Effects of synthetic cannabinoids on psychomotor, sensory and cognitive functions relevant for safe driving
Anno: 2022
Rivista: FRONTIERS IN PSYCHIATRY
Autori/autrici: Orazietti, Vasco; Basile, Giuseppe; Giorgetti, Raffaele; Giorgetti, Arianna
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327973
Citazioni:
Effects of synthetic cannabinoids on psychomotor, sensory and cognitive functions relevant for safe driving / Orazietti, V., Basile, G., Giorgetti, R., Giorgetti, A.. - In: FRONTIERS IN PSYCHIATRY. - ISSN 1664-0640. - 13:(2022). [10.3389/fpsyt.2022.998828]
Abstract:
Recreational use of Synthetic Cannabinoids (SCs), one of the largest groups of New Psychoactive Substances (NPS), has increased globally over the past few years. Driving is a structured process requiring the cooperation of several cognitive and psychomotor functions, organized in different levels of... complexity. Each of these functions can be affected when Driving Under the Influence (DUI) of SCs. In order to reduce the likelihood of SC-related road accidents, it is essential to understand which areas of psychomotor performance are most affected by these substances, as well as the severity of impairment. For this purpose, a multiple database- literature review of recent experimental studies in humans and animals regarding the psychomotor effects of SCs has been performed. Despite the many limitations connected to experimental studies on humans, results showed a consistency between animal and human data. SCs appear to impair psychomotor performance in humans, affecting different domains related to safe driving even at low doses. Cases of DUI of SC have been repeatedly reported, although the exact prevalence is likely to be underestimated due to current analytical and interpretative issues. For this reason, an accurate physical examination performed by trained and experienced personnel has a primary role in recognizing signs of impairment in case of strong suspicion of SC consumption. The identification of a suspected case should be followed by reliable laboratory examination.
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Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study
Anno: 2022
Rivista: AGING CLINICAL AND EXPERIMENTAL RESEARCH
Autori/autrici: Sidoli, C.; Zambon, A.; Tassistro, E.; Rossi, E.; Mossello, E.; Inzitari, M.; Cherubini, A.; Marengoni, A.; Morandi, A.; Bellelli, G.; Tarasconi, A.; Sella, M.; Paterno, G.; Faggian, G.; Lucarelli, C.; De Grazia, N.; Alberto, C.; Porcella, L.; Nardiello, I.; Chimenti, E.; Zeni, M.; Romairone, E.; Minaglia, C.; Ceccotti, C.; Guerra, G.; Mantovani, G.; Monacelli, F.; Minaglia, C.; Candiani, T.; Santolini, F.; Minaglia, C.; Rosso, M.; Bono, V.; Sibilla, S.; Dal Santo, P.; Ceci, M.; Barone, P.; Schirinzi, T.; Formenti, A.; Nastasi, G.; Isaia, G.; Gonella, D.; Battuello, A.; Casson, S.; Calvani, D.; Boni, F.; Ciaccio, A.; Rosa, R.; Sanna, G.; Manfredini, S.; Cortese, L.; Rizzo, M.; Prestano, R.; Greco, A.; Lauriola, M.; Gelosa, G.; Piras, V.; Arena, M.; Cosenza, D.; Bellomo, A.; Lamontagna, M.; Gabbani, L.; Lambertucci, L.; Perego, S.; Parati, G.; Basile, G.; Gallina, V.; Pilone, G.; Giudice, C.; Pietrogrande, L.; Mosca, M.; Corazzin, I.; Rossi, P.; Nunziata, V.; D'Amico, F.; Grippa, A.; Giardini