Determinants of Left Atrial Thrombus in Patients Undergoing Catheter Ablation for Atrial Fibrillation and Atrial Flutter
Anno: 2026
Rivista: PACING AND CLINICAL ELECTROPHYSIOLOGY
Autori/autrici: Barbarossa, Alessandro; Coraducci, Francesca; Torselletti, Lorenzo; Gatti, Chiara; Gaudenzi, Tommaso; Stronati, Giulia; Siragusa, Nicoletta; Principi, Samuele; Compagnucci, Paolo; Casella, Michela; Russo, Antonio Dello; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/354460
Citazioni:
Determinants of Left Atrial Thrombus in Patients Undergoing Catheter Ablation for Atrial Fibrillation and Atrial Flutter / Barbarossa, A., Coraducci, F., Torselletti, L., Gatti, C., Gaudenzi, T., Stronati, G., Siragusa, N., Principi, S., Compagnucci, P., Casella, M., Russo, A.D., Guerra, F.. - In: PACING AND CLINICAL ELECTROPHYSIOLOGY. - ISSN 0147-8389. - 49:3(2026), pp. 339-346. [10.1111/pace.70117]
Abstract:
Background: Catheter ablation (CA) is a first-line therapy for rhythm control in patients with atrial fibrillation (AF) and atrial flutter (AFL). Left atrial thrombus (LAT) is an absolute contraindication to CA due to the increased risk of periprocedural ischemic complications. A recent consensus st...atement from the European Heart Rhythm Association (EHRA) recommended the exclusion of LAT before CA in patients receiving oral anticoagulant therapy (OAT) for less than three weeks or in patients at high risk, despite the substantial reduction in the rate of periprocedural stroke achieved by anticoagulation in recent years. Consequently, many patients are frequently screened by transesophageal echocardiography (TOE) despite the lack of evidence that such a procedure is actually useful. Methods: All consecutive patients undergoing TOE before AF or AFL CA were enrolled between January 2019 and April 2024. Inclusion criteria were AF/AFL with less than 3 weeks of optimal OAT, persistent AF/AFL, or paroxysmal AF/AFL with CHA2DS2-VASc ≥ 2. Three experienced operators performed all TOEs and were blinded to the clinical data. Risk factors associated with LAT were tested by regression analysis. Results: Five hundred eighty-six patients were enrolled (age 66 ± 6 years; 72% male). A total of 14 thrombi were identified (2.4% of all patients), all located in the left atrial appendage. Patients with LAT had a higher prevalence of coronary artery disease (CAD), heart failure (HF), and persistent AF (11 vs. 3 patients, p = 0.048) as well as lower left ventricular ejection fraction (56 vs. 49%, p = 0.01) and higher systolic pulmonary artery pressure (sPAP). No LAT was found in patients with atrial flutter. According to univariate analysis, higher sPAP, CAD, HF, and persistent AF were identified as predictors of LAT formation, while LVEF > 50% was associated with lower LAT prevalence. Conclusions: LAT is a rare occurrence in candidates for CA. Patients with persistent AF, a history of CAD or HF (particularly with low ejection fraction), and higher sPAP present an elevated risk and should be considered for TOE prior to CA. Patients with AFL and no structural disease have an extremely low risk of LAT.
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Long-term prognosis of pure and impure tachycardiomyopathy
Anno: 2025
Rivista: ESC HEART FAILURE
Autori/autrici: Stronati, Giulia; Alfieri, Michele; Tombolesi, Niki; Barbarossa, Alessandro; Principi, Samuele; Gullì, Federico; Massari, Arianna; Bastianoni, Gianmarco; Roccetti, Francesca; Casella, Michela; Dello Russo, Antonio; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/356364
Citazioni:
Long-term prognosis of pure and impure tachycardiomyopathy / Stronati, G., Alfieri, M., Tombolesi, N., Barbarossa, A., Principi, S., Gullì, F., Massari, A., Bastianoni, G., Roccetti, F., Casella, M., Dello Russo, A., Guerra, F.. - In: ESC HEART FAILURE. - ISSN 2055-5822. - 12:6(2025), pp. 4288-4298. [10.1002/ehf2.15444]
Abstract:
Background and aims: Tachycardia-induced cardiomyopathy (TCM) is a reversible form of heart failure (HF) driven by arrhythmias, often atrial fibrillation (AF). While reversible, TCM's long-term prognosis remains unclear, especially in comparison to HF with reduced ejection fraction (HFrEF). Thi...s study examines the prognosis of pure and impure TCM against other causes of HFrEF. Methods: Prospective, monocentric, observational study of 456 patients hospitalized with de novo, acute decompensated HFrEF, classified into pure TCM, impure TCM, ischaemic HF and non-ischaemic HF. The primary endpoint was all-cause mortality, and the secondary endpoint was the incidence of unplanned cardiovascular hospitalisations. Sensitivity analyses were performed using propensity score matching between the four groups. Results: During a median follow-up of 3 years (interquartile range 1.5–5.1 years), pure TCM had the highest survival rate, and ischaemic HF had the lowest (pure TCM 78.2%; impure TCM 64.8%; non-ischaemic HF 73.4%; ischaemic HF 58.5%; log-rank P < 0.0001). Pure and impure TCM presented the lowest free-from-readmission estimates over follow-up (pure TCM 43.2%; impure TCM 60.0%; non-ischaemic HF 83.2%; ischaemic HF 69.9%; log-rank P < 0.0001). An initial rhythm control strategy was associated with better overall survival in TCM (79% vs. 63%; log-rank P < 0.0001) but similar rates of unplanned hospitalization. Conclusions: Pure TCM shows a favourable survival prognosis but high readmission rates, emphasizing the need for early rhythm control and sustained monitoring for arrhythmia recurrence. An initial rhythm control strategy seems associated with an increased survival, highlighting the importance of early recognition of arrhythmias as a culprit of HF worsening.
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Temporal trends of characteristics and management of patients with suspected MINOCA
Anno: 2025
Rivista: INTERNATIONAL JOURNAL OF CARDIOLOGY
Autori/autrici: Ciliberti, Giuseppe; Fortuni, Federico; Santucci, Andrea; Timi, Alessandro; Barnoffi, Emanuel; Coiro, Stefano; Guerra, Federico; Del Pinto, Maurizio; Compagnucci, Paolo; Sclafani, Rocco; Casella, Michela; Savino, Ketty; Dello Russo, Antonio; Ambrosio, Giuseppe; Carluccio, Erberto
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/356372
Citazioni:
Temporal trends of characteristics and management of patients with suspected MINOCA / Ciliberti, G., Fortuni, F., Santucci, A., Timi, A., Barnoffi, E., Coiro, S., Guerra, F., Del Pinto, M., Compagnucci, P., Sclafani, R., Casella, M., Savino, K., Dello Russo, A., Ambrosio, G., Carluccio, E.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 424:(2025). [10.1016/j.ijcard.2025.133039]
Abstract:
Background: Myocardial infarction without obstructive coronary artery disease (MINOCA) is a challenging condition which requires appropriate management and therapy. Although specific guidelines and recommendations for this condition have been introduced, there are few data about management implement...ation over time. The aim of this study is to compare two cohorts of patients affected by suspected MINOCA to assess the temporal trends change in the clinical characteristics and management. Methods: Two patient cohorts were retrospectively selected from a single centre (Cardiology Department of Perugia University Hospital) and compared to investigate the differences in characteristics and management before and after the release of 2018 MINOCA guidelines. The Group included patients enrolled from January 2006 to December 2014, and the Group 2 from July 1st, 2020, to July 31st, 2023. Results: Group 1 included 150 patients and Group 2 83 patients. Compared to group 1, group 2 showed higher prevalence of hypercholesterolemia (57 % vs 27 % p < 0,001), prior acute myocardial infarction (23 % vs 5 %, p <0,001), preserved left ventricular ejection fraction (90 % vs 67 %, p = 0,03), use of cardiovascular magnetic resonance (27 % vs 0 %,p < 0.001), prescription of beta-blockers (69 % vs 31 %,p < 0.001), calcium channel blockers (46 % vs 16 %, p < 0.001), statins (81 % vs 59 %, p = 0.03) and a less frequent occurrence of ST-elevation on admission ECG (9 % vs 24 %, p = 0.005), prescription of dual antiplatelet therapy (20 % vs 58 %, p < 0.001) and nitrates (12 % vs 54 %, p < 0.001). Conclusions: In the present study, characteristics and management of patients with suspected MINOCA has significantly changed over time. However, discrepancies with guidelines recommendation still exist and implementation strategies are needed to fill this gap and improve clinical practice.
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Long-Term Risk Assessment in Athletes With Complex Ventricular Arrhythmias
Anno: 2025
Rivista: CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY
Autori/autrici: Compagnucci, Paolo; Casella, Michela; Narducci, Maria Lucia; Conte, Edoardo; Cammarano, Michela; Pelargonio, Gemma; Andreini, Daniele; Palmieri, Vincenzo; Stronati, Giulia; Lo Russo, Gerardo V.; Brusamolino, Matteo; Pontone, Gianluca; Guerra, Federico; Natale, Andrea; Tondo, Claudio; Crea, Filippo; Zeppilli, Paolo; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/356353
Citazioni:
Long-Term Risk Assessment in Athletes With Complex Ventricular Arrhythmias / Compagnucci, P., Casella, M., Narducci, M.L., Conte, E., Cammarano, M., Pelargonio, G., Andreini, D., Palmieri, V., Stronati, G., Lo Russo, G.V., Brusamolino, M., Pontone, G., Guerra, F., Natale, A., Tondo, C., Crea, F., Zeppilli, P., Dello Russo, A.. - In: CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY. - ISSN 1941-3149. - 18:6(2025), pp. 447-457. [10.1161/circep.124.013480]
Abstract:
BACKGROUND: Ventricular arrhythmias (VAs) are a major concern in athletes. We sought to determine the prognostic role of noninvasive and invasive assessments in athletes with complex VAs. METHODS: One-hundred-ninety athletes (82% men; 28 [19-43] years; 148 [78%] competitive athletes) with frequent o...r exercise-induced premature ventricular complexes or nonsustained ventricular tachycardia were included in a multicenter cohort study and categorized based on VA ECG morphology into common (n=99) and uncommon (n=91) VA groups. Each athlete underwent a comprehensive diagnostic workup, including cardiac magnetic resonance in 94% (n=178) and electrophysiology study/electroanatomical mapping in 87% (n=166). The primary end point was the occurrence of sudden death or sustained VAs during long-term follow-up. RESULTS: Athletes with uncommon VA morphology had higher rates of abnormal findings at multimodality assessment and more final diagnoses of structural heart disease. Over a median follow-up of 6.2 (4.3-8.1) years, 7 (4%) athletes experienced a primary outcome event, including 1 sudden death. Interestingly, no events occurred in athletes with common morphology VAs. In univariable Cox models, factors associated with the primary end point included uncommon VA morphology (P=0.003), lack of VA suppression (P=0.049), and nonsustained ventricular tachycardia/ventricular tachycardia induction (P=0.010) during stress testing, late gadolinium enhancement (P=0.045), electroanatomical scar regions (P=0.022), and sustained VA inducibility by electrophysiology study (P<0.001). Incorporating findings of invasive tests improved prediction of primary outcome events over clinical/noninvasive findings in isolation (log-likelihood ratio for nested models, P=0.004). A survival tree model based on VA morphology, late gadolinium enhancement, VA response to exercise testing, and electroanatomical mapping allowed risk stratification, identifying subgroups of athletes without primary outcome events during follow-up. Among 148 competitive athletes, 101 (68%) regained eligibility after 3 months of detraining, but only 42 (28%) continued long-term. CONCLUSIONS: A comprehensive diagnostic assessment integrating ECG, stress testing, and imaging findings, along with the selective use of invasive electrophysiology assessments, may help refine the prognostic evaluation of athletes with complex VAs.
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How to Approach Left Ventricular Hypertrabeculation: A Practical Guide and Literature Review
Anno: 2025
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Alfieri, Michele; Principi, Samuele; Barbarossa, Alessandro; Stronati, Giulia; Antonicelli, Roberto; Casella, Michela; Dello Russo, Antonio; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/356363
Citazioni:
How to Approach Left Ventricular Hypertrabeculation: A Practical Guide and Literature Review / Alfieri, M., Principi, S., Barbarossa, A., Stronati, G., Antonicelli, R., Casella, M., Dello Russo, A., Guerra, F.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 14:3(2025). [10.3390/jcm14030695]
Abstract:
Left ventricular hypertrabeculation is one of the most debated conditions in modern cardiology. Many studies have tried to characterise this disease by addressing the various clinical risks and diagnostic tools, but its very nosological existence is currently being challenged. The latest ESC guideli...nes on cardiomyopathies state that it should be addressed as a morphologic trait rather than an intrinsic disease of the cardiac muscle. Despite the huge number of diagnostic criteria and possible phenocopies, no specific consensus identifies a specific flowchart regarding the management of patients with suspected hypertrabeculation. This review aims to provide a clinical approach for patients with a phenotypical appearance of excessive trabeculation.
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Advancing diagnosis in a cardiac arrest case and suspected MINOCA: the complementary roles of imaging, biopsy, and genetic testing
Anno: 2024
Rivista: EUROPEAN HEART JOURNAL. IMAGING METHODS AND PRACTICE
Autori/autrici: Ciliberti, Giuseppe; Compagnucci, Paolo; Casella, Michela; Schiavone, Francesco; De Gaspari, Monica; Rizzo, Stefania; Basso, Cristina; Giovagnoni, Andrea; Guerra, Federico; Tortora, Giada; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/345762
Citazioni:
Advancing diagnosis in a cardiac arrest case and suspected MINOCA: the complementary roles of imaging, biopsy, and genetic testing / Ciliberti, G., Compagnucci, P., Casella, M., Schiavone, F., De Gaspari, M., Rizzo, S., Basso, C., Giovagnoni, A., Guerra, F., Tortora, G., Dello Russo, A.. - In: EUROPEAN HEART JOURNAL. IMAGING METHODS AND PRACTICE. - ISSN 2755-9637. - 2:3(2024). [10.1093/ehjimp/qyae135]

Posterior wall ablation for persistent atrial fibrillation: Very-high-power short-duration versus standard-power radiofrequency ablation
Anno: 2024
Rivista: HEART RHYTHM O2
Autori/autrici: Compagnucci, Paolo; Volpato, Giovanni; Cipolletta, Laura; Parisi, Quintino; Valeri, Yari; Campanelli, Francesca; D'Angelo, Leonardo; Ciliberti, Giuseppe; Stronati, Giulia; Carboni, Laura; Giovagnoni, Andrea; Guerra, Federico; Natale, Andrea; Casella, Michela; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/345754
Citazioni:
Posterior wall ablation for persistent atrial fibrillation: Very-high-power short-duration versus standard-power radiofrequency ablation / Compagnucci, P., Volpato, G., Cipolletta, L., Parisi, Q., Valeri, Y., Campanelli, F., D'Angelo, L., Ciliberti, G., Stronati, G., Carboni, L., Giovagnoni, A., Guerra, F., Natale, A., Casella, M., Dello Russo, A.. - In: HEART RHYTHM O2. - ISSN 2666-5018. - 5:6(2024), pp. 374-384. [10.1016/j.hroo.2024.04.011]
Abstract:
Background: Posterior wall ablation (PWA) is commonly added to pulmonary vein isolation (PVI) during catheter ablation (CA) of persistent atrial fibrillation (AF). Objective: The purpose of this study was to compare PVI plus PWA using very-high-power short-duration (vHPSD) vs standard-power (SP) abl...ation index-guided CA among consecutive patients with persistent AF and to determine the voltage correlation between microbipolar and bipolar mapping in AF. Methods: We compared 40 patients undergoing PVI plus PWA using vHPSD to 40 controls receiving PVI plus PWA using SP. The primary efficacy endpoint was recurrence of atrial tachyarrhythmias after a 3-month blanking period. The primary safety outcome was a composite of major complications within 30 days after CA. In the vHPSD group, high-density mapping of the posterior wall was performed using both a multipolar catheter and microelectrodes on the tip of the ablation catheter. Results: PVI was more commonly obtained with vHPSD compared to SP ablation (98%vs 75%; P = .007), despite shorter procedural and fluoroscopy times (P <.001). Survival free from recurrent atrial tachyarrhythmias at 18 months was 68% and 47% in the vHPSD and SP groups, respectively (log-rank P = .071), without major adverse events. The vHPSD approach was significantly associated with reduced risk of recurrent AF at multivariable analysis (hazard ratio 0.39; P = .030). Microbipolar voltage cutoffs of 0.71 and 1.69 mV predicted minimum bipolar values of 0.16 and 0.31 mV in AF, respectively, with accuracies of 0.67 and 0.88. Conclusion: vHPSD PWA plus PVI may be faster and as safe as SP CA among patients with persistent AF, with a trend for superior efficacy. Adapted voltage cutoffs should be used for identifying atrial low-voltage areas with microbipolar mapping.
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Multimodality Imaging for Transcatheter Tricuspid Regurgitation Interventions: Novel Approaches to the Forgotten Valve
Anno: 2024
Rivista: ECHOCARDIOGRAPHY
Autori/autrici: Coraducci, Francesca; Barbarossa, Alessandro; Lofiego, Carla; Vagnarelli, Fabio; Schicchi, Nicolo; Fogante, Marco; Piva, Tommaso; Capestro, Filippo; Casella, Michela; Di Eusanio, Marco; Guerra, Federico; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/345757
Citazioni:
Multimodality Imaging for Transcatheter Tricuspid Regurgitation Interventions: Novel Approaches to the Forgotten Valve / Coraducci, F., Barbarossa, A., Lofiego, C., Vagnarelli, F., Schicchi, N., Fogante, M., Piva, T., Capestro, F., Casella, M., Di Eusanio, M., Guerra, F., Dello Russo, A.. - In: ECHOCARDIOGRAPHY. - ISSN 0742-2822. - 41:12(2024). [10.1111/echo.70044]
Abstract:
Tricuspid regurgitation (TR) poses a significant healthcare burden and is a major concern for patients who experience debilitating symptoms and face a poorer prognosis. Cardiologists are showing renewed interest in TR, as the previous belief that it was merely a bystander of left-sided heart disease... has evolved. As a result, more transcatheter techniques addressing TR are emerging. Although a clear impact on mortality from these transcatheter tricuspid valve interventions (TTVI) has not yet been demonstrated, the improvement in symptoms and quality of life for patients is substantial, leading to increased use of these procedures in clinical practice. In this review, we focus on multimodality imaging as an essential tool for quantifying TR severity, assessing right ventricular (RV) function, understanding the underlying mechanisms, selecting the appropriate intervention, and ensuring thorough and accurate preprocedural planning to minimize complications.
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Characteristics and Clinical Value of Electroanatomic Voltage Mapping in Cardiac Amyloidosis
Anno: 2024
Rivista: CANADIAN JOURNAL OF CARDIOLOGY
Autori/autrici: Casella, Michela; Compagnucci, Paolo; Ciliberti, Giuseppe; Falanga, Umberto; Barbarossa, Alessandro; Valeri, Yari; Cipolletta, Laura; Volpato, Giovanni; Stronati, Giulia; Rizzo, Stefania; De Gaspari, Monica; Vagnarelli, Fabio; Lofiego, Carla; Perna, Gian Piero; Giovagnoni, Andrea; Natale, Andrea; Basso, Cristina; Guerra, Federico; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327544
Citazioni:
Characteristics and Clinical Value of Electroanatomic Voltage Mapping in Cardiac Amyloidosis / Casella, M., Compagnucci, P., Ciliberti, G., Falanga, U., Barbarossa, A., Valeri, Y., Cipolletta, L., Volpato, G., Stronati, G., Rizzo, S., De Gaspari, M., Vagnarelli, F., Lofiego, C., Perna, G.P., Giovagnoni, A., Natale, A., Basso, C., Guerra, F., Dello Russo, A.. - In: CANADIAN JOURNAL OF CARDIOLOGY. - ISSN 0828-282X. - 40:3(2024), pp. 372-384. [10.1016/j.cjca.2023.10.022]
Abstract:
Background: Cardiac amyloidoses (CAs) are an increasingly recognised group of infiltrative cardiomyopathies associated with high risk of adverse cardiac events. We sought to characterise the characteristics and clinical value of right ventricular (RV) electroanatomic voltage mapping (EVM) in CA. Met...hods: Fifteen consecutive patients undergoing endomyocardial biopsy (EMB) for suspected CA (median age 75 years, 1st-3rd quartiles 64-78 years], 67% male) were enrolled in an observational prospective study. Each patient underwent RV high-density EVM using a multipolar catheter and EMB. The primary outcome was death or heart failure hospitalisation at 1-year follow-up. We recorded electrographic features at EMB sampling sites and electroanatomic data in the overall RV, and explored their correlations with histopathologic findings and primary outcomes events. Results: A final EMB-proven diagnosis of immunoglobulin light chain or transthyretin CA was formulated in 6 and 9 patients, respectively. Electrogram amplitudes in the bipolar and unipolar configurations averaged 1.55 ± 0.44 mV and 5.14 ± 1.50 mV, respectively, in the overall RV, with lower values in AL CA patients. We found a significant inverse correlation between both bipolar and unipolar electrogram amplitude and amyloid burden according to EMB (P = 0.001 and P = 0.025, respectively). At 1-year follow-up, 7 patients (47%) experienced a primary outcome event; the extent of bipolar dense scar area at RV EVM was an independent predictor of primary outcome events at multivariable analysis (odds ratio 2.40; P = 0.037). Conclusions: In CA, electrogram amplitudes are around the lower limit of normal yet disproportionately low compared with the increased wall thickness. Out data suggest that RV electrogram amplitude may be a quantitative marker of amyloid burden, and that RV EVM may have prognostic value.
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Speckle-tracking global longitudinal strain predicts death and cardiovascular events in patients with systemic sclerosis
Anno: 2024
Rivista: EUROPEAN HEART JOURNAL OPEN
Autori/autrici: Stronati, Giulia; Guerra, Federico; Benfaremo, Devis; Dichiara, Cristina; Paolini, Federico; Bastianoni, Gianmarco; Brugiatelli, Leonardo; Alfieri, Michele; Compagnucci, Paolo; Dello Russo, Antonio; Moroncini, Gianluca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330170
Citazioni:
Speckle-tracking global longitudinal strain predicts death and cardiovascular events in patients with systemic sclerosis / Stronati, G., Guerra, F., Benfaremo, D., Dichiara, C., Paolini, F., Bastianoni, G., Brugiatelli, L., Alfieri, M., Compagnucci, P., Dello Russo, A., Moroncini, G.. - In: EUROPEAN HEART JOURNAL OPEN. - ISSN 2752-4191. - 4:2(2024). [10.1093/ehjopen/oeae023]
Abstract:
Aims: Albeit often asymptomatic, heart involvement in systemic sclerosis (SSc) represents a negative prognostic factor, accounting for nearly one-fourth of all deaths. Global longitudinal strain (GLS) is accurate in detecting heart involvement in patients with SSc and no overt cardiac disease and al...lows early detection and longitudinal monitoring, but its association with clinical endpoints has not been tested so far. The primary outcome was the association between left and right GLS and mortality for all causes. The secondary outcome was the association between left and right GLS and hospitalizations. Methods and results: A prospective longitudinal study enrolling all consecutive patients with SSc without structural heart disease or previous cardiovascular event.A total of 164 patients were enrolled, of whom 19 (11.5%) died during follow-up and 48 (29.3%) were hospitalized. Both left (LV) and right ventricle (RV) GLS at enrolment were independently associated with an increased risk of death for all causes and hospitalizations. Patients with biventricular GLS impairment, respectively, had a 4.2-, 4.9-, and 13.9-fold increased risk of death when compared with patients with only LV, only RV, or no impairment (P < 0.001). The incidence of hospitalization in patients with biventricular GLS impairment was nearly four times higher when compared with patients with only LV or only RV impairment, and nine times higher when compared with normal biventricular GLS (P < 0.001). Conclusion: Biventricular GLS is associated with an increased risk of death and hospitalization in patients with SSc during a median of 3-year follow-up, acting as a reliable and accurate prognostic tool in everyday practice.
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Cardiac Masses and Pseudomasses: An Overview about Diagnostic Imaging and Clinical Background
Anno: 2024
Rivista: MEDICINA
Autori/autrici: Tagliati, C.; Fogante, M.; Palmisano, A.; Catapano, F.; Lisi, C.; Monti, L.; Lanni, G.; Cerimele, F.; Bernardini, A.; Procaccini, L.; Argalia, G.; Esposto Pirani, P.; Marcucci, M.; Rebonato, A.; Cerimele, C.; Luciano, A.; Cesarotto, M.; Belgrano, M.; Pagnan, L.; Sarno, A.; Cova, M. A.; Ventura, F.; Regnicolo, L.; Polonara, G.; Uguccioni, L.; Quaranta, A.; Balardi, L.; Barbarossa, A.; Stronati, G.; Guerra, F.; Chiocchi, M.; Francone, M.; Esposito, A.; Schicchi, N.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326637
Citazioni:
Cardiac Masses and Pseudomasses: An Overview about Diagnostic Imaging and Clinical Background / Tagliati, C., Fogante, M., Palmisano, A., Catapano, F., Lisi, C., Monti, L., Lanni, G., Cerimele, F., Bernardini, A., Procaccini, L., Argalia, G., Esposto Pirani, P., Marcucci, M., Rebonato, A., Cerimele, C., Luciano, A., Cesarotto, M., Belgrano, M., Pagnan, L., Sarno, A., et al.. - In: MEDICINA. - ISSN 1010-660X. - 60:1(2024). [10.3390/medicina60010070]
Abstract:
A cardiac lesion detected at ultrasonography might turn out to be a normal structure, a benign tumor or rarely a malignancy, and lesion characterization is very important to appropriately manage the lesion itself. The exact relationship of the mass with coronary arteries and the knowledge of possibl...e concomitant coronary artery disease are necessary preoperative information. Moreover, the increasingly performed coronary CT angiography to evaluate non-invasively coronary artery disease leads to a rising number of incidental findings. Therefore, CT and MRI are frequently performed imaging modalities when echocardiography is deemed insufficient to evaluate a lesion. A brief comprehensive overview about diagnostic radiological imaging and the clinical background of cardiac masses and pseudomasses is reported.
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Use of instant messaging in electrophysiological clinical practice in Latin America: a LAHRS survey
Anno: 2023
Rivista: EUROPACE
Autori/autrici: de Oliveira Figueiredo, Márcio Jansen; Cuesta, Alejandro; Duncker, David; Boveda, Serge; Guerra, Federico; Márquez, Manlio F
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314231
Citazioni:
Use of instant messaging in electrophysiological clinical practice in Latin America: a LAHRS survey / de Oliveira Figueiredo, M.J., Cuesta, A., Duncker, D., Boveda, S., Guerra, F., Márquez, M.F.. - In: EUROPACE. - ISSN 1099-5129. - 25:1(2023), pp. 59-64. [10.1093/europace/euac080]
Abstract:
Aims: Instant messaging (IM) platforms are a prominent component of telemedicine and a practical tool for sharing clinical data and counselling. Purpose of the survey was to inquire about the use of IM, the platforms used, frequency, recipients, and contents in Latin America region. Methods and resu...lts: An online survey was sent to medical community via newsletter and social media channels. The survey consisted in 22 questions, in Spanish and Portuguese, collected on SurveyMonkey. A total of 125 responders from 13 Latin-American countries (79% male, mean age 46.1 ± 9.7 years) completed the survey. Most of the responders declared that they send (88.8%) and receive (97.6%) clinical data through IM apps. Most senders declare that they anonymize clinical data before sending (71.0 ± 38.3%), but that the data received is anonymized only in 51.4 ± 33.5%. The most common tests shared with other physicians were 12-lead electrocardiograms (99.2%), followed by Holter recordings (68.0%) and tracings from electrophysiological studies (63.2%). The majority (55.2%) said that are unaware of legal data protection rules in their countries. Conclusions: IM apps are used by medical professionals worldwide to share and discuss clinical data and are preferred to many other methods of data sharing and are often used to share many different types of clinical data. They are perceived as a fast and easy way of communication, but medical professionals should be aware of the appropriate use of IM to prevent legal and privacy issues.
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Effectiveness and safety of implantable loop recorder and clinical utility of remote monitoring in patients with unexplained, recurrent, traumatic syncope
Anno: 2023
Rivista: EXPERT REVIEW OF MEDICAL DEVICES
Autori/autrici: Palmisano, Pietro; Guerra, Federico; Aspromonte, Vittorio; Dell'Era, Gabriele; Pellegrino, Pier Luigi; Laffi, Mattia; Uran, Carlo; De Bonis, Silvana; Accogli, Michele; Dello Russo, Antonio; Patti, Giuseppe; Santoro, Francesco; Torriglia, Antonella; Nigro, Gerardo; Bisignani, Antonio; Coluccia, Giovanni; Stronati, Giulia; Russo, Vincenzo; Ammendola, Ernesto
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315556
Citazioni:
Effectiveness and safety of implantable loop recorder and clinical utility of remote monitoring in patients with unexplained, recurrent, traumatic syncope / Palmisano, P., Guerra, F., Aspromonte, V., Dell'Era, G., Pellegrino, P.L., Laffi, M., Uran, C., De Bonis, S., Accogli, M., Dello Russo, A., Patti, G., Santoro, F., Torriglia, A., Nigro, G., Bisignani, A., Coluccia, G., Stronati, G., Russo, V., Ammendola, E.. - In: EXPERT REVIEW OF MEDICAL DEVICES. - ISSN 1743-4440. - 20:1(2023), pp. 45-54. [10.1080/17434440.2023.2168189]
Abstract:
BackgroundImplantable loop recorder (ILR) is still underutilized in clinical practice, especially in the setting of elderly patients with recurrent, traumatic, unexplained syncope. Data on the actual risk of traumatic syncopal recurrence during ILR monitoring in this specific patient setting are lac...king.Research design and methodsProspective, multicentre registry enrolling consecutive patients undergoing ILR insertion for unexplained, recurrent, traumatic syncope. In a proportion of enrolled patients, remote monitoring (RM) was used for device follow-up. The risk of traumatic and non-traumatic syncopal recurrences during ILR observation were prospectively assessed.ResultsA total of 483 consecutive patients (68 +/- 14 years, 59% male) were enrolled. During a median follow-up of 18 months, a final diagnosis was reached in 270 patients (55.9%). The risk of syncopal and traumatic syncopal recurrence was of 26.5 and 9.3%, respectively. RM significantly reduced the time to diagnosis (19.7 +/- 10.3 vs. 22.1 +/- 10.8 months; p=0.015) and was associated with a significant reduction in the risk of syncope recurrence of 48% (p<0.001), and of traumatic syncope recurrence of 49% (p=0.018).ConclusionsILR monitoring is effective and safe in patients with unexplained, recurrent, traumatic syncope. RM reduces the time to diagnosis and significantly reduces the risk of traumatic and non-traumatic syncopal relapses.
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Characteristics of patients with recurrent acute myocardial infarction after MINOCA
Anno: 2023
Rivista: PROGRESS IN CARDIOVASCULAR DISEASES
Autori/autrici: Ciliberti, Giuseppe; Guerra, Federico; Pizzi, Carmine; Merlo, Marco; Zilio, Filippo; Bianco, Francesco; Mancone, Massimo; Zaffalon, Denise; Gioscia, Rocco; Bergamaschi, Luca; Compagnucci, Paolo; Armillotta, Matteo; Casella, Michela; Sansonetti, Angelo; Marini, Marco; Paolisso, Pasquale; Stronati, Giulia; Gallina, Sabina; Dello Russo, Antonio; Perna, Gian Piero; Fedele, Francesco; Bonmassari, Roberto; De Luca, Giuseppe; Tritto, Isabella; Piva, Tommaso; Sinagra, Gianfranco; Ambrosio, Giuseppe; Kaski, Juan Carlos; Verdoia, Monica
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327543
Citazioni:
Characteristics of patients with recurrent acute myocardial infarction after MINOCA / Ciliberti, G., Guerra, F., Pizzi, C., Merlo, M., Zilio, F., Bianco, F., Mancone, M., Zaffalon, D., Gioscia, R., Bergamaschi, L., Compagnucci, P., Armillotta, M., Casella, M., Sansonetti, A., Marini, M., Paolisso, P., Stronati, G., Gallina, S., Dello Russo, A., Perna, G.P., et al.. - In: PROGRESS IN CARDIOVASCULAR DISEASES. - ISSN 0033-0620. - 81:(2023), pp. 42-47. [10.1016/j.pcad.2023.10.006]
Abstract:
Background: Myocardial infarction (MI) with non-obstructed coronary arteries (MINOCA) is an increasingly recognized condition with challenging management. Some MINOCA patients ultimately experience recurrent acute MI (re-AMI) during follow-up; however, clinical and angiographic factors predisposing ...to re-AMI are still poorly defined.Methods: In this retrospective multicenter cohort study we enrolled consecutive patients fulfilling diagnostic criteria of MINOCA according to the IV universal definition of myocardial infarction; characteristics of patients experiencing re-AMI during the follow-up were compared to a group of MINOCA patients without re-AMI.Results: 54 patients (mean age 66 +/- 13) experienced a subsequent re-AMI after MINOCA and follow-up was available in 44 (81%). Compared to MINOCA patients without re-AMI (n = 695), on first invasive coronary angiography (ICA) MINOCA patients with re-AMI showed less frequent angiographically normal coronaries (37 versus 53%, p = 0.032) and had a higher prevalence of atherosclerosis involving 3 vessels or left main stem (17% versus 8%, p = 0.049).Twenty-four patients (44%) with re-AMI underwent a new ICA: 25% had normal coronary arteries, 12.5% had mild luminal irregularities (<30%), 20.8% had moderate coronary atherosclerosis (30-49%), and 41.7% showed obstructive coronary atherosclerosis (>= 50% stenosis).Among patients undergoing new ICA, atherosclerosis progression was observed in 11 (45.8%), 37.5% received revascularization, only 4.5% had low-density lipoprotein cholesterol (LDL_C) under 55 mg/dL and 33% experienced a new cardiovascular disease (CVD) event (death, AMI, heart failure, stroke) at subsequent follow-up.Conclusions: In the present study, only a minority of MINOCA patients with re-AMI underwent a repeated ICA, nearly one out of two showed atherosclerosis progression, often requiring revascularization. Recommended LDL-C levels were achieved only in a minority of the cases, indicating a possible underestimation of CVD risk in this population.
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Characteristics and Prognosis of a Contemporary Cohort with Myocardial Infarction with Non-Obstructed Coronary Arteries (MINOCA) Presenting Different Patterns of Late Gadolinium Enhancements in Cardiac Magnetic Resonance Imaging
Anno: 2023
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Bucciarelli, Valentina; Bianco, Francesco; Di Francesco, Alessia; Vitulli, Piergiusto; Biasi, Annaclara; Primavera, Martina; Belleggia, Sara; Ciliberti, Giuseppe; Guerra, Federico; Seferovic, Jelena; Dello Russo, Antonio; Gallina, Sabina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315551
Citazioni:
Characteristics and Prognosis of a Contemporary Cohort with Myocardial Infarction with Non-Obstructed Coronary Arteries (MINOCA) Presenting Different Patterns of Late Gadolinium Enhancements in Cardiac Magnetic Resonance Imaging / Bucciarelli, V., Bianco, F., Di Francesco, A., Vitulli, P., Biasi, A., Primavera, M., Belleggia, S., Ciliberti, G., Guerra, F., Seferovic, J., Dello Russo, A., Gallina, S.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:6(2023). [10.3390/jcm12062266]
Abstract:
Background: To analyze the characteristics and prognosis of a contemporary cohort of patients with myocardial infarction with non-obstructed coronaries (MINOCA) were referred for cardiac magnetic resonance (CMR) imaging, focusing on late gadolinium enhancement (LGE) patterns. Methods: We retrospecti...vely examined and prospectively followed up with 135 patients (49 ± 21 years old, 48% female) undergoing CMR imaging due to a MINOCA diagnosis from 2014 to 2016. We grouped and analyzed the sample according to ischemic (focal or transmural) and non-ischemic LGE patterns. The primary outcome was cardiac-related death; the secondary outcome was a composite of cardiac-related rehospitalizations, the new occurrence of acute myocardial infarction (AMI), heart failure (HF), or arrhythmias. Results: CMR exams were performed after a median of 28 days from the acute event. One-third of the ischemic MINOCA were first managed as myocarditis, while CMR helped to adopt a different therapy regimen in 22% of patients (30/135). After a median follow-up of 2.3 years, more cardiac-related deaths occurred in the ischemic than non-ischemic group (2 vs. 1, p = 0.36), but it was not statistically significant. The ischemic group also experienced more cardiac-related-rehospitalizations (42%, p &lt; 0.001). In a multivariable Cox regression model, dyslipidemia, reduced left ventricular ejection fraction, ST-elevation at the hospitalization, and the LGE transmural pattern were the independent predictors of cardiac-related rehospitalizations. Conclusions: In a contemporary cohort of MINOCA patients who underwent CMR, ischemic and non-ischemic patterns had distinct features and outcomes. Among the MINOCA patients, CMR can identify patients at higher risk who require more aggressive therapeutic approached and strict follow-up.
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Left atrial function predicts early adverse outcomes in patients with acute myocardial infarction
Anno: 2023
Rivista: JOURNAL OF CARDIOVASCULAR MEDICINE
Autori/autrici: Malagoli, Alessandro; Tondi, Stefano; Torlai Triglia, Laura; Cameli, Matteo; Guerra, Federico; Benfari, Giovanni
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315555
Citazioni:
Left atrial function predicts early adverse outcomes in patients with acute myocardial infarction / Malagoli, A., Tondi, S., Torlai Triglia, L., Cameli, M., Guerra, F., Benfari, G.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2027. - 24:2(2023), pp. 138-140. [10.2459/JCM.0000000000001401]

Anti-arrhythmic drugs in atrial fibrillation: tailor-made treatments
Anno: 2023
Rivista: EUROPEAN HEART JOURNAL SUPPLEMENTS
Autori/autrici: Capucci, Alessandro; Stronati, Giulia; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315558
Citazioni:
Anti-arrhythmic drugs in atrial fibrillation: tailor-made treatments / Capucci, A., Stronati, G., Guerra, F.. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1554-2815. - 25:C(2023), pp. 12-14. [10.1093/eurheartjsupp/suad033]
Abstract:
During the last decades, many improvements have been made regarding the treatment of atrial fibrillation in terms of risk prevention, anti-coagulation strategies, and gain in quality of life. Among those, anti-arrhythmic drugs (AADs) have progressively fallen behind and overtaken by technological as...pects as devices as procedures are now the standards of care for many patients. But is this it? Are AADs doomed to be relegated to an obscure and rarely read paragraph of the European recommendations? Or could they be still employed safely and effectively? In the present paper, we will discuss contemporary evidence in order to define where AADs still play a pivotal role, how should AADs be used, and whether a tailored approach can be the way to propose the right treatment to the right patient.
