on BP levels, we divided the subjects into 3 groups: I) Hypertensive subjects, II) Treated hypertensive subjects, III) Normotensive subjects (control group). The Systolic Arterial Pressure (SAP) in normotensive subjects reached maximum levels during the first medical visit and then decreased in the following two controls (p<0.001). The Diastolic Arterial Pressure (DAP) did not show any significant changes during the three measurements (p=n.s.). Instead the maximum level of SAP in the hypertensive group did not appear at the first measurement but only after 5 minutes and was seen to decrease towards the end ot the visit (p<0.001). Even DAP showed different levels compared to the normotensives: a decrease in BP levels was registered after 15 minutes respect to earlier measurements (p<0.01). The levels of group II were similar lo those of normotensive subjects.
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The Camerano study on hypertension: the problem of arterial hypertension in the elderly.
Anno: 1992
Rivista: ARCHIVES OF GERONTOLOGY AND GERIATRICS
Autori/autrici: Antonicelli, R; Gesuita, Rosaria; Zingaretti, Primo; Amadio, L; Pagelli, P; Cusi, D; Paciaroni, E.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/76074
Citazioni:
The Camerano study on hypertension: the problem of arterial hypertension in the elderly / Antonicelli, R., Gesuita, R., Zingaretti, P., Amadio, L., Pagelli, P., Cusi, D., Paciaroni, E.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 15 Suppl 1:(1992), pp. 17-26. [10.1016/S0167-4943(05)80003-2]
Abstract:
The Camerano study on arterial hypertension (AH) was a cross-sectional study, carried out on a large population sample in a small town in central Italy. The main goal was to reveal both the prevalence and certain characteristics of AH in the population examined. The main results, can be summarized a...s follows: (i) The occurrence of AH in the old (65-74 years) and very old (> or = 75 years) groups was 43.3 and 57.4%, respectively. (ii) isolated systolic hypertension (ISH) was found in 1.7, 23.6 and 3.9% in the adult, old and very old subjects, respectively. (iii) The association of AH with some of the more common cardiovascular risk factors (dyslipidemia, hyperglycemia, obesity, etc.) was significant for all the risk factors in the adult group, while in the old group there was a significant association only with the body mass index. (iv) Blood pressure (BP) values during the medical visits were evaluated, and adult versus old subjects were compared, but no significant differences were found.
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Studio di Camerano sui fattori di rischio cardiovascolari: livelli di colesterolemia in relazione alle fasce di età
Anno: 1991
Autori/autrici: R., Antonicelli; Gesuita, Rosaria; Zingaretti, Primo; E., Paciaroni
Lingua: ITA
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83413
Citazioni:
Studio di Camerano sui fattori di rischio cardiovascolari: livelli di colesterolemia in relazione alle fasce di età / R., A., Gesuita, R., Zingaretti, P., E., P.. - (1991), pp. 44-44.

Studio di Camerano sui fattori di rischio cardiovascolari: valutazione della variabilità pressoria
Anno: 1991
Autori/autrici: R., Antonicelli; Gesuita, Rosaria; L., Amadio; Zingaretti, Primo; D., Cusi; E., Paciaroni
Lingua: ITA
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83411
Citazioni:
Studio di Camerano sui fattori di rischio cardiovascolari: valutazione della variabilità pressoria / R., A., Gesuita, R., L., A., Zingaretti, P., D., C., E., P.. - (1991), pp. 43-43.

Studio di Camerano sui fattori di rischio cardiovascolari: prevalenza nei soggetti ipertesi
Anno: 1991
Autori/autrici: R., Antonicelli; L., Amadio; Gesuita, Rosaria; Zingaretti, Primo; D., Cusi; E., Paciaroni
Lingua: ITA
Classificazione IRIS: 4.2 Abstract in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/83409
Citazioni:
Studio di Camerano sui fattori di rischio cardiovascolari: prevalenza nei soggetti ipertesi / R., A., L., A., Gesuita, R., Zingaretti, P., D., C., E., P.. - (1991), pp. 33-33.