, S.; Barucci, R.; Cossu, A.; Fiorin, L.; Arena, M.; Distefano, M.; Lunardelli, M.; Brunori, M.; Ruffini, I.; Abraham, E.; Varutti, A.; Fabbro, E.; Catalano, A.; Martino, G.; Leotta, D.; Marchet, A.; Dell'Aquila, G.; Scrimieri, A.; Davoli, M.; Casella, M.; Cartei, A.; Polidori, G.; Basile, G.; Brischetto, D.; Motta, S.; Saponara, R.; Perrone, P.; Russo, G.; Del, D.; Car, C.; Pirina, T.; Franzoni, S.; Cotroneo, A.; Ghiggia, F.; Volpi, G.; Menichetti, C.; Bo, M.; Panico, A.; Calogero, P.; Corvalli, G.; Mauri, M.; Lupia, E.; Manfredini, R.; Fabbian, F.; March, A.; Pedrotti, M.; Veronesi, M.; Strocchi, E.; Borghi, C.; Bianchetti, A.; Crucitti, A.; Difrancesco, V.; Fontana, G.; Geriatria, A.; Bonanni, L.; Barbone, F.; Serrati, C.; Ballardini, G.; Simoncelli, M.; Ceschia, G.; Scarpa, C.; Brugiolo, R.; Fusco, S.; Ciarambino, T.; Biagini, C.; Tonon, E.; Porta, M.; Venuti, D.; Delsette, M.; Poeta, M.; Barbagallo, G.; Trovato, G.; Delitala, A.; Arosio, P.; Reggiani, F.; Zuliani, G.; Ortolani, B.; Mussio, E.; Girardi, A.; Coin, A.; Ruotolo, G.; Castagna, A.; Masina, M.; Cimino, R.; Pinciaroli, A.; Tripodi, G.; Cassadonte, F.; Vatrano, M.; Scaglione, L.; Fogliacco, P.; Muzzuilini, C.; Romano, F.; Padovani, A.; Rozzini, L.; Cagnin, A.; Fragiacomo, F.; Desideri, G.; Liberatore, E.; Bruni, A.; Orsitto, G.; Franco, M.; Bonfrate, L.; Bonetto, M.; Pizio, N.; Magnani, G.; Cecchetti, G.; Longo, A.; Bubba, V.; Marinan, L.; Cotelli, M.; Turla, M.; Brunori, M.; Sessa, M.; Abruzzi, L.; Castoldi, G.; Lovetere, D.; Musacchio, C.; Novello, M.; Cavarape, A.; Bini, A.; Leonardi, A.; Seneci, F.; Grimaldi, W.; Seneci, F.; Fimognari, F.; Bambar, V.; Saitta, A.; Corica, F.; Braga, M.; Servi, ; Ettorre, E.; Camellini Bellelli, C. G.; Annoni, G.; Marengoni, A.; Bruni, A.; Crescenzo, A.; Noro, G.; Turco, R.; Ponzetto, M.; Giuseppe, L.; Mazzei, B.; Maiuri, G.; Costaggiu, D.; Damato, R.; Fabbro, E.; Formilan, M.; Patrizia, G.; Santuar, L.; Gallucci, M.; Minaglia, C.; Paragona, M.; Bini, P.; Modica, D.; Abati, C.; Clerici, M.; Barbera, I.; Nigroimperiale, F.; Manni, A.; Votino, C.; Castiglioni, C.; Di, M.; Degl'Innocenti, M.; Moscatelli, G.; Guerini, S.; Casini, C.; Dini, D.; Denotariis, S.; Bonometti, F.; Paolillo, C.; Riccardi, A.; Tiozzo, A.; Samysalamafahmy, A.; Riccardi, A.; Paolillo, C.; Dibari, M.; Vanni, S.; Scarpa, A.; Zara, D.; Ranieri, P.; Alessandro, M.; Calogero, P.; Corvalli, G.; Di, F.; Pezzoni, D.; Platto, C.; D'Ambrosio, V.; Ivaldi, C.; Milia, P.; Desalvo, F.; Solaro, C.; Strazzacappa, M.; Bo, M.; Panico, A.; Cazzadori, M.; Bonetto, M.; Grasso, M.; Troisi, E.; Magnani, G.; Cecchetti, G.; Guerini, V.; Bernardini, B.; Corsini, C.; Boffelli, S.; Filippi, A.; Delpin, K.; Faraci, B.; Bertoletti, E.; Vannucci, M.; Crippa, P.; Malighetti, A.; Caltagirone, C.; Disant, S.; Bettini, D.; Maltese, F.; Formilan, M.; Abruzzese, G.; Minaglia, C.; Cosimo, D.; Azzini, M.; Cazzadori, M.; Colombo, M.; Procino, G.; Fascendini, S.; Barocco, F.; Del, P.; D'Amico, F.; Grippa, A.; Mazzone, A.; Cottino, M.; Vezzadini, G.; Avanzi, S.; Brambilla, C.; Orini, S.; Sgrilli, F.; Mello, A.; Lombardi