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High-power short-duration catheter ablation of atrial fibrillation: is it really a new era? Comparison between new and old radiofrequency contact force–sensing catheters
Anno: 2023
Rivista: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
Autori/autrici: Dello Russo, Antonio; D’Angelo, Leonardo; Compagnucci, Paolo; Cipolletta, Laura; Parisi, Quintino; Valeri, Yari; Campanelli, Francesca; Volpato, Giovanni; Carboni, Laura; Ciliberti, Giuseppe; Stronati, Giulia Emily; Barbarossa, Alessandro; La Piscopia, Valentina; Bondavalli, Barbara; Guerra, Federico; Natale, Andrea; Casella, Michela
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327540
Citazioni:
High-power short-duration catheter ablation of atrial fibrillation: is it really a new era? Comparison between new and old radiofrequency contact force–sensing catheters / Dello Russo, A., D’Angelo, L., Compagnucci, P., Cipolletta, L., Parisi, Q., Valeri, Y., Campanelli, F., Volpato, G., Carboni, L., Ciliberti, G., Stronati, G.E., Barbarossa, A., La Piscopia, V., Bondavalli, B., Guerra, F., Natale, A., Casella, M.. - In: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. - ISSN 1572-8595. - (2023). [10.1007/s10840-023-01612-x]
Abstract:
Background The clinical performance of high-power, short-duration (HPSD) pulmonary vein isolation (PVI) with the novel flexible tip TactiFlex (TM) (TFSE) catheter, as compared to standard-power, long-duration (SPLD) PVI using the TactiCath (TM) (TCSE) catheter among patients undergoing catheter abla...tion (CA) of atrial fibrillation (AF) is currently unknown.Methods We conducted a prospective, observational, single-centre study including 40 consecutive patients undergoing PVI for paroxysmal/persistent AF, using HPSD ablation with the novel TFSE catheter (HPSD/TFSE group). Based on propensity score-matching, forty patients undergoing SPLD PVI with the TCSE catheter were identified (SPLD/TCSE group). In the HPSD/TFSE group, RF lesions were performed by delivering 40-50 W for 10-20 s, while in the SPLD/TCSE group, RF power was 30-35 W, targeting a lesion size index (LSI) of 4.0-5.5. The co-primary study outcomes were time required to complete PVI and first pass isolation (FPI).Results PVI was achieved in 100% of patients in both groups, and no major adverse events were observed. Remarkably, PVI time was shorter in the HPSD/TFSE, compared to the SPLD/TCSE group(9 [7-9] min vs. 50 [37-54] min; p < 0.001), while FPI rate was non-significantly higher in the former group(91% [146/160] vs 83% [134/160]; p = 0.063). Shorter procedural (108 [91-120] min vs. 173 [139-187] min, p < 0.001), total RF (9 [7-11] min vs. 43 [32-53] min, p < 0.001), fluoroscopy times(15 [10-19] min vs. 18 [13-26] min, p = 0.014), and lower DAP (1461 [860-2181] vs. 7200 [3400-20,800], p < 0.001) were recorded in the HPSD/TFSE group. A higher average impedance drop was obtained with HPSD/TFSE CA(17[17-18]O vs. 16 [15-17]O, p < 0.001).Conclusions In our initial clinical experience, HPSD PVI with the TFSE catheter proved faster than SPLD PVI with the TCSE catheter, at least equally effective in terms of FPI, and it was associated with greater impedance drop.[GRAPHICS]
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Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study
Anno: 2023
Rivista: HEART AND VESSELS
Autori/autrici: Russo, Vincenzo; Caturano, Alfredo; Guerra, Federico; Migliore, Federico; Mascia, Giuseppe; Rossi, Andrea; Nesti, Martina; Santobuono, Vincenzo Ezio; Attena, Emilio; Tola, Gianfranco; Sciarra, Luigi; Conte, Giulio; Paoletti Perini, Alessandro; Francia, Pietro; Dendramis, Gregory; Palamà, Zefferino; Albani, Stefano; Ottonelli Ghidini, Andrea; Calò, Leonardo; D'Onofrio, Antonio; Baldi, Enrico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315553
Citazioni:
Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study / Russo, V., Caturano, A., Guerra, F., Migliore, F., Mascia, G., Rossi, A., Nesti, M., Santobuono, V.E., Attena, E., Tola, G., Sciarra, L., Conte, G., Paoletti Perini, A., Francia, P., Dendramis, G., Palamà, Z., Albani, S., Ottonelli Ghidini, A., Calò, L., D'Onofrio, A., et al.. - In: HEART AND VESSELS. - ISSN 0910-8327. - 38:5(2023), pp. 680-688. [10.1007/s00380-022-02204-x]
Abstract:
No real-world data are available about the complications rate in drug-induced type 1 Brugada Syndrome (BrS) patients with an implantable cardioverter-defibrillator (ICD). Aim of our study is to compare the device-related complications, infections, and inappropriate therapies among drug-induced type ...1 BrS patients with transvenous- ICD (TV-ICD) versus subcutaneous-ICD (S-ICD). Data for this study were sourced from the IBRYD (Italian BRugada sYnDrome) registry which includes 619 drug-induced type-1 BrS patients followed at 20 Italian tertiary referral hospitals. For the present analysis, we selected 258 consecutive BrS patients implanted with ICD. 198 patients (76.7%) received a TV-ICD, while 60 a S-ICD (23.4%). And were followed-up for a median time of 84.3 [46.5-147] months. ICD inappropriate therapies were experienced by 16 patients (6.2%). 14 patients (7.1%) in the TVICD group and 2 patients (3.3%) in S-ICD group (log-rank P = 0.64). ICD-related complications occurred in 31 patients (12%); 29 (14.6%) in TV-ICD group and 2 (3.3%) in S-ICD group (log-rank P = 0.41). ICD-related infections occurred in 10 patients (3.88%); 9 (4.5%) in TV-ICD group and 1 (1.8%) in S-ICD group (log-rank P = 0.80). After balancing for potential confounders using the propensity score matching technique, no differences were found in terms of clinical outcomes between the two groups. In a real-world setting of drug-induced type-1 BrS patients with ICD, no significant differences in inappropriate ICD therapies, device-related complications, and infections were shown among S-ICD vs TV-ICD. However, a reduction in lead-related complications was observed in the S-ICD group. In conclusion, our evidence suggests that S-ICD is at least non-inferior to TV-ICD in this population and may also reduce the risk of lead-related complications which can expose the patients to the necessity of lead extractions.
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Reply to: Clinical utility of remote monitoring using multiparametric implantable defibrillators algorithm
Anno: 2023
Rivista: CLINICAL CARDIOLOGY
Autori/autrici: Guerra, F.; Stronati, G.; Campari, M.; Valsecchi, S.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315549
Citazioni:
Reply to: Clinical utility of remote monitoring using multiparametric implantable defibrillators algorithm / Guerra, F., Stronati, G., Campari, M., Valsecchi, S.. - In: CLINICAL CARDIOLOGY. - ISSN 0160-9289. - 46:2(2023), pp. 236-237. [10.1002/clc.23961]

Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry
Anno: 2023
Rivista: EUROPEAN HEART JOURNAL OPEN
Autori/autrici: Santoro, Francesco; J Núñez Gil, Iván; Stiermaier, Thomas; El-Battrawy, Ibrahim; Moeller, Christian; Guerra, Federico; Novo, Giuseppina; Arcari, Luca; Musumeci, Beatrice; Cacciotti, Luca; Mariano, Enrica; Romeo, Francesco; Cannone, Michele; Caldarola, Pasquale; Giannini, Irene; Mallardi, Adriana; Leopizzi, Alessandra; Vitale, Enrica; Montisci, Roberta; Meloni, Luigi; Raimondo, Pasquale; Di Biase, Matteo; Almendro-Delia, Manuel; Sionis, Alessandro; Uribarri, Aitor; Akin, Ibrahim; Thiele, Holger; Eitel, Ingo; Daniele Brunetti, Natale
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315552
Citazioni:
Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry / Santoro, F., J Núñez Gil, I., Stiermaier, T., El-Battrawy, I., Moeller, C., Guerra, F., Novo, G., Arcari, L., Musumeci, B., Cacciotti, L., Mariano, E., Romeo, F., Cannone, M., Caldarola, P., Giannini, I., Mallardi, A., Leopizzi, A., Vitale, E., Montisci, R., Meloni, L., et al.. - In: EUROPEAN HEART JOURNAL OPEN. - ISSN 2752-4191. - 3:1(2023), pp. 1-7. [10.1093/ehjopen/oead003]
Abstract:
Aims: Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pum...ping (IABP) on mortality in this setting. Methods and results: In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P &lt; 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4-18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0.98), length of hospitalization (18.9 vs. 16.7 days, P = 0.51), and need of invasive ventilation (35% vs. 41%, P = 0.60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0.73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0.72). Conclusions: In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short- and long-term follow-up in patients with TTS and CS.
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Implantable defibrillator-detected heart failure status predicts ventricular tachyarrhythmias
Anno: 2023
Rivista: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Autori/autrici: Compagnucci, Paolo; Casella, Michela; Bianchi, Valter; Franculli, Fabio; Vitali, Francesco; Santini, Luca; Savarese, Gianluca; Santobuono, Vincenzo Ezio; Chianese, Raffaele; Lavalle, Carlo; Amellone, Claudia; Pecora, Domenico; Calvanese, Raimondo; Stronati, Giulia; Santoro, Amato; Ziacchi, Matteo; Campari, Monica; Valsecchi, Sergio; Calò, Leonardo; Guerra, Federico; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315559
Citazioni:
Implantable defibrillator-detected heart failure status predicts ventricular tachyarrhythmias / Compagnucci, P., Casella, M., Bianchi, V., Franculli, F., Vitali, F., Santini, L., Savarese, G., Santobuono, V.E., Chianese, R., Lavalle, C., Amellone, C., Pecora, D., Calvanese, R., Stronati, G., Santoro, A., Ziacchi, M., Campari, M., Valsecchi, S., Calò, L., Guerra, F., et al.. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1540-8167. - 34:5(2023), pp. 1257-1267. [10.1111/jce.15898]
Abstract:
Introduction: The prediction of ventricular tachyarrhythmias among patients with implantable cardioverter defibrillators is difficult with available clinical tools. We sought to assess whether in patients with heart failure (HF) and reduced ejection fraction with defibrillators, physiological sensor...-based HF status, as summarized by the HeartLogic index, could predict appropriate device therapies. Methods: Five hundred and sixty-eight consecutive HF patients with defibrillators (n = 158, 28%) or cardiac resynchronization therapy-defibrillators (n = 410, 72%) were included in this prospective observational multicenter analysis. The association of both HeartLogic index and its physiological components with defibrillator shocks and overall appropriate therapies was assessed in regression and time-dependent Cox models. Results: Over a follow-up of 25 (15-35) months, 122 (21%) patients received an appropriate device therapy (shock, n = 74, 13%), while the HeartLogic index crossed the threshold value (alert, HeartLogic ≥ 16) 1200 times (0.71 alerts/patient-year) in 370 (65%) subjects. The occurrence of ≥1 HeartLogic alert was significantly associated with both appropriate shocks (Hazard ratios [HR]: 2.44, 95% confidence interval [CI]: 1.49-3.97, p = .003), and any appropriate defibrillator therapies. In multivariable time-dependent Cox models, weekly IN-alert state was the strongest predictor of appropriate defibrillator shocks (HR: 2.94, 95% CI: 1.73-5.01, p &lt; .001) and overall therapies. Compared with stable patients, patients with appropriate shocks had significantly higher values of HeartLogic index, third heart sound amplitude, and resting heart rate 30-60 days before device therapy. Conclusion: The HeartLogic index is an independent dynamic predictor of appropriate defibrillator therapies. The combined index and its individual physiological components change before the arrhythmic event occurs.
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Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a multicentre network study
Anno: 2023
Rivista: EUROPEAN JOURNAL OF HEART FAILURE
Autori/autrici: Tini, Giacomo; Milani, Paolo; Zampieri, Mattia; Caponetti, Angelo G; Fabris, Francesca; Foli, Andrea; Argirò, Alessia; Mazzoni, Carlotta; Gagliardi, Christian; Longhi, Simone; Saturi, Giulia; Vergaro, Giuseppe; Aimo, Alberto; Russo, Domitilla; Varrà, Guerino G; Serenelli, Matteo; Fabbri, Gioele; De Michieli, Laura; Palmiero, Giuseppe; Ciliberti, Giuseppe; Carigi, Samuela; Sessarego, Eugenio; Mandoli, Giulia E; Ricci Lucchi, Giulia; Rella, Valeria; Monti, Enrico; Gardini, Elisa; Bartolotti, Michela; Crotti, Lia; Merli, Elisa; Mussinelli, Roberta; Vianello, Pier Filippo; Cameli, Matteo; Marzo, Francesca; Guerra, Federico; Limongelli, Giuseppe; Cipriani, Alberto; Perlini, Stefano; Obici, Laura; Perfetto, Federico; Autore, Camillo; Porto, Italo; Rapezzi, Claudio; Sinagra, Gianfranco; Merlo, Marco; Musumeci, Beatrice; Emdin, Michele; Biagini, Elena; Cappelli, Francesco; Palladini, Giovanni; Canepa, Marco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315557
Citazioni:
Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a multicentre network study / Tini, G., Milani, P., Zampieri, M., Caponetti, A.G., Fabris, F., Foli, A., Argirò, A., Mazzoni, C., Gagliardi, C., Longhi, S., Saturi, G., Vergaro, G., Aimo, A., Russo, D., Varrà, G.G., Serenelli, M., Fabbri, G., De Michieli, L., Palmiero, G., Ciliberti, G., et al.. - In: EUROPEAN JOURNAL OF HEART FAILURE. - ISSN 1388-9842. - 25:6(2023), pp. 845-853. [10.1002/ejhf.2823]
Abstract:
Aim Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization of pathways leading to ATTRwt-CA diagnosis is of key importance, and potentially informative of disease course and prognosis. The aim of this study was to describe the charac...teristics of contemporary pathways leading to ATTRwt-CA diagnosis, and their potential association with survival.Methods and results This was a retrospective study of patients diagnosed with ATTRwt-CA at 17 Italian referral centres for CA. Patients were categorized into different 'pathways' according to the medical reason that triggered the diagnosis of ATTRwt-CA (hypertrophic cardiomyopathy [HCM] pathway, heart failure [HF] pathway, incidental imaging or incidental clinical pathway). Prognosis was investigated with all-cause mortality as endpoint. Overall, 1281 ATTRwt-CA patients were included in the study. The diagnostic pathway leading to ATTRwt-CA diagnosis was HCM in 7% of patients, HF in 51%, incidental imaging in 23%, incidental clinical in 19%. Patients in the HF pathway, as compared to the others, were older and had a greater prevalence of New York Heart Association (NYHA) class III-IV and chronic kidney disease. Survival was significantly worse in the HF versus other pathways, but similar among the three others. In multivariate model, older age at diagnosis, NYHA class III-IV and some comorbidities but not the HF pathway were independently associated with worse survival.Conclusions Half of contemporary ATTRwt-CA diagnoses occur in a HF setting. These patients had worse clinical profile and outcome than those diagnosed either due to suspected HCM or incidentally, although prognosis remained primarily related to age, NYHA functional class and comorbidities rather than the diagnostic pathway itself.
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Electrocardiographic Approach to Atrial Flutter: Classifications and Differential Diagnosis
Anno: 2022
Rivista: CARDIAC ELECTROPHYSIOLOGY CLINICS
Autori/autrici: Bagliani, G.; Leonelli, F.; De Ponti, R.; Casella, M.; Massara, F.; Tofoni, P.; Guerra, F.; Ciliberti, G.; Russo, A. D.
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305700
Citazioni:
Electrocardiographic Approach to Atrial Flutter: Classifications and Differential Diagnosis / Bagliani, G., Leonelli, F., De Ponti, R., Casella, M., Massara, F., Tofoni, P., Guerra, F., Ciliberti, G., Russo, A.D.. - In: CARDIAC ELECTROPHYSIOLOGY CLINICS. - ISSN 1877-9182. - (2022). [10.1016/j.ccep.2022.05.007]

Clinical Profiles and CMR Findings of Young Adults and Pediatrics with Acute Myocarditis Following mRNA COVID-19 Vaccination: A Case Series
Anno: 2022
Rivista: VACCINES
Autori/autrici: Manfredi, R.; Bucciarelli, V.; Ciliberti, G.; Guerra, F.; Schicchi, N.; Tavio, M.; Berton, E.; Surace, F. C.; Colaneri, M.; Gallina, S.; Pozzi, M.; Bianco, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313890
Citazioni:
Clinical Profiles and CMR Findings of Young Adults and Pediatrics with Acute Myocarditis Following mRNA COVID-19 Vaccination: A Case Series / Manfredi, R., Bucciarelli, V., Ciliberti, G., Guerra, F., Schicchi, N., Tavio, M., Berton, E., Surace, F.C., Colaneri, M., Gallina, S., Pozzi, M., Bianco, F.. - In: VACCINES. - ISSN 2076-393X. - 10:2(2022). [10.3390/vaccines10020169]
Abstract:
Messenger RNA (mRNA) coronavirus disease of 2019 (COVID-19) vaccines have been recently associated with acute myocarditis, predominantly in healthy young males. Out of 231,989 vaccines administrated in our region (Marche, Italy), we report a case series of six healthy patients (four males and two fe...males, 16.5 years old (Q1, Q3: 15, 18)) that experienced mRNA-COVID-19-vaccines side effects. All patients were hospitalized due to fever and troponins elevation following the second dose of an mRNA-based COVID-19 vaccine. Cardiovascular magnetic resonance (CMR) was per-formed 72–96 h after vaccination. All patients were treated with colchicine and ibuprofen. Myocarditis was prevalent in males. It was characterized by myocardial edema and late gadolinium enhance-ment (LGE) in the lateral wall of the left ventricle (LV). One patient showed sole right ventricular involvement, while the females presented with myopericarditis (myocarditis + pericardial effusion). All patients in our series had preserved LV ejection fraction and remained clinically stable during a relatively short inpatient hospital stay. One case presented with atrial tachycardia. At the follow-up, no significant CMR findings were documented after a three-month medical treatment. According to other recently published case series, our report suggests a possible association between acute myocarditis and myopericarditis with mRNA COVID-19 vaccination in healthy young adults and pediatric patients. Not only males are involved, while some arrhythmic manifestations are possible, such as atrial tachycardia. Conversely, we here highlight the benign nature of such complications and the absence of CMR findings after a three-month medical treatment with colchicine and ibuprofen.
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Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry
Anno: 2022
Rivista: HEART
Autori/autrici: Santoro, Francesco; Nuñez-Gil, Ivan Javier; Vitale, Enrica; Viana-Llamas, Maria C; Reche-Martinez, Begoña; Romero-Pareja, Rodolfo; Feltez Guzman, Gisela; Fernandez Rozas, Inmaculada; Uribarri, Aitor; Becerra-Muñoz, Víctor Manuel; Alfonso-Rodriguez, Emilio; Garcia-Aguado, Marcos; Huang, Jia; Ortega-Armas, María Elizabeth; Garcia Prieto, Juan F; Corral Rubio, Eva Maria; Ugo, Fabrizio; Bianco, Matteo; Mulet, Alba; Raposeiras-Roubin, Sergio; Jativa Mendez, Jorge Luis; Espejo Paeres, Carolina; Albarrán, Adrián Rodríguez; Marín, Francisco; Guerra, Federico; Akin, Ibrahim; Cortese, Bernardo; Ramakrishna, Harish; Macaya, Carlos; Fernandez-Ortiz, Antonio; Brunetti, Natale Daniele
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313083
Citazioni:
Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry / Santoro, F., Nuñez-Gil, I.J., Vitale, E., Viana-Llamas, M.C., Reche-Martinez, B., Romero-Pareja, R., Feltez Guzman, G., Fernandez Rozas, I., Uribarri, A., Becerra-Muñoz, V.M., Alfonso-Rodriguez, E., Garcia-Aguado, M., Huang, J., Ortega-Armas, M.E., Garcia Prieto, J.F., Corral Rubio, E.M., Ugo, F., Bianco, M., Mulet, A., Raposeiras-Roubin, S., et al.. - In: HEART. - ISSN 1355-6037. - 108:2(2022), pp. 130-136. [10.1136/heartjnl-2021-319552]
Abstract:
Background Standard therapy for COVID-19 is continuously evolving. Autopsy studies showed high prevalence of platelet-fibrin-rich microthrombi in several organs. The aim of the study was therefore to evaluate the safety and efficacy of antiplatelet therapy (APT) in hospitalised patients with COVID-1...9 and its impact on survival.Methods 7824 consecutive patients with COVID-19 were enrolled in a multicentre international prospective registry (Health Outcome Predictive Evaluation-COVID-19 Registry). Clinical data and in-hospital complications were recorded. Data on APT, including aspirin and other antiplatelet drugs, were obtained for each patient.Results During hospitalisation, 730 (9%) patients received single APT (93%, n=680) or dual APT (7%, n=50). Patients treated with APT were older (74 +/- 12 years vs 63 +/- 17 years, p<0.01), more frequently male (68% vs 57%, p<0.01) and had higher prevalence of diabetes (39% vs 16%, p<0.01). Patients treated with APT showed no differences in terms of in-hospital mortality (18% vs 19%, p=0.64), need for invasive ventilation (8.7% vs 8.5%, p=0.88), embolic events (2.9% vs 2.5% p=0.34) and bleeding (2.1% vs 2.4%, p=0.43), but had shorter duration of mechanical ventilation (8 +/- 5 days vs 11 +/- 7 days, p=0.01); however, when comparing patients with APT versus no APT and no anticoagulation therapy, APT was associated with lower mortality rates (log-rank p<0.01, relative risk 0.79, 95% CI 0.70 to 0.94). On multivariable analysis, in-hospital APT was associated with lower mortality risk (relative risk 0.39, 95% CI 0.32 to 0.48, p<0.01).Conclusions APT during hospitalisation for COVID-19 could be associated with lower mortality risk and shorter duration of mechanical ventilation, without increased risk of bleeding.
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Derivation and Validation of a Clinical Score for Predicting Postoperative Atrial Fibrillation in Noncardiac Elective Surgery (the HART Score)
Anno: 2022
Rivista: THE AMERICAN JOURNAL OF CARDIOLOGY
Autori/autrici: Stronati, Giulia; Mondelli, Carlo; Urbinati, Alessia; Ciliberti, Giuseppe; Barbarossa, Alessandro; Compagnucci, Paolo; Casella, Michela; Dello Russo, Antonio; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/305288
Citazioni:
Derivation and Validation of a Clinical Score for Predicting Postoperative Atrial Fibrillation in Noncardiac Elective Surgery (the HART Score) / Stronati, G., Mondelli, C., Urbinati, A., Ciliberti, G., Barbarossa, A., Compagnucci, P., Casella, M., Dello Russo, A., Guerra, F.. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - 170:(2022), pp. 56-62. [10.1016/j.amjcard.2022.01.020]
Abstract:
Postoperative atrial fibrillation (POAF) represents the most frequent cardiac arrhythmia in the surgical setting. It affects almost 3% of all patients over 45 years old who underwent noncardiovascular surgery and is associated with a higher risk of stroke, heart failure, myocardial infarction, and c...ardiac arrest. The study aimed to assess independent predictors of POAF and derive and validate a score for risk prediction in clinical practice. This was a retrospective cohort study including all consecutive candidates to all types of noncardiac elective surgery attending a cardiological preoperative assessment from 2016 to 2019. Exclusion criteria were a previous diagnosis of AF and the cancelation of the planned surgery. A total of 2,048 patients were enrolled (1350 men, aged 72 ± 12 years). A total of 44 patients experienced POAF (2.1%) - median 3 days (first to third quartile 2 to 4 days). Age (odds ratio [OR] 1.03 for each year, 95% confidence interval [CI] 1.01 to 1.07), hypertension (OR 3.43, 95% CI 1.22 to 9.63), thyroid dysfunction (OR 2.47, 95% CI 1.22 to 5.01), and intermediate or high-risk surgery (OR 18.28, 95% CI 2.51 to 33.09) resulted as independent predictors of POAF (all p <0.05). The Hypertension, Age, surgery Risk, and Thyroid dysfunction score (OR 2.59 for each point, 95% CI 1.79 to 3.75, p <0.001) was then created based on those 4 items. A cut-off score ≥6 had a 70% sensitivity and a 72% specificity in detecting POAF (area under the curve 0.76). Bootstrapping for internal validation confirmed the overall results (area under the curve 0.72). In conclusion, POAF complicates around 2% of all noncardiac surgery. A 4-item risk score, such as the Hypertension, Age, surgery Risk, and Thyroid dysfunction score, could be effective in implementing POAF screening and improving management.
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Angina in 2022: Current Perspectives
Anno: 2022
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Manfredi, Roberto; Verdoia, Monica; Compagnucci, Paolo; Barbarossa, Alessandro; Stronati, Giulia; Casella, Michela; Dello Russo, Antonio; Guerra, Federico; Ciliberti, Giuseppe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315554
Citazioni:
Angina in 2022: Current Perspectives / Manfredi, R., Verdoia, M., Compagnucci, P., Barbarossa, A., Stronati, G., Casella, M., Dello Russo, A., Guerra, F., Ciliberti, G.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:23(2022), p. 6891. [10.3390/jcm11236891]
Abstract:
Angina is the main symptom of ischemic heart disease; mirroring a mismatch between oxygen supply and demand. Epicardial coronary stenoses are only responsible for nearly half of the patients presenting with angina; whereas in several cases; symptoms may underlie coronary vasomotor disorders; such as... microvascular dysfunction or epicardial spasm. Various medications have been proven to improve the prognosis and quality of life; representing the treatment of choice in stable angina and leaving revascularization only in particular coronary anatomies or poorly controlled symptoms despite optimal medical therapy. Antianginal medications aim to reduce the oxygen supply-demand mismatch and are generally effective in improving symptoms; quality of life; effort tolerance and time to ischemia onset and may improve prognosis in selected populations. Since antianginal medications have different mechanisms of action and side effects; their use should be tailored according to patient history and potential drug-drug interactions. Angina with non-obstructed coronary arteries patients should be phenotyped with invasive assessment and treated accordingly. Patients with refractory angina represent a higher-risk population in which some therapeutic options are available to reduce symptoms and improve quality of life; but robust data from large randomized controlled trials are still lacking.
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Usefulness of the maggic score in predicting the competing risk of non-sudden death in heart failure patients receiving an implantable cardioverter-defibrillator: A sub-analysis of the observo-icd registry
Anno: 2022
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Canepa, M.; Palmisano, P.; Dell'Era, G.; Ziacchi, M.; Ammendola, E.; Accogli, M.; Occhetta, E.; Biffi, M.; Nigro, G.; Ameri, P.; Stronati, G.; Porto, I.; Russo, A. D.; Guerra, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313084
Citazioni:
Usefulness of the maggic score in predicting the competing risk of non-sudden death in heart failure patients receiving an implantable cardioverter-defibrillator: A sub-analysis of the observo-icd registry / Canepa, M., Palmisano, P., Dell'Era, G., Ziacchi, M., Ammendola, E., Accogli, M., Occhetta, E., Biffi, M., Nigro, G., Ameri, P., Stronati, G., Porto, I., Russo, A.D., Guerra, F.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:1(2022). [10.3390/jcm11010121]
Abstract:
The role of prognostic risk scores in predicting the competing risk of non-sudden death in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverterdefibrillator (ICD) is unclear. To this goal, we evaluated the accuracy and usefulness of the MetaAnalysis Glo...bal Group in Chronic Heart Failure (MAGGIC) score. The present analysis included 1089 HFrEF ICD recipients enrolled in the OBSERVO-ICD registry (NCT02735811). During a median follow-up of 36 months (1st–3rd IQR 25–48 months), 193 patients (17.7%) experienced at least one appropriate ICD therapy, and 133 patients died (12.2%) without experiencing any ICD therapy. The frequency of patients receiving ICD therapies was stable around 17–19% across increasing tertiles of 3-year MAGGIC probability of death, whereas non-sudden mortality increased (6.4% to 9.8% to 20.8%, p &lt; 0.0001). Accuracy of MAGGIC score was 0.60 (95% CI, 0.56–0.64) for the overall outcome, 0.53 (95% CI, 0.49–0.57) for ICD therapies and 0.65 (95% CI, 0.60–0.70) for non-sudden death. In patients with higher 3-year MAGGIC probability of death, the increase in the competing risk of non-sudden death during follow-up was greater than that of receiving an appropriate ICD therapy. Results were unaffected when analysis was limited to ICD shocks only. The MAGGIC risk score proved accurate and useful in predicting the competing risk of non-sudden death in HFrEF ICD recipients. Estimation of mortality risk should be taken into greater consideration at the time of ICD implantation.
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Impact of atrioventricular junction ablation and CRT-D on long-term mortality in patients with left ventricular dysfunction, permanent, refractory atrial fibrillation, and narrow QRS: Results of a propensity-matched analysis
Anno: 2022
Rivista: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Autori/autrici: Palmisano, Pietro; Ziacchi, Matteo; Ammendola, Ernesto; Dell'Era, Gabriele; Guerra, Federico; Donateo, Paolo; Del Giorno, Giuseppe; Laffi, Mattia; Coluccia, Giovanni; Bartoli, Lorenzo; Gaggioli, Germano; Carbone, Angelo; Senes, Jacopo; Dello Russo, Antonio; Patti, Giuseppe; Nigro, Gerardo; Biffi, Mauro; Accogli, Michele
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314233
Citazioni:
Impact of atrioventricular junction ablation and CRT-D on long-term mortality in patients with left ventricular dysfunction, permanent, refractory atrial fibrillation, and narrow QRS: Results of a propensity-matched analysis / Palmisano, P., Ziacchi, M., Ammendola, E., Dell'Era, G., Guerra, F., Donateo, P., Del Giorno, G., Laffi, M., Coluccia, G., Bartoli, L., Gaggioli, G., Carbone, A., Senes, J., Dello Russo, A., Patti, G., Nigro, G., Biffi, M., Accogli, M.. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1045-3873. - 33:11(2022), pp. 2288-2296. [10.1111/jce.15645]
Abstract:
Introduction In patients with symptomatic permanent atrial fibrillation (PEAF) and narrow QRS, atrio-ventricular junction ablation (AVJA) plus cardiac resynchronization therapy (CRT) is superior to medical therapy in reducing heart failure (HF) hospitalization and all-cause mortality. To compare the... mortality of a population of patients with HF, reduced EF (rEF), and PEAF treated with AVJA plus CRT with that of a contemporary cohort of patients in sinus rhythm (SR) with similar baseline characteristics. Methods and Results In this prospective, multicentre, observational study, all-cause mortality in a group of consecutive patients undergoing AVJA and implantable cardioverter-defibrillator (ICD) combined with CRT implantation for HFrEF, narrow QRS, and PEAF with uncontrolled ventricular rate was compared with that of a contemporary cohort of patients in SR undergoing ICD implantation (not combined with CRT) for HFrEF and narrow QRS. Individual 1:1 propensity matching of baseline characteristics was performed. A total of 824 patients were enrolled. Propensity matching yielded 107 matched pairs. After a median follow-up of 52 months, all-cause mortality was similar in patients treated with AVJA plus CRT and in the control group (p = .434). In AVJA plus CRT patients, mortality was significantly lower than in control group patients with a history of paroxysmal/persistent AF (n = 45, p = .020), and similar to that of patients without a history of AF (n = 62, p = .459). Conclusions After adjustment for patient characteristics, the long-term prognosis of patients with HFrEF, narrow QRS, and PEAF who underwent AVJA plus CRT was similar to that of a population of patients in SR with similar characteristics.
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Management of older patients with unexplained, recurrent, traumatic syncope and bifascicular block: Implantable loop recorder versus empiric pacemaker implantation-Results of a propensity-matched analysis
Anno: 2022
Rivista: HEART RHYTHM
Autori/autrici: Palmisano, Pietro; Guerra, Federico; Aspromonte, Vittorio; Dell'Era, Gabriele; Pellegrino, Pier Luigi; Laffi, Mattia; Uran, Carlo; De Bonis, Silvana; Accogli, Michele; Dello Russo, Antonio; Patti, Giuseppe; Santoro, Francesco; Torriglia, Antonella; Nigro, Gerardo; Bisignani, Antonio; Coluccia, Giovanni; Stronati, Giulia; Russo, Vincenzo; Ammendola, Ernesto
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314230
Citazioni:
Management of older patients with unexplained, recurrent, traumatic syncope and bifascicular block: Implantable loop recorder versus empiric pacemaker implantation-Results of a propensity-matched analysis / Palmisano, P., Guerra, F., Aspromonte, V., Dell'Era, G., Pellegrino, P.L., Laffi, M., Uran, C., De Bonis, S., Accogli, M., Dello Russo, A., Patti, G., Santoro, F., Torriglia, A., Nigro, G., Bisignani, A., Coluccia, G., Stronati, G., Russo, V., Ammendola, E.. - In: HEART RHYTHM. - ISSN 1547-5271. - 19:10(2022), pp. 1696-1703. [10.1016/j.hrthm.2022.05.023]
Abstract:
BACKGROUND In patients with unexplained syncope and bifascicular block (BFB), syncope may be caused by intermittent atrioventricular (AV) block. When a correlation between syncope and bradyarrhythmia is not documented in these patients, 2 alternative management strategies can be adopted: (1) empiric... pacemaker (PM) implantation or (2) long-term continuous electrocardio-graphic monitoring by implantable loop recorder (ILR).OBJECTIVE The purpose of this study was to compare the risk of syncope recurrence associated with empiric PM implantation or ILR monitoring.METHODS A prospective, multicenter, observational study enrolled consecutive patients with unexplained, recurrent, traumatic syncope and BFB who underwent ILR monitoring or empiric PM implantation. The risk and causes of syncope recurrence were assessed and compared between the 2 groups. Individual 1:1 propensity matching of baseline characteristics was performed.RESULTS A total of 309 consecutive patients (age 77.2 +/- 12.2 years; 60.8% male) were enrolled. Propensity matching yielded 89 matched pairs. After median follow-up of 33 months, empiric PM implantation was associated with a significantly lower risk of syncope recurrence than ILR monitoring (19.1 vs 46.1%; P <.001). A total of 35 patients (39.3%) who underwent ILR monitoring developed bradyarrhythmias (68.6% paroxysmal AV block) requiring PM implantation during follow-up. Excluding bradyarrhythmic syncope, the most frequent causes of syncope recurrence in both study groups were reflex syncope and orthostatic hypotension.CONCLUSION In patients with unexplained, recurrent, traumatic syncope and BFB, empiric PM implantation significantly reduced the risk of syncope recurrence in comparison with ILR monitoring. A high rate of patients who underwent ILR monitoring developed bradyarrhythmias requiring PM implantation.
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ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients
Anno: 2022
Rivista: EUROPEAN HEART JOURNAL. DIGITAL HEALTH
Autori/autrici: E Dilaveris, Polychronis; Konstantinos Antoniou, Christos; G Caiani, Enrico; Casado-Arroyo, Ruben; Μ Climent, Andreu; Cluitmans, Matthijs; R Cowie, Martin; Doehner, Wolfram; Guerra, Federico; T Jensen, Magnus; Kalarus, Zbigniew; Teresa Locati, Emanuela; Platonov, Pyotr; Simova, Iana; B Schnabel, Renate; J Schuuring, Mark; Tsivgoulis, Georgios; Lumens, Joost
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314248
Citazioni:
ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients / E Dilaveris, P., Konstantinos Antoniou, C., G Caiani, E., Casado-Arroyo, R., Μ Climent, A., Cluitmans, M., R Cowie, M., Doehner, W., Guerra, F., T Jensen, M., Kalarus, Z., Teresa Locati, E., Platonov, P., Simova, I., B Schnabel, R., J Schuuring, M., Tsivgoulis, G., Lumens, J.. - In: EUROPEAN HEART JOURNAL. DIGITAL HEALTH. - ISSN 2634-3916. - 3:3(2022), pp. 341-358. [10.1093/ehjdh/ztac026]
Abstract:
: The role of subclinical atrial fibrillation as a cause of cryptogenic stroke is unambiguously established. Long-term electrocardiogram (ECG) monitoring remains the sole method for determining its presence following a negative initial workup. This position paper of the European Society of Cardiolog...y Working Group on e-Cardiology first presents the definition, epidemiology, and clinical impact of cryptogenic ischaemic stroke, as well as its aetiopathogenic association with occult atrial fibrillation. Then, classification methods for ischaemic stroke will be discussed, along with their value in providing meaningful guidance for further diagnostic efforts, given disappointing findings of studies based on the embolic stroke of unknown significance construct. Patient selection criteria for long-term ECG monitoring, crucial for determining pre-test probability of subclinical atrial fibrillation, will also be discussed. Subsequently, the two major classes of long-term ECG monitoring tools (non-invasive and invasive) will be presented, with a discussion of each method's pitfalls and related algorithms to improve diagnostic yield and accuracy. Although novel mobile health (mHealth) devices, including smartphones and smartwatches, have dramatically increased atrial fibrillation detection post ischaemic stroke, the latest evidence appears to favour implantable cardiac monitors as the modality of choice; however, the answer to whether they should constitute the initial diagnostic choice for all cryptogenic stroke patients remains elusive. Finally, institutional and organizational issues, such as reimbursement, responsibility for patient management, data ownership, and handling will be briefly touched upon, despite the fact that guidance remains scarce and widespread clinical application and experience are the most likely sources for definite answers.
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Gender Differences in Takotsubo Syndrome
Anno: 2022
Rivista: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Autori/autrici: Arcari, Luca; Núñez Gil, Iván J; Stiermaier, Thomas; El-Battrawy, Ibrahim; Guerra, Federico; Novo, Giuseppina; Musumeci, Beatrice; Cacciotti, Luca; Mariano, Enrica; Caldarola, Pasquale; Parisi, Giuseppe; Montisci, Roberta; Vitale, Enrica; Sclafani, Matteo; Volpe, Massimo; Corbì-Pasqual, Miguel; Martinez-Selles, Manuel; Almendro-Delia, Manuel; Sionis, Alessandro; Uribarri, Aitor; Akin, Ibrahim; Thiele, Holger; Brunetti, Natale Daniele; Eitel, Ingo; Santoro, Francesco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313892
Citazioni:
Gender Differences in Takotsubo Syndrome / Arcari, L., Núñez Gil, I.J., Stiermaier, T., El-Battrawy, I., Guerra, F., Novo, G., Musumeci, B., Cacciotti, L., Mariano, E., Caldarola, P., Parisi, G., Montisci, R., Vitale, E., Sclafani, M., Volpe, M., Corbì-Pasqual, M., Martinez-Selles, M., Almendro-Delia, M., Sionis, A., Uribarri, A., et al.. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 79:21(2022), pp. 2085-2093. [10.1016/j.jacc.2022.03.366]
Abstract:
BACKGROUND Male sex in takotsubo syndrome (TTS) has a low incidence and it is still not well characterized.OBJECTIVES The aim of the present study is to describe TTS sex differences.METHODS TTS patients enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry were ...analyzed. Comparisons between sexes were performed within the overall cohort and using an adjusted analysis with 1:1 propensity score matching for age, comorbidities, and kind of trigger.RESULTS In total, 286 (11%) of 2,492 TTS patients were men. Male patients were younger (age 69 +/- 13 years vs 71 +/- 11 years; P = 0.005), with higher prevalence of comorbid conditions (diabetes mellitus 25% vs 19%; P = 0.01; pulmonary diseases 21% vs 15%; P = 0.006; malignancies 25% vs 13%; P < 0.001) and physical trigger (55 vs 32% P < 0.01). Propensity-score matching yielded 207 patients from each group. After 1:1 propensity matching, male patients had higher rates of cardiogenic shock and in-hospital mortality (16% vs 6% and 8% vs 3%, respectively; both P < 0.05). Long-term mortality rate was 4.3% per patient-year (men 10%, women 3.8%). Survival analysis showed higher mortality rate in men during the acute phase in both cohorts (overall: P < 0.001; matched: P = 0.001); mortality rate after 60 days was higher in men in the overall (P = 0.002) but not in the matched cohort (P = 0.541). Within the overall population, male sex remained independently associated with both in-hospital (OR: 2.26; 95% CI: 1.16-4.40) and long-term mortality (HR: 1.83; 95% CI: 1.32-2.52).CONCLUSIONS Male TTS is featured by a distinct high-risk phenotype requiring close in-hospital monitoring and longterm follow-up. (C) 2022 by the American College of Cardiology Foundation.
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Reimbursement practices for use of digital devices in atrial fibrillation and other arrhythmias: a European Heart Rhythm Association survey
Anno: 2022
Rivista: EUROPACE
Autori/autrici: Boriani, G.; Svennberg, E.; Guerra, F.; Linz, D.; Casado-Arroyo, R.; Malaczynska-Rajpold, K.; Duncker, D.; Boveda, S.; Merino, J. L.; Leclercq, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315550
Citazioni:
Reimbursement practices for use of digital devices in atrial fibrillation and other arrhythmias: a European Heart Rhythm Association survey / Boriani, G., Svennberg, E., Guerra, F., Linz, D., Casado-Arroyo, R., Malaczynska-Rajpold, K., Duncker, D., Boveda, S., Merino, J.L., Leclercq, C.. - In: EUROPACE. - ISSN 1099-5129. - 24:11(2022), pp. 1834-1843. [10.1093/europace/euac142]
Abstract:
Since digital devices are increasingly used in cardiology for assessing cardiac rhythm and detecting arrhythmias, especially atrial fibrillation (AF), our aim was to evaluate the expectations and opinions of healthcare professionals in Europe on reimbursement policies for the use of digital devices ...(including wearables) in AF and other arrhythmias. An anonymous survey was proposed through announcements on the European Heart Rhythm Association website, social media channels, and mail newsletter. Two hundred and seventeen healthcare professionals participated in the survey: 32.7%, reported regular use of digital devices, 45.2% reported that they sometimes use these tools, 18.6% that they do not use but would like to. Only a minority (3.5%) reported a lack of trust in digital devices. The survey highlighted a general propensity to provide medical consultation for suspected AF or other arrhythmias detected by a consumer-initiated use of digital devices, even if time constraints and reimbursement availability emerged as important elements. More than 85% of respondents agreed that reimbursement should be applied for clinical use of digital devices, also in different settings such as post-stroke, post-cardioversion, post-ablation, and in patients with palpitations or syncope. Finally, 73.6% of respondents confirmed a lack of reimbursement fees in their country for physicians’ consultations (tracings interpretation) related to digital devices. Digital devices, including wearables, are increasingly and widely used for assessing cardiac rhythm and detecting AF, but a definition of reimbursement policies for physicians’ consultations is needed.
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Aspirin Therapy on Prophylactic Anticoagulation for Patients Hospitalized With COVID-19: A Propensity Score-Matched Cohort Analysis of the HOPE-COVID-19 Registry
Anno: 2022
Rivista: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE
Autori/autrici: Santoro, Francesco; Núñez-Gil, Ivan J; Vitale, Enrica; Viana-Llamas, María C; Romero, Rodolfo; Maroun Eid, Charbel; Feltes Guzman, Gisela; Becerra-Muñoz, Victor Manuel; Fernández Rozas, Inmaculada; Uribarri, Aitor; Alfonso-Rodriguez, Emilio; García Aguado, Marcos; Huang, Jia; Castro Mejía, Alex Fernando; Garcia Prieto, Juan Fortunato; Elola, Javier; Ugo, Fabrizio; Cerrato, Enrico; Signes-Costa, Jaime; Raposeiras Roubin, Sergio; Jativa Mendez, Jorge Luis; Espejo Paeres, Carolina; López Masjuan, Alvaro; Marin, Francisco; Guerra, Federico; El-Battrawy, Ibrahim; Cortese, Bernardo; Ramakrishna, Harish; Perez-Villacastín, Julian; Fernandez-Ortiz, Antonio; Brunetti, Natale Daniele
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314232
Citazioni:
Aspirin Therapy on Prophylactic Anticoagulation for Patients Hospitalized With COVID-19: A Propensity Score-Matched Cohort Analysis of the HOPE-COVID-19 Registry / Santoro, F., Núñez-Gil, I.J., Vitale, E., Viana-Llamas, M.C., Romero, R., Maroun Eid, C., Feltes Guzman, G., Becerra-Muñoz, V.M., Fernández Rozas, I., Uribarri, A., Alfonso-Rodriguez, E., García Aguado, M., Huang, J., Castro Mejía, A.F., Garcia Prieto, J.F., Elola, J., Ugo, F., Cerrato, E., Signes-Costa, J., Raposeiras Roubin, S., et al.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 11:13(2022), p. e024530. [10.1161/JAHA.121.024530]
Abstract:
Background COVID-19 is an infectious illness, featured by an increased risk of thromboembolism. However, no standard antithrombotic therapy is currently recommended for patients hospitalized with COVID-19. The aim of this study was to evaluate safety and efficacy of additional therapy with aspirin o...ver prophylactic anticoagulation (PAC) in patients hospitalized with COVID-19 and its impact on survival. Methods and Results A total of 8168 patients hospitalized for COVID-19 were enrolled in a multicenter-international prospective registry (HOPE COVID-19). Clinical data and in-hospital complications, including mortality, were recorded. Study population included patients treated with PAC or with PAC and aspirin. A comparison of clinical outcomes between patients treated with PAC versus PAC and aspirin was performed using an adjusted analysis with propensity score matching. Of 7824 patients with complete data, 360 (4.6%) received PAC and aspirin and 2949 (37.6%) PAC. Propensity-score matching yielded 298 patients from each group. In the propensity score-matched population, cumulative incidence of in-hospital mortality was lower in patients treated with PAC and aspirin versus PAC (15% versus 21%, Log Rank P=0.01). At multivariable analysis in propensity matched population of patients with COVID-19, including age, sex, hypertension, diabetes, kidney failure, and invasive ventilation, aspirin treatment was associated with lower risk of in-hospital mortality (hazard ratio [HR], 0.62; [95% CI 0.42-0.92], P=0.018). Conclusions Combination PAC and aspirin was associated with lower mortality risk among patients hospitalized with COVID-19 in a propensity score matched population compared to PAC alone.
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Decongestive treatment adjustments in heart failure patients remotely monitored with a multiparametric implantable defibrillators algorithm
Anno: 2022
Rivista: CLINICAL CARDIOLOGY
Autori/autrici: Guerra, F.; D'Onofrio, A.; De Ruvo, E.; Manzo, M.; Santini, L.; Giubilato, G.; La Greca, C.; Petracci, B.; Stronati, G.; Bianchi, V.; Martino, A.; Franculli, F.; Compagnucci, P.; Campari, M.; Valsecchi, S.; Dello Russo, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313891
Citazioni:
Decongestive treatment adjustments in heart failure patients remotely monitored with a multiparametric implantable defibrillators algorithm / Guerra, F., D'Onofrio, A., De Ruvo, E., Manzo, M., Santini, L., Giubilato, G., La Greca, C., Petracci, B., Stronati, G., Bianchi, V., Martino, A., Franculli, F., Compagnucci, P., Campari, M., Valsecchi, S., Dello Russo, A.. - In: CLINICAL CARDIOLOGY. - ISSN 0160-9289. - 45:6(2022), pp. 670-678. [10.1002/clc.23832]
Abstract:
Aims: HeartLogic algorithm combines data from multiple implantable defibrillators (ICD)-based sensors to predict impending heart failure (HF) decompensation. A treatment protocol to manage algorithm alerts is not yet known, although decongestive treatment adjustments are the most frequent alert-trig...gered actions reported in clinical practice. We describe the implementation of HeartLogic for remote monitoring of HF patients, and we evaluate the approach to diuretic dosing and timing of the intervention in patients with device alerts. Methods: The algorithm was activated in 229 ICD patients at eight centers. The median follow-up was 17 months (25th–75th percentile: 11–24). Remote data reviews and patient phone contacts were undertaken at the time of HeartLogic alerts, to assess the patient's status and to prevent HF worsening. We analyzed alert-triggered augmented HF treatments, consisting of isolated increases in diuretics dosage. Results: We reported 242 alerts (0.8 alerts/patient-year) in 123 patients, 137 (56%) alerts triggered clinical actions to treat HF. The HeartLogic index decreased after the 56 actions consisting of diuretics increase. Specifically, alerts resolved more quickly when the increases in dosing of diuretics were early rather than late: 28 days versus 62 days, p <.001. The need of hospitalization for further treatments to resolve the alert condition was associated with higher HeartLogic index values on the day of the diuretics increase (odds ratio: 1.11, 95% CI: 1.02–1.20, p =.013) and with late interventions (odds ratio: 5.11, 95% CI: 1.09–24.48, p =.041). No complications were reported after drug adjustments. Conclusions: Decongestive treatment adjustments triggered by alerts seem safe and effective. The early use of decongestive treatment and the use of high doses of diuretics seem to be associated with more favorable outcomes.
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The association between language exposure and nonword repetition performance in bilingual children: A systematic review and meta-analysis
Anno: 2022
Rivista: BILINGUALISM
Autori/autrici: Farabolini, Gianmatteo; Taboh, Analí R.; Ceravolo, Maria Gabriella; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/309918
Citazioni:
The association between language exposure and nonword repetition performance in bilingual children: A systematic review and meta-analysis / Farabolini, G., Taboh, A.R., Ceravolo, M.G., Guerra, F.. - In: BILINGUALISM. - ISSN 1366-7289. - ELETTRONICO. - (2022), pp. 1-15. [10.1017/S1366728922000906]
Abstract:
We conducted a systematic review and meta-analysis on the association between nonword repetition (NWR) and language exposure in bilingual children and explored whether the association is influenced by other variables. We performed a blind literature review on ERIC and Google Scholar, a random-effect...s model meta-analysis and subgroup analyses to test potential moderators. Out of 822 screened articles, we identified 24 works including 1399 children. Significant associations were found using either cumulative or current exposure, language-like nonwords, phoneme NWR scoring, in children with typical language development. Nonsignificant associations were found in studies either using age of first exposure, on children older than six, with less than 50 participants, using NWR lists containing 16-24 nonwords or with participants having different native languages. Weak associations were found when considering whole-word scoring or gray literature. We highlight the contributions of different variables to NWR, and evidence to optimally design NWR for bilingual language assessment.
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Happy Heart Syndrome: Frequency, Characteristics, and Outcome of Takotsubo Syndrome Triggered by Positive Life Events
Anno: 2022
Rivista: JACC. HEART FAILURE
Autori/autrici: Stiermaier, Thomas; Walliser, Alexandra; El-Battrawy, Ibrahim; Pätz, Toni; Mezger, Matthias; Rawish, Elias; Andrés, Mireia; Almendro-Delia, Manuel; Martinez-Sellés, Manuel; Uribarri, Aitor; Pérez-Castellanos, Alberto; Guerra, Federico; Novo, Giuseppina; Mariano, Enrica; Musumeci, Maria Beatrice; Arcari, Luca; Cacciotti, Luca; Montisci, Roberta; Akin, Ibrahim; Thiele, Holger; Brunetti, Natale Daniele; Núñez-Gil, Ivan J; Santoro, Francesco; Eitel, Ingo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314249
Citazioni:
Happy Heart Syndrome: Frequency, Characteristics, and Outcome of Takotsubo Syndrome Triggered by Positive Life Events / Stiermaier, T., Walliser, A., El-Battrawy, I., Pätz, T., Mezger, M., Rawish, E., Andrés, M., Almendro-Delia, M., Martinez-Sellés, M., Uribarri, A., Pérez-Castellanos, A., Guerra, F., Novo, G., Mariano, E., Musumeci, M.B., Arcari, L., Cacciotti, L., Montisci, R., Akin, I., Thiele, H., et al.. - In: JACC. HEART FAILURE. - ISSN 2213-1779. - 10:7(2022), pp. 459-466. [10.1016/j.jchf.2022.02.015]
Abstract:
BACKGROUND The association with a preceding stressor is a characteristic feature of takotsubo syndrome (TTS). Negative emotions before TTS are common and led to the popular term "broken heart syndrome." In contrast, pleasant triggers ("happy heart syndrome") are rare and are scar...cely investigated.OBJECTIVES The authors analyzed the frequency, clinical characteristics, and prognostic implications of positive emotional stressors in the multicenter GEIST (GErman-Italian-Spanish Takotsubo) Registry. METHODS Patients enrolled in the registry were categorized according to their stressors. This analysis compared patients with pleasant emotional events with patients with negative emotional events.RESULTS Of 2,482 patients in the registry, 910 patients (36.7%) exhibited an emotional trigger consisting of 873 "broken hearts" (95.9%) and 37 "happy hearts" (4.1%). Consequently, the prevalence of pleasant emotional triggers was 1.5% of all TTS cases. Compared with patients with TTS with negative preceding events, patients with happy heart syndrome were more frequently male (18.9% vs 5.0%; P &lt; 0.01) and had a higher prevalence of atypical ballooning patterns (27.0% vs 12.5%; P = 0.01), particularly midventricular ballooning. In-hospital complications, including death, pulmonary edema, cardiogenic shock, or stroke (8.1% vs 12.3%; P = 0.45), and long-term mortality rates (2.7% vs 8.8%; P = 0.20) were similar in "happy hearts" and "broken hearts."CONCLUSIONS Happy heart syndrome is a rare type of TTS characterized by a higher prevalence of male patients and atypical, nonapical ballooning compared with patients with negative emotional stressors. Despite similar short-and long-term outcomes in our study, additional data are needed to explore whether numerically lower event rates in "happy hearts" would be statistically significant in a larger sample size. (GErman-Italian-Spanish Takotsubo Registry [GEIST Registry]; NCT04361994) (J Am Coll Cardiol HF 2022;10:459-466)
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The use of social media for professional purposes by healthcare professionals: the #intEHRAct survey
Anno: 2022
Rivista: EUROPACE
Autori/autrici: Guerra, F.; Linz, D.; Garcia, R.; Kommata, V.; Kosiuk, J.; Chun, J.; Boveda, S.; Duncker, D.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313082
Citazioni:
The use of social media for professional purposes by healthcare professionals: the #intEHRAct survey / Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J., Boveda, S., Duncker, D.. - In: EUROPACE. - ISSN 1099-5129. - 24:4(2022), pp. 691-696. [10.1093/europace/euab244]
Abstract:
Social media (SoMe) represents a medium of communication in everyday life and has gained importance for professional use among clinicians. In the #intEHRAct survey, we aimed to describe the use of SoMe by the healthcare community in a professional setting. The EHRA e-Communication Committee and the ...Scientific Initiatives Committee prepared a questionnaire and distributed it via newsletters, Twitter, LinkedIn, and Facebook. The survey consisted of 19 questions made on an individual basis and collected anonymously. Two hundred and eighty-five responders from 35 countries (72.3% male, age 49 ± 11 years old) completed the survey. Most respondents (42.7%) declared to use SoMe as passive users while 38.3% and 19.0% declared to share content on a non-daily and daily basis, respectively. The respondents estimated they spent a median of 5 (Q1-Q3: 2-10) h per week on SoMe. The most widely used SoMe was LinkedIn (60.8%), but the use of each platform was heterogeneous between countries. Among the advantages of SoMe, respondents indicated the chance of being updated on recent publications (66.0%), networking (48.5%), and the availability of rare or interesting cases (47.9%) as the most useful. Regarding the disadvantages of SoMe, the respondents underlined the loss of personal contact (40.7%), the inability to get 'hands-on' training (38.7%), and the lack of control regarding quality of scientific evidence (37.1%). Social media is increasingly used for professional purposes for scientific updating, networking, and case-based learning. The results of this survey encourage scientific societies, journals, and authors to enhance the quality, reach and impact of scientific content provided through SoMe.
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Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study
Anno: 2021
Rivista: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
Autori/autrici: Araiza-Garaygordobil, D; Montalto, C; Martinez-Amezcua, P; Cabello-Lopez, A; Gopar-Nieto, R; Alabrese, R; Almaghraby, A; Catoya-Villa, S; Chacon-Diaz, M; Kaufmann, C C; Corbi-Pascual, M; Deharo, P; El-Tahlawi, M; Elgohari-Abdelwahab, A; Guerra, F; Jarakovic, M; Martinez-Gomez, E; Moderato, L; Montero, S; Morejon-Barragan, P; Omar, A M; Jorge-Pérez, P; Przybyło, P; Selim, E; Sinan, U Y; Stratinaki, M; Tica, O; Trêpa, M; Uribarri, A; Uzokov, J; Wilk, K; Czerwińska-Jelonkiewicz, K; Sionis, A; Gierlotka, M; Leonardi, S; Krychtiuk, K A; Tavazzi, G
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313067
Citazioni:
Impact of the COVID-19 pandemic on hospitalizations for acute coronary syndromes: a multinational study / Araiza-Garaygordobil, D., Montalto, C., Martinez-Amezcua, P., Cabello-Lopez, A., Gopar-Nieto, R., Alabrese, R., Almaghraby, A., Catoya-Villa, S., Chacon-Diaz, M., Kaufmann, C.C., Corbi-Pascual, M., Deharo, P., El-Tahlawi, M., Elgohari-Abdelwahab, A., Guerra, F., Jarakovic, M., Martinez-Gomez, E., Moderato, L., Montero, S., Morejon-Barragan, P., et al.. - In: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. - ISSN 1460-2725. - 114:9(2021), pp. 642-647. [10.1093/qjmed/hcab013]
Abstract:
Background: COVID-19 has challenged the health system organization requiring a fast reorganization of diagnostic/therapeutic pathways for patients affected by time-dependent diseases such as acute coronary syndromes (ACS).Aim: To describe ACS hospitalizations, management, and complication rate befor...e and after the COVID-19 pandemic was declared.Design: Ecological retrospective study. Methods: We analyzed aggregated epidemiological data of all patients > 18 years old admitted for ACS in twenty-nine hub cardiac centers from 17 Countries across 4 continents, from December 1st, 2019 to April 15th, 2020. Data from December 2018 to April 2019 were used as historical period.Results: A significant overall trend for reduction in the weekly number of ACS hospitalizations was observed (20.2%; 95% confidence interval CI [1.6, 35.4] P = 0.04). The incidence rate reached a 54% reduction during the second week of April (incidence rate ratio: 0.46, 95% CI [0.36, 0.58]) and was also significant when compared to the same months in 2019 (March and April, respectively IRR: 0.56, 95%CI [0.48, 0.67]; IRR: 0.43, 95%CI [0.32, 0.58] p < 0.001). A significant increase in door-to-balloon, door-to-needle, and total ischemic time (p <0.04 for all) in STEMI patents were reported during pandemic period. Finally, the proportion of patients with mechanical complications was higher (1.98% vs. 0.98%; P = 0.006) whereas GRACE risk score was not different.Conclusions: Our results confirm that COVID-19 pandemic was associated with a significant decrease in ACS hospitalizations rate, an increase in total ischemic time and a higher rate of mechanical complications on a international scale.
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Prognostic Role of Myocardial Edema as Evidenced by Early Cardiac Magnetic Resonance in Survivors of Out‐of‐Hospital Cardiac Arrest: A Multicenter Study
Anno: 2021
Rivista: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE
Autori/autrici: Zorzi, Alessandro; Mattesi, Giulia; Baldi, Enrico; Toniolo, Mauro; Guerra, Federico; Maria Cauti, Filippo; Cipriani, Alberto; De Lazzari, Manuel; Muser, Daniele; Stronati, Giulia; Marcantoni, Lina; Manfrin, Massimiliano; Calò, Leonardo; Lanzillo, Chiara; Perazzolo Marra, Martina; Savastano, Simone; Corrado, Domenico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313079
Citazioni:
Prognostic Role of Myocardial Edema as Evidenced by Early Cardiac Magnetic Resonance in Survivors of Out‐of‐Hospital Cardiac Arrest: A Multicenter Study / Zorzi, A., Mattesi, G., Baldi, E., Toniolo, M., Guerra, F., Maria Cauti, F., Cipriani, A., De Lazzari, M., Muser, D., Stronati, G., Marcantoni, L., Manfrin, M., Calò, L., Lanzillo, C., Perazzolo Marra, M., Savastano, S., Corrado, D.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 10:22(2021), p. e021861. [10.1161/JAHA.121.021861]
Abstract:
Background Sudden cardiac arrest (SCA) may be caused by an acute and reversible myocardial injury, a chronic and irreversible myocardial damage, or a primary ventricular arrhythmia. Cardiac magnetic resonance imaging may identify myocardial edema (ME), which denotes acute and reversible myocardial d...amage. We evaluated the arrhythmic outcome of SCA survivors during follow-up and tested the prognostic role of ME. Methods and Results We included a consecutive series of 101 (71% men, median age 47 years) SCA survivors from 9 collaborative centers who underwent early (<1 month) cardiac magnetic resonance imaging and received an implantable cardioverter-defibrillator (ICD). On T2-weighted sequences, ME was found in 18 of 101 (18%) patients. According to cardiac magnetic resonance imaging findings, the arrhythmic SCA was ascribed to acute myocardial injury (either ischemic [n=10] or inflammatory [n=8]), to chronic structural heart diseases (ischemic heart disease [n=11], cardiomyopathy [n=20], or other [n=23]), or to primarily arrhythmic syndrome (n=29). During a follow-up of 47 months (28 to 67 months), 24 of 101 (24%) patients received an appropriate ICD intervention. ME was associated with a significantly higher survival free from both any ICD interventions (log-rank=0.04) and ICD shocks (log-rank=0.03) and remained an independent predictor of better arrhythmic outcome after adjustment for left ventricular ejection fraction and late gadolinium enhancement. The risk of appropriate ICD intervention was unrelated to the type of underlying heart disease. Conclusions ME on early cardiac magnetic resonance imaging, which denotes an acute and transient arrhythmogenic substrate, predicted a favorable long-term arrhythmic outcome of SCA survivors. These findings may have a substantial impact on future guidelines on the management of SCA survivors.
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[2019 Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing]
Anno: 2021
Rivista: GIORNALE ITALIANO DI CARDIOLOGIA
Autori/autrici: Stabile, Giuseppe; Guerra, Federico; Tola, Gianfranco; Bertaglia, Emanuele; Palmisano, Pietro; Berisso, Massimo Zoni; Soldati, Ezio; Bisignani, Giovanni; Forleo, Giovanni Battista; Zanotto, Gabriele; Landolina, Maurizio; Boriani, Giuseppe; D'Onofrio, Antonio; De Ponti, Roberto; Ricci, Renato Pietro
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313080
Citazioni:
[2019 Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing] / Stabile, G., Guerra, F., Tola, G., Bertaglia, E., Palmisano, P., Berisso, M.Z., Soldati, E., Bisignani, G., Forleo, G.B., Zanotto, G., Landolina, M., Boriani, G., D'Onofrio, A., De Ponti, R., Ricci, R.P.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 22:12(2021), pp. 1034-1037. [10.1714/3698.36883]
Abstract:
Background: This report describes the findings of the 2019 Italian Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC). Methods: Data collection was retrospective. A standardized questionnaire was completed by each of the participating centers. Results: A... total of 15 201 ablation procedures were performed by 91 institutions. Most (78%) of the centers has one electrophysiology laboratory, and 17% of them has a hybrid cardiac surgery laboratory. Almost all (98%) centers have a 3D mapping system. The median number of electrophysiologists and nurses involved in the electrophysiology laboratory was 3 and an electrophysiology technician was involved in 30% of all centers. In 88.4% of cases, ablations were performed for supraventricular arrhythmias, and among these the most frequently treated arrhythmia was atrial fibrillation (32.9%), followed by atrioventricular nodal reentrant tachycardia (23.9%), and common atrial flutter (11.7%). In 10 256 (67.4%) patients catheter ablation was performed by means of a 3D mapping system, with a "near-zero" fluoroscopic approach in 4626 (30.4%) of all patients. Conclusions: The 2019 Italian Catheter Ablation Registry confirmed that atrial fibrillation is the most commonly treated arrhythmia in the ablation centers with an increasing number of procedures performed with a 3D mapping system and a "near-zero" approach.
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Organization and procedures in contemporary catheter ablation centres: data from the 2018 Italian Catheter Ablation Registry
Anno: 2021
Rivista: JOURNAL OF CARDIOVASCULAR MEDICINE
Autori/autrici: Stabile, Giuseppe; Bertaglia, Emanuele; Guerra, Federico; Palmisano, Pietro; Zoni Berisso, Massimo; Soldati, Ezio; Bisignani, Giovanni; Forleo, Giovan Battista; Zanotto, Gabriele; Landolina, Maurizio; Boriani, Giuseppe; D'Onofrio, Antonio; De Ponti, Roberto; Ricci, Renato Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313074
Citazioni:
Organization and procedures in contemporary catheter ablation centres: data from the 2018 Italian Catheter Ablation Registry / Stabile, G., Bertaglia, E., Guerra, F., Palmisano, P., Zoni Berisso, M., Soldati, E., Bisignani, G., Forleo, G.B., Zanotto, G., Landolina, M., Boriani, G., D'Onofrio, A., De Ponti, R., Ricci, R.P.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2027. - 22:8(2021), pp. 631-636. [10.2459/JCM.0000000000001183]
Abstract:
Aims This report describes the findings of the 2018 Italian Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC). Methods The Italian Catheter Ablation Registry systematically collects data on the ablation procedures performed in Italy. Data collection was... retrospective. A standardized questionnaire was completed by participating centres. Results We collected data on 15 714 catheter ablation procedures performed in Italy during 2018 in 94 electrophysiology centres. In most centres (75/94, 80%), a single electrophysiology laboratory was available, and a hybrid electrophysiology laboratory was available in 15% (14/94) of centres. In most (93%) centres, at least two electrophysiologists were involved in the catheter ablation procedures. In only 13 out of 94 (14%) electrophysiology laboratories, an anaesthesiologist assists every electrophysiology procedure; in most cases (74/94, 79%), an on-demand anaesthesiology service was available. On-site cardiothoracic surgery was reported in 43 out of 94 (46%) centres. Nonfluoroscopic navigation systems were available in most centres (88/94, 93%). Intracardiac echocardiography was used in 59 out of 94 (63%) electrophysiology laboratories. Atrial fibrillation (31%) was the most frequently treated ablation target, followed by atrioventricular nodal re-entrant tachycardia (20%) and cavo-tricuspid isthmus (15%). In 61.7% of all procedures, a 3D mapping system was used. In about one-third of procedures, a near-zero approach was performed. Conclusion In most Italian electrophysiology centres, a single electrophysiology laboratory was available and at least two electrophysiologists were involved in the ablation procedures. An increasing number of procedures were performed by means of a nonfluoroscopic mapping system with a near-zero approach.
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Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry
Anno: 2021
Rivista: BIOMEDICAL PAPERS OF THE THE FACULTY OF MEDICINE OF PALACKÝ UNIVERSITY, OLOMOUC CZECH REPUBLIC
Autori/autrici: Pazdernik, Michal; Gramegna, Mario; Bohm, Allan; Trepa, Maria; Vandenbriele, Christophe; De Rosa, Salvatore; Uzokov, Jamol; Aleksic, Milica; Jarakovic, Milana; El Tahlawi, Mohammad; Mostafa, Morsy; Stratinaki, Maria; Araiza-Garaygordobil, Diego; Gubareva, Ekaterina; Duplyakova, Polina; Chacon-Diaz, Manuel; Refaat, Hesham; Guerra, Federico; Cappelletti, Alberto Maria; Berka, Vojtech; Westermann, Dirk; Schrage, Benedikt
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313078
Citazioni:
Regional differences in presentation characteristics, use of treatments and outcome of patients with cardiogenic shock: Results from multicenter, international registry / Pazdernik, M., Gramegna, M., Bohm, A., Trepa, M., Vandenbriele, C., De Rosa, S., Uzokov, J., Aleksic, M., Jarakovic, M., El Tahlawi, M., Mostafa, M., Stratinaki, M., Araiza-Garaygordobil, D., Gubareva, E., Duplyakova, P., Chacon-Diaz, M., Refaat, H., Guerra, F., Cappelletti, A.M., Berka, V., et al.. - In: BIOMEDICAL PAPERS OF THE THE FACULTY OF MEDICINE OF PALACKÝ UNIVERSITY, OLOMOUC CZECH REPUBLIC. - ISSN 1213-8118. - 165:3(2021), pp. 291-297. [10.5507/bp.2021.046]
Abstract:
Background. Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients and is therefore limited. The aim of this study was to investigate these regional differences. Methods. To investigate regional differences in presenta...tion characteristics, treatments and outcomes of patients treated with all types of cardiogenic shock (CS) in a single calendar year on a multi-national level. Consecutive patients from 19 tertiary care hospitals in 13 countries with CS who were treated between January 1, 2018 and December 31, 2018 were enrolled in this study. Results. In total, 699 cardiogenic shock patients were included in this study. Of these patients, 440 patients (63%) were treated in European hospitals and 259 (37%) were treated in Non-European hospitals. Female patients (P<0.01) and patients with a previous myocardial infarction (P=0.02) were more likely to present at Non-European hospitals; whereas older patients (P=0.01) and patients with cardiogenic shock due to acute heart failure (P<0.01) were more likely to present at European hospitals. Vasopressor use was more likely in Non-European hospitals (P=0.04), whereas use of mechanical circulatory support (MCS) was more likely in European hospitals (P<0.01). Despite adjustment for relevant confounders, 30-day in-hospital mortality risk was comparably high in CS patients treated in European vs. Non-European hospitals (hazard ratio 1.08, 95% CI 0.84-1.39, P=0.56). Conclusion. Despite marked heterogeneity in characteristics and treatment of CS patients, including fewer use of MCS but more frequent use of vasopressors in Non-European hospitals, 30-day in-hospital mortality did not differ between regions.
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The practice of deep sedation in electrophysiology and cardiac pacing laboratories: Results of an italian survey promoted by the aiac (italian association of arrhythmology and cardiac pacing)
Anno: 2021
Rivista: JOURNAL OF CLINICAL MEDICINE
Autori/autrici: Palmisano, P.; Ziacchi, M.; Angeletti, A.; Guerra, F.; Forleo, G. B.; Bertini, M.; Notarstefano, P.; Accogli, M.; Lavalle, C.; Bisignani, G.; Landolina, M.; Zanotto, G.; D'Onofrio, A.; Ricci, R. P.; De Ponti, R.; Boriani, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313076
Citazioni:
The practice of deep sedation in electrophysiology and cardiac pacing laboratories: Results of an italian survey promoted by the aiac (italian association of arrhythmology and cardiac pacing) / Palmisano, P., Ziacchi, M., Angeletti, A., Guerra, F., Forleo, G.B., Bertini, M., Notarstefano, P., Accogli, M., Lavalle, C., Bisignani, G., Landolina, M., Zanotto, G., D'Onofrio, A., Ricci, R.P., De Ponti, R., Boriani, G.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:21(2021), p. 5035. [10.3390/jcm10215035]
Abstract:
The aim of this survey, which was open to all Italian cardiologists involved in arrhythmia, was to assess common practice regarding sedation and analgesia in interventional electrophysiology procedures in Italy. The survey consisted of 28 questions regarding the approach to sedation used for electiv...e direct-current cardioversion (DCC), subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation, atrial fibrillation (AF) ablation, ventricular tachycardia (VT) ablation, and transvenous lead extraction procedures. A total of 105 cardiologists from 92 Italian centres took part in the survey. The rate of centres where DCC, S-ICD implantation, AF ablation, VT ablation and lead extraction procedures were performed without anaesthesiologic assistance was 60.9%, 23.6%, 51.2%, 37.3%, and 66.7%, respectively. When these procedures were performed without anaesthesiologic assistance, the drugs (in addition to local anaesthetics) commonly administered were benzodiazepines (from 64.3% to 79.6%), opioids (from 74.4% to 88.1%), and general anaesthetics (from 7.1% to 30.4%). Twenty-three (21.9%) of the 105 cardiologists declared that they routinely administered propofol, without the supervision of an anaesthesiologist, in at least one of the above-mentioned procedures. In current Italian clinical practice, there is a lack of uniformity in the sedation/analgesia approach used in interventional electrophysiology procedures.
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Current patterns of beta-blocker prescription in cardiac amyloidosis: an Italian nationwide survey
Anno: 2021
Rivista: ESC HEART FAILURE
Autori/autrici: Tini, Giacomo; Cappelli, Francesco; Biagini, Elena; Musumeci, Beatrice; Merlo, Marco; Crotti, Lia; Cameli, Matteo; Di Bella, Gianluca; Cipriani, Alberto; Marzo, Francesca; Guerra, Federico; Forleo, Cinzia; Gagliardi, Christian; Zampieri, Mattia; Carigi, Samuela; Vianello, Pier Filippo; Mandoli, Giulia Elena; Ciliberti, Giuseppe; Lichelli, Luca; Mariani, Davide; Porcari, Aldostefano; Russo, Domitilla; Licordari, Roberto; Ponziani, Alberto; Porto, Italo; Perfetto, Federico; Autore, Camillo; Rapezzi, Claudio; Sinagra, Giafranco; Canepa, Marco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313071
Citazioni:
Current patterns of beta-blocker prescription in cardiac amyloidosis: an Italian nationwide survey / Tini, G., Cappelli, F., Biagini, E., Musumeci, B., Merlo, M., Crotti, L., Cameli, M., Di Bella, G., Cipriani, A., Marzo, F., Guerra, F., Forleo, C., Gagliardi, C., Zampieri, M., Carigi, S., Vianello, P.F., Mandoli, G.E., Ciliberti, G., Lichelli, L., Mariani, D., et al.. - In: ESC HEART FAILURE. - ISSN 2055-5822. - 8:4(2021), pp. 3369-3374. [10.1002/ehf2.13411]
Abstract:
Aims The use of beta-blocker therapy in cardiac amyloidosis (CA) is debated. We aimed at describing patterns of beta-blocker prescription through a nationwide survey.Methods and results From 11 referral centres, we retrospectively collected data of CA patients with a first evaluation after 2016 (n =... 642). Clinical characteristics at first and last evaluation were collected, with a focus on medical therapy. For patients in whom beta-blocker therapy was started, stopped, or continued between first and last evaluation, the main reason for beta-blocker management was requested. Median age of study population was 77 years; 81% were men. Arterial hypertension was found in 58% of patients, atrial fibrillation (AF) in 57%, and coronary artery disease in 16%. Left ventricular ejection fraction was preserved in 62% of cases, and 74% of patients had advanced diastolic dysfunction. Out of the 250 CA patients on beta-blockers at last evaluation, 215 (33%) were already taking this therapy at first evaluation, while 35 (5%) were started it, in both cases primarily because of high-rate AF. One-hundred-nineteen patients (19%) who were on beta-blocker at first evaluation had this therapy withdrawn, mainly because of intolerance in the presence of heart failure with advanced diastolic dysfunction. The remaining 273 patients (43%) had never received beta-blocker therapy. Beta-blockers usage was similar between CA aetiologies. Patients taking vs. not taking beta-blockers differed only for a greater prevalence of arterial hypertension, coronary artery disease, AF, and non-restrictive filling pattern (P < 0.01 for all) in the former group.Conclusions Beta-blockers prescription is not infrequent in CA. Such therapy may be tolerated in the presence of co-morbidities for which beta-blockers are routinely used and in the absence of advanced diastolic dysfunction.
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Intensive cardiac care unit admission trends during the COVID-19 outbreak in Italy: a multi-center study
Anno: 2021
Rivista: INTERNAL AND EMERGENCY MEDICINE
Autori/autrici: Campanile, Alfonso; Verdecchia, Paolo; Ravera, Amelia; Coiro, Stefano; Mattei, Cristian; Scavelli, Francesca; Bearzot, Luca; Cutolo, Ada; Centola, Marco; Carugo, Stefano; De Rosa, Salvatore; Guerra, Federico; Marini, Marco; Perna, Gian Piero; Indolfi, Ciro; Cavallini, Claudio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313070
Citazioni:
Intensive cardiac care unit admission trends during the COVID-19 outbreak in Italy: a multi-center study / Campanile, A., Verdecchia, P., Ravera, A., Coiro, S., Mattei, C., Scavelli, F., Bearzot, L., Cutolo, A., Centola, M., Carugo, S., De Rosa, S., Guerra, F., Marini, M., Perna, G.P., Indolfi, C., Cavallini, C.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 16:8(2021), pp. 2077-2086. [10.1007/s11739-021-02718-8]
Abstract:
A significant decline in the admission to intensive cardiac care unit (ICCU) has been noted in Italy during the COVID-19 outbreak. Previous studies have provided data on clinical features and outcome of these patients, but information is still incomplete. In this multicenter study conducted in six I...CCUs, we enrolled consecutive adult patients admitted to ICCU in three specific time intervals: from February 8 to March 9, 2020 [before national lockdown (pre-LD)], from March 10 to April 9, 2020 [during the first period of national lockdown (in-LD)] and from May 18 to June 17, 2020 [soon after the end of all containment measures (after-LD)]. Compared to pre-LD, in-LD was associated with a significant drop in the admission to ICCU for all causes (- 35%) and acute coronary syndrome (ACS; - 49%), with a rebound soon after-LD. The in-LD reduction was greater for women (- 49%) and NSTEMI (- 61%) compared to men (- 28%) and STEMI (- 33%). Length-of-stay, and in-hospital mortality did not show any significant change from to pre-LD to in-LD in the whole population as well as in the ACS group. This study confirms a notable reduction in the admissions to ICCUs from pre-LD to in-LD followed by an increment in the admission rates after-LD. These data strongly suggest that people, particularly women and patients with NSTEMI, are reluctant to seek medical care during lockdown, possibly due to the fear of viral infection. Such a phenomenon, however, was not associated with a rise in mortality among patients who get hospitalization.
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Use and misuse of instant messaging in clinical data sharing: The EHRA-SMS survey
Anno: 2021
Rivista: EUROPACE
Autori/autrici: Guerra, F.; Linz, D.; Garcia, R.; Kommata, V.; Kosiuk, J.; Chun, J.; Boveda, S.; Duncker, D.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313068
Citazioni:
Use and misuse of instant messaging in clinical data sharing: The EHRA-SMS survey / Guerra, F., Linz, D., Garcia, R., Kommata, V., Kosiuk, J., Chun, J., Boveda, S., Duncker, D.. - In: EUROPACE. - ISSN 1099-5129. - 23:8(2021), pp. 1326-1330. [10.1093/europace/euab063]
Abstract:
Instant messaging (IM) enables medical professionals to quickly share clinical data to their peers for counselling. Purpose of this survey is to assess the habits related to IM, their application in clinical practice and the perceived pros and cons. An online survey was distributed to the medical co...mmunity via newsletters, Twitter, LinkedIn, and Facebook. The survey consisted of 22 questions made on an individual-basis and collected anonymously on SurveyMonkey. A total of 287 subjects from 33 countries responded to the survey (mean age 43 years, 74.8% male). Of all respondents, 88.3% routinely send and 90.3% receive clinical data through IM which was second only to face-To-face contact as the preferred method for sharing clinical data. Twelve-lead electrocardiograms (88.6%), medical history (61.4%), and echo loops (55.7%) were the data shared most often. Nearly half of the clinical data that are sent (43%) or received (44%) are not anonymized. In the same way, 29.3% of the respondents were not aware of the European General Data Protection Regulation (GDPR) at the time of the survey. IM apps are used by medical professionals worldwide to share and discuss clinical data and are preferred to many other methods of data sharing, being second only to face-To-face contact. IM are often used to share many different types of clinical data, being perceived as a fast and easy way of communication. Medical professionals should be aware of the appropriate use of IM to prevent legal and privacy issues.
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Reprocessing of electrophysiology material in EHRA countries: an EHRA Young EP survey
Anno: 2021
Rivista: EUROPACE
Autori/autrici: Duncker, David; Svetlosak, Martin; Guerra, Federico; Nagy, Klaudia Vivien; Vanduynhoven, Philippe; Mikhaylov, Evgeny N; Kosiuk, Jedrzej
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313060
Citazioni:
Reprocessing of electrophysiology material in EHRA countries: an EHRA Young EP survey / Duncker, D., Svetlosak, M., Guerra, F., Nagy, K.V., Vanduynhoven, P., Mikhaylov, E.N., Kosiuk, J.. - In: EUROPACE. - ISSN 1099-5129. - 23:3(2021), pp. 479-485. [10.1093/europace/euaa250]
Abstract:
Data on reprocessing of electrophysiology (EP) materials are sparse. Reprocessing of catheters and other materials in daily routine varies through countries and may depend on specific material characteristics, supplier, or federal law. The aim of this study was to collect data on reprocessing usage ...through EHRA countries. An online survey consisting of 27 questions was distributed to EHRA Young EP members and members of national EP working groups. Two hundred and two participants from 34 EHRA countries completed the survey. One hundred and seven respondents (53.0%) reported having used and using reprocessed EP material, 30 (14.9%) respondents have used reprocessed EP material in the past but not at the time of the survey, 65 (32.2%) had never used reprocessed EP material. The most reprocessed EP materials include cables (70%), diagnostic EP catheters with deflectable (64%) or fixed curve (63%), non-irrigated ablation catheters (51%), and other conventional diagnostic catheters (41%). The most durable material was diagnostic EP catheters with a fixed curve (61%), the most sensitive material was ablation catheters with contact force sensors (21%). Important benefits were seen in reducing costs for the providing hospital (65%) and the healthcare provider (42%) and making EP procedures available for a greater number of patients (42%). Main concerns were on quality aspects (58%), contamination (52%), and loss of precision (47%). Reprocessing of EP materials is heterogeneously managed among EHRA countries. The present survey shows that European electrophysiologists consider the use of reprocessed EP material as generally safe and cost-effective.
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Sinergy between drugs and devices in the fight against sudden cardiac death and heart failure
Anno: 2021
Rivista: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Autori/autrici: Boriani, G.; De Ponti, R.; Guerra, F.; Palmisano, P.; Zanotto, G.; D'Onofrio, A.; Ricci, R. P.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313061
Citazioni:
Sinergy between drugs and devices in the fight against sudden cardiac death and heart failure / Boriani, G., De Ponti, R., Guerra, F., Palmisano, P., Zanotto, G., D'Onofrio, A., Ricci, R.P.. - In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - ISSN 2047-4873. - 28:1(2021), pp. 110-123. [10.1093/eurjpc/zwaa015]
Abstract:
The impact of sudden cardiac death (SCD) in heart failure (HF) patients is important and prevention of SCD is a reasonable and clinically justified endpoint if associated with a reduction in all-cause mortality. According to literature, in HF with reduced ejection fraction, only three classes of age...nts were found effective in reducing SCD and all-cause mortality: beta-blockers, mineralcorticoid receptor antagonists and, more recently, angiotensin-receptor neprilysin-inhibitors. In the PARADIGM trial that tested sacubitril/valsartan vs. enalapril, the 20% relative risk reduction in cardiovascular deaths obtained with sacubitril/valsartan was attributable to reductions in the incidence of both SCD and death due to HF worsening and this effect can be added to the known positive effect of implantable cardioverter-defibrillators in appropriately selected patients. In order to maximize the implementation of all the available treatments, patients with HF should be included in virtuous networks with a dialogue between all the physician involved, with commitment by all these physicians for appropriate decision-making on application of pharmacological and device treatments according to available evidence, as well as commitment for drug titration before and after device implant, taking advantage from remote monitoring, and with the safety of back up device therapy when indicated. There are potential synergistic effects of drug therapy, with all the therapies acting on neuro-hormonal and sympathetic activation, but specifically with sacubitril/valsartan, and device therapy, in particular cardiac resynchronization therapy, with added incremental benefits on positive cardiac remodelling, prevention of HF progression, and prevention of ventricular tachyarrhythmias.
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Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome: Results From the GEIST Registry
Anno: 2021
Rivista: CHEST
Autori/autrici: El-Battrawy, Ibrahim; Santoro, Francesco; Stiermaier, Thomas; Möller, Christian; Guastafierro, Francesca; Novo, Giuseppina; Novo, Salvatore; Mariano, Enrica; Romeo, Francesco; Romeo, Fabiana; Thiele, Holger; Guerra, Federico; Capucci, Alessandro; Giannini, Irene; Brunetti, Natale Daniele; Eitel, Ingo; Akin, Ibrahim
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313081
Citazioni:
Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome: Results From the GEIST Registry / El-Battrawy, I., Santoro, F., Stiermaier, T., Möller, C., Guastafierro, F., Novo, G., Novo, S., Mariano, E., Romeo, F., Romeo, F., Thiele, H., Guerra, F., Capucci, A., Giannini, I., Brunetti, N.D., Eitel, I., Akin, I.. - In: CHEST. - ISSN 0012-3692. - 160:4(2021), pp. 1433-1441. [10.1016/j.chest.2021.04.072]
Abstract:
BACKGROUND: The short-and long-term prognosis of Takotsubo syndrome (TTS) presenting with right ventricular (RV) involvement remains poorly understood.RESEARCH QUESTION: What is the incidence and clinical outcome of RV involvement in TTS?STUDY DESIGN AND METHODS: This study analyzed 839 consecutive ...patients with TTS (758 female subjects and 81 male subjects) in a multicenter registry. RV involvement was defined as wall motion abnormality of the RV free wall, with or without apical involvement. The median long-term follow-up was 2.1 years (interquartile range, 0.3-4.5 years). The primary outcome was in-hospital and out-of-hospital all-cause mortality. The secondary end point was a composite of in-hospital death, thromboembolic events, cardiogenic shock, pulmonary edema, and malignant arrhythmias.RESULTS: The incidence of RV involvement in TTS was 11% (n = 93). More often patients with RV involvement were male compared with patients without RV involvement (P = .02). There was a slight difference in the left ventricular ejection fraction measured in patients with RV involvement vs those patients with isolated left ventricular TTS (38 +/- 10% vs 40 +/- 10%; P = .03). No major differences in terms of comorbidities were observed between groups except regarding a history of cancer, which was significantly more prevalent in patients with TTS presenting with RV involvement (P = .03). Physical stressors were more prevalent in the RV group (P < .01), whereas emotional stressors were less prevalent (P < .01). Patients with RV involvement had a higher incidence of in-hospital cardiogenic shock (P = .02). The primary outcome (in-and out-of-hospital all-cause mortality) was observed in 12.8% of patients without RV involvement compared with 29% of patients with RV involvement. Although the in-hospital mortality rate was similar in both groups, a higher out-of-hospital all-cause mortality rate (log-rank test, P = .008) was observed in the RV involvement group. The Cox multivariable regression analysis showed that physical triggers were independent predictors of RV involvement.INTERPRETATION: RV involvement defines a high-risk cohort of patients with TTS.