Muti, L. E.; Dijk, B.; Fenu, S.; Pes, C.; Gareri, P.; Castagna, A.; Passamonte, M.; Rigo, R.; Locusta, L.; Caser, L.; Rosso, G.; Cesarini, S.; Cozzi, R.; Santini, C.; Carbone, P.; Cazzaniga, I.; Lovati, R.; Cantoni, A.; Ranzani, P.; Barra, D.; Pompilio, G.; Dimori, S.; Cernesi, S.; Ricco, C.; Piazzolla, F.; Capittini, E.; Rota, C.; Gottardi, F.; Merla, L.; Barelli, A.; Millul, A.; De, G.; Morrone, G.; Bigolari, M.; Minaglia, C.; Macchi, M.; Zambon, F.; D'Amico, F.; D'Amico, F.; Pizzorni, C.; Dicasaleto, G.; Menculini, G.; Marcacci, M.; Catanese, G.; Sprini, D.; Dicasalet, T.; Bocci, M.; Borga, S.; Caironi, P.; Cat, C.; Cingolani, E.; Avalli, L.; Greco, G.; Citerio, G.; Gandini, L.; Cornara, G.; Lerda, R.; Brazzi, L.; Simeone, F.; Caciorgna, M.; Alampi, D.; Francesconi, S.; Beck, E.; Antonini, B.; Vettoretto, K.; Meggiolaro, M.; Garofalo, E.; Bruni, A.; Notaro, S.; Varutti, R.; Bassi, F.; Mistraletti, G.; Marino, A.; Rona, R.; Rondelli, E.; Riva, I.; Cortegiani, A.; Pistidda, L.; D'Andrea, R.; Querci, L.; Gnesin, P.; Todeschini, M.; Lugano, M.; Castelli, G.; Ortolani, M.; Cotoia, A.; Maggiore, S.; Ditizio, L.; Graziani, R.; Testa, I.; Ferretti, E.; Castioni, C.; Lombardi, F.; Caserta, R.; Pasqua, M.; Simoncini, S.; Baccarini, F.; Rispoli, M.; Grossi, F.; Cancelliere, L.; Carnelli, M.; Puccini, F.; Biancofiore, G.; Siniscalchi, A.; Laici, C.; Mossello, E.; Torrini, M.; Pasetti, G.; Palmese, S.; Oggioni, R.; Mangani, V.; Pini, S.; Martelli, M.; Rigo, E.; Zuccala, F.; Cherri, A.; Spina, R.; Calamai, I.; Petrucci, N.; Caicedo, A.; Ferri, F.; Gritti, P.; Brienza, N.; Fonnesu, R.; Dessena, M.; Fullin, G.; Saggioro, D.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330341
Citazioni:
Prevalence and features of delirium in older patients admitted to rehabilitation facilities: a multicenter study / Sidoli, C., Zambon, A., Tassistro, E., Rossi, E., Mossello, E., Inzitari, M., Cherubini, A., Marengoni, A., Morandi, A., Bellelli, G., Tarasconi, A., Sella, M., Paterno, G., Faggian, G., Lucarelli, C., De Grazia, N., Alberto, C., Porcella, L., Nardiello, I., Chimenti, E., et al.. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - STAMPA. - (2022). [10.1007/s40520-022-02099-8]
Abstract:
Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three... editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected in 226 patients (18%), and the most recurrent motor subtype was mixed (37%), followed by hypoactive (26%), hyperactive (21%) and non-motor one (16%). In a multivariate Poisson regression model with robust variance, factors associated with delirium were: disability in basic (PR 1.48, 95%CI: 1.17–1.9, p value 0.001) and instrumental activities of daily living (PR 1.58, 95%CI: 1.08–2.32, p value 0.018), dementia (PR 2.10, 95%CI: 1.62–2.73, p value < 0.0001), typical antipsychotics (PR 1.47, 95%CI: 1.10–1.95, p value 0.008), antidepressants other than selective serotonin reuptake inhibitors (PR 1.3, 95%CI: 1.02–1.66, p value 0.035), and physical restraints (PR 2.37, 95%CI: 1.68–3.36, p value < 0.0001). Conclusion: This multicenter study reports that 2 out 10 patients admitted to rehabilitations had delirium on the index day. Mixed delirium was the most prevalent subtype. Delirium was associated with unmodifiable (dementia, disability) and modifiable (physical restraints, medications) factors. Identification of these factors should prompt specific interventions aimed to prevent or mitigate delirium.