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Management of patients explanted for implantable cardioverter defibrillator infections: Bridge therapy with external temporary ICD
Anno: 2021
Rivista: PACING AND CLINICAL ELECTROPHYSIOLOGY
Autori/autrici: Dell'Era, Gabriele; Prenna, Eleonora; Ziacchi, Matteo; Diemberger, Igor; Varalda, Marco; Guerra, Federico; Biffi, Mauro; Occhetta, Eraldo; Patti, Giuseppe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313075
Citazioni:
Management of patients explanted for implantable cardioverter defibrillator infections: Bridge therapy with external temporary ICD / Dell'Era, G., Prenna, E., Ziacchi, M., Diemberger, I., Varalda, M., Guerra, F., Biffi, M., Occhetta, E., Patti, G.. - In: PACING AND CLINICAL ELECTROPHYSIOLOGY. - ISSN 0147-8389. - 44:11(2021), pp. 1884-1889. [10.1111/pace.14355]
Abstract:
Aims and methods In case of cardiacimplantable electronicdevice (CIED)-related infections, it is mandatory to completely remove the device and administer prolonged antibiotic therapy. The management of patients explanted for an implantable defibrillator (ICD) infection is complex especially in patie...nts needing anti-bradycardia pacing or tachyarrhythmia protection. We tested the efficacy and safety of a conventional ICD externally connected to a transvenous dual-coil lead as bridging therapy before the reimplant, comparing outcomes with a historical cohort of patients (N = 113) treated with temporary transvenous pacing. We enrolled 18 patients explanted for ICD infection and needing prolonged antibiotic therapy in three high-volume Italian centers. They received an external ICD stand-by for a mean of 16.5 (4-30) days before the reimplant. Results No patient experienced malfunction of the system, with a significant reduction of this complication versus temporary transfemoral pacing (37%, p = .004). Post-procedural occurrence of other complications (infection, relevant local bleeding, ventricular tachycardia during insertion of the lead, cardiac perforation, and venous thromboembolism) was low and not different in the two groups. One patient experienced an electrical storm, effectively recognized by the external ICD and treated with anti-tachycardia pacings (ATPs) and shocks. Conclusions An approach with an external ICD seems to be a safe and viable option as bridging therapy in patients requiring ICD explant for CIED infection.
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Twitter for professional use in electrophysiology: practical guide for #EPeeps
Anno: 2021
Rivista: EUROPACE
Autori/autrici: Linz, Dominik; Garcia, Rodrigue; Guerra, Federico; Kommata, Varvara; Bollmann, Andreas; Duncker, David
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313069
Citazioni:
Twitter for professional use in electrophysiology: practical guide for #EPeeps / Linz, D., Garcia, R., Guerra, F., Kommata, V., Bollmann, A., Duncker, D.. - In: EUROPACE. - ISSN 1099-5129. - 23:8(2021), pp. 1192-1199. [10.1093/europace/euab048]
Abstract:
Social media (SoMe) becomes more and more popular in the cardiological community. Among them, Twitter is an emerging and dynamic medium to connect, communicate and educate academic and clinical cardiologists. However, in contrast to traditional scientific communications, the content provided through... SoMe is not peer-reviewed and may not necessarily always represent scientific evidence or may even be used to unjustifiably promote therapies for commercial purposes. For the unintended, this means of communication might be appear difficult to handle. This article aims to provide a practical guide on how to use Twitter efficiently for professional use to keep yourself up-to-date about new techniques, the Latest study results and news presented at national or international conferences. Additionally, important limitations will be discussed.
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Risk prediction models in atrial fibrillation: From theory to practice
Anno: 2021
Rivista: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Autori/autrici: Guerra, F.; Stronati, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313073
Citazioni:
Risk prediction models in atrial fibrillation: From theory to practice / Guerra, F., Stronati, G.. - In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - ISSN 2047-4873. - 28:6(2021), pp. 584-585. [10.1093/eurjpc/zwaa133]

Current status and needs for changes in critical care training: the voice of the young cardiologists
Anno: 2021
Rivista: EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE
Autori/autrici: Czerwińska-Jelonkiewicz, Katarzyna; Montero, Santiago; Bañeras, J; Wood, A; Zeid, A; De Rosa, S; Guerra, F; Tica, O; Serrano, F; Bohm, A; Ahrens, I; Gierlotka, M; Masip, J; Bonnefoy, E; Lettino, M; Kirchhof, P; Sionis, A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313066
Citazioni:
Current status and needs for changes in critical care training: the voice of the young cardiologists / Czerwińska-Jelonkiewicz, K., Montero, S., Bañeras, J., Wood, A., Zeid, A., De Rosa, S., Guerra, F., Tica, O., Serrano, F., Bohm, A., Ahrens, I., Gierlotka, M., Masip, J., Bonnefoy, E., Lettino, M., Kirchhof, P., Sionis, A.. - In: EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE. - ISSN 2048-8726. - 10:1(2021), pp. 94-101. [10.1093/ehjacc/zuaa027]
Abstract:
Aims The implementation of the 2013 European Society of Cardiology (ESC) Core Curriculum guidelines for acute cardiovascular care (acc) training among European countries is unknown. We aimed to evaluate the current status of acc training among cardiology trainees and young cardiologists (<40 year...s) from ESC countries.Methods and results The survey (March-July 2019) asked about details of cardiology training, self-confidence in acc technical and nontechnical skills, access to training opportunities, and needs for further training in the field. Overall 614 young doctors, 31 (26-43) years old, 55% males were surveyed. Place and duration of acc training differed between countries and between centres in the same country. Although the majority of the respondents (91%) had completed their acc training, the average self-confidence to perform invasive procedures and to manage acc clinical scenarios was low-44% (27.3-70.4). The opportunities for simulation-based learning were scarce-18% (5.8-51.3), as it was previous leadership training (32%) and knowledge about key teamwork principles was poor (48%). The need for further acc training was high-81% (61.9-94.3). Male gender, higher level of training centres, professional qualifications of respondents, longer duration of acc/intensive care training, debriefings, and previous leadership training as well as knowledge about teamwork were related to higher self-confidence in all investigated aspects.Conclusions The current cardiology training program is burdened by deficits in acc technical/non-technical skills, substantial variability in programs across ESC countries, and a clear gender-related disparity in outcomes. The forthcoming ESC Core Curriculum for General Cardiology is expected to address these deficiencies.
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Sports Activity and Arrhythmic Risk in Cardiomyopathies and Channelopathies: A Critical Review of European Guidelines on Sports Cardiology in Patients with Cardiovascular Diseases
Anno: 2021
Rivista: MEDICINA
Autori/autrici: Volpato, Giovanni; Falanga, Umberto; Cipolletta, Laura; Conti, Manuel Antonio; Grifoni, Gino; Ciliberti, Giuseppe; Urbinati, Alessia; Barbarossa, Alessandro; Stronati, Giulia; Fogante, Marco; Bergonti, Marco; Catto, Valentina; Guerra, Federico; Giovagnoni, Andrea; Dello Russo, Antonio; Casella, Michela; Compagnucci, Paolo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293103
Citazioni:
Sports Activity and Arrhythmic Risk in Cardiomyopathies and Channelopathies: A Critical Review of European Guidelines on Sports Cardiology in Patients with Cardiovascular Diseases / Volpato, G., Falanga, U., Cipolletta, L., Conti, M.A., Grifoni, G., Ciliberti, G., Urbinati, A., Barbarossa, A., Stronati, G., Fogante, M., Bergonti, M., Catto, V., Guerra, F., Giovagnoni, A., Dello Russo, A., Casella, M., Compagnucci, P.. - In: MEDICINA. - ISSN 1648-9144. - 57:4(2021). [10.3390/medicina57040308]
Abstract:
The prediction and prevention of sudden cardiac death is the philosopher's stone of clinical cardiac electrophysiology. Sports can act as triggers of fatal arrhythmias and therefore it is essential to promptly frame the athlete at risk and to carefully evaluate the suitability for both competit...ive and recreational sports activity. A history of syncope or palpitations, the presence of premature ventricular complexes or more complex arrhythmias, a reduced left ventricular systolic function, or the presence of known or familiar heart disease should prompt a thorough evaluation with second level examinations. In this regard, cardiac magnetic resonance and electrophysiological study play important roles in the diagnostic work-up. The role of genetics is increasing both in cardiomyopathies and in channelopathies, and a careful evaluation must be focused on genotype positive/phenotype negative subjects. In addition to being a trigger for fatal arrhythmias in certain cardiomyopathies, sports also play a role in the progression of the disease itself, especially in the case arrhythmogenic right ventricular cardiomyopathy. In this paper, we review the latest European guidelines on sport cardiology in patients with cardiovascular diseases, focusing on arrhythmic risk stratification and the management of cardiomyopathies and channelopathies.
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Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID-19
Anno: 2021
Rivista: JOURNAL OF HOSPITAL MEDICINE
Autori/autrici: Biolè, Carloalberto; Bianco, Matteo; Núñez-Gil, Iván J; Cerrato, Enrico; Spirito, Amanda; Roubin, Sergio Raposeiras; Viana-Llamas, María C; Gonzalez, Adelina; Castro-Mejía, Alex F; Eid, Charbel Maroun; Fernández-Pérez, Cristina; Uribarri, Aitor; Alfonso-Rodriguez, Emilio; Ugo, Fabrizio; Guerra, Federico; Feltes, Gisela; Akin, Ibrahim; Fernández-Rozas, Inmaculada; Blasco-Angulo, Natividad; Huang, Jia; Aguado, Marcos Garcia; Pepe, Martino; Romero, Rodolfo; Becerra-Muñoz, Víctor Manuel; Estrada, Vicente; Macaya, Carlos
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313072
Citazioni:
Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID-19 / Biolè, C., Bianco, M., Núñez-Gil, I.J., Cerrato, E., Spirito, A., Roubin, S.R., Viana-Llamas, M.C., Gonzalez, A., Castro-Mejía, A.F., Eid, C.M., Fernández-Pérez, C., Uribarri, A., Alfonso-Rodriguez, E., Ugo, F., Guerra, F., Feltes, G., Akin, I., Fernández-Rozas, I., Blasco-Angulo, N., Huang, J., et al.. - In: JOURNAL OF HOSPITAL MEDICINE. - ISSN 1553-5592. - 16:6(2021), pp. 349-352. [10.12788/jhm.3594]
Abstract:
Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enroll...ed patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia/anosmia. Laboratory tests in men presented alterations consistent with a more severe COVID-19 infection (eg, significantly higher C-reactive protein, troponin, transaminases, lymphocytopenia, thrombocytopenia, and ferritin). Systemic inflammatory response syndrome, bilateral pneumonia, respiratory insufficiency, and renal failure were significantly more frequent in men. Men more often required pronation, corticosteroids, and tocilizumab administration. A significantly higher 30-day mortality was observed in men vs women (23.4% vs 19.2%; P =.039). (C) 2021 Society of Hospital Medicine.
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Cost-minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
Anno: 2021
Rivista: CLINICAL CARDIOLOGY
Autori/autrici: Boriani, G.; Mantovani, L. G.; Cortesi, P. A.; De Ponti, R.; D'Onofrio, A.; Arena, G.; Curnis, A.; Forleo, G.; Guerra, F.; Porcu, M.; Sgarito, G.; Botto, G. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313077
Citazioni:
Cost-minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications / Boriani, G., Mantovani, L.G., Cortesi, P.A., De Ponti, R., D'Onofrio, A., Arena, G., Curnis, A., Forleo, G., Guerra, F., Porcu, M., Sgarito, G., Botto, G.L.. - In: CLINICAL CARDIOLOGY. - ISSN 0160-9289. - 44:11(2021), pp. 1497-1505. [10.1002/clc.23709]
Abstract:
Aims: Patients with permanently increased risk of sudden cardiac death (SCD) can be protected by implantable cardioverter defibrillators (ICD). If an ICD must be removed due to infection, for example, immediate reimplantation might not be possible or indicated. The wearable cardioverter defibrillato...r (WCD) is an established, safe and effective solution to protect patients from SCD during this high-risk bridging period. Very few economic evaluations on WCD use are currently available. Methods: We conducted a systematic review to evaluate the available evidence of WCD in patients undergoing ICD explant/lead extraction. Additionally, a decision model was developed to compare use and costs of the WCD with standard therapy (in-hospital stay). For this purpose, a cost-minimization analysis was conducted, and complemented by a one-way sensitivity analysis. Results: In the base case scenario, the WCD was less expensive compared to standard therapy. The cost-minimization analysis showed a cost reduction of €1782 per patient using the WCD. If costs of standard care were changed, cost savings associated with the WCD varied from €3500 to €0, assuming costs for standard care of €6800 to €3600. Conclusion: After ICD explantation, patients can be safely and effectively protected from SCD after hospital discharge through WCD utilization. Furthermore, the use of a WCD for this patient group is cost saving when compared to standard therapy.
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Pharmacological therapy for the prevention of cardiovascular events in patients with myocardial infarction with non-obstructed coronary arteries (MINOCA): Insights from a multicentre national registry
Anno: 2021
Rivista: INTERNATIONAL JOURNAL OF CARDIOLOGY
Autori/autrici: Ciliberti, G.; Verdoia, M.; Merlo, M.; Zilio, F.; Vatrano, M.; Mancone, M.; Zaffalon, D.; Bonci, A.; Boscutti, A.; Infusino, F.; Coiro, S.; Stronati, G.; Tritto, I.; Gioscia, R.; Dello Russo, A.; Fedele, F.; Gallina, S.; Cassadonte, F.; Ambrosio, G.; Bonmassari, R.; De Luca, G.; Sinagra, G.; Capucci, A.; Kaski, J. C.; Guerra, F.; Bianco, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293096
Citazioni:
Pharmacological therapy for the prevention of cardiovascular events in patients with myocardial infarction with non-obstructed coronary arteries (MINOCA): Insights from a multicentre national registry / Ciliberti, G., Verdoia, M., Merlo, M., Zilio, F., Vatrano, M., Mancone, M., Zaffalon, D., Bonci, A., Boscutti, A., Infusino, F., Coiro, S., Stronati, G., Tritto, I., Gioscia, R., Dello Russo, A., Fedele, F., Gallina, S., Cassadonte, F., Ambrosio, G., Bonmassari, R., et al.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 327:(2021), pp. 9-14. [10.1016/j.ijcard.2020.11.040]
Abstract:
Aims: To assess the effect of pharmacological therapy on long-term prognosis of patients with MINOCA. Methods and results: In this retrospective multicentre cohort study involving 9 Hub Hospitals across Italy we enrolled consecutive patients 18 years and older with diagnosis of MINOCA discharged fro...m 1st March 2012 to 31st March 2018. Data on baseline characteristics and pharmacological therapy at discharge (ACEI/ARB, angiotensin-converting enzyme inhibitors/angiotensin receptor antagonists; ASA, acetylsalicylic acid; beta-blockers; CCB, calcium-channel blockers; DAPT, dual anti-platelet therapy; statins), were collected systematically. The primary endpoint (PE) of the study was a composite of all cause death or acute myocardial infarction or acute coronary syndrome or heart failure leading to hospitalization or stroke. A total of 621 patients were included (mean [SD] age 65.1 [13.9] years; 344 [55.4%] female), of whom 106 (17.1%) experienced PE, including 27 patients (4.3%) who died. Multivariable analysis, after correction for all baseline differences, showed a significant association between pharmacological therapy at discharge and an increased risk of PE for aspirin (HR[95%CI] = 2.47[1.05–5.78], adjusted p = 0.04), whereas beta-blockers were associated with a significant benefit (HR[95%CI] = 0.49 [0.31–0.79], adjusted p = 0.02). Conclusion: The use of beta-blockers was significantly associated to a less frequent occurrence of adverse outcomes at long-term follow-up among patients with MINOCA, whereas ASA displayed a potentially harmful impact on prognosis. The findings in the study may be relevant for the design of future studies which should take into account possible heterogeneity among MINOCA patients.
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Reduction in acute coronary syndromes during coronavirus disease 2019 global pandemic: data from the Marche region of Italy
Anno: 2021
Rivista: JOURNAL OF CARDIOVASCULAR MEDICINE
Autori/autrici: Flori, Marco; Marinucci, Lucia; Gabrielli, Gabriele; Baiocco, Erika; Accardi, Roberto; Scalone, Giancarla; Grossi, Pierfrancesco; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313062
Citazioni:
Reduction in acute coronary syndromes during coronavirus disease 2019 global pandemic: data from the Marche region of Italy / Flori, M., Marinucci, L., Gabrielli, G., Baiocco, E., Accardi, R., Scalone, G., Grossi, P., Guerra, F.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2027. - 22:5(2021), pp. 350-356. [10.2459/JCM.0000000000001130]
Abstract:
Aims During the novel severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) pandemic, a worldwide reduction in total acute coronary syndrome (ACS) has been reported. In early 2020, Italy became the most affected country and national lockdown was declared early on in March. We de...scribed trends in ACS from all the Marche coronary catheterization laboratories (CCL) during the global pandemic. Methods Retrospective study of all consecutive patients admitted to the four regional CCL. The coronavirus disease 2019 period (20 February 2020 to 15 April 2020) was compared with the interyear control period (1 January 2020 to 19 February 2020) and to the intrayear control period (20 February 2019 to 15 April 2019). All patients with an initial diagnosis of ACS were included in the analysis, and further stratified into ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI)/unstable angina. Results A total of 1239 patients were enrolled. Daily incidence of ACS was 6.1, 6.3 and 4.5 for the interyear control period, the intrayear control period and the case period, respectively. There was no difference in overall STEMI daily incidence while NSTEMI/unstable angina fell from 3.6 and 3.3-1.8 during the case period (P = 0.01). Incidence rate ratios were significantly lower when the case period was compared with the intrayear control period (incidence rate ratios: 0.49, 95% confidence interval 0.41-0.59, P = 0.001) and the interyear control period (incidence rate ratios: 0.67, 95% confidence interval 0.50-0.90, P = 0.008). Conclusion During the global pandemic there was a significant reduction in total ACS and NSTEMI in the Marche region. Unlike previous reports, there was no difference in overall access to CCL for STEMI during the same period.
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Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry
Anno: 2021
Rivista: INTERNAL AND EMERGENCY MEDICINE
Autori/autrici: Núñez-Gil, Iván J; Fernández-Pérez, Cristina; Estrada, Vicente; Becerra-Muñoz, Víctor M; El-Battrawy, Ibrahim; Uribarri, Aitor; Fernández-Rozas, Inmaculada; Feltes, Gisela; Viana-Llamas, María C; Trabattoni, Daniela; López-País, Javier; Pepe, Martino; Romero, Rodolfo; Castro-Mejía, Alex F; Cerrato, Enrico; Astrua, Thamar Capel; D'Ascenzo, Fabrizio; Fabregat-Andres, Oscar; Moreu, José; Guerra, Federico; Signes-Costa, Jaime; Marín, Francisco; Buosenso, Danilo; Bardají, Alfredo; Raposeiras-Roubín, Sergio; Elola, Javier; Molino, Ángel; Gómez-Doblas, Juan J; Abumayyaleh, Mohammad; Aparisi, Álvaro; Molina, María; Guerri, Asunción; Arroyo-Espliguero, Ramón; Assanelli, Emilio; Mapelli, Massimo; García-Acuña, José M; Brindicci, Gaetano; Manzone, Edoardo; Ortega-Armas, María E; Bianco, Matteo; Trung, Chinh Pham; Núñez, María José; Castellanos-Lluch, Carmen; García-Vázquez, Elisa; Cabello-Clotet, Noemí; Jamhour-Chelh, Karim; Tellez, María J; Fernández-Ortiz, Antonio; Macaya, Carlos
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313063
Citazioni:
Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry / Núñez-Gil, I.J., Fernández-Pérez, C., Estrada, V., Becerra-Muñoz, V.M., El-Battrawy, I., Uribarri, A., Fernández-Rozas, I., Feltes, G., Viana-Llamas, M.C., Trabattoni, D., López-País, J., Pepe, M., Romero, R., Castro-Mejía, A.F., Cerrato, E., Astrua, T.C., D'Ascenzo, F., Fabregat-Andres, O., Moreu, J., Guerra, F., et al.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 16:4(2021), pp. 957-966. [10.1007/s11739-020-02543-5]
Abstract:
Recently the coronavirus disease (COVID-19) outbreak has been declared a pandemic. Despite its aggressive extension and significant morbidity and mortality, risk factors are poorly characterized outside China. We designed a registry, HOPE COVID-19 (NCT04334291), assessing data of 1021 patients disch...arged (dead or alive) after COVID-19, from 23 hospitals in 4 countries, between 8 February and 1 April. The primary end-point was all-cause mortality aiming to produce a mortality risk score calculator. The median age was 68 years (IQR 52-79), and 59.5% were male. Most frequent comorbidities were hypertension (46.8%) and dyslipidemia (35.8%). A relevant heart or lung disease were depicted in 20%. And renal, neurological, or oncological disease, respectively, were detected in nearly 10%. Most common symptoms were fever, cough, and dyspnea at admission. 311 patients died and 710 were discharged alive. In the death-multivariate analysis, raised as most relevant: age, hypertension, obesity, renal insufficiency, any immunosuppressive disease, 02 saturation < 92% and an elevated C reactive protein (AUC = 0.87; Hosmer-Lemeshow test, p > 0.999; bootstrap-optimist: 0.0018). We provide a simple clinical score to estimate probability of death, dividing patients in four grades (I-IV) of increasing probability. Hydroxychloroquine (79.2%) and antivirals (67.6%) were the specific drugs most commonly used. After a propensity score adjustment, the results suggested a slight improvement in mortality rates (adjusted-ORhydroxychloroquine 0.88; 95% CI 0.81-0.91, p = 0.005; adjusted-ORantiviral 0.94; 95% CI 0.87-1.01; p = 0.115). COVID-19 produces important mortality, mostly in patients with comorbidities with respiratory symptoms. Hydroxychloroquine could be associated with survival benefit, but this data need to be confirmed with further trials. Trial Registration: NCT04334291/EUPAS34399.
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Rate and impact on patient outcome and healthcare utilization of complications requiring surgical revision: Subcutaneous versus transvenous implantable defibrillator therapy
Anno: 2021
Rivista: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Autori/autrici: Palmisano, P.; Ziacchi, M.; Ammendola, E.; D'Onofrio, A.; Dell'Era, G.; Laffi, M.; Biffi, M.; Nigro, G.; Bianchi, W.; Prenna, E.; Angeletti, A.; Guido, A.; Stronati, G.; Gaggioli, G.; Dello Russo, A.; Accogli, M.; Guerra, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293151
Citazioni:
Rate and impact on patient outcome and healthcare utilization of complications requiring surgical revision: Subcutaneous versus transvenous implantable defibrillator therapy / Palmisano, P., Ziacchi, M., Ammendola, E., D'Onofrio, A., Dell'Era, G., Laffi, M., Biffi, M., Nigro, G., Bianchi, W., Prenna, E., Angeletti, A., Guido, A., Stronati, G., Gaggioli, G., Dello Russo, A., Accogli, M., Guerra, F.. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1045-3873. - 32:6(2021), pp. 1712-1723. [10.1111/jce.15080]
Abstract:
Introduction: Comparison data on management of device-related complications and their impact on patient outcome and healthcare utilization between subcutaneous implantable cardioverter–defibrillator (S-ICD) and transvenous ICD (TV-ICD) are lacking. We designed this prospective, multicentre, ob...servational registry to compare the rate, nature, and impact of long-term device-related complications requiring surgical revision on patient outcome and healthcare utilization between patients undergoing S-ICD or TV-ICD implantation. Methods and Results: A total of 1099 consecutive patients who underwent S-ICD or TV-ICD implantation were enrolled. Propensity matching for baseline characteristics yielded 169 matched pairs. Rate, nature, management, and impact on patient outcome of device-related complications were analyzed and compared between two groups. During a mean follow-up of 30 months, device-related complications requiring surgical revision were observed in 20 patients: 3 in S-ICD group (1.8%) and 17 in TV-ICD group (10.1%; p =.002). Compared with TV-ICD patients, S-ICD patients showed a significantly lower risk of lead-related complications (0% vs. 5.9%; p =.002) and a similar risk of pocket-related complications (0.6 vs. 2.4; p =.215) and device infection (0.6% vs. 1.2%; p = 1.000). Complications observed in S-ICD patients resulted in a significantly lower number of complications-related rehospitalizations (median 0 vs. 1; p =.013) and additional hospital treatment days (1.0 ± 1.0 vs. 6.5 ± 4.4 days; p =.048) compared with TV-ICD patients. Conclusions: Compared with TV-ICD, S-ICD is associated with a lower risk of complications, mainly due to a lower risk of lead-related complications. The management of S-ICD complications requires fewer and shorter rehospitalizations.
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Cardiac imaging in athlete’s heart: The role of the radiologist
Anno: 2021
Rivista: MEDICINA
Autori/autrici: Fogante, M.; Agliata, G.; Basile, M. C.; Compagnucci, P.; Volpato, G.; Falanga, U.; Stronati, G.; Guerra, F.; Vignale, D.; Esposito, A.; Russo, A. D.; Casella, M.; Giovagnoni, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293084
Citazioni:
Cardiac imaging in athlete’s heart: The role of the radiologist / Fogante, M., Agliata, G., Basile, M.C., Compagnucci, P., Volpato, G., Falanga, U., Stronati, G., Guerra, F., Vignale, D., Esposito, A., Russo, A.D., Casella, M., Giovagnoni, A.. - In: MEDICINA. - ISSN 1010-660X. - 57:5(2021), p. 455. [10.3390/medicina57050455]
Abstract:
Athlete’s heart (AH) is the result of morphological and functional cardiac modifications due to long-lasting athletic training. Athletes can develop very marked structural myocardial changes, which may simulate or cover unknown cardiomyopathies. The differential diagnosis between AH and cardio...myopathy is necessary to prevent the risk of catastrophic events, such as sudden cardiac death, but it can be a challenging task. The improvement of the imaging modalities and the introduction of the new technologies in cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT) can allow overcoming this challenge. Therefore, the radiologist, specialized in cardiac imaging, could have a pivotal role in the differential diagnosis between structural adaptative changes observed in the AH and pathological anomalies of cardiomyopathies. In this review, we summarize the main CMR and CCT techniques to evaluate the cardiac morphology, function, and tissue characterization, and we analyze the imaging features of the AH and the key differences with the main cardiomyopathies.
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Compassionate drug use for patients with transthyretin amyloid cardiomyopathy
Anno: 2021
Rivista: JOURNAL OF CARDIOVASCULAR MEDICINE
Autori/autrici: Ciliberti, G.; Urbinati, A.; Barbarossa, A.; Stronati, G.; Silenzi, M.; Principi, S.; Falanga, U.; Capucci, A.; Casella, M.; Dello Russo, A.; Guerra, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293085
Citazioni:
Compassionate drug use for patients with transthyretin amyloid cardiomyopathy / Ciliberti, G., Urbinati, A., Barbarossa, A., Stronati, G., Silenzi, M., Principi, S., Falanga, U., Capucci, A., Casella, M., Dello Russo, A., Guerra, F.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2035. - 22:10(2021), pp. 792-794. [10.2459/JCM.0000000000001192]

Prior myocarditis and ventricular arrhythmias: the importance of scar pattern
Anno: 2021
Rivista: HEART RHYTHM
Autori/autrici: Casella, Michela; Bergonti, Marco; Narducci, Maria Lucia; Persampieri, Simone; Gasperetti, Alessio; Conte, Edoardo; Catto, Valentina; Carbucicchio, Corrado; Guerra, Federico; Pontone, Gianluca; Andreini, Daniele; Basso, Cristina; Di Biase, Luigi; Santangeli, Pasquale; Natale, Andrea; Pelargonio, Gemma; Russo, Antonio Dello; Tondo, Claudio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286070
Citazioni:
Prior myocarditis and ventricular arrhythmias: the importance of scar pattern / Casella, M., Bergonti, M., Narducci, M.L., Persampieri, S., Gasperetti, A., Conte, E., Catto, V., Carbucicchio, C., Guerra, F., Pontone, G., Andreini, D., Basso, C., Di Biase, L., Santangeli, P., Natale, A., Pelargonio, G., Russo, A.D., Tondo, C.. - In: HEART RHYTHM. - ISSN 1547-5271. - (2021). [10.1016/j.hrthm.2020.12.016]
Abstract:
multiple studies have already addressed the importance of anteroseptal scar in patients with non-ischemic cardiomyopathy. However, this pattern has never been fully evaluated in patients with prior myocarditis.

Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study
Anno: 2021
Rivista: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Autori/autrici: Guerra, F.; Ammendola, E.; Ziacchi, M.; Aspromonte, V.; Pellegrino, P. L.; Del Giorno, G.; Dell'Era, G.; Pimpini, L.; Santoro, F.; Floris, R.; Stronati, G.; Nigro, G.; Paolisso, P.; Guido, A.; Maglia, G.; Brunetti, N. D.; Carbone, A.; Gravellone, M.; Antonicelli, R.; Cannone, M.; Accogli, M.; Dello Russo, A.; Palmisano, P.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293146
Citazioni:
Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study / Guerra, F., Ammendola, E., Ziacchi, M., Aspromonte, V., Pellegrino, P.L., Del Giorno, G., Dell'Era, G., Pimpini, L., Santoro, F., Floris, R., Stronati, G., Nigro, G., Paolisso, P., Guido, A., Maglia, G., Brunetti, N.D., Carbone, A., Gravellone, M., Antonicelli, R., Cannone, M., et al.. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - 77:12(2021), pp. 1835-1842. [10.1007/s00228-021-03189-8]
Abstract:
Purpose: Sacubitril/valsartan has been associated with a positive reverse left ventricular remodelling in patients with heart failure with reduced ejection fraction (HFrEF). These patients may also benefit from an ICD implant. We aimed to assess EF improvement after 6 months of treatment with s...acubitril/valsartan, evaluating when ICD as primary prevention was no longer indicated. Methods: Multicentre, observational, prospective study enrolling all consecutive patients with HFrEF and EF ≤ 35% with an ICD as primary prevention and starting treatment with sacubitril/valsartan (NCT03935087). Resynchronization therapy and patients experiencing appropriate ICD therapies before sacubitril/valsartan were excluded. Results: Two-hundred-and-thirty patients were enrolled (73.9% males, mean age 64.3 ± 12.1 years) After 6 months of treatment, a reduction in left ventricular end-diastolic and end-systolic volumes was noted and LVEF increased from 28.3 ± 5.6% to 32.2 ± 6.5% (p < 0.001). At 6 months, a non-ischemic aetiology of cardiomyopathy and a final dose of sacubitril/valsartan > 24/26 mg twice daily were associated with a higher probability of an absolute increase of > 5% in LVEF. A total of 5.3% of primary prevention patients still had an arrhythmic event in the first 6 months after treatment with sacubitril/valsartan started. Conclusions: Sacubitril/valsartan improves systolic function in HFrEF, mainly due to reverse left ventricular remodelling. Improvement in EF after 6 months of treatment could help prevent ICD implantation in nearly one out of four patients, with important clinical and economic implications. However, the risk of sudden cardiac death in this recovered HFrEF population has not been thoroughly studied, and the present data should be interpreted only as hypothesis-generating.
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Long-Term Outcomes of Near-Zero Radiation Ablation of Paroxysmal Supraventricular Tachycardia: A Comparison With Fluoroscopy-Guided Approach
Anno: 2021
Rivista: JACC. CLINICAL ELECTROPHYSIOLOGY
Autori/autrici: Bergonti, M.; Dello Russo, A.; Sicuso, R.; Ribatti, V.; Compagnucci, P.; Catto, V.; Gasperetti, A.; Zucchetti, M.; Cellucci, S.; Vettor, G.; Dessanai, M. A.; Majocchi, B.; Moltrasio, M.; Russo, E.; Stronati, G.; Guerra, F.; Di Biase, L.; Natale, A.; Tondo, C.; Casella, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293109
Citazioni:
Long-Term Outcomes of Near-Zero Radiation Ablation of Paroxysmal Supraventricular Tachycardia: A Comparison With Fluoroscopy-Guided Approach / Bergonti, M., Dello Russo, A., Sicuso, R., Ribatti, V., Compagnucci, P., Catto, V., Gasperetti, A., Zucchetti, M., Cellucci, S., Vettor, G., Dessanai, M.A., Majocchi, B., Moltrasio, M., Russo, E., Stronati, G., Guerra, F., Di Biase, L., Natale, A., Tondo, C., Casella, M.. - In: JACC. CLINICAL ELECTROPHYSIOLOGY. - ISSN 2405-500X. - 7:9(2021), pp. 1108-1117-1117. [10.1016/j.jacep.2021.02.017]
Abstract:
Objectives: This study aimed to assess the long-term outcomes of minimally fluoroscopic approach (MFA) compared with conventional fluoroscopic ablation (ConvA) in terms of recurrences of arrhythmia and long-term complications. Background: Catheter ablation (CA) of supraventricular tachycardia (SVT) ...with an MFA, under the guidance of electroanatomic mapping (EAM) systems, results in a significant reduction in exposure to ionizing radiations without impairing acute procedural success and complication rate. However, data regarding long-term outcomes of MFA compared with ConvA are lacking. Methods: This is a retrospective observational study. All patients undergoing MFA CA of SVT (atrioventricular nodal re-entrant tachycardia and atrioventricular re-entrant tachycardia) between 2010 and 2015 were enrolled and were compared with matched subjects (1 MFA: 2 ConvA) undergoing ConvA during the same period. The 2 co-primary outcomes were recurrence of arrhythmias and long-term complications. Results: Six-hundred eighteen patients (mean age 38 ± 15 years, 60% female) were enrolled. MFA included 206 patients, whereas 412 were treated with ConvA. Acute success (99% vs. 97%; p = 0.10) and acute complications (2.4% vs. 5.3%; p = 0.14) were similar in the 2 groups. During a median follow-up of 4.4 years, 5.9% of patients experienced recurrence of arrhythmias. At multivariate analysis, ConvA (hazard ratio [HR]: 3.03) and procedural success (HR: 0.10) were independently associated with recurrence of arrhythmias. Late complications (i.e., advance atrioventricular block and need for pacemaker implantation) occurred more frequently in ConvA (3.4% vs. 0.5%; p = 0.03) compared with MFA. Conclusions: CA guided by EAM systems with MFA provided better long-term results and reduced risk of complications compared with ConvA.
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Ventricular arrhythmias in athletes: Role of a comprehensive diagnostic workup
Anno: 2021
Rivista: HEART RHYTHM
Autori/autrici: Dello Russo, A.; Compagnucci, P.; Casella, M.; Gasperetti, A.; Riva, S.; Dessanai, M. A.; Pizzamiglio, F.; Catto, V.; Guerra, F.; Stronati, G.; Andreini, D.; Pontone, G.; Bonomi, A.; Rizzo, S.; Di Biase, L.; Capucci, A.; Natale, A.; Basso, C.; Fiorentini, C.; Zeppilli, P.; Tondo, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293098
Citazioni:
Ventricular arrhythmias in athletes: Role of a comprehensive diagnostic workup / Dello Russo, A., Compagnucci, P., Casella, M., Gasperetti, A., Riva, S., Dessanai, M.A., Pizzamiglio, F., Catto, V., Guerra, F., Stronati, G., Andreini, D., Pontone, G., Bonomi, A., Rizzo, S., Di Biase, L., Capucci, A., Natale, A., Basso, C., Fiorentini, C., Zeppilli, P., et al.. - In: HEART RHYTHM. - ISSN 1547-5271. - (2021). [10.1016/j.hrthm.2021.09.013]
Abstract:
Background: Ventricular arrhythmias (VAs) represent a critical issue with regard to sports eligibility assessment in athletes. The ideal diagnostic evaluation of competitive and leisure-time athletes with complex VAs has not been clearly defined. Objective: The purpose of this study was to assess th...e clinical implications of invasive electrophysiological assessments and endomyocardial biopsy (EMB) among athletes with VAs. Methods: We evaluated 227 consecutive athletes who presented to our institutions after being disqualified from participating in sports because of VAs. After noninvasive tests, electrophysiological study (EPS), electroanatomic mapping (EAM), and EAM- or cardiac magnetic resonance imaging–guided EMB was performed, following a prespecified protocol. Sports eligibility status was redefined at 6-month follow-up. Results: From our sample, 188 athletes (82.8%) underwent EAM and EPS, and 42 (15.2%) underwent EMB. A diagnosis of heart disease could be formulated in 30% of the study population (67/227; 95% confidence interval [CI] 0.24–0.36) after noninvasive tests; in 37% (83/227; 95% CI 31%–43%) after EPS and EAM; and in 45% (102/227; 95% CI 39%–51%) after EMB. In the subset of athletes undergoing EMB, invasive diagnostic workup allowed diagnostic reclassification of half of the athletes (n = 21 [50%]). Reclassification was particularly common among subjects without definitive findings after noninvasive evaluation (n = 23; 87% reclassified). History of syncope, abnormal echocardiogram, presence of late gadolinium enhancement, and abnormal EAM were linked to sports ineligibility at 6-month follow-up. Conclusion: A comprehensive invasive workup provided additional diagnostic elements and could improve the sports eligibility assessment of athletes presenting with VAs. The extensive invasive evaluation presented could be especially helpful when noninvasive tests show unclear findings.
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Myocardial inflammation, sports practice, and sudden cardiac death: 2021 update
Anno: 2021
Rivista: MEDICINA
Autori/autrici: Compagnucci, P.; Volpato, G.; Falanga, U.; Cipolletta, L.; Conti, M. A.; Grifoni, G.; Ciliberti, G.; Stronati, G.; Fogante, M.; Bergonti, M.; Sommariva, E.; Guerra, F.; Giovagnoni, A.; Russo, A. D.; Casella, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293083
Citazioni:
Myocardial inflammation, sports practice, and sudden cardiac death: 2021 update / Compagnucci, P., Volpato, G., Falanga, U., Cipolletta, L., Conti, M.A., Grifoni, G., Ciliberti, G., Stronati, G., Fogante, M., Bergonti, M., Sommariva, E., Guerra, F., Giovagnoni, A., Russo, A.D., Casella, M.. - In: MEDICINA. - ISSN 1010-660X. - 57:3(2021), p. 277. [10.3390/medicina57030277]
Abstract:
Myocardial inflammation is an important cause of cardiovascular morbidity and sudden cardiac death in athletes. The relationship between sports practice and myocardial inflammation is complex, and recent data from studies concerning cardiac magnetic resonance imaging and endomy-ocardial biopsy have ...substantially added to our understanding of the challenges encountered in the comprehensive care of athletes with myocarditis or inflammatory cardiomyopathy (ICM). In this review, we provide an overview of the current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of myocarditis, ICM, and myopericarditis/perimyocarditis in athletes, with a special emphasis on arrhythmias, patient-tailored therapies, and sports eligibility issues.
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Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry
Anno: 2021
Rivista: HEART RHYTHM
Autori/autrici: Palmisano, P.; Dell'Era, G.; Pellegrino, P. L.; Ammendola, E.; Ziacchi, M.; Guerra, F.; Aspromonte, V.; Laffi, M.; Pimpini, L.; Santoro, F.; Boggio, E.; Guido, A.; Patti, G.; Brunetti, N. D.; Nigro, G.; Biffi, M.; Dello Russo, A.; Gaggioli, G.; Accogli, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293089
Citazioni:
Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry / Palmisano, P., Dell'Era, G., Pellegrino, P.L., Ammendola, E., Ziacchi, M., Guerra, F., Aspromonte, V., Laffi, M., Pimpini, L., Santoro, F., Boggio, E., Guido, A., Patti, G., Brunetti, N.D., Nigro, G., Biffi, M., Dello Russo, A., Gaggioli, G., Accogli, M.. - In: HEART RHYTHM. - ISSN 1547-5271. - 18:5(2021), pp. 770-777. [10.1016/j.hrthm.2021.01.010]
Abstract:
Background: Few studies have examined the causes of syncope/collapse recurrences in patients with a previously implanted pacemaker for bradyarrhythmic syncope. Objective: The purpose of this study was to assess the causes of syncope/collapse recurrences after pacemaker implantation for bradyarrhythm...ic syncope in a large patient population. Methods: The SYNCOpal recurrences in patients treated with permanent PACing for bradyarrhythmic syncope (SYNCOPACED) registry was a prospective multicenter observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for bradyarrhythmic syncope. During follow-up, the time to the first syncope/collapse recurrence was recorded. Patients with syncope/collapse recurrences underwent a predefined diagnostic workup aimed at establishing the mechanism of syncope/collapse. Results: During a median follow-up of 50 months, 213 patients (15.6%) reported at least 1 syncope/collapse recurrence. The risk of syncope/collapse recurrence was highest in patients who underwent implantation for cardioinhibitory vasovagal syncope (26.4%), followed by unexplained syncope and chronic bifascicular block (21.5%), cardioinhibitory carotid sinus syndrome (17.2%), atrial fibrillation needing pacing (15.5%), atrioventricular block (13.6%), and sinus node disease (12.5%) (P = .017). The most frequent cause of syncope/collapse recurrence was reflex syncope (27.7%), followed by orthostatic hypotension (26.3%), pacemaker or lead malfunction (5.6%), structural cardiac disease (5.2%), and atrial and ventricular tachyarrhythmias (4.7% and 3.8%, respectively). In 26.8% of cases, the mechanism of syncope/collapse remained unexplained. Conclusion: In patients receiving a pacemaker for bradyarrhythmic syncope, reflex syncope and orthostatic hypotension are the most frequent mechanisms of syncope/collapse recurrence after implantation. Pacing system malfunction, structural cardiac diseases, and tachyarrhythmias are rare mechanisms. The mechanism remains unexplained in >25% of patients.
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Ventricular fibrillation recurrences in successfully shocked out-of-hospital cardiac arrests
Anno: 2021
Rivista: MEDICINA
Autori/autrici: Aschieri, D.; Guerra, F.; Pelizzoni, V.; Paolini, E.; Stronati, G.; Moderato, L.; Losi, G.; Compagnucci, P.; Coccia, M.; Casella, M.; Dello Russo, A.; Bardy, G. H.; Capucci, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293087
Citazioni:
Ventricular fibrillation recurrences in successfully shocked out-of-hospital cardiac arrests / Aschieri, D., Guerra, F., Pelizzoni, V., Paolini, E., Stronati, G., Moderato, L., Losi, G., Compagnucci, P., Coccia, M., Casella, M., Dello Russo, A., Bardy, G.H., Capucci, A.. - In: MEDICINA. - ISSN 1010-660X. - 57:4(2021), p. 358. [10.3390/medicina57040358]
Abstract:
Background and Objectives: The prognostic impact of ventricular fibrillation (VF) recurrences after a successful shock in out-of-hospital cardiac arrest (OOHCA) is still poorly understood, and some evidence suggests a potential pro-arrhythmic effect of chest compressions in this setting. In the pres...ent analysis, we looked at the short-term and long-term prognosis of VF recurrences in OOHCA. And their potential association with chest compressions. Materials and Methods: The Progetto Vita, prospectively collecting data on all resuscitation efforts in the Piacenza province (Italy), was used for the present analysis. From the 461 OOHCAs found in a shockable rhythm, only those with optimal ECG tracings and good audio recordings (160) were assessed. Rhythms other than VF postshock were analyzed five seconds after shock delivery and survival to hospital admission, hospital discharge, and long-term survival data over a 14-year follow-up were collected. Results: Population mean age was 64.4 ± 16.9 years, and 31.9% of all patients were female. Mean time to EMS arrival was 5.9 ± 4.5 min. Short-and long-term survival without neurological impairment were higher in patients without VF recurrence when compared to patients with VF recurrence, independently from the pre-induction rhythm (p < 0.001). After shock delivery, VF recurrence was higher when chest compressions were resumed early after discharge and more vigorously. Conclusions: VF recurrences after a shock could worsen short and long-term survival. The potential pro-arrhythmic effect of chest compressions should be factored in when considering the real risks and benefits of this procedure.
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Etiology and device therapy in complete atrioventricular block in pediatric and young adult population: Contemporary review and new perspectives
Anno: 2021
Rivista: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Autori/autrici: Cioffi, G. M.; Gasperetti, A.; Tersalvi, G.; Schiavone, M.; Compagnucci, P.; Sozzi, F. B.; Casella, M.; Guerra, F.; Dello Russo, A.; Forleo, G. B.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/293092
Citazioni:
Etiology and device therapy in complete atrioventricular block in pediatric and young adult population: Contemporary review and new perspectives / Cioffi, G.M., Gasperetti, A., Tersalvi, G., Schiavone, M., Compagnucci, P., Sozzi, F.B., Casella, M., Guerra, F., Dello Russo, A., Forleo, G.B.. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1045-3873. - 32:11(2021), pp. 3082-3094. [10.1111/jce.15255]
Abstract:
Complete atrioventricular block (CAVB) is a total dissociation between the atrial and ventricular activity, in the absence of atrioventricular conduction. Several diseases may result in CAVB in the pediatric and young-adult population. Permanent right ventricular (RV) pacing is required in permanent... CAVB, when the cause is neither transient nor reversible. Continuous RV apical pacing has been associated with unfavorable outcomes in several studies due to the associated ventricular dyssynchrony. This study aims to summarize the current literature regarding CAVB in the pediatric and young adult population and to explore future treatment perspectives.
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Prevalence, management, and outcome of adverse rhythm disorders in takotsubo syndrome: insights from the international multicenter GEIST registry
Anno: 2020
Rivista: HEART FAILURE REVIEWS
Autori/autrici: El-Battrawy, I.; Santoro, F.; Stiermaier, T.; Moller, C.; Guastafierro, F.; Novo, G.; Novo, S.; Santangelo, A.; Mariano, E.; Romeo, F.; Romeo, F.; Thiele, H.; Guerra, F.; Capucci, A.; Giannini, I.; Caldarola, P.; Brunetti, N. D.; Eitel, I.; Akin, I.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313047
Citazioni:
Prevalence, management, and outcome of adverse rhythm disorders in takotsubo syndrome: insights from the international multicenter GEIST registry / El-Battrawy, I., Santoro, F., Stiermaier, T., Moller, C., Guastafierro, F., Novo, G., Novo, S., Santangelo, A., Mariano, E., Romeo, F., Romeo, F., Thiele, H., Guerra, F., Capucci, A., Giannini, I., Caldarola, P., Brunetti, N.D., Eitel, I., Akin, I.. - In: HEART FAILURE REVIEWS. - ISSN 1382-4147. - 25:3(2020), pp. 505-511. [10.1007/s10741-019-09856-4]
Abstract:
One important complication related to takotsubo syndrome (TTS) is adverse rhythm disorders. Our study was conducted to determine the incidence and management of adverse rhythm disorders in TTS and its long-term prognostic impact. We analyzed 906 TTS patients from 9 European centers. Patients were di...vided into the adverse rhythm disorders group (encompassing ventricular tachycardia, ventricular fibrillation, torsade de pointes, and asystole or complete atrioventricular block) and non-adverse rhythm disorders group. In our study cohort, we identified 67 (7.4%) patients with presence of adverse rhythm disorders. TTS patients were followed up over a period of 2.8 years. In the adverse rhythm disorders group, 18% of patients presented adverse rhythm disorders before hospital admission. Asystole and/or AV block were significantly more presented before admission (13 patients versus 8 patients; p < 0.01), whereas ventricular tachyarrhythmias were more presented in-hospital (4 patients versus 42 patients; p < 0.01). Adverse rhythm disorders patients suffered more frequently from cardiogenic shock (31% versus 7.6%, p < 0.01) and in-hospital death (10.9% versus 3.6%; p < 0.01). Furthermore, the long-term survival was significantly impaired in adverse rhythm disorders patients as compared with non-adverse rhythm disorders patients; (log-rank p < 0.01). Using multivariate Cox regression analysis, cardiogenic shock (HR 2.86, 95% CI 1.1–6.9; p = 0.02) was identified as independent predictors of adverse rhythm disorders. The short- and long-term mortality rate of TTS patients presenting with adverse rhythm disorders was significantly higher than in TTS patients presenting without it. Therefore, TTS patients with adverse rhythm disorders should be carefully monitored during hospital stay and at long-term follow-up.
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Patterns of anticoagulation for atrial fibrillation in cancer patients referred to cardio-oncological evaluation
Anno: 2020
Rivista: EUROPEAN JOURNAL OF INTERNAL MEDICINE
Autori/autrici: Toma, Matteo; Rrapaj, Edlira; Spallarossa, Paolo; Guerra, Federico; Ameri, Pietro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313057
Citazioni:
Patterns of anticoagulation for atrial fibrillation in cancer patients referred to cardio-oncological evaluation / Toma, M., Rrapaj, E., Spallarossa, P., Guerra, F., Ameri, P.. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 82:(2020), pp. 128-129. [10.1016/j.ejim.2020.08.004]

Impact of atrial fibrillation in critically ill patients admitted to a stepdown unit
Anno: 2020
Rivista: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
Autori/autrici: Falsetti, Lorenzo; Proietti, Marco; Zaccone, Vincenzo; Guerra, Federico; Nitti, Cinzia; Salvi, Aldo; Viticchi, Giovanna; Riccomi, Francesca; Sampaolesi, Mattia; Silvestrini, Mauro; Moroncini, Gianluca; Lip, Gregory Y H; Capucci, Alessandro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313053
Citazioni:
Impact of atrial fibrillation in critically ill patients admitted to a stepdown unit / Falsetti, L., Proietti, M., Zaccone, V., Guerra, F., Nitti, C., Salvi, A., Viticchi, G., Riccomi, F., Sampaolesi, M., Silvestrini, M., Moroncini, G., Lip, G.Y.H., Capucci, A.. - In: THE EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - STAMPA. - 50:11(2020). [10.1111/eci.13317]
Abstract:
Background Limited data are available on the clinical course of patients with history of atrial fibrillation (AF) when admitted in an intensive care environment. We aimed to describe the occurrence of major adverse events in AF patients admitted to a stepdown care unit (SDU) and to analyse clinical ...factors associated with outcomes, impact of dicumarolic oral anticoagulant (OAC) therapy impact and performance of clinical risk scores in this setting. Materials and methods Single-centre, observational retrospective analysis on a population of subjects with AF history admitted to a SDU. Therapeutic failure (composite of transfer to ICU or death) was considered the main study outcome. Occurrence of stroke and major bleeding (MH) was considered as secondary outcomes. The performance of clinical risk scores was evaluated. Results A total of 1430 consecutive patients were enrolled. 194 (13.6%) reported the main outcome. Using multivariate logistic regression, age (odds ratio [OR]: 1.03, 95% confidence interval [CI]: 1.01-1.05), acute coronary syndrome (OR:3.10, 95% CI: 1.88-5.12), cardiogenic shock (OR:10.06, 95% CI: 5.37-18.84), septic shock (OR:5.19,95%CI:3.29-18.84), acute respiratory failure (OR:2.49, 95% CI: 1.67-3.64) and OAC use (OR: 1.61, 95% CI: 1.02-2.55) were independently associated with main outcome. OAC prescription was associated with stroke risk reduction and to both MH and main outcome risk increase. CHA(2)DS(2)-VASc (c-index: 0.545,P = .117 for stroke) and HAS-BLED (c-index:0.503,P = .900 for MH) did not significantly predict events occurrence. Conclusions In critically ill AF patients admitted to a SDU, adverse outcomes are highly prevalent. OAC use is associated to an increased risk of therapeutic failure, clinical scores seem unhelpful in predicting stroke and MH, suggesting a highly individualized approach in AF management in this setting.
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[Position paper of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) on driving by patients with cardiac implantable electronic devices]
Anno: 2020
Rivista: GIORNALE ITALIANO DI CARDIOLOGIA
Autori/autrici: Palmisano, Pietro; Guerra, Federico; Bisignani, Giovanni; Forleo, Giovanni Battista; Landolina, Maurizio; Soldati, Ezio; Stabile, Giuseppe; Zanotto, Gabriele; Berisso, Massimo Zoni; De Ponti, Roberto; Boriani, Giuseppe; Ricci, Renato Pietro
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313050
Citazioni:
[Position paper of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) on driving by patients with cardiac implantable electronic devices] / Palmisano, P., Guerra, F., Bisignani, G., Forleo, G.B., Landolina, M., Soldati, E., Stabile, G., Zanotto, G., Berisso, M.Z., De Ponti, R., Boriani, G., Ricci, R.P.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 21:10(2020), pp. 819-825. [10.1714/3431.34209]
Abstract:
: In patients with cardiac implantable electronic devices (CIEDs) (implantable cardioverter-defibrillators [ICDs] and pacemakers [PMs]), the potential risk of suddenly being unable to drive, and hence of causing road accidents, is higher than in the general population. In ICD patients, this risk ste...ms from the possibility that an arrhythmic event leading to loss of consciousness may occur while driving. In PM patients, it may be the result of a device malfunction in a PM-dependent patient. To determine a CIED patient's ability to drive, two variables must be taken into account: (i) the risk of events, which depends on the type of underlying heart disease (ICD patients have a higher risk than PM patients); (ii) the time spent driving and the type of vehicle driven (professional drivers are at higher risk than private drivers). This position paper reports the recommendations of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) regarding driving by patients with CIEDs, on the basis of the available literature and the European reference recommendations.
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Qualità e performance in Elettrostimolazione ed Elettrofisiologia.: Aggiornamento al documento dell'Associazione Italiana di Aritmologia e Cardiostimolazione (AIAC) - Federazione Italiana di Cardiologia (FIC) 2010 "Struttura e organizzazione funzionale dell'Aritmologia"
Anno: 2020
Rivista: GIORNALE ITALIANO DI CARDIOLOGIA
Autori/autrici: Occhetta, E.; Rillo, M.; Berisso, M. Z.; Bisignani, G.; Forleo, G. B.; Guerra, F.; Landolina, M.; Palmisano, P.; Soldati, E.; Stabile, G.; Zanotto, G.; De Ponti, R.; Ricci, R. P.
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313049
Citazioni:
Qualità e performance in Elettrostimolazione ed Elettrofisiologia.: Aggiornamento al documento dell'Associazione Italiana di Aritmologia e Cardiostimolazione (AIAC) - Federazione Italiana di Cardiologia (FIC) 2010 "Struttura e organizzazione funzionale dell'Aritmologia" / Occhetta, E., Rillo, M., Berisso, M.Z., Bisignani, G., Forleo, G.B., Guerra, F., Landolina, M., Palmisano, P., Soldati, E., Stabile, G., Zanotto, G., De Ponti, R., Ricci, R.P.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 21:5(2020), pp. 385-393. [10.1714/3343.33141]
Abstract:
In the last decade the field of cardiac pacing and electrophysiology underwent major advancements thanks to both new ways of arrhythmia management and technological innovations. At the same time, the clinical competence and the procedural qualitative level of Cardiac Rhythm Centers have increased si...gnificantly. In 2010 an ad hoc Committee of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) and the Italian Federation of Cardiology (FIC) published a consensus document on the organization of Cardiac Rhythm Centers and on the standards of professional practice in pacing and electrophysiology in Italy. In particular, this document focused on the minimal requirements of a Center to be qualified as suitable to perform first, second and third-level cardiac pacing and electrophysiology activities. However, most of these indicators have been overcome over time. Thus, an update of the previously published organizational model appeared necessary. In this document several new requirements and indicators about the organization and performance of both operators and Cardiac Arrhythmia Centers have been introduced. These include: (i) "structural and procedural requirements" (types of diagnostic and therapeutic procedures performed, logistic structures, healthcare staff and technologies), (ii) "activity indicators" (number of procedures performed); (iii) "appropriateness indicators" (adherence to guideline recommendations); (iv) "outcome indicators" (procedural success and complications); and (v) "quality of care indicators" (management and continuity of care levels). By applying these requirements and indicators, each center can optimize its procedures, increasing its performance and effectiveness. Finally, a new model for the organization of the Italian network of Cardiac Arrhythmia Centers is also suggested.
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[The unmet needs of sudden cardiac death. The role of the wearable cardioverter defibrillator when the risk is transient or uncertain]
Anno: 2020
Rivista: GIORNALE ITALIANO DI CARDIOLOGIA
Autori/autrici: Guerra, Federico; Palmisano, Pietro; Bisignani, Giovanni; Forleo, Giovanni; Landolina, Maurizio; Soldati, Ezio; Stabile, Giuseppe; Zanotto, Gabriele; Berisso, Massimo Zoni; Boriani, Giuseppe; De Ponti, Roberto; Ricci, Renato Pietro
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313052
Citazioni:
[The unmet needs of sudden cardiac death. The role of the wearable cardioverter defibrillator when the risk is transient or uncertain] / Guerra, F., Palmisano, P., Bisignani, G., Forleo, G., Landolina, M., Soldati, E., Stabile, G., Zanotto, G., Berisso, M.Z., Boriani, G., De Ponti, R., Ricci, R.P.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 21:10(2020), pp. 764-767. [10.1714/3431.34202]
Abstract:
Sudden cardiac death is defined as a natural death due to termination of cardiac activity associated with loss of consciousness, spontaneous breathing and circulation. Nowadays, the prevention of sudden cardiac death represents a major issue and many areas of uncertainty are not met by current evide...nces. Among those, reliable tools for risk stratification are still lacking, as well as solution for patients in which the risk of sudden cardiac death is due to a transient or correctable condition.The concept of the wearable cardioverter defibrillator is based on a potential solution for such grey areas. It merges long-term monitoring capabilities, shockable rhythm discrimination and shock delivery without the need for bystander assistance or invasive procedures. The present review aims to summarize current problems in dealing with this insidious condition, and to discuss potential options for patients in whom sudden cardiac death could be prevented more safely and cost-effectively.
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Electrocardiogram for the Diagnosis of Acute Myocardial Infarction in Patients with Right Ventricular Paced Rhythm: Old but Gold
Anno: 2020
Rivista: JOURNAL OF ELECTROCARDIOLOGY
Autori/autrici: Ciliberti, Giuseppe; Tocci, Giampaolo; Turturiello, Dario; Sabatini, Maria; Guerra, Federico; Dello Russo, Antonio; Ambrosio, Giuseppe; Cavallini, Claudio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313056
Citazioni:
Electrocardiogram for the Diagnosis of Acute Myocardial Infarction in Patients with Right Ventricular Paced Rhythm: Old but Gold / Ciliberti, G., Tocci, G., Turturiello, D., Sabatini, M., Guerra, F., Dello Russo, A., Ambrosio, G., Cavallini, C.. - In: JOURNAL OF ELECTROCARDIOLOGY. - ISSN 0022-0736. - 62:(2020), pp. 1-4. [10.1016/j.jelectrocard.2020.07.006]
Abstract:
Ventricular pacing may interfere with the interpretation of ECG among patients with suspected acute myocardial infarction (AMI), with possible delay of reperfusion therapy. Since left bundle branch block has a similar ECG morphology to right ventricular paced rhythm, Sgarbossa and modified Sgarbossa... criteria could be useful in this setting. We present four clinical cases in which a recently proposed clinical-instrumental algorithm has been adopted to manage patients with right ventricular paced rhythm and suspected AMI. (c) 2020 Elsevier Inc. All rights reserved.
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Myocardial Infarction Without Obstructive Coronary Artery Disease (MINOCA): A Practical Guide for Clinicians
Anno: 2020
Rivista: CURRENT PROBLEMS IN CARDIOLOGY
Autori/autrici: Ciliberti, Giuseppe; Compagnucci, Paolo; Urbinati, Alessia; Bianco, Francesco; Stronati, Giulia; Lattanzi, Simona; Dello Russo, Antonio; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286203
Citazioni:
Myocardial Infarction Without Obstructive Coronary Artery Disease (MINOCA): A Practical Guide for Clinicians / Ciliberti, G., Compagnucci, P., Urbinati, A., Bianco, F., Stronati, G., Lattanzi, S., Dello Russo, A., Guerra, F.. - In: CURRENT PROBLEMS IN CARDIOLOGY. - ISSN 0146-2806. - 46:3(2020), p. 100761. [10.1016/j.cpcardiol.2020.100761]
Abstract:
Myocardial infarction without obstructive coronary artery disease (MINOCA) is defined by the evidence of spontaneous acute myocardial infarction (MI) and angiographic exclusion of coronary stenoses ≥50% in any potential infarct related artery, after having ruled out other clinically overt causes ...for the acute presentation. The introduction of this new concept was meant to encourage discovery of putative pathophysiological mechanisms and development of specific therapeutic measures. In recent years, we have witnessed significant advances in the fields of epidemiology, pathophysiology, diagnosis, prognosis estimation and therapeutics of MINOCA. So far, however, the definition of MINOCA has been rather heterogeneous since specific cardiac conditions such as myocarditis and Takotsubo syndrome have often been included, generating conflicting results. In this review, we summarize the current state-of-the-art in the expanding MINOCA field and propose a comprehensive stepwise approach for the rational diagnostic assessment of these challenging patients. Our aim is to provide clinicians with an "Ariadne's thread" according to the recent fourth universal definition of MI in order to not get lost in MINOCA's labyrinth.
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Impact of COVID-19 pandemic on the clinical activities related to arrhythmias and electrophysiology in Italy: results of a survey promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing)
Anno: 2020
Rivista: INTERNAL AND EMERGENCY MEDICINE
Autori/autrici: Boriani, Giuseppe; Palmisano, Pietro; Guerra, Federico; Bertini, Matteo; Zanotto, Gabriele; Lavalle, Carlo; Notarstefano, Pasquale; Accogli, Michele; Bisignani, Giovanni; Forleo, Giovanni Battista; Landolina, Maurizio; D'Onofrio, Antonio; Ricci, Renato; De Ponti, Roberto
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313058
Citazioni:
Impact of COVID-19 pandemic on the clinical activities related to arrhythmias and electrophysiology in Italy: results of a survey promoted by AIAC (Italian Association of Arrhythmology and Cardiac Pacing) / Boriani, G., Palmisano, P., Guerra, F., Bertini, M., Zanotto, G., Lavalle, C., Notarstefano, P., Accogli, M., Bisignani, G., Forleo, G.B., Landolina, M., D'Onofrio, A., Ricci, R., De Ponti, R.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 15:8(2020), pp. 1445-1456. [10.1007/s11739-020-02487-w]
Abstract:
COVID-19 outbreak had a major impact on the organization of care in Italy, and a survey to evaluate provision of for arrhythmia during COVID-19 outbreak (March-April 2020) was launched. A total of 104 physicians from 84 Italian arrhythmia centres took part in the survey. The vast majority of partici...pating centres (95.2%) reported a significant reduction in the number of elective pacemaker implantations during the outbreak period compared to the corresponding two months of year 2019 (50.0% of centres reported a reduction of > 50%). Similarly, 92.9% of participating centres reported a significant reduction in the number of implantable cardioverter-defibrillator (ICD) implantations for primary prevention, and 72.6% a significant reduction of ICD implantations for secondary prevention (> 50% in 65.5 and 44.0% of the centres, respectively). The majority of participating centres (77.4%) reported a significant reduction in the number of elective ablations (> 50% in 65.5% of the centres). Also the interventional procedures performed in an emergency setting, as well as acute management of atrial fibrillation had a marked reduction, thus leading to the conclusion that the impact of COVID-19 was disrupting the entire organization of health care, with a massive impact on the activities and procedures related to arrhythmia management in Italy.
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Subclinical progression of systemic sclerosis-related cardiomyopathy
Anno: 2020
Rivista: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
Autori/autrici: Stronati, Giulia; Manfredi, Lucia; Ferrarini, Alessia; Zuliani, Lucia; Fogante, Marco; Schicchi, Nicolò; Capucci, Alessandro; Giovagnoni, Andrea; Russo, Antonio Dello; Gabrielli, Armando; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313051
Citazioni:
Subclinical progression of systemic sclerosis-related cardiomyopathy / Stronati, G., Manfredi, L., Ferrarini, A., Zuliani, L., Fogante, M., Schicchi, N., Capucci, A., Giovagnoni, A., Russo, A.D., Gabrielli, A., Guerra, F.. - In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - ISSN 2047-4873. - 27:17(2020), pp. 1876-1886. [10.1177/2047487320916591]
Abstract:
Cardiac involvement in patients with systemic sclerosis (SSc) is frequent and represents a negative prognostic factor. Recent studies have described subclinical heart involvement of both the right ventricle (RV) and left ventricle (LV) via speckle-tracking-derived global longitudinal strain (GLS). I...t is currently unknown if SSc-related cardiomyopathy progresses through time. Our aim was to assess the progression of subclinical cardiac involvement in patients with SSc via speckle-tracking-derived GLS.MethodsThis was a prospective longitudinal study enrolling 72 consecutive patients with a diagnosis of SSc and no structural heart disease nor pulmonary hypertension. A standard echocardiographic exam and GLS calculations were performed at baseline and at follow-up.ResultsTraditional echocardiographic parameters did not differ from baseline to 20-month follow-up. LV GLS, despite being already impaired at baseline, worsened significantly during follow-up (from -19.8 +/- 3.5% to -18.7 +/- 3.5%, p = .034). RV GLS impairment progressed through the follow-up period (from -20.9 +/- 6.1% to -18.7 +/- 5.4%, p = .013). The impairment was more pronounced for the endocardial layers of both LV (from -22.5 +/- 3.9% to -21.4 +/- 3.9%, p = .041) and RV (-24.2 +/- 6.2% to -20.6 +/- 5.9%, p = .001). A 1% worsening in RV GLS was associated with an 18% increased risk of all-cause death or major cardiovascular event (p = .03) and with a 55% increased risk of pulmonary hypertension (p = .043).ConclusionSSC-related cardiomyopathy progresses over time and can be detected by speckle-tracking GLS. The highest progression towards reduced deformation was registered for the endocardial layers, which supports the hypothesis that microvascular dysfunction is the main determinant of heart involvement in SSc patients and starts well before overt pulmonary hypertension.
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Risk of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: role of correlation between symptoms and electrocardiogram findings
Anno: 2020
Rivista: EUROPACE
Autori/autrici: Palmisano, Pietro; Pellegrino, Pier Luigi; Ammendola, Ernesto; Ziacchi, Matteo; Guerra, Federico; Aspromonte, Vittorio; Laffi, Mattia; Pimpini, Lorenzo; Santoro, Francesco; Boggio, Enrico; Guido, Alessandro; Patti, Giuseppe; Brunetti, Natale Daniele; Nigro, Gerardo; Biffi, Mauro; Dello Russo, Antonio; Gaggioli, Germano; Accogli, Michele; Dell'Era, Gabriele
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313059
Citazioni:
Risk of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: role of correlation between symptoms and electrocardiogram findings / Palmisano, P., Pellegrino, P.L., Ammendola, E., Ziacchi, M., Guerra, F., Aspromonte, V., Laffi, M., Pimpini, L., Santoro, F., Boggio, E., Guido, A., Patti, G., Brunetti, N.D., Nigro, G., Biffi, M., Dello Russo, A., Gaggioli, G., Accogli, M., Dell'Era, G.. - In: EUROPACE. - ISSN 1099-5129. - 22:11(2020), pp. 1729-1736. [10.1093/europace/euaa188]
Abstract:
Aims To evaluate the risk of syncopal recurrences after pacemaker implantation in a population of patients with syncope of suspected bradyarrhythmic aetiology.Methods and results Prospective, multicentre, observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation fo...r syncope of bradyarrhythmic aetiology (proven or presumed). Before pacemaker implantation, all patients underwent a cardiac work-up in order to establish the bradyarrhythmic aetiology of syncope. According to the results of the diagnostic work-up, patients were divided into three groups: Group A, patients in whom a syncope-electrocardiogram (ECG) correlation was established (n = 329, 24.1%); Group B, those in whom clinically significant bradyarrhythmias were detected without a documented syncope-ECG correlation (n= 877, 64.3%); and Group C, those in whom bradyarrhythmias were not detected and the bradyarrhythmic origin of syncope remained presumptive (n = 158, 11.6%). During a median follow-up of 50 months, 213 patients (15.6%) reported at least one syncopal recurrence. Patients in Groups B and C showed a significantly higher risk of syncopal recurrences than those in Group A [hazard ratios (HRs): 1.60 and 166, respectively, P < 0.05]. Failure to establish a syncope-ECG correlation during diagnostic work-up before pacemaker implantation was an independent predictor of syncopal recurrence on multivariate analysis (HR: 1.90; P= 0.002).Conclusion In selecting patients with syncope of suspected bradyarrhythmic aetiology for pacemaker implantation, establishing a correlation between syncope and bradyarrhythmias maximizes the efficacy of pacing and reduces the risk of syncopal recurrences.
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Incidence, determinants and prognostic relevance of dyspnea at admission in patients with Takotsubo syndrome: results from the international multicenter GEIST registry
Anno: 2020
Rivista: SCIENTIFIC REPORTS
Autori/autrici: Arcari, Luca; Musumeci, Maria Beatrice; Stiermaier, Thomas; El-Battrawy, Ibrahim; Möller, Christian; Guerra, Federico; Novo, Giuseppina; Mariano, Enrica; Limite, Luca Rosario; Cacciotti, Luca; Semeraro, Raffaella; Volpe, Massimo; Romeo, Francesco; Caldarola, Pasquale; Thiele, Holger; Akin, Ibrahim; Brunetti, Natale Daniele; Eitel, Ingo; Santoro, Francesco
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313055
Citazioni:
Incidence, determinants and prognostic relevance of dyspnea at admission in patients with Takotsubo syndrome: results from the international multicenter GEIST registry / Arcari, L., Musumeci, M.B., Stiermaier, T., El-Battrawy, I., Möller, C., Guerra, F., Novo, G., Mariano, E., Limite, L.R., Cacciotti, L., Semeraro, R., Volpe, M., Romeo, F., Caldarola, P., Thiele, H., Akin, I., Brunetti, N.D., Eitel, I., Santoro, F.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 10:1(2020), p. 13603. [10.1038/s41598-020-70445-9]
Abstract:
Clinical presentation of Takotsubo syndrome (TTS) may range from acute chest pain to dyspnea: the prognostic role of clinical onset is still controversial. Aim of this study was therefore to investigate the prognostic relevance of dyspnea at presentation in patients with TTS. We analyzed 1,071 TTS p...atients (median age 72 years, 90% female) enrolled in the international multicenter GEIST registry. Patients were divided according to the presence or absence of dyspnea at hospital admission, as clinically assessed by the accepting physician. The primary endpoint was occurrence of in-hospital complications defined as a composite of pulmonary edema, cardiogenic shock and death. Overall, 316 (30%) patients presented with dyspnea at hospital admission. Diabetes, lower left ventricular ejection fraction and presence of pulmonary disease or atrial fibrillation were independently associated with dyspnea. In-hospital pulmonary edema, cardiogenic shock and death (17% vs. 3%, p<0.001; 12% vs. 7%, p=0.009; 5% vs. 2%, p=0.004 respectively) and long-term overall mortality (22% vs. 11%, p<0.001) occurred more frequently in patients with dyspnea than in those without. At multivariable analysis, dyspnea at presentation remained independently associated to both the composite primary endpoint [odds ratio 2.98 (95% confidence interval (CI) 1.95-4.59, p<0.001] and all-cause mortality [hazard ratio 2.03 (95% CI 1.37-2.99), p<0.001]. Dyspnea at presentation is common in TTS and is independently associated with in-hospital complications and impaired long-term prognosis. Thorough symptom assessment including dyspnea therefore represents a valuable tool to potentially optimize risk-stratification models for TTS patients.
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Impact on All-Cause and Cardiovascular Mortality of Cardiac Implantable Electronic Device Complications: Results From the POINTED Registry
Anno: 2020
Rivista: JACC. CLINICAL ELECTROPHYSIOLOGY
Autori/autrici: Palmisano, P.; Guerra, F.; Dell'Era, G.; Ammendola, E.; Ziacchi, M.; Laffi, M.; Troiano, F.; Prenna, E.; Russo, V.; Angeletti, A.; Guido, A.; Occhetta, E.; Nigro, G.; Biffi, M.; Gaggioli, G.; Capucci, A.; Accogli, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/313048
Citazioni:
Impact on All-Cause and Cardiovascular Mortality of Cardiac Implantable Electronic Device Complications: Results From the POINTED Registry / Palmisano, P., Guerra, F., Dell'Era, G., Ammendola, E., Ziacchi, M., Laffi, M., Troiano, F., Prenna, E., Russo, V., Angeletti, A., Guido, A., Occhetta, E., Nigro, G., Biffi, M., Gaggioli, G., Capucci, A., Accogli, M.. - In: JACC. CLINICAL ELECTROPHYSIOLOGY. - ISSN 2405-500X. - 6:4(2020), pp. 382-392. [10.1016/j.jacep.2019.11.005]
Abstract:
Objectives: This study aimed to determine how CIED-related complications affect all-cause and cardiovascular mortality over a long-term follow-up. Background: Although complications related to implantable electronic device (CIED) implantation are steadily increasing in Europe, little is known about ...the impact of complications other than device infection on mortality. Methods: The POINTED (Impact on Patient Outcome and health care utilization of cardiac ImplaNTable Electronic Device complications) registry was a prospective, multicenter, observational study designed to collect data on complications in patients undergoing de novo CIED implantation (NCT03612635). All consecutive patients were enrolled in 6 high-volume centers between January 2010 and December 2012 and followed up for at least 3 years. A complication was defined as any CIED-related adverse event requiring surgical revision after implantation. Results: During follow-up (median 56.9 months), we observed 283 complications in 263 of 2811 consecutive patients (71 ± 14 years of age, 66.7% men). Early complications (≤30 days) were associated with significantly lower cumulative survival from cardiovascular death in comparison with late complications and with freedom from complications. On multivariate analysis, early complication, pneumothorax, and pocket hematoma were significantly associated with a higher risk of all-cause death, while device infection remained the only complication significantly associated with a higher risk of cardiovascular death. Conclusions: All CIED-related complications are associated with an increased risk of cardiovascular mortality, and early complications are associated with an increased risk of all-cause mortality. These data underline the importance of specific measures aimed at reducing CIED complications and improving their management.
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Global Longitudinal Strain as a Predictor of First and Subsequent Arrhythmic Events in Remotely Monitored ICD Patients With Structural Heart Disease
Anno: 2020
Rivista: JACC. CARDIOVASCULAR IMAGING
Autori/autrici: Guerra, F.; Malagoli, A.; Contadini, D.; Baiocco, E.; Menditto, A.; Bonelli, P.; Rossi, L.; Sticozzi, C.; Zanni, A.; Cai, J.; Maitra, P.; Villani, G. Q.; Capucci, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276750
Citazioni:
Global Longitudinal Strain as a Predictor of First and Subsequent Arrhythmic Events in Remotely Monitored ICD Patients With Structural Heart Disease / Guerra, F., Malagoli, A., Contadini, D., Baiocco, E., Menditto, A., Bonelli, P., Rossi, L., Sticozzi, C., Zanni, A., Cai, J., Maitra, P., Villani, G.Q., Capucci, A.. - In: JACC. CARDIOVASCULAR IMAGING. - ISSN 1936-878X. - 13:1(2020), pp. 1-9. [10.1016/j.jcmg.2018.12.020]
Abstract:
Objectives: This study sought to assess speckle-tracking–derived parameters as predictors of first and subsequent ventricular events in patients with structural heart disease and implantable cardioverter-defibrillators (ICD). Background: Left ventricular ejection fraction (LVEF), the current p...rimary parameter of risk stratification for ventricular arrhythmias (VAs) in structural heart diseases is burdened by many limitations. Methods: In this retrospective, observational study, all consecutive patients with structural heart disease were admitted for ICD implantation. Patients not followed by a home-monitoring system were excluded. Two-dimensional (2D) speckle-tracking analysis was used to derive global longitudinal strain (GLS), mechanical dispersion (MD), and delta contraction duration (DCD) of all patients at enrollment. Home monitoring was checked weekly to detect all VAs and ICD therapies. A recurrent event statistical approach (Prentice, Williams, and Peterson model) was applied to evaluate subsequent events after the first ones. Results: A total of 203 patients were consecutively enrolled and followed for a median of 2.2 years. Kaplan-Meier curves showed an increased risk of antitachycardia pacing or shock (log-rank p = 0.003) and VAs (log-rank p = 0.001) associated with lower quartiles of GLS. An impaired GLS was independently associated with an increased risk for the first ICD therapy (hazard ratio [HR]: 1.94; 95% confidence interval [CI]: 1.30 to 2.91; p = 0.001) and (HR: 1.42; 95% CI: 1.01 to 1.98; p = 0.04) for the first VA. GLS impairment was not significantly associated with an increased risk of recurrent ICD therapies or VAs. LVEF, MD, and DCD were not associated with an increased risk of first, second, and third ICD therapies or VA. Conclusions: Impaired GLS is associated with an increased risk of VAs and appropriate ICD therapies in a consecutive “real-world,” unselected population of remotely monitored patients with structural heart disease, although it does not seem reliable in predicting further arrhythmic events after the first one. MD and DCD do not predict first or subsequent arrhythmic events in ICD patients with structural heart disease.
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Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on a Tertiary-Level Electrophysiology Laboratory in Italy
Anno: 2020
Rivista: CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY
Autori/autrici: Compagnucci, Paolo; Volpato, Giovanni; Pascucci, Riccardo; Falanga, Umberto; Misiani, Agostino; Molini, Silvano; Spinucci, Giulio; Cipolletta, Laura; Conti, Manuel; Grifoni, Gino; Carboni, Laura; Perna, Gian Piero; Munch, Christopher; Di Eusanio, Marco; Capucci, Alessandro; Casella, Michela; Guerra, Federico; Dello Russo, Antonio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/283409
Citazioni:
Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on a Tertiary-Level Electrophysiology Laboratory in Italy / Compagnucci, P., Volpato, G., Pascucci, R., Falanga, U., Misiani, A., Molini, S., Spinucci, G., Cipolletta, L., Conti, M., Grifoni, G., Carboni, L., Perna, G.P., Munch, C., Di Eusanio, M., Capucci, A., Casella, M., Guerra, F., Dello Russo, A.. - In: CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY. - ISSN 1941-3149. - (2020). [10.1161/CIRCEP.120.008774]

Cardiac arrhythmia catheter ablation procedures guided by x-ray imaging: N-acetylcysteine protection against radiation-induced cellular damage (CARAPACE study): study design
Anno: 2020
Rivista: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
Autori/autrici: Catto, V.; Stronati, G.; Porro, B.; Fiorelli, S.; Ricci, V.; Vavassori, C.; Russo, E.; Guerra, F.; Gasperetti, A.; Ribatti, V.; Sicuso, R.; Dello Russo, A.; Veglia, F.; Tondo, C.; Cavalca, V.; Colombo, G. I.; Tremoli, E.; Casella, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/285128
Citazioni:
Cardiac arrhythmia catheter ablation procedures guided by x-ray imaging: N-acetylcysteine protection against radiation-induced cellular damage (CARAPACE study): study design / Catto, V., Stronati, G., Porro, B., Fiorelli, S., Ricci, V., Vavassori, C., Russo, E., Guerra, F., Gasperetti, A., Ribatti, V., Sicuso, R., Dello Russo, A., Veglia, F., Tondo, C., Cavalca, V., Colombo, G.I., Tremoli, E., Casella, M.. - In: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. - ISSN 1383-875X. - (2020). [10.1007/s10840-020-00853-4]
Abstract:
Purpose: Catheter ablation (CA) procedures are characterized by exposure to ionizing radiations (IR). IR can cause DNA damage and may lead to carcinogenesis if not efficiently repaired. The primary endpoint of this study is to investigate whether intravenous administration of N-acetylcysteine prior ...to CA procedure may prevent systemic oxidative stress and genomic DNA damage induced by exposure to IR. Methods: The “Cardiac Arrhythmia catheter ablation procedures guided by x-Ray imaging: N-Acetylcysteine Protection Against radiation induced Cellular damagE” (CARAPACE) study is a prospective, randomized, single-blinded, parallel-arm monocenter study enrolling 550 consecutive patients undergoing CA at the Arrhythmology Unit of Centro Cardiologico Monzino (CCM). Inclusion criteria are age ≥ 18, indication for CA procedure guided by IR imaging, and written informed consent. IR levels will be measured via fluoroscopy time, effective dose, and dose area product. Glutathione and glutathione disulfide concentrations will be measured, and urinary levels of 8-iso-prostaglandin-F2α and 8-hydroxy-2-deoxyguanosine will be quantified. The enrolled patients will be randomized 1:1 to the N-acetylcysteine group or to the control group. Results: We expect that pre-operative administration of N-acetylcysteine will prevent IR-induced systemic oxidative stress. The study will provide data on oxidative DNA damage assessed by urinary 8-hydroxy-2-deoxyguanosine levels and direct evidence of genomic DNA damage in blood cells by comet assay. Conclusion: Catheter ablation procedures can lead to IR exposure and subsequent DNA damage. N-acetylcysteine administration prior to the procedure may prevent them and therefore lead to less possible complications. Trial registration: www.clinicaltrials.gov (NCT04154982)
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Procedural sedation for direct current cardioversion: a feasibility study between two management strategies in the emergency department
Anno: 2020
Rivista: BMC CARDIOVASCULAR DISORDERS
Autori/autrici: Stronati, Giulia; Capucci, Alessandro; Dello Russo, Antonio; Adrario, Erica; Carsetti, Andrea; Casella, Michela; Donati, Abele; Guerra, Federico
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/283645
Citazioni:
Procedural sedation for direct current cardioversion: a feasibility study between two management strategies in the emergency department / Stronati, G., Capucci, A., Dello Russo, A., Adrario, E., Carsetti, A., Casella, M., Donati, A., Guerra, F.. - In: BMC CARDIOVASCULAR DISORDERS. - ISSN 1471-2261. - ELETTRONICO. - 20:1(2020), pp. 1-8. [10.1186/s12872-020-01664-1]
Abstract:
Background: A cardiologist-only approach to procedural sedation with midazolam in the setting of elective cardioversion (DCC) for AF has already been proven as safe as sedation with propofol and anaesthesiologist assistance. No data exist regarding the safety of such a strategy during emergency proc...edures. The aim of this study is to compare the feasibility of sedation with midazolam, administered by a cardiologist, to an anaesthesiologist-assisted protocol with propofol in emergency DCC. Methods: Single centre, prospective, open blinded, randomized study including all consecutive patients admitted to the Emergency Department requiring urgent or emergency DCC. Patients were randomized in a 1:1 fashion to either propofol or midazolam treatment arm. Patients in the midazolam group were managed by the cardiologist only, while patients treated with propofol group underwent DCC with anaesthesiologist assistance. Results: Sixty-nine patients were enrolled and split into two groups. Eighteen patients (26.1%) experienced peri- procedural adverse events (bradycardia, severe hypotension and severe hypoxia), which were similar between the two groups and all successfully managed by the cardiologist. No deaths, stroke or need for invasive ventilation were registered. Patients treated with propofol experienced a greater decrease in systolic and diastolic blood pressure when compared with those treated with midazolam. As the procedure was shorter when midazolam was used, the median cost of urgent/emergency DCC with midazolam was estimated to be 129.0 € (1st-3rd quartiles 114.6–151.6) and 195.6 € (1st-3rd quartiles 147.3–726.7) with propofol (p < .001). Conclusions: Procedural sedation with midazolam given by the cardiologist alone was feasible, well-tolerated and cost-effective in emergency DCC.