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Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study
Anno: 2021
Rivista: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
Autori/autrici: Morandi, A.; Inzitari, M.; Udina, C.; Gual, N.; Mota, M.; Tassistro, E.; Andreano, A.; Cherubini, A.; Gentile, S.; Mossello, E.; Marengoni, A.; Olive, A.; Riba, F.; Ruiz, D.; de Jaime, E.; Bellelli, G.; Tarasconi, A.; Sella, M.; Auriemma, S.; Paterno, G.; Faggian, G.; Lucarelli, C.; De Grazia, N.; Alberto, C.; Margola, A.; Porcella, L.; Nardiello, I.; Chimenti, E.; Zeni, M.; Giani, A.; Famularo, S.; Romairone, E.; Minaglia, C.; Ceccotti, C.; Guerra, G.; Mantovani, G.; Monacelli, F.; Candiani, T.; Ballestrero, A.; Santolini, F.; Rosso, M.; Bono, V.; Sibilla, S.; Dal Santo, P.; Ceci, M.; Barone, P.; Schirinzi, T.; Formenti, A.; Nastasi, G.; Isaia, G.; Gonella, D.; Battuello, A.; Casson, S.; Calvani, D.; Boni, F.; Ciaccio, A.; Rosa, R.; Sanna, G.; Manfredini, S.; Cortese, L.; Rizzo, M.; Prestano, R.; Greco, A.; Lauriola, M.; Gelosa, G.; Piras, V.; Arena, M.; Cosenza, D.; Bellomo, A.; Lamontagna, M.; Gabbani, L.; Lambertucci, L.; Perego, S.; Parati, G.; Basile, G.; Gallina, V.; Pilone, G.; Giudice, C.; De, F.; Pietrogrande, L.; De, B.; Mosca, M.; Corazzin, I.; Rossi, P.; Nunziata, V.; D'Amico, F.; Grippa, A.; Giardini, S.; Barucci, R.; Cossu, A.; Fiorin, L.; Distefano, M.; Lunardelli, M.; Brunori, M.; Ruffini, I.; Abraham, E.; Varutti, A.; Fabbro, E.; Catalano, A.; Martino, G.; Leotta, D.; Marchet, A.; Dell'Aquila, G.; Scrimieri, A.; Davoli, M.; Casella, M.; Cartei, A.; Polidori, G.; Brischetto, D.; Motta, S.; Saponara, R.; Perrone, P.; Russo, G.; Del, D.; Car, C.; Pirina, T.; Franzoni, S.; Cotroneo, A.; Ghiggia, F.; Volpi, G.; Menichetti, C.; Bo, M.; Panico, A.; Calogero, P.; Corvalli, G.; Mauri, M.; Lupia, E.; Manfredini, R.; Fabbian, F.; March, A.; Pedrotti, M.; Veronesi, M.; Strocchi, E.; Borghi, C.; Bianchetti, A.; Crucitti, A.; Difrancesco, V.; Fontana, G.; Bonanni, L.; Barbone, F.; Serrati, C.; Ballardini, G.; Simoncelli, M.; Ceschia, G.; Scarpa, C.; Brugiolo, R.; Fusco, S.; Ciarambino, T.; Biagini, C.; Tonon, E.; Porta, M.; Venuti, D.; Delsette, M.; Poeta, M.; Barbagallo, G.; Trovato, G.; Delitala, A.; Arosio, P.; Reggiani, F.; Zuliani, G.; Ortolani, B.; Mussio, E.; Girardi, A.; Coin, A.; Ruotolo, G.; Castagna, A.; Masina, M.; Cimino, R.; Pinciaroli, A.; Tripodi, G.; Cannistra, U.; Cassadonte, F.; Vatrano, M.; Scaglione, L.; Fogliacco, P.; Muzzuilini, C.; Romano, F.; Padovani, A.; Rozzini, L.; Cagnin, A.; Fragiacomo, F.; Desideri, G.; Liberatore, E.; Bruni, A.; Orsitto, G.; Franco, M.; Bonfrate, L.; Bonetto, M.; Pizio, N.; Magnani, G.; Cecchetti, G.; Longo, A.; Bubba, V.; Marinan, L.; Cotelli, M.; Turla, M.; Sessa, M.; Abruzzi, L.; Castoldi, G.; Lovetere, D.; Musacchio, C.; Novello, M.; Cavarape, A.; Bini, A.; Leonardi, A.; Seneci, F.; Grimaldi, W.; Fimognari, F.; Bambara, V.; Saitta, A.; Corica, F.; Braga, M.; Ettorre, E.; Camellini, C.; Bellelli, G.; Annoni, G.; Crescenzo, A.; Noro, G.; Turco, R.; Ponzetto, M.; Giuseppe, L.; Mazzei, B.; Maiuri, G.; Costaggiu, D.; Damato, R.; Formilan, M.; Patrizia, G.; Gallucci, M.; Paragona, M.; Bini, P.; Modica, D.; Abati, C.; Clerici, M.; Barbera, I.; Nigroimperiale, F.; Manni, A.; Votino, C.; Castiglioni, C.; Di, M.; Degl'Innocenti, M.; Moscatelli, G.; Guerini, S.; Casini, C.; Dini, D.; D'Imporzano, E.; Denotariis, S.; Bonometti, F.; Paolillo, C.; Riccardi, A.; Tiozzo, A.; Dibari, M.; Vanni, S.; Scarpa, A.; Zara, D.; Ranieri, P.; Alessandro, M.; Di, F.; Pezzoni, D.; Platto, C.; D'Ambrosio, V.; Ivaldi, C.; Milia, P.; Desalvo, F.; Solaro, C.; Strazzacappa, M.; Cazzadori, M.; Confente, S.; Grasso, M.; Troisi, E.; Guerini, V.; Bernardini, B.; Corsini, C.; Boffelli, S.; Filippi, A.; Delpin, K.; Faraci, B.; Bertoletti, E.; Vannucci, M.; Tesi, F.; Crippa, P.; Malighetti, A.; Bettini, D.; Maltese, F.; Abruzzese, G.; Cosimo, D.; Azzini, M.; Colombo, M.; Procino, G.; Fascendini, S.; Barocco, F.; Del, P.; Mazzone, A.; Riva, E.; Dell'Acqua, D.; Cottino, M.; Vezzadini, G.; Avanzi, S.; Brambilla, C.; Orini, S.; Sgrilli, F.; Mello, A.; Lombardi, L.; Muti, E.; Dijk, B.; Fenu, S.; Pes, C.; Gareri, P.; Passamonte, M.; Rigo, R.; Locusta, L.; Caser, L.; Rosso, G.; Cesarini, S.; Cozzi, R.; Santini, C.; Carbone, P.; Cazzaniga, I.; Lovati, R.; Cantoni, A.; Ranzani, P.; Barra, D.; Pompilio, G.; Dimori, S.; Cernesi, S.; Ricco, C.; Piazzolla, F.; Capittini, E.; Rota, C.; Gottardi, F.; Merla, L.; Barelli, A.; Millul, A.; De, G.; Morrone, G.; Bigolari, M.; Macchi, M.; Zambon, F.; Pizzorni, C.; Dicasaleto, G.; Menculini, G.; Marcacci, M.; Catanese, G.; Sprini, D.; Dicasalet, T.; Bocci, M.; Borga, S.; Caironi, P.; Cat, C.; Cingolani, E.; Avalli, L.; Greco, G.; Citerio, G.; Gandini, L.; Cornara, G.; Lerda, R.; Brazzi, L.; Simeone, F.; Caciorgna, M.; Alampi, D.; Francesconi, S.; Beck, E.; Antonini, B.; Vettoretto, K.; Meggiolaro, M.; Garofalo, E.; Notaro, S.; Varutti, R.; Bassi, F.; Mistraletti, G.; Marino, A.; Rona, R.; Rondelli, E.; Riva, I.; Scapigliati, A.; Cortegiani, A.; Vitale, F.; Pistidda, L.; D'Andrea, R.; Querci, L.; Gnesin, P.; Todeschini, M.; Lugano, M.; Castelli, G.; Ortolani, M.; Cotoia, A.; Maggiore, S.; Ditizio, L.; Graziani, R.; Testa, I.; Ferretti, E.; Castioni, C.; Lombardi, F.; Caserta, R.; Pasqua, M.; Simoncini, S.; Baccarini, F.; Rispoli, M.; Grossi, F.; Cancelliere, L.; Carnelli, M.; Puccini, F.; Biancofiore, G.; Siniscalchi, A.; Laici, C.; Mossello, E.; Torrini, M.; Pasetti, G.; Palmese, S.; Oggioni, R.; Mangani, V.; Pini, S.; Martelli, M.; Rigo, E.; Zuccala, F.; Cherri, A.; Spina, R.; Calamai, I.; Petrucci, N.; Caicedo, A.; Ferri, F.; Gritti, P.; Brienza, N.; Fonnesu, R.; Dessena, M.; Fullin, G.; Saggioro, D.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330581