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Recent advances in three-dimensional electroanatomical mapping guidance for the ablation of complex atrial and ventricular arrhythmias
Anno: 2020
Rivista: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
Autori/autrici: Compagnucci, P.; Volpato, G.; Falanga, U.; Cipolletta, L.; Conti, M.; Grifoni, G.; Verticelli, L.; Schicchi, N.; Giovagnoni, A.; Casella, M.; Guerra, F.; Dello Russo, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/283408
Citazioni:
Recent advances in three-dimensional electroanatomical mapping guidance for the ablation of complex atrial and ventricular arrhythmias / Compagnucci, P., Volpato, G., Falanga, U., Cipolletta, L., Conti, M., Grifoni, G., Verticelli, L., Schicchi, N., Giovagnoni, A., Casella, M., Guerra, F., Dello Russo, A.. - In: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. - ISSN 1383-875X. - (2020). [10.1007/s10840-020-00781-3]
Abstract:
Purpose: To provide a brief overview of some relevant technological advances in the field of three-dimensional electroanatomical mapping (3D-EAM) that have recently entered the clinical arena and their role in guiding catheter ablation (CA) of complex atrial and ventricular arrhythmias. Methods: In ...this technical report, we describe the general features of three novel algorithms featured in the updated CARTO PRIME™ mapping module for CARTO®3 version 7 3D-EAM system (Biosense Webster Inc., Diamond Bar, CA, USA): local activation time (LAT) hybrid, coherent mapping and map replay modules. We also report three challenging arrhythmia cases in which CA was successfully guided by these softwares. Results: The LAT hybrid module was used in a case of premature ventricular complex originating from the right coronary cusp. This algorithm facilitated safe positioning of the ablation catheter away from the right coronary ostium, avoiding potential harm to this vital structure. The coherent mapping module helped to identify the critical as well as a bystander isthmus of an atrial macro-re-entrant tachycardia in a grown-up patient with congenital heart disease. The map replay module allowed rapid retrospective activation mapping of two unstable ventricular tachycardias in a case of nonischemic cocaine-associated cardiomyopathy. Conclusion: 3D-EAM systems offer significant advantages in the management of challenging arrhythmias, and the introduction of novel algorithms underpins improvements in patients’ outcomes. Given the increasing sophistication of these systems, however, a close collaboration among cardiac electrophysiologists, engineers and technicians is highly needed in order to get the best from the available technology.
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Speckle tracking echocardiography in systemic sclerosis: how far have we arrived and where can we go
Anno: 2020
Rivista: CLINICAL RHEUMATOLOGY
Autori/autrici: Stronati, G.; Guerra, F.; Gabrielli, A.; Capucci, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276752
Citazioni:
Speckle tracking echocardiography in systemic sclerosis: how far have we arrived and where can we go / Stronati, G., Guerra, F., Gabrielli, A., Capucci, A.. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 39:1(2020), pp. 125-126. [10.1007/s10067-019-04774-0]

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients with Atrial Fibrillation: A Report from the GARFIELD-AF Registry
Anno: 2019
Rivista: JAMA CARDIOLOGY
Autori/autrici: Corbalan, R.; Bassand, J. -P.; Illingworth, L.; Ambrosio, G.; Camm, A. J.; Fitzmaurice, D. A.; Fox, K. A. A.; Goldhaber, S. Z.; Goto, S.; Haas, S.; Kayani, G.; Mantovani, L. G.; Misselwitz, F.; Pieper, K. S.; Turpie, A. G. G.; Verheugt, F. W. A.; Kakkar, A. K.; Hacke, W.; Gersh, B. J.; Luciardi, H. L.; Gibbs, H.; Brodmann, M.; Cools, F.; Barretto, A. C. P.; Connolly, S. J.; Spyropoulos, A.; Eikelboom, J.; Hu, D.; Jansky, P.; Nielsen, J. D.; Ragy, H.; Raatikainen, P.; Le Heuzey, J. -Y.; Darius, H.; Keltai, M.; Kakkar, S.; Sawhney, J. P. S.; Agnelli, G.; Koretsune, Y.; Diaz, C. J. S.; ten Cate, H.; Atar, D.; Stepinska, J.; Panchenko, E.; Lim, T. W.; Jacobson, B.; Oh, S.; Vinolas, X.; Rosenqvist, M.; Steffel, J.; Angchaisuksiri, P.; Parkhomenko, A.; Al Mahmeed, W.; Chen, K. N.; Zhao, Y. S.; Zhang, H. Q.; Chen, J. Z.; Cao, S. P.; Wang, D. W.; Yang, Y. J.; Li, W. H.; Yin, Y. H.; Tao, G. Z.; Yang, P.; Chen, Y. M.; He, S. H.; Wang, Y.; Wang, Y.; Fu, G. S.; Li, X.; Wu, T. G.; Cheng, X. S.; Yan, X. W.; Zhao, R. P.; Chen, M. S.; Xiong, L. G.; Chen, P.; Jiao, Y.; Guo, Y.; Xue, L.; Wang, F. Z.; Li, H.; Yang, Z. M.; Bai, C. L.; Chen, J.; Chen, J. Y.; Chen, X.; Feng, S.; Fu, Q. H.; Gao, X. J.; Guo, W. N.; He, R. H.; He, X. A.; Hu, X. S.; Huang, X. F.; Li, B.; Li, J.; Li, L.; Li, Y. H.; Liu, T. T.; Liu, W. L.; Liu, Y. Y.; Lu, Z. C.; Luo, X. L.; Ma, T. Y.; Peng, J. Q.; Sheng, X.; Shi, X. J.; Sun, Y. H.; Tian, G.; Wang, K.; Wang, L.; Wu, R. N.; Xie, Q.; Xu, R. Y.; Yang, J. S.; Yang, L. L.; Yang, Q.; Ye, Y.; Yu, H. Y.; Yu, J. H.; Yu, T.; Zhai, H.; Zhan, Q.; Zhang, G. S.; Zhang, Q.; Zhang, R.; Zhang, Y.; Zheng, W. Y.; Zhou, B.; Zhou, Z. H.; Zhu, X. Y.; Jadhav, P.; Durgaprasad, R.; Ravi Shankar, A. G.; Rajput, R. K.; Bhargava, K.; Sarma, R.; Srinivas, A.; Roy, D.; Nagamalesh, U. M.; Chopda, M.; Kishore, R.; Kulkarni, G.; Chandwani, P.; Pothiwala, R. A.; Padinhare Purayil, M.; Shah, S.; Chawla, K.; Kothiwale, V. A.; Raghuraman, B.; Vijayaraghavan, G.; Vijan, V. M.; Bantwal, G.; Bisne, V.; Khan, A.; Gupta, J. B.; Kumar, S.; Jain, D.; Abraham, S.; Adak, D.; Barai, A.; Begum, H.; Bhattacharjee, P.; Dargude, M.; Davies, D.; Deshpande, B.; Dhakrao, P.; Dhyani, V.; Duhan, S.; Earath, M.; Ganatra, A.; Giradkar, S.; Jain, V.; Karthikeyan, R.; Kasala, L.; Kaur, S.; Krishnappa, S.; Lawande, A.; Lokesh, B.; Madarkar, N.; Meena, R.; More, P.; Naik, D.; Prashanth, K.; Rao, M.; Rao, N. M.; Sadhu, N.; Shah, D.; Sharma, M.; Shiva, P.; Singhal, S.; Suresh, S.; Vanajakshamma, V.; Panse, S. G.; Kanamori, S.; Yamamoto, K.; Kumagai, K.; Katsuda, Y.; Sadamatsu, K.; Toyota, F.; Mizuno, Y.; Misumi, I.; Noguchi, H.; Ando, S.; Suetsugu, T.; Minamoto, M.; Oda, H.; Shiraishi, K.; Adachi, S.; Chiba, K.; Norita, H.; Tsuruta, M.; Koyanagi, T.; Ando, H.; Higashi, T.; Okada, K.; Azakami, S.; Komaki, S.; Kumeda, K.; Murayama, T.; Matsumura, J.; Oba, Y.; Sonoda, R.; Goto, K.; Minoda, K.; Haraguchi, Y.; Suefuji, H.; Miyagi, H.; Kato, H.; Nakamura, T.; Nakamura, T.; Nandate, H.; Zaitsu, R.; Fujiura, Y.; Yoshimura, A.; Numata, H.; Ogawa, J.; Tatematsu, H.; Kamogawa, Y.; Murakami, K.; Wakasa, Y.; Yamasawa, M.; Maekawa, H.; Abe, S.; Kihara, H.; Tsunoda, S.; Saito, K.; Saito, K.; Fudo, T.; Obunai, K.; Tachibana, H.; Oba, I.; Kuwahata, T.; Higa, S.; Gushiken, M.; Eto, T.; Yoshida, H.; Ikeda, D.; Fujiura, Y.; Ishizawa, M.; Nakatsuka, M.; Murata, K.; Ogurusu, C.; Shimoyama, M.; Akutsu, M.; Takamura, I.; Hoshino, F.; Yokota, N.; Iwao, T.; Tsuchida, K.; Takeuchi, M.; Hatori, Y.; Kitami, Y.; Nakamura, Y.; Oyama, R.; Ageta, M.; Oda, H.; Go, Y.; Mishima, K.; Unoki, T.; Morii, S.; Shiga, Y.; Sumi, H.; Nagatomo, T.; Sanno, K.; Fujisawa, K.; Atsuchi, Y.; Nagoshi, T.; Seto, T.; Tabuchi, T.; Kameko, M.; Nii, K.; Oshiro, K.; Takezawa, H.; Nagano, S.; Miyamoto, N.; Iwaki, M.; Nakamura, Y.; Fujii, M.; Okawa, M.; Abe, M.; Abe, M.; Abe, M.; Saito, T.; Mito, T.; Nagao, K.; Minami, J.; Mita, T.; Sakuma, I.; Taguchi, T.; Marusaki, S.; Doi, H.; Tanaka, M.; Fujito, T.; Matsuta, M.; Kusumoto, T.; Kakinoki, S.; Ashida, K.; Yoshizawa, N.; Agata, J.; Arasaki, O.; Manita, M.; Ikemura, M.; Fukuoka, S.; Murakami, H.; Matsukawa, S.; Hata, Y.; Taniguchi, T.; Ko, T.; Kubo, H.; Imamaki, M.; Akiyama, M.; Inagaki, M.; Odakura, H.; Ueda, T.; Katsube, Y.; Nakata, A.; Watanabe, H.; Techigawara, M.; Igarashi, M.; Taga, K.; Kimura, T.; Tomimoto, S.; Shibuya, M.; Nakano, M.; Ito, K.; Seo, T.; Hiramitsu, S.; Hosokawa, H.; Hoshiai, M.; Hibino, M.; Miyagawa, K.; Horie, H.; Sugishita, N.; Shiga, Y.; Soma, A.; Neya, K.; Yoshida, T.; Yoshida, T.; Mizuguchi, M.; Ishiguro, M.; Minagawa, T.; Wada, M.; Mukawa, H.; Okuda, F.; Nagasaka, S.; Abe, Y.; Adachi, S.; Adachi, S.; Adachi, T.; Akahane, K.; Amano, T.; Aoki, K.; Aoyama, T.; Arai, H.; Arima, S.; Arino, T.; Asano, H.; Asano, T.; Azuma, J.; Baba, T.; Betsuyaku, T.; Chibana, H.; Date, H.; Doiuchi, J.; Emura, Y.; Endo, M.; Fujii, Y.; Fujiki, R.; Fujisawa, A.; Fujisawa, Y.; Fukuda, T.; Fukui, T.; Furukawa, N.; Furukawa, T.; Furumoto, W.; Goto, T.; Hamaoka, M.; Hanazono, N.; Hasegawa, K.; Hatsuno, T.; Hayashi, Y.; Higuchi, K.; Hirasawa, K.; Hirayama, H.; Hirose, M.; Hirota, S.; Honda, M.; Horie, H.; Ido, T.; Iiji, O.; Ikeda, H.; Ikeda, K.; Ikeoka, K.; Imaizumi, M.; Inaba, H.; Inoue, T.; Iseki, F.; Ishihara, A.; Ishioka, N.; Ito, N.; Iwase, T.; Kakuda, H.; Kamata, J.; Kanai, H.; Kanda, H.; Kaneko, M.; Kano, H.; Kasai, T.; Kato, T.; Kato, Y.; Kawada, Y.; Kawai, K.; Kawakami, K.; Kawakami, S.; Kawamoto, T.; Kawano, S.; Kim, J.; Kira, T.; Kitazawa, H.; Kitazumi, H.; Kito, T.; Kobayashi, T.; Koeda, T.; Kojima, J.; Komatsu, H.; Komatsu, I.; Koshibu, Y.; Kotani, T.; Kozuka, T.; Kumai, Y.; Kumazaki, T.; Maeda, I.; Maeda, K.; Maruyama, Y.; Matsui, S.; Matsushita, K.; Matsuura, Y.; Mineoi, K.; Mitsuhashi, H.; Miura, N.; Miyaguchi, S.; Miyajima, S.; Miyamoto, H.; Miyashita, A.; Miyata, S.; Mizuguchi, I.; Mizuno, A.; Mori, T.; Moriai, O.; Morishita, K.; Murai, O.; Nagai, S.; Nagai, S.; Nagata, E.; Nagata, H.; Nakagomi, A.; Nakahara, S.; Nakamura, M.; Nakamura, R.; Nakanishi, N.; Nakayama, T.; Nakazato, R.; Nanke, T.; Nariyama, J.; Niijima, Y.; Niinuma, H.; Nishida, Y.; Nishihata, Y.; Nishino, K.; Nishioka, H.; Nishizawa, K.; Niwa, I.; Nomura, K.; Nomura, S.; Nozoe, M.; Ogawa, T.; Ohara, N.; Okada, M.; Okamoto, K.; Okita, H.; Okuyama, M.; Ono, H.; Ono, T.; Pearce, Y. O.; Oriso, S.; Ota, A.; Otaki, E.; Saito, Y.; Sakai, H.; Sakamoto, N.; Sakamoto, Y.; Samejima, Y.; Sasagawa, Y.; Sasaguri, H.; Sasaki, A.; Sasaki, T.; Sato, K.; Sato, K.; Sawano, M.; Seki, S.; Sekine, Y.; Seta, Y.; Sezaki, K.; Shibata, N.; Shiina, Y.; Shimono, H.; Shimoyama, Y.; Shindo, T.; Shinohara, H.; Shinohe, R.; Shinozuka, T.; Shirai, T.; Shiraiwa, T.; Shozawa, Y.; Suga, T.; Sugimoto, C.; Suzuki, K.; Suzuki, K.; Suzuki, S.; Suzuki, S.; Suzuki, S.; Suzuki, Y.; Tada, M.; Taguchi, A.; Takagi, T.; Takagi, Y.; Takahashi, K.; Takahashi, S.; Takai, H.; Takanaka, C.; Take, S.; Takeda, H.; Takei, K.; Takenaka, K.; Tana, T.; Tanabe, G.; Taya, K.; Teragawa, H.; Tohyo, S.; Toru, S.; Tsuchiya, Y.; Tsuji, T.; Tsuzaki, K.; Uchiyama, H.; Ueda, O.; Ueyama, Y.; Wakaki, N.; Wakiyama, T.; Washizuka, T.; Watanabe, M.; Yamada, T.; Yamagishi, T.; Yamaguchi, H.; Yamamoto, K.; Yamamoto, K.; Yamamoto, K.; Yamamoto, T.; Yamaura, M.; Yamazoe, M.; Yasui, K.; Yokoyama, Y.; Yoshida, K.; Ching, C. K.; Foo, C. G.; Chow, J. H.; Chen, D. D.; Jaufeerally, F. R.; Lee, Y. M.; Li, H.; Lim, G.; Lim, W. T.; Thng, S.; Yap, S. Y.; Yeo, C.; Pak, H. N.; Kim, J. -B.; Kim, J. H.; Jang, S. -W.; Kim, D. H.; Kim, J.; Ryu, D. R.; Park, S. W.; Kim, D. -K.; Choi, D. J.; Oh, Y. S.; Cho, M. -C.; Kim, S. -H.; Jeon, H. -K.; Shin, D. -G.; Park, J. S.; Park, H. K.; Han, S. -J.; Sung, J. H.; Cho, J. -G.; Nam, G. -B.; On, Y. K.; Lim, H. E.; Kwak, J. J.; Cha, T. -J.; Hong, T. J.; Park, S. H.; Yoon, J. H.; Kim, N. -H.; Kim, K. -S.; Jung, B. C.; Hwang, G. -S.; Kim, C. -J.; Kim, D. B.; Ahn, J. J.; An, H. J.; Bae, H.; Baek, A. L.; Chi, W. J.; Choi, E. A.; Choi, E. H.; Choi, H. K.; Choi, H. S.; Han, S.; Heo, E. S.; Her, K. O.; Hwang, S. W.; Jang, E. M.; Jang, H. -S.; Jang, S.; Jeon, H. -G.; Jeon, S. R.; Jeon, Y. R.; Jeong, H. K.; Jung, I. -A.; Kim, H. J.; Kim, H. J.; Kim, J. S.; Kim, J. S.; Kim, J. A.; Kim, K. T.; Kim, M. S.; Kim, S. H.; Kim, S. H.; Kim, Y. -I.; Lee, C. S.; Lee, E. H.; Lee, G. H.; Lee, H. Y.; Lee, H. -Y.; Lee, K. H.; Lee, K. R.; Lee, M. S.; Lee, M. -Y.; Lee, R. W.; Lee, S. E.; Lee, S. H.; Lee, S.; Lee, W. Y.; Noh, I. K.; Park, A. R.; Park, B. R.; Park, H. N.; Park, J. H.; Park, M.; Park, Y.; Seo, S. -Y.; Shim, J.; Sim, J. H.; Sohn, Y. M.; Son, W. S.; Son, Y. S.; Song, H. J.; Wi, H. K.; Woo, J. J.; Ye, S.; Yim, K. H.; Yoo, K. M.; Yoon, E. J.; Yun, S. Y.; Chawanadelert, S.; Mongkolwongroj, P.; Kanokphatcharakun, K.; Cheewatanakornkul, S.; Laksomya, T.; Pattanaprichakul, S.; Chantrarat, T.; Rungaramsin, S.; Silaruks, S.; Wongcharoen, W.; Siriwattana, K.; Likittanasombat, K.; Katekangplu, P.; Boonyapisit, W.; Cholsaringkarl, D.; Chatlaong, B.; Chattranukulchai, P.; Santanakorn, Y.; Hutayanon, P.; Khunrong, P.; Bunyapipat, T.; Jai-Aue, S.; Kaewsuwanna, P.; Bamungpong, P.; Gunaparn, S.; Hongsuppinyo, S.; Inphontan, R.; Khattaroek, R.; Khunkong, K.; Kitmapawanont, U.; Kongsin, C.; Naratreekoon, B.; Ninwaranon, S.; Phangyota, J.; Phrommintikul, A.; Phunpinyosak, P.; Pongmorakot, K.; Poomiphol, S.; Pornnimitthum, N.; Pumprueg, S.; Ratchasikaew, S.; Sanit, K.; Sawanyawisuth, K.; Silaruks, B.; Sirichai, R.; Sriwichian, A.; Suebjaksing, W.; Sukklad, P.; Suttana, T.; Tangsirira, A.; Thangpet, O.; Tiyanon, W.; Vorasettakarnkij, Y.; Wisaratapong, T.; Wongtheptien, W.; Wutthimanop, A.; Yawila, S.; Altun, A.; Ozdogru, I.; Ozdemir, K.; Yilmaz, O.; Aydinlar, A.; Yilmaz, M. B.; Yeter, E.; Ongen, Z.; Cayli, M.; Pekdemir, H.; Ozdemir, M.; Sucu, M.; Sayin, T.; Demir, M.; Yorgun, H.; Ersanli, M.; Okuyan, E.; Aras, D.; Abdelrahman, H.; Aktas, O.; Alpay, D.; Aras, F.; Bireciklioglu, M. F.; Budeyri, S.; Buyukpapuc, M.; Caliskan, S.; Esen, M.; Felekoglu, M. A.; Genc, D.; Ikitimur, B.; Karaayvaz, E. B.; Karatas, S. K.; Okutucu, S.; Ozcelik, E.; Quisi, A.; Sag, H.; Sahiner, L.; Sayin, B. Y.; Seker, T.; Alkan, D. U.; Yildirim, E.; Yildirim, R.; Yilmaz, F.; Yuksekdag, V.; Vensentini, N.; Ingaramo, A. C.; Sambadaro, G. A.; Caputi, V. F.; Berman, S. G.; Dragotto, P.; Kleiban, A. J.; Centurion, N.; Giacomi, G.; Guerrero, R. A. A.; Conde, D.; Zapata, G.; Di Paola, L. A.; Ramos, J. L.; Dran, R. D.; Egido, J.; Fernandez, A. A.; Fosco, M. J.; Sassone, S.; Sinisi, V. A.; Cartasegna, L. R.; Berli, M. A.; Vilamajo, O. A. G.; Ferroni, F.; Alaguibe, E. D.; D'Amelio, A. A.; Arabetti, C.; Arias, L.; Belardi, J. A.; Bergesio, L.; Berli, F.; Berli, M.; Borchowiec, S.; Buzzetti, C.; Cabrini, R.; Campisi, V.; Cappi, A. L.; Carrizo, R.; Berra, F. C.; Costabel, J. P.; Costamagna, O. J. A.; Damonte, A. A.; De Urquiza, I. N.; Diez, F.; Eden, M. F.; Fanuele, M.; Voena, F. F.; Torres, M. F.; Funosas, C.; Giacomi, M. P.; Gimenez, C. H.; Gurfinkel, E. P.; Had, M. D. L. M.; Hansen, V.; Hrabar, A. D.; Ingratta, M.; Lopez, A.; Maehara, G.; Maffei, L.; Martinelli, A.; Martinelli, C.; Matkovich, J.; Mautner, B.; Meirino, A.; Munguia, R.; Navarro, A.; Novas, V.; Prados, G. P.; Pontoriero, J.; Potito, R. N.; Ricotti, C.; Rodriguez, M. A.; Rolandi, F.; Palladino, M. E. S.; Salinger, M.; Sanziani, L. S.; Schygiel, P. O.; Sossich, A.; Tinto, J. F.; Tonelli, L.; Tufare, A. L.; Vallejo, M.; Yunis, M. E.; Zillo, M.; Zurbrigk, F. J.; Filho, D. C. S.; Jaber, J.; Armaganijan, D.; Neto, J. F.; Steffens, A.; de Souza, W. K. S. B.; de Souza Neto, J. D.; Ribeiro, J. M.; Teixeira, M. S.; Rossi, P. R. F.; Pires, L.; Moreira, D.; Jorge, J. C. M.; Filho, A. M. L.; Bodanese, L. C.; Montera, M. W.; Del Carlo, C. H.; Rodrigues, T. D. R.; da Costa, F. A. A.; Lopes, A.; Lopes, R.; Araujo, G. R.; Manenti, E. R. F.; Saraiva, J. F. K.; Braga, J. C. F.; Negri, A.; Souto, L.; Moncada, C.; Precoma, D. B.; Roquette, F.; Reis, G.; Filho, R. A. R.; Figueiredo, E. L.; Botelho, R. V.; Tavares, C. M. D. F.; Frack, C. R. C.; Saad, J. A.; Finimundi, H. C.; Pisani, C.; Chemello, D.; Martins, M. P.; Franca, C. C. B.; Alban, F.; Rosito, G. B. A.; Moraes Junior, J. B. M. X.; Tumelero, R. T.; Maia, L. N.; de Almeida, R. S.; do Carmo Borges, N. C.; Ferreira, L. G. G.; Agliardi, P.; Gomes, J. A. O.; Araujo, V.; Nakazone, M. A.; Barbosa, T.; Barroso, S.; Falchetto, E. B.; Lopes, H. B.; Lemos, M. A. B. T.; Biazus, G.; Queiroz, L. B.; Camazzola, F. E.; Caporale, M.; Cardoso Boscato, S.; Chieza, F.; Chokr, M. O.; Mingireanov, R. C.; Goes, N. C.; Correa, C.; Costa, M.; Ortiz, C. C.; da Silva, L. S.; Paulitsch, F. D. S.; da Silveira, J. A.; Daros, E.; de Araujo, G. R.; Del Monaco, M. I.; Dias, C.; Dias, M. A.; Wainstein, A. P. D.; Pizzato, P. E.; Esteves, D. C.; Fabri, P.; Fonseca, T. F. L.; Fernandes, E.; Fonseca, C.; Costantini, C. R. F.; Ferraz, R. F.; Freire, F.; Gottardo, P.; Guanaes, D.; Guizzardi, S.; Magedanz, E. H.; Igansi, F.; Jannuzzi, F.; Junior, G.; Komar, D.; Lino, E. G.; Lopes, D.; Junior, O. L. D. S.; Lustosa, E.; Macagnan, A. P.; Marinho, M. C.; Mazzoni, M.; Melo, G.; Mortari, L.; Mouco, O. M. C. C.; Vital, C. N.; Ormundo, C.; Emmer, S. O.; Palmegiani, E.; Pavani, R.; Pereira, L.; Pereira, V. L.; Perreira, R.; Poletti, S.; Fortunato, S. C. Q.; Queirantes, C.; Pereira, N. R.; Rech, R. L.; Ribeiro, S.; Rodrigues, A.; Roesch, H.; Reichert, T. R.; Santos, D.; Santos, I.; Santos, M.; Seroqui, M. V.; Silva, S.; Soares, L.; Spolaor, L.; Stoll, C.; Duda, N. T.; Trama, L.; Unterkircher, B.; Valois, M. V.; Vargas, T.; Viana, T.; Vicente, C.; Armaganijan, L. V.; Homem, R. V.; Torres, L. 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A.; Avena, R.; Chavarria, M.; Espinosa, I.; Silva, F. F.; Nava, R. H. G.; Godoy, K.; Felix, E. J. G.; Garcia, C. L. G.; Salas, L. G. G.; Guajardo, P.; Gonzalez, S. H.; Izquierdo, T.; Ortiz, M. C. M.; Vasquez, D. M.; Mendoza, N.; Morales, J.; Nikitina, N.; Aybar, S. O.; Ortiz, A.; Macias, P. P.; Perez, F.; Sanchez, J. A. P.; Toledano, S. P.; Gonzalez, M. R.; Ramos, C. R.; Castro, V. R.; Cardona, G. R.; Cornejo, M. R.; Salinas, A.; Santana, G.; Perez, P. S.; Castaneda, A. C. T.; Cortes, R. 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B.; Marquand, A.; Destrac, S.; Piot, O.; Delarche, N.; Cebron, J. -P.; Boveda, S.; Guenoun, M.; Guedj-Meynier, D.; Galley, D.; Ohayon, J.; Assouline, S.; Zuber, M.; Amarenco, P.; Ellie, E.; Kadouch, J.; Fournier, P. -Y.; Huberman, J. -P.; Lemaire, M.; Rodier, G.; Milandre, L.; Vandamme, X.; Sibon, I.; Neau, J. -P.; Mahagne, M. H.; Mielot, A.; Bonnefoy, M.; Churet, J. -B.; Navarre, V.; Sellem, F.; Monniot, G.; Boyes, J. -P.; Doucet, B.; Martelet, M.; Obadia, D.; Crousillat, B.; Mouallem, J.; Bearez, E.; Nazeyrollas, P.; Brugnaux, J. 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M.; Martini, G.; Tessitori, M.; Cappelli, R.; Poli, D.; Quintavalla, R.; Melone, F.; Cosmi, F.; Pizzini, A.; Piseddu, G.; Fanelli, R.; Latella, C.; Santi, R.; Pancaldi, L.; De Cristofaro, R.; Palareti, G.; De Blasio, A.; Salerno Uriarte, J.; Minetti, F.; Pogliani, E. M.; Lonati, L. M.; Accogli, M.; Ciampani, N.; Malengo, S.; Feola, M.; Raisaro, A.; Fattore, L.; Grilli, P.; Germini, F.; Settimi, M.; Alunni, M.; Duranti, G.; Tedeschi, L.; Baglioni, G.; Avanzino, G.; Berardi, M.; Pannacci, V.; Giombolini, A.; Nicoli, S.; Scarponi, T.; Allasia, B.; Ricciarini, P.; Nasorri, R.; Argena, A.; Bossolasco, P.; Ronchini, P.; Filippi, A.; Tradati, F.; Bulla, C.; Donzelli, L.; Foppa, L.; Bottarelli, M. L.; Tomasello, A.; Mauric, A.; Femiano, C.; Reggio, R.; Lillo, F.; Mariani, A.; Forcignano, F.; Volpe, M.; D'Avino, M.; Bongiorni, M. G.; Severi, S.; Capucci, A.; Lodigiani, C.; Salomone, E.; Serviddio, G.; Tondo, C.; Golino, P.; Mazzone, C.; Iacopino, S.; Pengo, V.; Galvani, M.; Moretti, L.; Ambrosino, P.; Banfi, E.; Biagioli, V.; Bianchi, A.; Boggian, G.; Breschi, M.; Brusorio, S.; Calcagnoli, F.; Campagna, G.; Carpenedo, M.; Ciabatta, C.; Ciliberti, G.; Cimmino, G.; D'Arienzo, C.; Di Gennaro, L.; Fedele, M.; Ferrini, P. M.; Granzow, K.; Guazzaloca, G.; Guerra, F.; Lo Buglio, A.; Longo, S.; Macellari, F.; Mesolella, E.; Mollica Poeta, E.; Occhilupo, P.; Oriana, V.; Rangel, G.; Salomone, L.; Scaccianoce, A.; Scarone, C.; Segreti, L.; Sottilota, G.; Villani, R.; Zecca, C.; Ruiter, J. H.; Klomps, H.; Bongaerts, M.; Pieterse, M. G. C.; Guldener, C.; Herrman, J. -P.; Lochorn, G.; Lucassen, A.; Adriaansen, H.; The, S. H. K.; Nierop, P. R.; Hoogslag, P. A. M.; Hermans, W.; Groenemeijer, B. E.; Terpstra, W.; Buiks, C.; Boersma, L. V. A.; Boersma-Slootweg, M.; Bosman, F.; Bosschaert, M.; Bruin, S.; Danse, I.; De Graaf, J.; de Graauw, J.; Debordes, M.; Dols, S.; Geerlings, F.; Gorrebeeck, K.; Jerzewski, A.; Jetten, W.; Kelderman, M.; Kloosterman, T.; Koomen, E. M.; Krikken, J.; Melman, P.; Mulder, R.; Pronk, A.; Stallinga-de Vos, A.; te Kaat, J.; Tonino, P.; Uppelschoten, B.; van de Loo, R.; van der Kley, T.; van Leeuwen, G.; van Putten, J. J.; Westerman, L.; Berge, E.; Sirnes, P. A.; Gjertsen, E.; Hole, T.; Erga, K.; Hallaraker, A.; Skjelvan, G.; Ostrem, A.; Ghezai, B.; Svilaas, A.; Christersson, P.; Oien, T.; Hoegh Henrichsen, S.; Berg-Johansen, J.; Otterstad, J. E.; Antonsen, H.; Ausen, K.; Claussen, H.; Dominguez, I.; Jekthammer, A.; Lensebraaten, A. 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K.; Kremis, E.; Kruczyk, D.; Krzesiak-Lodyga, A.; Krzyzanowski, M.; Kurdzielewicz, W.; Kustrzycka-Kratochwil, D.; Lesniewska-Krynska, D.; Leszczynski, J.; Lewicka, E.; Lichota, E.; Lip, K.; Loboz-Rudnicka, M.; Luka, J.; Lysek-Jozefowicz, A.; Machnikowska, M.; Majewska, K.; Mariankowski, R.; Markiewicz, A.; Mazur, M.; Metzgier-Gumiela, A.; Miedlar, E.; Mielcarek, M.; Neubauer-Geryk, J.; Niedek, J.; Niemirycz-Makurat, A.; Nowak, A.; Nowak, S.; Opielowska-Nowak, B.; Ozgowicz, M.; Pawelska-Buczen, A.; Pawlik-Rak, E.; Piotrowicz, R.; Ptaszynski, P.; Raczynska, A.; Rogowski, W.; Romanek, J.; Romaszkiewicz, R.; Rostoff, P.; Roszczyk, N.; Rozewska-Furmanek, D.; Rychta, J.; Rzyczkowska, B.; Sidor, A.; Skalska, J.; Smichura, M.; Splawski, M.; Staneta, P.; Staniszewska, E.; Starak-Marciniak, J.; Stopyra-Poczatek, M.; Sukiennik-Kujawa, M.; Szafranski, J.; Szalecki, P.; Szczepanska, A.; Szkrobka, W.; Szuchnik, E.; Szulowska, A.; Szumczyk-Muszytowska, G.; Szwoch, M.; Traczyk, T.; Troszczynska, M.; Trzcinski, G.; Tybura, S.; Walasik, P.; Wegrzynowska, M.; Wesolowska, K.; Wieczorek, W.; Wierzbicka, A.; Wilczewski, P.; Wilgat-Szecowka, M.; Wojewoda, P.; Wojnowski, L.; Wrobel, M.; Zakutynska-Kowalczyk, K.; Zyczynska-Szmon, M.; Eltishcheva, V.; Libis, R.; Tereshchenko, S.; Popov, S.; Kamalov, G.; Belenky, D.; Zateyshchikova, A.; Kropacheva, E.; Kolesnikova, A.; Nikolaev, K.; Egorova, L.; Khokhlov, A.; Yakupov, E.; Poltavskaya, M.; Zateyshchikov, D.; Drapkina, O.; Vishnevsky, A.; Barbarash, O.; Miller, O.; Aleksandrova, E.; Chizhov, P.; Sergeev, M.; Shutemova, E.; Mazur, E.; Zrazhevskiy, K.; Novikova, T.; Kostenko, V.; Moiseeva, Y.; Polkanova, E.; Sobolev, K.; Rossovskaya, M.; Zubeeva, G.; Shapovalova, Y.; Nagibovich, O.; Edin, A.; Agakhanyan, A.; Batalov, R.; Belenkova, Y.; Bitakova, F.; Chugunnaya, S.; Dumikyan, A.; Erofeeva, S.; Gorbunova, E.; Gorshkova, T.; Gubanov, A.; Gurmach, M.; Ivanova, Y.; Kolesova, T.; Konyushenko, D.; Korneeva, O.; Kropova, O.; Kuchuk, P.; Kungurtseva, O.; Kupriyanova, T.; Kurylo, B.; Kuvanova, M.; Lebedeva, O.; Lileeva, E.; Machilskaya, O.; Medvedeva, T.; Monako, G.; Motylev, I.; Nagibovich, G.; Novikova, E.; Orlov, Y.; Osmolovskaya, Y.; Ovsannikova, A.; Platonov, D.; Rachkova, S.; Sinitsina, O.; Speshilova, S.; Suslova, O.; Ushakov, A.; Volodicheva, O.; Zemlianskaia, O.; Zhirov, I.; Zhuravleva, E.; Zotova, I.; Garcia, P. A.; Fernandez, M. F. L.; Tercedor, L.; Iparraguirre, S. T.; Monserrat, P. T.; Contreras, E. M.; Rafecas, J. I.; Carrasco, J. M.; Pavia, P. G.; Pajuelo, C. G.; Serrano, C. M.; Alonso, L. F. I.; Ruiz, A. G.; Klein, J. M.; Juanatey, J. R. G.; Esquivias, G. B.; Collado, I. M.; Piquero, H. P.; Cuixart, C. B.; Morato, M. R.; Llibre, J. B. I.; Vicente, C. C.; Gutierrez, M. V.; Gonzalo, F. E.; Fernandez, C. A. A.; Plana, N. D. V.; Montserrat, E. E.; Alia, J. J. M.; Gonzalez, M. B.; Oliva, M. A. M.; Sanmartin, J. I.; Gonzalez, M. J.; Alvarez, M. R.; Melenchon, J. H.; Vera, T. R.; Soriano, F. R.; Riesco, L. G.; Macian, M. D. M.; Granado, J. Q.; Navarro, M. J.; Sales, J. C.; Perez, J. V. V.; Caamano, M. V.; Torres, M. F. A.; Gomez, G. M.; Romo, A. I.; Diaz, M. A. P.; Alonso, C.; Alonso, C.; Alvarez, D.; Alvarez, M.; Amaro, M.; Andere, N.; Villar, J. A.; Ochoa, R. A.; Austria, A.; Barbeira, S.; Feu, E. B.; Bartes, A.; Munoz, V. B.; Jimenez, F. J. B.; Tijuan, A. B.; Ramirez, J. C.; Ramos, M. C.; Martinez, E. C.; Moreno, M. C.; Corchado, G. C.; Gil, M. C.; Orive, M. C.; Fernandez, D. C.; del Misterio, M. C.; Alsina, R. C.; Cabrera, A. C.; de Faria, J. C. P. P.; Costas, S.; Marco, M. I. C.; Dachs, M.; Lopez, C. M. D.; Borras, A. D.; Madariaga, A. E.; Espallargas, A.; Fernandez, M.; Escobar, E. F.; Mas, E. F.; Ferrer, A.; Fosch, J.; Bermudez, M. G.; Millan, V. G.; Saenz, M. G.; Garcia, C. G.; Gomez, C.; Perez, Y. G.; Segovia, A. G.; Gonzalez, P.; Grigorian, L.; Molina, A. G.; del Val, M. C. G.; Maeso, B. H.; Rodriguez, E. H.; Garcia, A. I.; Fernandez, M. J. J.; Besa, B. J.; Salvadores, P. J.; Bouzamayor, M. B. L.; Lasuncion, I.; Gort, L. E. L.; Molina, M. L.; Lopez, M.; Rey, A. M.; Guerra, J. M.; Marcus, S.; Vila, A. M.; Mena, M. M.; Mazon, P.; Zurita, F. M.; Millan, G.; Molina, M.; Alia, P. M.; Montes, D.; Gonzalez, M. M.; Munoz, R. B. M.; Palma, A. N.; Figueroa, H. N. O.; Ortega, V. M.; Cortes, C. O.; Tomera, D. O.; Merchan, N. P.; Ibar, I. P.; Garcia, E. P.; Armayor, M. P.; Carasa, M. P.; Prieto, I.; Quintern, V.; Renom, R.; Diaz, L. M. R.; Rios, V.; Sola, L. R.; Rivera, R.; Robiro, X. R.; Roca, M.; Saumell, C. R.; Rodrigo, C.; Rodriguez, E.; Garcia, M. R.; Jimenez, S. S.; Calderon, P. S.; Mendez, L. S.; Parra, S. S.; Santolaya, C.; Sanz, M. R. S.; Blanco, A. S.; Serralvo, E.; Sierra, N.; Valero, C. S.; Lopez, J. S.; Fontanillas, M. T.; Riera, M. T.; Tobajas, G.; Torres, C.; Marques, J. T.; Pastor, M. U.; Wirdby, A.; Linden, J.; Henriksson, K.; Elmersson, M.; Egilsson, A.; Borjesson, U.; Svard, G.; Liu, B.; Lindh, A.; Olsson, L. -B.; Gustavsson, M.; Andersson, L.; Andersson, L.; Benson, L.; Bothin, C.; Hajimirsadeghi, A.; Kadir, K.; Ericsson, M.; Ohlsson, A.; Lindvall, H.; Svensson, P.; Thorne, K.; Handel, H.; Platonov, P.; Eriksson, B.; Timberg, I.; Romberg, K.; Crisby, M.; Karlsson, J. -E.; Jensen, S. A.; Andersson, A.; Malmqvist, L.; Martinsson, B.; Bernsten, F.; Engdahl, J.; Thulin, J.; Hot-Bjelac, A.; Stalby, P.; Aaroe, H.; Ahbeck, E.; Ahlmark, H.; Al-Khalili, F.; Bonkowski, G.; Dzeletovic, S.; Ekstrand, A. -B.; Eriksson, G. -B.; Floren, K.; Grassjo, C.; Hahn, S.; Jaensson, P.; Jansson, B.; Jansson, J. -H.; Kangert, R. -M.; Koch, A.; Kusiak, D.; Lettenstrom, A.; Lindberg, A.; Lindholm, C. -J.; Mannermyr, A.; Mansson, K.; Millborg, M.; Nilsson, C.; Ohlin, A. -M.; Olofsson, A.; Osberg, A.; Pedersen, A.; Risbecker, K.; Rosenberg, K.; Samuelsson, J.; Shayesteh, M.; Skoglund, K.; Stjernberg, M.; Thorsen, C.; Beer, J. H.; Shah, D.; Debrunner, J.; Amstutz, D.; Bruegger, J.; Elise, G.; Grau, A.; Guinand, A.; Henriette, I.; Saga, E.; Winnik, S.; Rudyk, I.; Tseluyko, V.; Karpenko, O.; Zhurba, S.; Kraiz, I.; Kupnovytska, I.; Serediuk, N.; Mostovoy, Y.; Ushakov, O.; Koval, O.; Kovalskyi, I.; Svyshchenko, Y.; Sychov, O.; Stanislavchuk, M.; Kraydashenko, O.; Yagensky, A.; Tykhonova, S.; Kurylo, B.; Fushtey, I.; Belegai, R.; Berko, G.; Burdeuna, L.; Chabanna, O.; Daniuk, I.; Ivanov, A.; Kamenska, E.; Kaplan, P.; Khyzhnyak, O.; Kizim, S.; Matova, O.; Medentseva, O.; Mochonyi, V.; Mospan, M.; Nemtsova, V.; Ovdiienko, T.; Palamarchuk, O.; Pavelko, M.; Petrovskyy, R.; Plevak, D.; Proshak, O.; Pyvovar, S.; Rasputina, L.; Romanenko, O.; Romanova, O.; Sapatyi, A.; Shumakov, O.; Stets, R.; Todoriuk, L.; Varenov, V.; Chauhan, N.; Goodwin, D.; Saunders, P.; Evans, R.; Leese, J.; Jhittay, P. S.; Ross, A.; Kainth, M. S.; Pickavance, G.; Mcdonnell, J.; Williams, A.; Gooding, T.; Wagner, H.; Suryani, S.; Singal, A.; Sircar, S.; Bilas, R.; Hutchinson, P.; Wakeman, A.; Stokes, M.; Paul, N.; Aziz, M.; Ramesh, C.; Wilson, P.; Franklin, S.; Fairhead, S.; Thompson, J.; St Joseph, V.; Taylor, G.; Tragen, D.; Seamark, D.; Paul, C.; Richardson, M.; Jefferies, A.; Sharp, H.; Jones, H.; Giles, C.; Page, M.; Oginni, O.; Aldegather, J.; Wetherwell, S.; Lumb, W.; Evans, P.; Scouller, F.; Macey, N.; Stipp, Y.; West, R.; Thurston, S.; Wadeson, P.; Matthews, J.; Pandya, P.; Gallagher, A.; Railton, T.; Sinha, B.; Russell, D.; Davies, J. A.; Ainsworth, P.; Jones, C. P.; Weeks, P.; Eden, J.; Kernick, D.; Murdoch, W.; Lumley, L.; Patel, R. P.; Wong, S. W.; Saigol, M.; Ladha, K.; Douglas, K.; Cumberlidge, D. F.; Bradshaw, C.; Van Zon, G.; Jones, K. P.; Thomas, M. J.; Watson, E.; Sarai, B.; Ahmad, N.; Willcock, W.; Cairns, J.; Sathananthan, S.; de Kare-Silver, N.; Gilliland, A.; Strieder, E.; Howitt, A.; Vishwanathan, B.; Bird, N.; Gray, D.; Clark, M.; Bisatt, J.; Litchfield, J.; Fisher, E.; Fooks, T.; Kelsall, A. R.; Alborough, E.; Wakeling, J.; Parfitt, M.; Milne, K.; Rogers, S.; Priyadharshan, R.; Oliver, J. L.; Davies, E.; Abushal, S.; Jacobs, M.; Hutton, C.; Walls, N. I.; Thompson, R.; Chigbo, C.; Zaidi, S. M. A.; Howard, M.; Butter, K. C.; Barrow, S.; Little, H.; Haq, I. U.; Gibbons, L.; Glencross, S.; Mcleod, A. J.; Poland, K.; Mulholland, C.; Warke, A.; Conn, P.; Burns, G.; Smith, R. N.; Lowe, S.; Kamath, R.; Dau, H. S.; Webster, J.; Hodgins, I.; Vercoe, S.; Roome, P. C.; Pinnock, H.; Patel, J. R. A.; Ali, A.; Hart, N.; Davies, R.; Stuart, E.; Neden, C. A.; Danielsen, M.; Heath, R.; Sharma, P.; Galloway, S.; Hawkins, C.; Oliver, R.; Aylward, M.; Mannion, S.; Braddick, M.; Edwards, D.; Rothwell, A. C.; Sabir, A.; Choudhary, F.; Khalaque, S.; Wilson, A.; Peters, S.; Coulson, W.; Roberts, N.; Heer, A.; Coates, S.; Ward, B.; Jackson, D.; Walton, S.; Shepherd, D.; Sterry, M.; Wong, T.; Boon, M.; Bunney, R.; Haria-Shah, R.; Baron, R. T.; Davies, S.; Schatzberger, T.; Hargreaves, N.; Stephenson, T.; Choi, H.; Batson, R.; Lucraft, L.; Myhill, T.; Estifano, S.; Geatch, D.; Wilkinson, J.; Veale, R.; Forshaw, K.; Davies, T.; Zaman, K.; Vinson, P.; Liley, C.; Bandrapalli, M.; Mcginty, P.; Wastling, R.; Mceleny, P.; Beattie, A.; Cooke, P.; Wong, M.; Gunasegaram, J.; Pugsley, M.; Ahmad, S.; A'Court, C.; Ayers, J.; Bennett, J.; Cartwright, S.; Dobson, S.; Dooldeniya, C.; Flynn, A.; Fox, R.; Goram, J.; Halpin, A.; Hay, A.; Jacobs, P.; Jeffers, L.; Lomax, L.; Munro, I.; Muvva, R.; Nadaph, M.; Powell, K.; Randfield, S.; Redpath, D.; Reed, R.; Rickenbach, M.; Rogers, G.; Saunders, P. B.; Seamark, C.; Shewring, J.; Simmons, P.; Simper, H.; Stoddart, H.; Sword, A.; Thomas, N.; Thomson, A.; Blenkhorn, A.; Singh, B.; Van Gaal, W.; Abhayaratna, W.; Lehman, R.; Roberts-Thomson, P.; Kilian, J.; Coulshed, D.; Catanchin, A.; Colquhoun, D.; Kiat, H.; Eccleston, D.; French, J.; Zimmett, L.; Ayres, B.; Phan, T.; Blombery, P.; Crimmins, D.; O'Donnell, D.; Choi, A.; Astridge, P.; Arstall, M.; Jepson, N.; Binnekamp, M.; Lee, A.; Rogers, J.; Starmer, G.; Carroll, P.; Faunt, J.; Aggarwala, A.; Barry, L.; Batta, C.; Beveridge, R.; Black, A.; Bonner, M.; Boys, J.; Buckley, E.; Campo, M.; Carlton, L.; Connelly, A.; Conway, B.; Cresp, D.; Dimitri, H.; Dixon, S.; Dolman, M.; Duroux, M.; Eskandari, M.; Eslick, R.; Ferreira-Jardim, A.; Fetahovic, T.; Fitzpatrick, D.; Geraghty, R.; Gibbs, J.; Grabek, T.; Modi, M. H.; Hayes, K.; Hegde, M. P.; Hesketh, L.; Hoffmann, B.; Johnson, K.; Juergens, C.; Kassam, I.; Lawlor, V.; Lehman, M.; Lehman, S.; Leung, D.; Mackay, S.; Mackenzie, M.; Mccarthy, C.; Mcintosh, C.; Mckeon, L.; Morrison, H.; Mussap, C.; Myers, J. -D.; Nagalingam, V.; Oldfield, G.; O'May, V.; Palmer, J.; Parsons, L.; Patching, K.; Patching, T.; Paul, V.; Plotz, M.; Preston, S.; Rashad, H.; Ratcliffe, M.; Raynes, S.; Rose, J.; Sanders, L.; Seremetkoska, M.; Setio, H.; Shone, S.; Shrestha, P.; Singh, C.; Singleton, C.; Stoyanov, N.; Sutcliffe, S.; Swaraj, K.; Tarrant, J.; Thomas, N.; Thompson, S.; Tsay, I. M.; Vorster, M.; Waldman, A.; Wallis, L.; Wilford, E.; Wong, K.; Luton, R.; Gupta, M.; Pandey, A. S.; Cheung, S.; Leader, R.; Beaudry, P.; Ayala-Paredes, F.; Berlingieri, J.; Heath, J.; Poirier, G.; Du Preez, M.; Nadeau, R.; Dresser, G.; Dhillon, R.; Hruczkowski, T.; Schweitzer, B.; Coutu, B.; Angaran, P.; Macdonald, P.; Vizel, S.; Fikry, S.; Parkash, R.; Lavoie, A.; Cha, J.; Ramjattan, B.; Bonet, J.; Ahmad, K.; Aro, L.; Aves, T.; Beaudry, K.; Bergeron, C.; Bigcanoe, J.; Bignell, N.; Breakwell, L.; Burke, E.; Carroll, L.; Clarke, B.; Cleveland, T.; Daheb, S.; Dehghani, P.; Denis, I.; Djaidani, Z.; Dorian, P.; Douglass, S.; Dunnigan, J.; Ewert, A.; Farquhar, D.; Fearon, A.; Ferleyko, L.; Fournier, D.; Fox, B.; Grenier, M. -C.; Gulliver, W.; Haveman, K.; Hines, C.; Hines, K.; Jackson, A. M.; Jean, C.; Jethoo, G.; Kahlon, R.; Kelly, S.; Kim, R.; Korley, V.; Kornder, J.; Kwan, L.; Largy, J.; Lewis, C.; Lewis, S.; Mangat, I.; Moor, R.; Navratil, J.; Neas, I.; Otis, J.; Otis, R.; Pandey, M.; Petrie, F.; Pinter, A.; Raines, M.; Roberts, P.; Robinson, M.; Sas, G.; Schulman, S.; Snell, L.; Spearson, S.; Stevenson, J.; Trahey, T.; Wong, S.; Wright, D.; El-Aziz, A. A.; Seif, S. K. A.; El Din, M. G.; El Etriby, S.; Elbahry, A.; El-Etreby, A.; Elkhadem, M.; Katta, A.; Khairy, T.; Mowafy, A.; Nawar, M.; Ohanissian, A.; Reda, A.; Reda, M.; Salem, H.; Sami, N.; Samir, S.; Setiha, M.; Sobhy, M.; Soliman, A.; Taha, N.; Tawfik, M.; Zaatout, E.; Kettles, D.; Bayat, J.; Siebert, H.; Horak, A.; Kelfkens, Y.; Garda, R.; Pillay, T.; Guerra, M.; van Zyl, L.; Theron, H.; Murray, A.; Louw, R.; Greyling, D.; Mntla, P.; Ueckermann, V.; Loghdey, R.; Ismail, S.; Ahmed, F.; Engelbrecht, J.; Ramdass, A.; Maharajh, S.; Oosthuysen, W.; Angel, G.; Bester, C.; Booysen, M.; Boshoff, C.; Cannon, C.; Cassimjee, S.; Chami, C.; Conway, G.; Davids, A.; de Meyer, L.; Du Plessis, G.; Ellis, T.; Henley, L.; Karsten, M.; Loyd, E.; Marks, J.; Mavhusa, L.; Mostert, M.; Page, A.; Rikhotso, L.; Salie, M.; Sasto, J.; Shaik, F.; Skein, A.; Smith, L.; Tarr, G.; Tau, T.; van Zyl, F.; Yousef, G.; Agrawal, A.; Nathani, M.; Ibrahim, M.; Esheiba, E. M.; Singh, R.; Naguib, A.; Abu-Mahfouz, M.; Al Omairi, M.; Al Naeemi, A.; Maruthanayagam, R.; Bazargani, N.; Wassef, A.; Gupta, R.; Khan, M.; Subbaraman, B.; Abdul, A.; Al Mulla, A.; El Bardisy, S.; Haridas, P.; Jadhav, S.; Magdaluyo, K.; Makdad, M.; Maqsood, I.; Mohamed, R.; Sharma, N.; Sharma, R.; Thanzeel, M.; Canosa, R.; Rama, P.; Blumberg, E.; Garcia, J.; Mullen, P.; Wilson, V.; Quick, A.; Ferrick, K.; Kutayli, W. M.; Cox, M.; Franco, M.; Falkowski, S.; Mendelson, R.; Williams, M.; Miller, S.; Beach, S.; Sharma, N.; Alfieri, A.; Gutowski, T.; Haque, I.; Reddy, R.; Ahmed, W.; Delafontaine, P.; Diercks, D.; Theodoro, D.; Remmel, K.; Alberts, M.; Ison, R.; Noveck, H.; Duffy, P.; Pitta, S.; Nishijima, D.; Treasure, C.; Asafu-Adjaye, N.; Ball, K.; Bartlett, M.; Bentley, M.; Bowers, S.; Brown, A.; Browne, A.; Cameron-Watts, J.; Canova, M.; Cassidy, D.; Cervellione, K.; Congal, S.; Depauw, J.; Dickerson, A.; Eley, M.; Evans, L.; Felpel, S.; Ferdinand, K.; Fielder, D.; Gentry, P.; Haideri, A.; Hakimi, F.; Harbour, T.; Hartranft, E.; Hawkins, B.; Headlee, M.; Henson, L.; Herrick, C.; Hicks, T.; Jasinski, S.; Johnson, K.; Jones, A.; Jones, L.; Jones, P.; Karl, S.; Keeling, M.; Kerr, J.; Knowles, P.; Langdon, J.; Lay, M.; Lee, J. A.; Lincoln, T.; Malone, E.; Merliss, A.; Merritt, D.; Minardo, J.; Mooso, B.; Orosco, C.; Palumbo, V.; Parker, M.; Parrott, T.; Paserchia, S.; Pearl, G.; Peterson, J.; Pickelsimer, N.; Purcell, T.; Raynor, J.; Raziano, S.; Richard, C.; Richardson, T.; Robertson, C.; Sage, A.; Sanghera, T.; Shaw, P.; Shoemaker, J.; Smith, K.; Stephanie, B.; Thatcher, A.; Theobald, H.; Thompson, N.; Treasure, L.; Tripti, T.; Verdi, C.; Worthy, V.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315579
Citazioni:
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients with Atrial Fibrillation: A Report from the GARFIELD-AF Registry / Corbalan, R., Bassand, J.-P., Illingworth, L., Ambrosio, G., Camm, A.J., Fitzmaurice, D.A., Fox, K.A.A., Goldhaber, S.Z., Goto, S., Haas, S., Kayani, G., Mantovani, L.G., Misselwitz, F., Pieper, K.S., Turpie, A.G.G., Verheugt, F.W.A., Kakkar, A.K., Hacke, W., Gersh, B.J., Luciardi, H.L., et al.. - In: JAMA CARDIOLOGY. - ISSN 2380-6583. - 4:6(2019), pp. 526-548. [10.1001/jamacardio.2018.4729]
Abstract:
Importance: Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes. Objective: To assess the treatment strategies and 1-year clinical outcomes of antithrombotic and CHF therapies for patients... with newly diagnosed AF with concomitant CHF stratified by etiology (ischemic cardiomyopathy [ICM] vs nonischemic cardiomyopathy [NICM]). Design, Setting, and Participants: The GARFIELD-AF registry is a prospective, noninterventional registry. A total of 52014 patients with AF were enrolled between March 2010 and August 2016. A total of 11738 patients 18 years and older with newly diagnosed AF (≤6 weeks' duration) and at least 1 investigator-determined stroke risk factor were included. Data were analyzed from December 2017 to September 2018. Exposures: One-year follow-up rates of death, stroke/systemic embolism, and major bleeding were assessed. Main Outcomes and Measures: Event rates per 100 person-years were estimated from the Poisson model and Cox hazard ratios (HRs) and 95% confidence intervals. Results: The median age of the population was 71.0 years, 22987 of 52013 were women (44.2%) and 31958 of 52014 were white (61.4%). Of 11738 patients with CHF, 4717 (40.2%) had ICM and 7021 (59.8%) had NICM. Prescription of oral anticoagulant and antiplatelet drugs was not balanced between groups. Oral anticoagulants with or without antiplatelet drugs were used in 2753 patients with ICM (60.1%) and 5082 patients with NICM (73.7%). Antiplatelets were prescribed alone in 1576 patients with ICM (34.4%) and 1071 patients with NICM (15.5%). Compared with patients with NICM, use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (72.6% [3439] vs 60.3% [4236]) and of β blockers (63.3% [2988] vs 53.2% [3737]) was higher in patients with ICM. Rates of all-cause and cardiovascular death per 100 patient-years were significantly higher in the ICM group (all-cause death: ICM, 10.2; 95% CI, 9.2-11.1; NICM, 7.0; 95% CI, 6.4-7.6; cardiovascular death: ICM, 5.1; 95% CI, 4.5-5.9; NICM, 2.9; 95% CI, 2.5-3.4). Stroke/systemic embolism rates tended to be higher in ICM groups compared with NICM groups (ICM, 2.0; 95% CI, 1.6-2.5; NICM, 1.5; 95% CI, 1.3-1.9). Major bleeding rates were significantly higher in the ICM group (1.1; 95% CI, 0.8-1.4) compared with the NICM group (0.7; 95% CI, 0.5-0.9). Conclusions and Relevance: Patients with ICM received oral anticoagulants with or without antiplatelet drugs less frequently and antiplatelets alone more frequently than patients with NICM, but they received angiotensin-converting enzyme inhibitors/angiotensin receptor blockers more often than patients with NICM. All-cause and cardiovascular death rates were higher in patients with ICM than patients with NICM. Trial Registration: ClinicalTrials.gov Identifier: NCT01090362.
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Incidence and Clinical Impact of Recurrent Takotsubo Syndrome: Results From the GEIST Registry
Anno: 2019
Rivista: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE
Autori/autrici: El-Battrawy, I.; Santoro, F.; Stiermaier, T.; Moller, C.; Guastafierro, F.; Novo, G.; Novo, S.; Mariano, E.; Fratesi, Romeo; Fratesi, Romeo; Thiele, H.; Guerra, F.; Capucci, A.; Giannini, I.; Brunetti, N. D.; Eitel, I.; Akin, I.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276740
Citazioni:
Incidence and Clinical Impact of Recurrent Takotsubo Syndrome: Results From the GEIST Registry / El-Battrawy, I., Santoro, F., Stiermaier, T., Moller, C., Guastafierro, F., Novo, G., Novo, S., Mariano, E., Fratesi, R., Fratesi, R., Thiele, H., Guerra, F., Capucci, A., Giannini, I., Brunetti, N.D., Eitel, I., Akin, I.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 8:9(2019), p. e010753. [10.1161/JAHA.118.010753]
Abstract:
Background: Current literature only reports variable information from single-center studies on the recurrence rate, the complications, and the outcome of patients with Takotsubo syndrome (TTS) experiencing recurrent TTS. Therefore, a detailed description of clinical characteristics, predictors, and ...the prognostic impact of patients with TTS and recurrences in a multicenter registry is needed. Methods and Results: We analyzed 749 patients with TTS from 9 European centers being part of the international, multicenter GEIST (German Italian Stress Cardiomyopathy) Registry. Patients were divided into the recurrence group and the nonrecurrence group. The recurrence rate at a median follow-up of 830 days (interquartile range, 118–1701 days) was 4%. Most recurrences were documented in the first 5 years after the index TTS episode. Up to 2 TTS recurrences were documented in 2 of 30 patients (6%). A variable ballooning pattern (n=6, 0.8%) with, in particular, involvement of the right ventricular occurred in 3 cases (0.4%) at the recurrence event. Except for the higher presence of arterial hypertension (86.7% versus 68.3%; P=0.03) in the recurrence group, no other baseline characteristics were different between groups. Observation of TTS complications during follow-up, including stroke, thromboembolic events, in-hospital death, and cardiogenic shock, revealed no significant differences between groups (P>0.05), except the higher presence of pulmonary edema in the recurrence group versus the nonrecurrence group (13.3% versus 4.9%; P=0.04). Conclusions: The incidence of TTS recurrence is estimated to be 4% in this multicenter TTS registry. A variable TTS pattern at recurrence is common in up to 20% of recurrence cases.
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Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation
Anno: 2019
Rivista: NEW ENGLAND JOURNAL OF MEDICINE
Autori/autrici: Compagnucci, P; Guerra, F; Capucci, A
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276741
Citazioni:
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation / Compagnucci, P., Guerra, F., Capucci, A.. - In: THE NEW ENGLAND JOURNAL OF MEDICINE. - ISSN 0028-4793. - 381:4(2019), pp. 386-386. [10.1056/NEJMc1906729]

Is there an 'atherosclerotic continuum' from angina with unobstructed coronary arteries to MINOCA?
Anno: 2019
Rivista: EUROPEAN HEART JOURNAL
Autori/autrici: Ciliberti, G.; Guerra, F.; Coiro, S.; Capucci, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276736
Citazioni:
Is there an 'atherosclerotic continuum' from angina with unobstructed coronary arteries to MINOCA? / Ciliberti, G., Guerra, F., Coiro, S., Capucci, A.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 40:24(2019), pp. 1987-1987. [10.1093/eurheartj/ehy914]

Flecainide: Electrophysiological properties, clinical indications, and practical aspects
Anno: 2019
Rivista: PHARMACOLOGICAL RESEARCH
Autori/autrici: Paolini, E.; Stronati, G.; Guerra, F.; Capucci, A.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276748
Citazioni:
Flecainide: Electrophysiological properties, clinical indications, and practical aspects / Paolini, E., Stronati, G., Guerra, F., Capucci, A.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 148:(2019), p. 104443. [10.1016/j.phrs.2019.104443]
Abstract:
Over the last 35 years, flecainide proved itself one of the most commonly used arrhythmic drugs, expanding its original indication for ventricular arrhythmias and results nowadays as the cornerstone of the rhythm control strategy in atrial fibrillation management of patients without structural heart... disease. While the increased mortality associated with flecainide in the Cardiac Arrhythmia Suppression Trial (CAST) still casts his shadow over flecainide clinical profile, this compound has subsequently demonstrated safe and is now used successfully for a plethora of indications, including pharmacological cardioversion of atrial fibrillation, cathecolaminergic polymorphic ventricular tachycardia, supraventricular tachyarrhythmias and ventricular pre-excitation. Moreover, the recent marketing of a controlled release formulation, along with the intravenous and immediate release formulations, increased the armamentarium to the clinician's disposal while improving patients’ compliance. In the present paper, we offer a comprehensive review of the anti-arrhythmic effects of flecainide, detailing its electrophysiological properties, its effects on the conduction system, its clinical use and the major side effects and contraindications in clinical practice.
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Predictors of NOAC versus VKA use for stroke prevention in patients with newly diagnosed atrial fibrillation: Results from GARFIELD-AF
Anno: 2019
Rivista: AMERICAN HEART JOURNAL
Autori/autrici: Haas, S.; Camm, A. J.; Bassand, J. -P.; Angchaisuksiri, P.; Cools, F.; Corbalan, R.; Gibbs, H.; Jacobson, B.; Koretsune, Y.; Mantovani, L. G.; Misselwitz, F.; Panchenko, E.; Ragy, H. I.; Stepinska, J.; Turpie, A. G.; Sawhney, J. P.; Steffel, J.; Lim, T. W.; Pieper, K. S.; Virdone, S.; Verheugt, F. W.; Kakkar, A. K.; Fitzmaurice, D. A.; Goto, S.; Hacke, W.; Gersh, B. J.; Luciardi, H. L.; Brodmann, M.; Barretto, A. C. P.; Connolly, S. J.; Spyropoulos, A.; Eikelboom, J.; Hu, D.; Jansky, P.; Nielsen, J. D.; Raatikainen, P.; Le Heuzey, J. -Y.; Darius, H.; Keltai, M.; Kakkar, S.; Agnelli, G.; Ambrosio, G.; Diaz, C. J. S.; ten Cate, H.; Atar, D.; Oh, S.; Vinolas, X.; Rosenqvist, M.; Parkhomenko, A.; Al Mahmeed, W.; Chen, K. N.; Zhao, Y. S.; Zhang, H. Q.; Chen, J. Z.; Cao, S. P.; Wang, D. W.; Yang, Y. J.; Li, W. H.; Yin, Y. H.; Tao, G. Z.; Yang, P.; Chen, Y. M.; He, S. H.; Wang, Y.; Wang, Y.; Fu, G. S.; Li, X.; Wu, T. G.; Cheng, X. S.; Yan, X. W.; Zhao, R. P.; Chen, M. S.; Xiong, L. G.; Chen, P.; Jiao, Y.; Guo, Y.; Xue, L.; Wang, F. Z.; Li, H.; Yang, Z. M.; Bai, C. L.; Chen, J.; Chen, J. Y.; Chen, X.; Feng, S.; Fu, Q. H.; Gao, X. J.; Guo, W. N.; He, R. H.; He, X. A.; Hu, X. S.; Huang, X. F.; Li, B.; Li, J.; Li, L.; Li, Y. H.; Liu, T. T.; Liu, W. L.; Liu, Y. Y.; Lu, Z. C.; Luo, X. L.; Ma, T. Y.; Peng, J. Q.; Sheng, X.; Shi, X. J.; Sun, Y. H.; Tian, G.; Wang, K.; Wang, L.; Wu, R. N.; Xie, Q.; Xu, R. Y.; Yang, J. S.; Yang, L. L.; Yang, Q.; Ye, Y.; Yu, H. Y.; Yu, J. H.; Yu, T.; Zhai, H.; Zhan, Q.; Zhang, G. S.; Zhang, Q.; Zhang, R.; Zhang, Y.; Zheng, W. Y.; Zhou, B.; Zhou, Z. H.; Zhu, X. Y.; Jadhav, P.; Durgaprasad, R.; Ravi Shankar, A. G.; Rajput, R. K.; Bhargava, K.; Sarma, R.; Srinivas, A.; Roy, D.; Nagamalesh, U. M.; Chopda, M.; Kishore, R.; Kulkarni, G.; Chandwani, P.; Pothiwala, R. A.; Padinhare Purayil, M.; Shah, S.; Chawla, K.; Kothiwale, V. A.; Raghuraman, B.; Vijayaraghavan, G.; Vijan, V. M.; Bantwal, G.; Bisne, V.; Khan, A.; Gupta, J. B.; Kumar, S.; Jain, D.; Abraham, S.; Adak, D.; Barai, A.; Begum, H.; Bhattacharjee, P.; Dargude, M.; Davies, D.; Deshpande, B.; Dhakrao, P.; Dhyani, V.; Duhan, S.; Earath, M.; Ganatra, A.; Giradkar, S.; Jain, V.; Karthikeyan, R.; Kasala, L.; Kaur, S.; Krishnappa, S.; Lawande, A.; Lokesh, B.; Madarkar, N.; Meena, R.; More, P.; Naik, D.; Prashanth, K.; Rao, M.; Rao, N. M.; Sadhu, N.; Shah, D.; Sharma, M.; Shiva, P.; Singhal, S.; Suresh, S.; Vanajakshamma, V.; Panse, S. G.; Kanamori, S.; Yamamoto, K.; Kumagai, K.; Katsuda, Y.; Sadamatsu, K.; Toyota, F.; Mizuno, Y.; Misumi, I.; Noguchi, H.; Ando, S.; Suetsugu, T.; Minamoto, M.; Oda, H.; Shiraishi, K.; Adachi, S.; Chiba, K.; Norita, H.; Tsuruta, M.; Koyanagi, T.; Ando, H.; Higashi, T.; Okada, K.; Azakami, S.; Komaki, S.; Kumeda, K.; Murayama, T.; Matsumura, J.; Oba, Y.; Sonoda, R.; Goto, K.; Minoda, K.; Haraguchi, Y.; Suefuji, H.; Miyagi, H.; Kato, H.; Nakamura, T.; Nakamura, T.; Nandate, H.; Zaitsu, R.; Fujiura, Y.; Yoshimura, A.; Numata, H.; Ogawa, J.; Tatematsu, H.; Kamogawa, Y.; Murakami, K.; Wakasa, Y.; Yamasawa, M.; Maekawa, H.; Abe, S.; Kihara, H.; Tsunoda, S.; Saito, K.; Saito, K.; Fudo, T.; Obunai, K.; Tachibana, H.; Oba, I.; Kuwahata, T.; Higa, S.; Gushiken, M.; Eto, T.; Yoshida, H.; Ikeda, D.; Fujiura, Y.; Ishizawa, M.; Nakatsuka, M.; Murata, K.; Ogurusu, C.; Shimoyama, M.; Akutsu, M.; Takamura, I.; Hoshino, F.; Yokota, N.; Iwao, T.; Tsuchida, K.; Takeuchi, M.; Hatori, Y.; Kitami, Y.; Nakamura, Y.; Oyama, R.; Ageta, M.; Oda, H.; Go, Y.; Mishima, K.; Unoki, T.; Morii, S.; Shiga, Y.; Sumi, H.; Nagatomo, T.; Sanno, K.; Fujisawa, K.; Atsuchi, Y.; Nagoshi, T.; Seto, T.; Tabuchi, T.; Kameko, M.; Nii, K.; Oshiro, K.; Takezawa, H.; Nagano, S.; Miyamoto, N.; Iwaki, M.; Nakamura, Y.; Fujii, M.; Okawa, M.; Abe, M.; Abe, M.; Abe, M.; Saito, T.; Mito, T.; Nagao, K.; Minami, J.; Mita, T.; Sakuma, I.; Taguchi, T.; Marusaki, S.; Doi, H.; Tanaka, M.; Fujito, T.; Matsuta, M.; Kusumoto, T.; Kakinoki, S.; Ashida, K.; Yoshizawa, N.; Agata, J.; Arasaki, O.; Manita, M.; Ikemura, M.; Fukuoka, S.; Murakami, H.; Matsukawa, S.; Hata, Y.; Taniguchi, T.; Ko, T.; Kubo, H.; Imamaki, M.; Akiyama, M.; Inagaki, M.; Odakura, H.; Ueda, T.; Katsube, Y.; Nakata, A.; Watanabe, H.; Techigawara, M.; Igarashi, M.; Taga, K.; Kimura, T.; Tomimoto, S.; Shibuya, M.; Nakano, M.; Ito, K.; Seo, T.; Hiramitsu, S.; Hosokawa, H.; Hoshiai, M.; Hibino, M.; Miyagawa, K.; Horie, H.; Sugishita, N.; Shiga, Y.; Soma, A.; Neya, K.; Yoshida, T.; Yoshida, T.; Mizuguchi, M.; Ishiguro, M.; Minagawa, T.; Wada, M.; Mukawa, H.; Okuda, F.; Nagasaka, S.; Abe, Y.; Adachi, S.; Adachi, S.; Adachi, T.; Akahane, K.; Amano, T.; Aoki, K.; Aoyama, T.; Arai, H.; Arima, S.; Arino, T.; Asano, H.; Asano, T.; Azuma, J.; Baba, T.; Betsuyaku, T.; Chibana, H.; Date, H.; Doiuchi, J.; Emura, Y.; Endo, M.; Fujii, Y.; Fujiki, R.; Fujisawa, A.; Fujisawa, Y.; Fukuda, T.; Fukui, T.; Furukawa, N.; Furukawa, T.; Furumoto, W.; Goto, T.; Hamaoka, M.; Hanazono, N.; Hasegawa, K.; Hatsuno, T.; Hayashi, Y.; Higuchi, K.; Hirasawa, K.; Hirayama, H.; Hirose, M.; Hirota, S.; Honda, M.; Horie, H.; Ido, T.; Iiji, O.; Ikeda, H.; Ikeda, K.; Ikeoka, K.; Imaizumi, M.; Inaba, H.; Inoue, T.; Iseki, F.; Ishihara, A.; Ishioka, N.; Ito, N.; Iwase, T.; Kakuda, H.; Kamata, J.; Kanai, H.; Kanda, H.; Kaneko, M.; Kano, H.; Kasai, T.; Kato, T.; Kato, Y.; Kawada, Y.; Kawai, K.; Kawakami, K.; Kawakami, S.; Kawamoto, T.; Kawano, S.; Kim, J.; Kira, T.; Kitazawa, H.; Kitazumi, H.; Kito, T.; Kobayashi, T.; Koeda, T.; Kojima, J.; Komatsu, H.; Komatsu, I.; Koshibu, Y.; Kotani, T.; Kozuka, T.; Kumai, Y.; Kumazaki, T.; Maeda, I.; Maeda, K.; Maruyama, Y.; Matsui, S.; Matsushita, K.; Matsuura, Y.; Mineoi, K.; Mitsuhashi, H.; Miura, N.; Miyaguchi, S.; Miyajima, S.; Miyamoto, H.; Miyashita, A.; Miyata, S.; Mizuguchi, I.; Mizuno, A.; Mori, T.; Moriai, O.; Morishita, K.; Murai, O.; Nagai, S.; Nagai, S.; Nagata, E.; Nagata, H.; Nakagomi, A.; Nakahara, S.; Nakamura, M.; Nakamura, R.; Nakanishi, N.; Nakayama, T.; Nakazato, R.; Nanke, T.; Nariyama, J.; Niijima, Y.; Niinuma, H.; Nishida, Y.; Nishihata, Y.; Nishino, K.; Nishioka, H.; Nishizawa, K.; Niwa, I.; Nomura, K.; Nomura, S.; Nozoe, M.; Ogawa, T.; Ohara, N.; Okada, M.; Okamoto, K.; Okita, H.; Okuyama, M.; Ono, H.; Ono, T.; Pearce, Y. O.; Oriso, S.; Ota, A.; Otaki, E.; Saito, Y.; Sakai, H.; Sakamoto, N.; Sakamoto, Y.; Samejima, Y.; Sasagawa, Y.; Sasaguri, H.; Sasaki, A.; Sasaki, T.; Sato, K.; Sato, K.; Sawano, M.; Seki, S.; Sekine, Y.; Seta, Y.; Sezaki, K.; Shibata, N.; Shiina, Y.; Shimono, H.; Shimoyama, Y.; Shindo, T.; Shinohara, H.; Shinohe, R.; Shinozuka, T.; Shirai, T.; Shiraiwa, T.; Shozawa, Y.; Suga, T.; Sugimoto, C.; Suzuki, K.; Suzuki, K.; Suzuki, S.; Suzuki, S.; Suzuki, S.; Suzuki, Y.; Tada, M.; Taguchi, A.; Takagi, T.; Takagi, Y.; Takahashi, K.; Takahashi, S.; Takai, H.; Takanaka, C.; Take, S.; Takeda, H.; Takei, K.; Takenaka, K.; Tana, T.; Tanabe, G.; Taya, K.; Teragawa, H.; Tohyo, S.; Toru, S.; Tsuchiya, Y.; Tsuji, T.; Tsuzaki, K.; Uchiyama, H.; Ueda, O.; Ueyama, Y.; Wakaki, N.; Wakiyama, T.; Washizuka, T.; Watanabe, M.; Yamada, T.; Yamagishi, T.; Yamaguchi, H.; Yamamoto, K.; Yamamoto, K.; Yamamoto, K.; Yamamoto, T.; Yamaura, M.; Yamazoe, M.; Yasui, K.; Yokoyama, Y.; Yoshida, K.; Ching, C. K.; Foo, C. G.; Chow, J. H.; Chen, D. D.; Jaufeerally, F. R.; Lee, Y. M.; Li, H.; Lim, G.; Lim, W. T.; Thng, S.; Yap, S. Y.; Yeo, C.; Pak, H. N.; Kim, J. -B.; Kim, J. H.; Jang, S. -W.; Kim, D. H.; Kim, J.; Ryu, D. R.; Park, S. W.; Kim, D. -K.; Choi, D. J.; Oh, Y. S.; Cho, M. -C.; Kim, S. -H.; Jeon, H. -K.; Shin, D. -G.; Park, J. S.; Park, H. K.; Han, S. -J.; Sung, J. H.; Cho, J. -G.; Nam, G. -B.; On, Y. K.; Lim, H. E.; Kwak, J. J.; Cha, T. -J.; Hong, T. J.; Park, S. H.; Yoon, J. H.; Kim, N. -H.; Kim, K. -S.; Jung, B. C.; Hwang, G. -S.; Kim, C. -J.; Kim, D. B.; Ahn, J. J.; An, H. J.; Bae, H.; Baek, A. L.; Chi, W. J.; Choi, E. A.; Choi, E. H.; Choi, H. K.; Choi, H. S.; Han, S.; Heo, E. S.; Her, K. O.; Hwang, S. W.; Jang, E. M.; Jang, H. -S.; Jang, S.; Jeon, H. -G.; Jeon, S. R.; Jeon, Y. R.; Jeong, H. K.; Jung, I. -A.; Kim, H. J.; Kim, H. J.; Kim, J. S.; Kim, J. S.; Kim, J. A.; Kim, K. T.; Kim, M. S.; Kim, S. H.; Kim, S. H.; Kim, Y. -I.; Lee, C. S.; Lee, E. H.; Lee, G. H.; Lee, H. Y.; Lee, H. -Y.; Lee, K. H.; Lee, K. R.; Lee, M. S.; Lee, M. -Y.; Lee, R. W.; Lee, S. E.; Lee, S. H.; Lee, S.; Lee, W. Y.; Noh, I. K.; Park, A. R.; Park, B. R.; Park, H. N.; Park, J. H.; Park, M.; Park, Y.; Seo, S. -Y.; Shim, J.; Sim, J. H.; Sohn, Y. M.; Son, W. S.; Son, Y. S.; Song, H. J.; Wi, H. K.; Woo, J. J.; Ye, S.; Yim, K. H.; Yoo, K. M.; Yoon, E. J.; Yun, S. Y.; Chawanadelert, S.; Mongkolwongroj, P.; Kanokphatcharakun, K.; Cheewatanakornkul, S.; Laksomya, T.; Pattanaprichakul, S.; Chantrarat, T.; Rungaramsin, S.; Silaruks, S.; Wongcharoen, W.; Siriwattana, K.; Likittanasombat, K.; Katekangplu, P.; Boonyapisit, W.; Cholsaringkarl, D.; Chatlaong, B.; Chattranukulchai, P.; Santanakorn, Y.; Hutayanon, P.; Khunrong, P.; Bunyapipat, T.; Jai-Aue, S.; Kaewsuwanna, P.; Bamungpong, P.; Gunaparn, S.; Hongsuppinyo, S.; Inphontan, R.; Khattaroek, R.; Khunkong, K.; Kitmapawanont, U.; Kongsin, C.; Naratreekoon, B.; Ninwaranon, S.; Phangyota, J.; Phrommintikul, A.; Phunpinyosak, P.; Pongmorakot, K.; Poomiphol, S.; Pornnimitthum, N.; Pumprueg, S.; Ratchasikaew, S.; Sanit, K.; Sawanyawisuth, K.; Silaruks, B.; Sirichai, R.; Sriwichian, A.; Suebjaksing, W.; Sukklad, P.; Suttana, T.; Tangsirira, A.; Thangpet, O.; Tiyanon, W.; Vorasettakarnkij, Y.; Wisaratapong, T.; Wongtheptien, W.; Wutthimanop, A.; Yawila, S.; Altun, A.; Ozdogru, I.; Ozdemir, K.; Yilmaz, O.; Aydinlar, A.; Yilmaz, M. B.; Yeter, E.; Ongen, Z.; Cayli, M.; Pekdemir, H.; Ozdemir, M.; Sucu, M.; Sayin, T.; Demir, M.; Yorgun, H.; Ersanli, M.; Okuyan, E.; Aras, D.; Abdelrahman, H.; Aktas, O.; Alpay, D.; Aras, F.; Bireciklioglu, M. F.; Budeyri, S.; Buyukpapuc, M.; Caliskan, S.; Esen, M.; Felekoglu, M. A.; Genc, D.; Ikitimur, B.; Karaayvaz, E. B.; Karatas, S. K.; Okutucu, S.; Ozcelik, E.; Quisi, A.; Sag, H.; Sahiner, L.; Sayin, B. Y.; Seker, T.; Alkan, D. U.; Yildirim, E.; Yildirim, R.; Yilmaz, F.; Yuksekdag, V.; Vensentini, N.; Ingaramo, A. C.; Sambadaro, G. A.; Caputi, V. F.; Berman, S. G.; Dragotto, P.; Kleiban, A. J.; Centurion, N.; Giacomi, G.; Guerrero, R. A. A.; Conde, D.; Zapata, G.; Di Paola, L. A.; Ramos, J. L.; Dran, R. D.; Egido, J.; Fernandez, A. A.; Fosco, M. J.; Sassone, S.; Sinisi, V. A.; Cartasegna, L. R.; Berli, M. A.; Vilamajo, O. A. G.; Ferroni, F.; Alaguibe, E. D.; D'Amelio, A. A.; Arabetti, C.; Arias, L.; Belardi, J. A.; Bergesio, L.; Berli, F.; Berli, M.; Borchowiec, S.; Buzzetti, C.; Cabrini, R.; Campisi, V.; Cappi, A. L.; Carrizo, R.; Berra, F. C.; Costabel, J. P.; Costamagna, O. J. A.; Damonte, A. A.; De Urquiza, I. N.; Diez, F.; Eden, M. F.; Fanuele, M.; Voena, F. F.; Torres, M. F.; Funosas, C.; Giacomi, M. P.; Gimenez, C. H.; Gurfinkel, E. P.; Had, M. D. L. M.; Hansen, V.; Hrabar, A. D.; Ingratta, M.; Lopez, A.; Maehara, G.; Maffei, L.; Martinelli, A.; Martinelli, C.; Matkovich, J.; Mautner, B.; Meirino, A.; Munguia, R.; Navarro, A.; Novas, V.; Prados, G. P.; Pontoriero, J.; Potito, R. N.; Ricotti, C.; Rodriguez, M. A.; Rolandi, F.; Palladino, M. E. S.; Salinger, M.; Sanziani, L. S.; Schygiel, P. O.; Sossich, A.; Tinto, J. F.; Tonelli, L.; Tufare, A. L.; Vallejo, M.; Yunis, M. E.; Zillo, M.; Zurbrigk, F. J.; Filho, D. C. S.; Jaber, J.; Armaganijan, D.; Neto, J. F.; Steffens, A.; de Souza, W. K. S. B.; de Souza Neto, J. D.; Ribeiro, J. M.; Teixeira, M. S.; Rossi, P. R. F.; Pires, L.; Moreira, D.; Jorge, J. C. M.; Filho, A. M. L.; Bodanese, L. C.; Montera, M. W.; Del Carlo, C. H.; Rodrigues, T. D. R.; da Costa, F. A. A.; Lopes, A.; Lopes, R.; Araujo, G. R.; Manenti, E. R. F.; Saraiva, J. F. K.; Braga, J. C. F.; Negri, A.; Souto, L.; Moncada, C.; Precoma, D. B.; Roquette, F.; Reis, G.; Filho, R. A. R.; Figueiredo, E. L.; Botelho, R. V.; Tavares, C. M. D. F.; Frack, C. R. C.; Saad, J. A.; Finimundi, H. C.; Pisani, C.; Chemello, D.; Martins, M. P.; Franca, C. C. B.; Alban, F.; Rosito, G. B. A.; Moraes Junior, J. B. M. X.; Tumelero, R. T.; Maia, L. N.; de Almeida, R. S.; do Carmo Borges, N. C.; Ferreira, L. G. G.; Agliardi, P.; Gomes, J. A. O.; Araujo, V.; Nakazone, M. A.; Barbosa, T.; Barroso, S.; Falchetto, E. B.; Lopes, H. B.; Lemos, M. A. B. T.; Biazus, G.; Queiroz, L. B.; Camazzola, F. E.; Caporale, M.; Cardoso Boscato, S.; Chieza, F.; Chokr, M. O.; Mingireanov, R. C.; Goes, N. C.; Correa, C.; Costa, M.; Ortiz, C. C.; da Silva, L. S.; Paulitsch, F. D. S.; da Silveira, J. A.; Daros, E.; de Araujo, G. R.; Del Monaco, M. I.; Dias, C.; Dias, M. A.; Wainstein, A. P. D.; Pizzato, P. E.; Esteves, D. C.; Fabri, P.; Fonseca, T. F. L.; Fernandes, E.; Fonseca, C.; Costantini, C. R. F.; Ferraz, R. F.; Freire, F.; Gottardo, P.; Guanaes, D.; Guizzardi, S.; Magedanz, E. H.; Igansi, F.; Jannuzzi, F.; Junior, G.; Komar, D.; Lino, E. G.; Lopes, D.; Junior, O. L. D. S.; Lustosa, E.; Macagnan, A. P.; Marinho, M. C.; Mazzoni, M.; Melo, G.; Mortari, L.; Mouco, O. M. C. C.; Vital, C. N.; Ormundo, C.; Emmer, S. O.; Palmegiani, E.; Pavani, R.; Pereira, L.; Pereira, V. L.; Perreira, R.; Poletti, S.; Fortunato, S. C. Q.; Queirantes, C.; Pereira, N. R.; Rech, R. L.; Ribeiro, S.; Rodrigues, A.; Roesch, H.; Reichert, T. R.; Santos, D.; Santos, I.; Santos, M.; Seroqui, M. V.; Silva, S.; Soares, L.; Spolaor, L.; Stoll, C.; Duda, N. T.; Trama, L.; Unterkircher, B.; Valois, M. V.; Vargas, T.; Viana, T.; Vicente, C.; Armaganijan, L. V.; Homem, R. V.; Torres, L. 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A.; Avena, R.; Chavarria, M.; Espinosa, I.; Silva, F. F.; Nava, R. H. G.; Godoy, K.; Felix, E. J. G.; Garcia, C. L. G.; Salas, L. G. G.; Guajardo, P.; Gonzalez, S. H.; Izquierdo, T.; Ortiz, M. C. M.; Vasquez, D. M.; Mendoza, N.; Morales, J.; Nikitina, N.; Aybar, S. O.; Ortiz, A.; Macias, P. P.; Perez, F.; Sanchez, J. A. P.; Toledano, S. P.; Gonzalez, M. R.; Ramos, C. R.; Castro, V. R.; Cardona, G. R.; Cornejo, M. R.; Salinas, A.; Santana, G.; Perez, P. S.; Castaneda, A. C. T.; Cortes, R. 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B.; Marquand, A.; Destrac, S.; Piot, O.; Delarche, N.; Cebron, J. -P.; Boveda, S.; Guenoun, M.; Guedj-Meynier, D.; Galley, D.; Ohayon, J.; Assouline, S.; Zuber, M.; Amarenco, P.; Ellie, E.; Kadouch, J.; Fournier, P. -Y.; Huberman, J. -P.; Lemaire, M.; Rodier, G.; Milandre, L.; Vandamme, X.; Sibon, I.; Neau, J. -P.; Mahagne, M. H.; Mielot, A.; Bonnefoy, M.; Churet, J. -B.; Navarre, V.; Sellem, F.; Monniot, G.; Boyes, J. -P.; Doucet, B.; Martelet, M.; Obadia, D.; Crousillat, B.; Mouallem, J.; Bearez, E.; Nazeyrollas, P.; Brugnaux, J. 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M.; Martini, G.; Tessitori, M.; Cappelli, R.; Poli, D.; Quintavalla, R.; Melone, F.; Cosmi, F.; Pizzini, A.; Piseddu, G.; Fanelli, R.; Latella, C.; Santi, R.; Pancaldi, L.; De Cristofaro, R.; Palareti, G.; De Blasio, A.; Salerno Uriarte, J.; Minetti, F.; Pogliani, E. M.; Lonati, L. M.; Accogli, M.; Ciampani, N.; Malengo, S.; Feola, M.; Raisaro, A.; Fattore, L.; Grilli, P.; Germini, F.; Settimi, M.; Alunni, M.; Duranti, G.; Tedeschi, L.; Baglioni, G.; Avanzino, G.; Berardi, M.; Pannacci, V.; Giombolini, A.; Nicoli, S.; Scarponi, T.; Allasia, B.; Ricciarini, P.; Nasorri, R.; Argena, A.; Bossolasco, P.; Ronchini, P.; Filippi, A.; Tradati, F.; Bulla, C.; Donzelli, L.; Foppa, L.; Bottarelli, M. L.; Tomasello, A.; Mauric, A.; Femiano, C.; Reggio, R.; Lillo, F.; Mariani, A.; Forcignano, F.; Volpe, M.; D'Avino, M.; Bongiorni, M. G.; Severi, S.; Capucci, A.; Lodigiani, C.; Salomone, E.; Serviddio, G.; Tondo, C.; Golino, P.; Mazzone, C.; Iacopino, S.; Pengo, V.; Galvani, M.; Moretti, L.; Ambrosino, P.; Banfi, E.; Biagioli, V.; Bianchi, A.; Boggian, G.; Breschi, M.; Brusorio, S.; Calcagnoli, F.; Campagna, G.; Carpenedo, M.; Ciabatta, C.; Ciliberti, G.; Cimmino, G.; D'Arienzo, C.; Di Gennaro, L.; Fedele, M.; Ferrini, P. M.; Granzow, K.; Guazzaloca, G.; Guerra, F.; Lo Buglio, A.; Longo, S.; Macellari, F.; Mesolella, E.; Mollica Poeta, E.; Occhilupo, P.; Oriana, V.; Rangel, G.; Salomone, L.; Scaccianoce, A.; Scarone, C.; Segreti, L.; Sottilota, G.; Villani, R.; Zecca, C.; Ruiter, J. H.; Klomps, H.; Bongaerts, M.; Pieterse, M. G. C.; Guldener, C.; Herrman, J. -P.; Lochorn, G.; Lucassen, A.; Adriaansen, H.; The, S. H. K.; Nierop, P. R.; Hoogslag, P. A. M.; Hermans, W.; Groenemeijer, B. E.; Terpstra, W.; Buiks, C.; Boersma, L. V. A.; Boersma-Slootweg, M.; Bosman, F.; Bosschaert, M.; Bruin, S.; Danse, I.; De Graaf, J.; de Graauw, J.; Debordes, M.; Dols, S.; Geerlings, F.; Gorrebeeck, K.; Jerzewski, A.; Jetten, W.; Kelderman, M.; Kloosterman, T.; Koomen, E. M.; Krikken, J.; Melman, P.; Mulder, R.; Pronk, A.; Stallinga-de Vos, A.; te Kaat, J.; Tonino, P.; Uppelschoten, B.; van de Loo, R.; van der Kley, T.; van Leeuwen, G.; van Putten, J. J.; Westerman, L.; Berge, E.; Sirnes, P. A.; Gjertsen, E.; Hole, T.; Erga, K.; Hallaraker, A.; Skjelvan, G.; Ostrem, A.; Ghezai, B.; Svilaas, A.; Christersson, P.; Oien, T.; Hoegh Henrichsen, S.; Berg-Johansen, J.; Otterstad, J. E.; Antonsen, H.; Ausen, K.; Claussen, H.; Dominguez, I.; Jekthammer, A.; Lensebraaten, A. 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K.; Kremis, E.; Kruczyk, D.; Krzesiak-Lodyga, A.; Krzyzanowski, M.; Kurdzielewicz, W.; Kustrzycka-Kratochwil, D.; Lesniewska-Krynska, D.; Leszczynski, J.; Lewicka, E.; Lichota, E.; Lip, K.; Loboz-Rudnicka, M.; Luka, J.; Lysek-Jozefowicz, A.; Machnikowska, M.; Majewska, K.; Mariankowski, R.; Markiewicz, A.; Mazur, M.; Metzgier-Gumiela, A.; Miedlar, E.; Mielcarek, M.; Neubauer-Geryk, J.; Niedek, J.; Niemirycz-Makurat, A.; Nowak, A.; Nowak, S.; Opielowska-Nowak, B.; Ozgowicz, M.; Pawelska-Buczen, A.; Pawlik-Rak, E.; Piotrowicz, R.; Ptaszynski, P.; Raczynska, A.; Rogowski, W.; Romanek, J.; Romaszkiewicz, R.; Rostoff, P.; Roszczyk, N.; Rozewska-Furmanek, D.; Rychta, J.; Rzyczkowska, B.; Sidor, A.; Skalska, J.; Smichura, M.; Splawski, M.; Staneta, P.; Staniszewska, E.; Starak-Marciniak, J.; Stopyra-Poczatek, M.; Sukiennik-Kujawa, M.; Szafranski, J.; Szalecki, P.; Szczepanska, A.; Szkrobka, W.; Szuchnik, E.; Szulowska, A.; Szumczyk-Muszytowska, G.; Szwoch, M.; Traczyk, T.; Troszczynska, M.; Trzcinski, G.; Tybura, S.; Walasik, P.; Wegrzynowska, M.; Wesolowska, K.; Wieczorek, W.; Wierzbicka, A.; Wilczewski, P.; Wilgat-Szecowka, M.; Wojewoda, P.; Wojnowski, L.; Wrobel, M.; Zakutynska-Kowalczyk, K.; Zyczynska-Szmon, M.; Eltishcheva, V.; Libis, R.; Tereshchenko, S.; Popov, S.; Kamalov, G.; Belenky, D.; Zateyshchikova, A.; Kropacheva, E.; Kolesnikova, A.; Nikolaev, K.; Egorova, L.; Khokhlov, A.; Yakupov, E.; Poltavskaya, M.; Zateyshchikov, D.; Drapkina, O.; Vishnevsky, A.; Barbarash, O.; Miller, O.; Aleksandrova, E.; Chizhov, P.; Sergeev, M.; Shutemova, E.; Mazur, E.; Zrazhevskiy, K.; Novikova, T.; Kostenko, V.; Moiseeva, Y.; Polkanova, E.; Sobolev, K.; Rossovskaya, M.; Zubeeva, G.; Shapovalova, Y.; Nagibovich, O.; Edin, A.; Agakhanyan, A.; Batalov, R.; Belenkova, Y.; Bitakova, F.; Chugunnaya, S.; Dumikyan, A.; Erofeeva, S.; Gorbunova, E.; Gorshkova, T.; Gubanov, A.; Gurmach, M.; Ivanova, Y.; Kolesova, T.; Konyushenko, D.; Korneeva, O.; Kropova, O.; Kuchuk, P.; Kungurtseva, O.; Kupriyanova, T.; Kurylo, B.; Kuvanova, M.; Lebedeva, O.; Lileeva, E.; Machilskaya, O.; Medvedeva, T.; Monako, G.; Motylev, I.; Nagibovich, G.; Novikova, E.; Orlov, Y.; Osmolovskaya, Y.; Ovsannikova, A.; Platonov, D.; Rachkova, S.; Sinitsina, O.; Speshilova, S.; Suslova, O.; Ushakov, A.; Volodicheva, O.; Zemlianskaia, O.; Zhirov, I.; Zhuravleva, E.; Zotova, I.; Garcia, P. A.; Fernandez, M. F. L.; Tercedor, L.; Iparraguirre, S. T.; Monserrat, P. T.; Contreras, E. M.; Rafecas, J. I.; Carrasco, J. M.; Pavia, P. G.; Pajuelo, C. G.; Serrano, C. M.; Alonso, L. F. I.; Ruiz, A. G.; Klein, J. M.; Juanatey, J. R. G.; Esquivias, G. B.; Collado, I. M.; Piquero, H. P.; Cuixart, C. B.; Morato, M. R.; Llibre, J. B. I.; Vicente, C. C.; Gutierrez, M. V.; Gonzalo, F. E.; Fernandez, C. A. A.; Plana, N. D. V.; Montserrat, E. E.; Alia, J. J. M.; Gonzalez, M. B.; Oliva, M. A. M.; Sanmartin, J. I.; Gonzalez, M. J.; Alvarez, M. R.; Melenchon, J. H.; Vera, T. R.; Soriano, F. R.; Riesco, L. G.; Macian, M. D. M.; Granado, J. Q.; Navarro, M. J.; Sales, J. C.; Perez, J. V. V.; Caamano, M. V.; Torres, M. F. A.; Gomez, G. M.; Romo, A. I.; Diaz, M. A. P.; Alonso, C.; Alonso, C.; Alvarez, D.; Alvarez, M.; Amaro, M.; Andere, N.; Villar, J. A.; Ochoa, R. A.; Austria, A.; Barbeira, S.; Feu, E. B.; Bartes, A.; Munoz, V. B.; Jimenez, F. J. B.; Tijuan, A. B.; Ramirez, J. C.; Ramos, M. C.; Martinez, E. C.; Moreno, M. C.; Corchado, G. C.; Gil, M. C.; Orive, M. C.; Fernandez, D. C.; del Misterio, M. C.; Alsina, R. C.; Cabrera, A. C.; de Faria, J. C. P. P.; Costas, S.; Marco, M. I. C.; Dachs, M.; Lopez, C. M. D.; Borras, A. D.; Madariaga, A. E.; Espallargas, A.; Fernandez, M.; Escobar, E. F.; Mas, E. F.; Ferrer, A.; Fosch, J.; Bermudez, M. G.; Millan, V. G.; Saenz, M. G.; Garcia, C. G.; Gomez, C.; Perez, Y. G.; Segovia, A. G.; Gonzalez, P.; Grigorian, L.; Molina, A. G.; del Val, M. C. G.; Maeso, B. H.; Rodriguez, E. H.; Garcia, A. I.; Fernandez, M. J. J.; Besa, B. J.; Salvadores, P. J.; Bouzamayor, M. B. L.; Lasuncion, I.; Gort, L. E. L.; Molina, M. L.; Lopez, M.; Rey, A. M.; Guerra, J. M.; Marcus, S.; Vila, A. M.; Mena, M. M.; Mazon, P.; Zurita, F. M.; Millan, G.; Molina, M.; Alia, P. M.; Montes, D.; Gonzalez, M. M.; Munoz, R. B. M.; Palma, A. N.; Figueroa, H. N. O.; Ortega, V. M.; Cortes, C. O.; Tomera, D. O.; Merchan, N. P.; Ibar, I. P.; Garcia, E. P.; Armayor, M. P.; Carasa, M. P.; Prieto, I.; Quintern, V.; Renom, R.; Diaz, L. M. R.; Rios, V.; Sola, L. R.; Rivera, R.; Robiro, X. R.; Roca, M.; Saumell, C. R.; Rodrigo, C.; Rodriguez, E.; Garcia, M. R.; Jimenez, S. S.; Calderon, P. S.; Mendez, L. S.; Parra, S. S.; Santolaya, C.; Sanz, M. R. S.; Blanco, A. S.; Serralvo, E.; Sierra, N.; Valero, C. S.; Lopez, J. S.; Fontanillas, M. T.; Riera, M. T.; Tobajas, G.; Torres, C.; Marques, J. T.; Pastor, M. U.; Wirdby, A.; Linden, J.; Henriksson, K.; Elmersson, M.; Egilsson, A.; Borjesson, U.; Svard, G.; Liu, B.; Lindh, A.; Olsson, L. -B.; Gustavsson, M.; Andersson, L.; Andersson, L.; Benson, L.; Bothin, C.; Hajimirsadeghi, A.; Kadir, K.; Ericsson, M.; Ohlsson, A.; Lindvall, H.; Svensson, P.; Thorne, K.; Handel, H.; Platonov, P.; Eriksson, B.; Timberg, I.; Romberg, K.; Crisby, M.; Karlsson, J. -E.; Jensen, S. A.; Andersson, A.; Malmqvist, L.; Martinsson, B.; Bernsten, F.; Engdahl, J.; Thulin, J.; Hot-Bjelac, A.; Stalby, P.; Aaroe, H.; Ahbeck, E.; Ahlmark, H.; Al-Khalili, F.; Bonkowski, G.; Dzeletovic, S.; Ekstrand, A. -B.; Eriksson, G. -B.; Floren, K.; Grassjo, C.; Hahn, S.; Jaensson, P.; Jansson, B.; Jansson, J. -H.; Kangert, R. -M.; Koch, A.; Kusiak, D.; Lettenstrom, A.; Lindberg, A.; Lindholm, C. -J.; Mannermyr, A.; Mansson, K.; Millborg, M.; Nilsson, C.; Ohlin, A. -M.; Olofsson, A.; Osberg, A.; Pedersen, A.; Risbecker, K.; Rosenberg, K.; Samuelsson, J.; Shayesteh, M.; Skoglund, K.; Stjernberg, M.; Thorsen, C.; Beer, J. H.; Shah, D.; Debrunner, J.; Amstutz, D.; Bruegger, J.; Elise, G.; Grau, A.; Guinand, A.; Henriette, I.; Saga, E.; Winnik, S.; Rudyk, I.; Tseluyko, V.; Karpenko, O.; Zhurba, S.; Kraiz, I.; Kupnovytska, I.; Serediuk, N.; Mostovoy, Y.; Ushakov, O.; Koval, O.; Kovalskyi, I.; Svyshchenko, Y.; Sychov, O.; Stanislavchuk, M.; Kraydashenko, O.; Yagensky, A.; Tykhonova, S.; Kurylo, B.; Fushtey, I.; Belegai, R.; Berko, G.; Burdeuna, L.; Chabanna, O.; Daniuk, I.; Ivanov, A.; Kamenska, E.; Kaplan, P.; Khyzhnyak, O.; Kizim, S.; Matova, O.; Medentseva, O.; Mochonyi, V.; Mospan, M.; Nemtsova, V.; Ovdiienko, T.; Palamarchuk, O.; Pavelko, M.; Petrovskyy, R.; Plevak, D.; Proshak, O.; Pyvovar, S.; Rasputina, L.; Romanenko, O.; Romanova, O.; Sapatyi, A.; Shumakov, O.; Stets, R.; Todoriuk, L.; Varenov, V.; Chauhan, N.; Goodwin, D.; Saunders, P.; Evans, R.; Leese, J.; Jhittay, P. S.; Ross, A.; Kainth, M. S.; Pickavance, G.; Mcdonnell, J.; Williams, A.; Gooding, T.; Wagner, H.; Suryani, S.; Singal, A.; Sircar, S.; Bilas, R.; Hutchinson, P.; Wakeman, A.; Stokes, M.; Paul, N.; Aziz, M.; Ramesh, C.; Wilson, P.; Franklin, S.; Fairhead, S.; Thompson, J.; St Joseph, V.; Taylor, G.; Tragen, D.; Seamark, D.; Paul, C.; Richardson, M.; Jefferies, A.; Sharp, H.; Jones, H.; Giles, C.; Page, M.; Oginni, O.; Aldegather, J.; Wetherwell, S.; Lumb, W.; Evans, P.; Scouller, F.; Macey, N.; Stipp, Y.; West, R.; Thurston, S.; Wadeson, P.; Matthews, J.; Pandya, P.; Gallagher, A.; Railton, T.; Sinha, B.; Russell, D.; Davies, J. A.; Ainsworth, P.; Jones, C. P.; Weeks, P.; Eden, J.; Kernick, D.; Murdoch, W.; Lumley, L.; Patel, R. P.; Wong, S. W.; Saigol, M.; Ladha, K.; Douglas, K.; Cumberlidge, D. F.; Bradshaw, C.; Van Zon, G.; Jones, K. P.; Thomas, M. J.; Watson, E.; Sarai, B.; Ahmad, N.; Willcock, W.; Cairns, J.; Sathananthan, S.; de Kare-Silver, N.; Gilliland, A.; Strieder, E.; Howitt, A.; Vishwanathan, B.; Bird, N.; Gray, D.; Clark, M.; Bisatt, J.; Litchfield, J.; Fisher, E.; Fooks, T.; Kelsall, A. R.; Alborough, E.; Wakeling, J.; Parfitt, M.; Milne, K.; Rogers, S.; Priyadharshan, R.; Oliver, J. L.; Davies, E.; Abushal, S.; Jacobs, M.; Hutton, C.; Walls, N. I.; Thompson, R.; Chigbo, C.; Zaidi, S. M. A.; Howard, M.; Butter, K. C.; Barrow, S.; Little, H.; Haq, I. U.; Gibbons, L.; Glencross, S.; Mcleod, A. J.; Poland, K.; Mulholland, C.; Warke, A.; Conn, P.; Burns, G.; Smith, R. N.; Lowe, S.; Kamath, R.; Dau, H. S.; Webster, J.; Hodgins, I.; Vercoe, S.; Roome, P. C.; Pinnock, H.; Patel, J. R. A.; Ali, A.; Hart, N.; Davies, R.; Stuart, E.; Neden, C. A.; Danielsen, M.; Heath, R.; Sharma, P.; Galloway, S.; Hawkins, C.; Oliver, R.; Aylward, M.; Mannion, S.; Braddick, M.; Edwards, D.; Rothwell, A. C.; Sabir, A.; Choudhary, F.; Khalaque, S.; Wilson, A.; Peters, S.; Coulson, W.; Roberts, N.; Heer, A.; Coates, S.; Ward, B.; Jackson, D.; Walton, S.; Shepherd, D.; Sterry, M.; Wong, T.; Boon, M.; Bunney, R.; Haria-Shah, R.; Baron, R. T.; Davies, S.; Schatzberger, T.; Hargreaves, N.; Stephenson, T.; Choi, H.; Batson, R.; Lucraft, L.; Myhill, T.; Estifano, S.; Geatch, D.; Wilkinson, J.; Veale, R.; Forshaw, K.; Davies, T.; Zaman, K.; Vinson, P.; Liley, C.; Bandrapalli, M.; Mcginty, P.; Wastling, R.; Mceleny, P.; Beattie, A.; Cooke, P.; Wong, M.; Gunasegaram, J.; Pugsley, M.; Ahmad, S.; A'Court, C.; Ayers, J.; Bennett, J.; Cartwright, S.; Dobson, S.; Dooldeniya, C.; Flynn, A.; Fox, R.; Goram, J.; Halpin, A.; Hay, A.; Jacobs, P.; Jeffers, L.; Lomax, L.; Munro, I.; Muvva, R.; Nadaph, M.; Powell, K.; Randfield, S.; Redpath, D.; Reed, R.; Rickenbach, M.; Rogers, G.; Saunders, P. B.; Seamark, C.; Shewring, J.; Simmons, P.; Simper, H.; Stoddart, H.; Sword, A.; Thomas, N.; Thomson, A.; Blenkhorn, A.; Singh, B.; Van Gaal, W.; Abhayaratna, W.; Lehman, R.; Roberts-Thomson, P.; Kilian, J.; Coulshed, D.; Catanchin, A.; Colquhoun, D.; Kiat, H.; Eccleston, D.; French, J.; Zimmett, L.; Ayres, B.; Phan, T.; Blombery, P.; Crimmins, D.; O'Donnell, D.; Choi, A.; Astridge, P.; Arstall, M.; Jepson, N.; Binnekamp, M.; Lee, A.; Rogers, J.; Starmer, G.; Carroll, P.; Faunt, J.; Aggarwala, A.; Barry, L.; Batta, C.; Beveridge, R.; Black, A.; Bonner, M.; Boys, J.; Buckley, E.; Campo, M.; Carlton, L.; Connelly, A.; Conway, B.; Cresp, D.; Dimitri, H.; Dixon, S.; Dolman, M.; Duroux, M.; Eskandari, M.; Eslick, R.; Ferreira-Jardim, A.; Fetahovic, T.; Fitzpatrick, D.; Geraghty, R.; Gibbs, J.; Grabek, T.; Modi, M. H.; Hayes, K.; Hegde, M. P.; Hesketh, L.; Hoffmann, B.; Johnson, K.; Juergens, C.; Kassam, I.; Lawlor, V.; Lehman, M.; Lehman, S.; Leung, D.; Mackay, S.; Mackenzie, M.; Mccarthy, C.; Mcintosh, C.; Mckeon, L.; Morrison, H.; Mussap, C.; Myers, J. -D.; Nagalingam, V.; Oldfield, G.; O'May, V.; Palmer, J.; Parsons, L.; Patching, K.; Patching, T.; Paul, V.; Plotz, M.; Preston, S.; Rashad, H.; Ratcliffe, M.; Raynes, S.; Rose, J.; Sanders, L.; Seremetkoska, M.; Setio, H.; Shone, S.; Shrestha, P.; Singh, C.; Singleton, C.; Stoyanov, N.; Sutcliffe, S.; Swaraj, K.; Tarrant, J.; Thomas, N.; Thompson, S.; Tsay, I. M.; Vorster, M.; Waldman, A.; Wallis, L.; Wilford, E.; Wong, K.; Luton, R.; Gupta, M.; Pandey, A. S.; Cheung, S.; Leader, R.; Beaudry, P.; Ayala-Paredes, F.; Berlingieri, J.; Heath, J.; Poirier, G.; Du Preez, M.; Nadeau, R.; Dresser, G.; Dhillon, R.; Hruczkowski, T.; Schweitzer, B.; Coutu, B.; Angaran, P.; Macdonald, P.; Vizel, S.; Fikry, S.; Parkash, R.; Lavoie, A.; Cha, J.; Ramjattan, B.; Bonet, J.; Ahmad, K.; Aro, L.; Aves, T.; Beaudry, K.; Bergeron, C.; Bigcanoe, J.; Bignell, N.; Breakwell, L.; Burke, E.; Carroll, L.; Clarke, B.; Cleveland, T.; Daheb, S.; Dehghani, P.; Denis, I.; Djaidani, Z.; Dorian, P.; Douglass, S.; Dunnigan, J.; Ewert, A.; Farquhar, D.; Fearon, A.; Ferleyko, L.; Fournier, D.; Fox, B.; Grenier, M. -C.; Gulliver, W.; Haveman, K.; Hines, C.; Hines, K.; Jackson, A. M.; Jean, C.; Jethoo, G.; Kahlon, R.; Kelly, S.; Kim, R.; Korley, V.; Kornder, J.; Kwan, L.; Largy, J.; Lewis, C.; Lewis, S.; Mangat, I.; Moor, R.; Navratil, J.; Neas, I.; Otis, J.; Otis, R.; Pandey, M.; Petrie, F.; Pinter, A.; Raines, M.; Roberts, P.; Robinson, M.; Sas, G.; Schulman, S.; Snell, L.; Spearson, S.; Stevenson, J.; Trahey, T.; Wong, S.; Wright, D.; El-Aziz, A. A.; Seif, S. K. A.; El Din, M. G.; El Etriby, S.; Elbahry, A.; El-Etreby, A.; Elkhadem, M.; Katta, A.; Khairy, T.; Mowafy, A.; Nawar, M.; Ohanissian, A.; Reda, A.; Reda, M.; Salem, H.; Sami, N.; Samir, S.; Setiha, M.; Sobhy, M.; Soliman, A.; Taha, N.; Tawfik, M.; Zaatout, E.; Kettles, D.; Bayat, J.; Siebert, H.; Horak, A.; Kelfkens, Y.; Garda, R.; Pillay, T.; Guerra, M.; van Zyl, L.; Theron, H.; Murray, A.; Louw, R.; Greyling, D.; Mntla, P.; Ueckermann, V.; Loghdey, R.; Ismail, S.; Ahmed, F.; Engelbrecht, J.; Ramdass, A.; Maharajh, S.; Oosthuysen, W.; Angel, G.; Bester, C.; Booysen, M.; Boshoff, C.; Cannon, C.; Cassimjee, S.; Chami, C.; Conway, G.; Davids, A.; de Meyer, L.; Du Plessis, G.; Ellis, T.; Henley, L.; Karsten, M.; Loyd, E.; Marks, J.; Mavhusa, L.; Mostert, M.; Page, A.; Rikhotso, L.; Salie, M.; Sasto, J.; Shaik, F.; Skein, A.; Smith, L.; Tarr, G.; Tau, T.; van Zyl, F.; Yousef, G.; Agrawal, A.; Nathani, M.; Ibrahim, M.; Esheiba, E. M.; Singh, R.; Naguib, A.; Abu-Mahfouz, M.; Al Omairi, M.; Al Naeemi, A.; Maruthanayagam, R.; Bazargani, N.; Wassef, A.; Gupta, R.; Khan, M.; Subbaraman, B.; Abdul, A.; Al Mulla, A.; El Bardisy, S.; Haridas, P.; Jadhav, S.; Magdaluyo, K.; Makdad, M.; Maqsood, I.; Mohamed, R.; Sharma, N.; Sharma, R.; Thanzeel, M.; Canosa, R.; Rama, P.; Blumberg, E.; Garcia, J.; Mullen, P.; Wilson, V.; Quick, A.; Ferrick, K.; Kutayli, W. M.; Cox, M.; Franco, M.; Falkowski, S.; Mendelson, R.; Williams, M.; Miller, S.; Beach, S.; Sharma, N.; Alfieri, A.; Gutowski, T.; Haque, I.; Reddy, R.; Ahmed, W.; Delafontaine, P.; Diercks, D.; Theodoro, D.; Remmel, K.; Alberts, M.; Ison, R.; Noveck, H.; Duffy, P.; Pitta, S.; Nishijima, D.; Treasure, C.; Asafu-Adjaye, N.; Ball, K.; Bartlett, M.; Bentley, M.; Bowers, S.; Brown, A.; Browne, A.; Cameron-Watts, J.; Canova, M.; Cassidy, D.; Cervellione, K.; Congal, S.; Depauw, J.; Dickerson, A.; Eley, M.; Evans, L.; Felpel, S.; Ferdinand, K.; Fielder, D.; Gentry, P.; Haideri, A.; Hakimi, F.; Harbour, T.; Hartranft, E.; Hawkins, B.; Headlee, M.; Henson, L.; Herrick, C.; Hicks, T.; Jasinski, S.; Johnson, K.; Jones, A.; Jones, L.; Jones, P.; Karl, S.; Keeling, M.; Kerr, J.; Knowles, P.; Langdon, J.; Lay, M.; Lee, J. A.; Lincoln, T.; Malone, E.; Merliss, A.; Merritt, D.; Minardo, J.; Mooso, B.; Orosco, C.; Palumbo, V.; Parker, M.; Parrott, T.; Paserchia, S.; Pearl, G.; Peterson, J.; Pickelsimer, N.; Purcell, T.; Raynor, J.; Raziano, S.; Richard, C.; Richardson, T.; Robertson, C.; Sage, A.; Sanghera, T.; Shaw, P.; Shoemaker, J.; Smith, K.; Stephanie, B.; Thatcher, A.; Theobald, H.; Thompson, N.; Treasure, L.; Tripti, T.; Verdi, C.; Worthy, V.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/315577
Citazioni:
Predictors of NOAC versus VKA use for stroke prevention in patients with newly diagnosed atrial fibrillation: Results from GARFIELD-AF / Haas, S., Camm, A.J., Bassand, J.-P., Angchaisuksiri, P., Cools, F., Corbalan, R., Gibbs, H., Jacobson, B., Koretsune, Y., Mantovani, L.G., Misselwitz, F., Panchenko, E., Ragy, H.I., Stepinska, J., Turpie, A.G., Sawhney, J.P., Steffel, J., Lim, T.W., Pieper, K.S., Virdone, S., et al.. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 213:(2019), pp. 35-46. [10.1016/j.ahj.2019.03.013]
Abstract:
Introduction: A principal aim of the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) was to document changes in treatment practice for patients with newly diagnosed atrial fibrillation during an era when non–vitamin K antagonist oral anticoagulants (NOACs) were bec...oming more widely adopted. In these analyses, the key factors which determined the choice between NOACs and vitamin K antagonists (VKAs) are explored. Methods: Logistic least absolute shrinkage and selection operator regression determined predictors of NOAC and VKA use. Data were collected from 24,137 patients who were initiated on AC ± antiplatelet (AP) therapy (NOAC [51.4%] or VKA [48.6%]) between April 2013 and August 2016. Results: The most significant predictors of AC therapy were country, enrolment year, care setting at diagnosis, AF type, concomitant AP, and kidney disease. Patients enrolled in emergency care or in the outpatient setting were more likely to receive a NOAC than those enrolled in hospital (OR 1.16 [95% CI: 1.04-1.30], OR: 1.15 [95% CI: 1.05-1.25], respectively). NOAC prescribing seemed to be favored in lower-risk groups, namely, patients with paroxysmal AF, normotensive patients, and those with moderate alcohol consumption, but also the elderly and patients with acute coronary syndrome. By contrast, VKAs were preferentially used in patients with permanent AF, moderate to severe kidney disease, heart failure, vascular disease, and diabetes and with concomitant AP. Conclusion: GARFIELD-AF data highlight marked heterogeneity in stroke prevention strategies globally. Physicians are adopting an individualized approach to stroke prevention where NOACs are favored in patients with a lower stroke risk but also in the elderly and patients with acute coronary syndrome.
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2017 Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing
Anno: 2019
Rivista: GIORNALE ITALIANO DI CARDIOLOGIA
Autori/autrici: Stabile, G.; Bertaglia, E.; Guerra, F.; Palmisano, P.; Berisso, M. Z.; Soldati, E.; Bisignani, G.; Forleo, G. B.; Zanotto, G.; Landolina, M.; De Ponti, R.; Boriani, G.; Ricci, R. P.
Lingua: ITA
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276749
Citazioni:
2017 Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing / Stabile, G., Bertaglia, E., Guerra, F., Palmisano, P., Berisso, M.Z., Soldati, E., Bisignani, G., Forleo, G.B., Zanotto, G., Landolina, M., De Ponti, R., Boriani, G., Ricci, R.P.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 1827-6806. - 20:10(2019), pp. 590-592. [10.1714/3228.32059]
Abstract:
Background. This report describes the findings of the 2017 Catheter Ablation Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC). Methods. Data collection was retrospective. A standardized questionnaire was completed by each of the participating centers. Results. A total o...f 15 601 ablation procedures were performed by 91 institutions, with a mean of 184 ± 213 procedures per center. The most frequently treated arrhythmia was atrial fibrillation (34%), followed by atrioventricular nodal reentrant tachycardia (25%) and common atrial flutter (14%). About 10% of overall ablation procedures were performed in patients with ventricular arrhythmias. On-site cardiothoracic surgery was available in 42% of the centers performing ablation and in 49% of the centers performing atrial fibrillation ablation. In most patients, the ablation procedure was guided by a three-dimensional mapping system, and in 15% of patients a near-zero X-ray strategy was used. Conclusions. The Italian Catheter Ablation Registry systematically collected 1-year data on ablation procedures performed in Italy, revealing that atrial fibrillation is the most commonly treated arrhythmia in the ablation centers with an increasing number of patients treated for ventricular tachycardia.
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Lead choice in cardiac implantable electronic devices: an Italian survey promoted by AIAC (Italian Association of Arrhythmias and Cardiac Pacing)
Anno: 2019
Rivista: EXPERT REVIEW OF MEDICAL DEVICES
Autori/autrici: Ziacchi, M.; Palmisano, P.; Biffi, M.; Guerra, F.; Stabile, G.; Forleo, G. B.; Zanotto, G.; D'Onofrio, A.; Landolina, M.; De Ponti, R.; Zoni Berisso, M.; Ricci, R. P.; Boriani, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276743
Citazioni:
Lead choice in cardiac implantable electronic devices: an Italian survey promoted by AIAC (Italian Association of Arrhythmias and Cardiac Pacing) / Ziacchi, M., Palmisano, P., Biffi, M., Guerra, F., Stabile, G., Forleo, G.B., Zanotto, G., D'Onofrio, A., Landolina, M., De Ponti, R., Zoni Berisso, M., Ricci, R.P., Boriani, G.. - In: EXPERT REVIEW OF MEDICAL DEVICES. - ISSN 1743-4440. - 16:9(2019), pp. 821-828. [10.1080/17434440.2019.1649134]
Abstract:
Background: Few data are available regarding lead preferences of electrophysiologists during cardiac implantable electronic devices (CIEDs) implantation. Aim of this survey is to evaluate the leads used, and the reasons behind these choices, in a large population of implanters. Methods: A questionna...ire was sent to all 314 Italian centers with experience in CIED implantation. Results: 103 operators from 100 centers (32% of centers) responded. For atrium, passive leads represented first choice for pacemakers and defibrillators (71% and 64% of physicians, respectively), mainly for safety. For right ventricle, active fixation was preferred (61% and 93% operators in pacemaker and defibrillator patients), for higher versatility in positioning and lower dislodgement risk. For left ventricular stimulation, quadripolar leads were preferred by more than 80% of respondents, for better phrenic nerve and myocardial threshold management; active-fixation leads represent a second choice, in order to prevent or manage dislodgement (78% and 17% of respondents, respectively), but 44% of operators considered them dangerous. Conclusions: The choice of leads is heterogeneous. Trends are toward active-fixation right ventricular leads and passive-fixation atrial leads (particularly in pacemaker patients, considered frailer). For left ventricular stimulation, operators’ majority want to disposition all kind of leads, although quadripolar leads are the favorites.
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Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation
Anno: 2019
Rivista: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Autori/autrici: Grigioni, F.; Benfari, G.; Vanoverschelde, J. -L.; Tribouilloy, C.; Avierinos, J. -F.; Bursi, F.; Suri, R. M.; Guerra, F.; Pasquet, A.; Rusinaru, D.; Marcelli, E.; Theron, A.; Barbieri, A.; Michelena, H.; Lazam, S.; Szymanski, C.; Nkomo, V. T.; Capucci, A.; Thapa, P.; Enriquez-Sarano, M.; Suri, R.; Clavel, M. A.; Maalouf, J.; Michelena, H.; Enriquez-Sarano, M.; Tribouilloy, C.; Trojette, F.; Szymanski, C.; Rusinaru, D.; Touati, G.; Remadi, J. P.; Guerra, F.; Capucci, A.; Grigioni, F.; Russo, A.; Biagini, E.; Pasquale, F.; Ferlito, M.; Rapezzi, C.; Savini, C.; Marinelli, G.; Pacini, D.; Gargiulo, G. D.; Di Bartolomeo, R.; Boulif, J.; de Meester, C.; El Khoury, G.; Gerber, B.; Lazam, S.; Pasquet, A.; Noirhomme, P.; Vancraeynest, D.; Vanoverschelde, J. -L.; Avierinos, J. F.; Collard, F.; Theron, A.; Habib, G.; Barbieri, A.; Bursi, F.; Mantovani, F.; Lugli, R.; Modena, M. G.; Boriani, G.; Bacchi-Reggiani, L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/276735
Citazioni:
Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation / Grigioni, F., Benfari, G., Vanoverschelde, J.-L., Tribouilloy, C., Avierinos, J.-F., Bursi, F., Suri, R.M., Guerra, F., Pasquet, A., Rusinaru, D., Marcelli, E., Theron, A., Barbieri, A., Michelena, H., Lazam, S., Szymanski, C., Nkomo, V.T., Capucci, A., Thapa, P., Enriquez-Sarano, M., et al.. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 73:3(2019), pp. 264-274. [10.1016/j.jacc.2018.10.067]
Abstract:
Background: Scientific guidelines consider atrial fibrillation (AF) complicating degenerative mitral regurgitation (DMR) a debated indication for surgery. Objectives: This study analyzed the prognostic/therapeutic implications of AF at DMR diagnosis and long-term. Methods: Patients were enrolled in ...the MIDA (Mitral Regurgitation International Database) registry, which reported the consecutive, multicenter, international experience with DMR due to flail leaflets echocardiographically diagnosed. Results: Among 2,425 patients (age 67 ± 13 years; 71% male, 67% asymptomatic, ejection fraction 64 ± 10%), 1,646 presented at diagnosis with sinus rhythm (SR), 317 with paroxysmal AD, and 462 with persistent AF. Underlying clinical/instrumental characteristics progressively worsened from SR to paroxysmal to persistent AF. During follow-up, paroxysmal and persistent AF were associated with excess mortality (10-year survival in SR and in paroxysmal and persistent AF was 74 ± 1%, 59 ± 3%, and 46 ± 2%, respectively; p < 0.0001), that persisted 20 years post-diagnosis and independently of all baseline characteristics (p values <0.0001). Surgery (n = 1,889, repair 88%) was associated with better survival versus medical management, regardless of all baseline characteristics and rhythm (adjusted hazard ratio: 0.26; 95% confidence interval: 0.23 to 0.30; p < 0.0001) but post-surgical outcome remained affected by AF (10-year post-surgical survival in SR and in paroxysmal and persistent AF was 82 ± 1%, 70 ± 4%, and 57 ± 3%, respectively; p < 0.0001). Conclusions: AF is a frequent occurrence at DMR diagnosis. Although AF is associated with older age and more severe presentation of DMR, it is independently associated with excess mortality long-term after diagnosis. Surgery is followed by improved survival in each cardiac rhythm subset, but persistence of excess risk is observed for each type of AF. Our study indicates that detection of AF, even paroxysmal, should trigger prompt consideration for surgery.
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