Citazioni:
Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study / Morandi, A., Inzitari, M., Udina, C., Gual, N., Mota, M., Tassistro, E., Andreano, A., Cherubini, A., Gentile, S., Mossello, E., Marengoni, A., Olive, A., Riba, F., Ruiz, D., de Jaime, E., Bellelli, G., Tarasconi, A., Sella, M., Auriemma, S., Paterno, G., et al.. - In: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. - ISSN 1525-8610. - 22:6(2021), pp. 1162-1167.e3. [10.1016/j.jamda.2020.09.032]
Abstract:
Objective: Sensory deficits are important risk factors for delirium but have been investigated in single-center studies and single clinical settings. This multicenter study aims to evaluate the association between hearing and visual impairment or bi-sensory impairment (visual and hearing impairment)... and delirium. Design: Cross-sectional study nested in the 2017 “Delirium Day” project. Setting and Participants: Patients 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes, and hospices in Italy. Methods: Delirium was assessed with the 4AT (a short tool for delirium assessment) and sensory deficits with a clinical evaluation. We assessed the association between delirium, hearing and visual impairment in multivariable logistic regression models, adjusting for: Model 1, we included predisposing factors for delirium (ie, dementia, weight loss and autonomy in the activities of daily living); Model 2, we added to Model 1 variables, which could be considered precipitating factors for delirium (ie, psychoactive drugs and urinary catheters). Results: A total of 3038 patients were included; delirium prevalence was 25%. Patients with delirium had a higher prevalence of hearing impairment (30.5% vs 18%; P <.001), visual impairment (24.2% vs 15.7%; P <.01) and bi-sensory impairment (16.2% vs 7.5%) compared with those without delirium. In the multivariable logistic regression analysis, the presence of bi-sensory impairment was associated with delirium in Model 1 [odds ratio (OR) 1.5, confidence interval (CI) 1.2–2.1; P =.00] and in Model 2 (OR 1.4; CI 1.1–1.9; P =.02), whereas the presence of visual and hearing impairment alone was not associated with delirium either in Model 1 (OR 0.8; CI 0.6–1.2, P =.36; OR 1.1; CI 0.8–1.4; P =.42) or in Model 2 (OR 0.8, CI 0.6–1.2, P =.27; OR 1.1, CI 0.8–1.4, P =.63). Conclusions and implications: Our findings support the importance of routine screening and specific interventions by a multidisciplinary team to implement optimal management of sensory impairments and hence prevention and the management of the patients with delirium.
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Drug prescription and delirium in older inpatients: Results from the nationwide multicenter Italian Delirium Day 2015-2016
Anno: 2019
Rivista: JOURNAL OF CLINICAL PSYCHIATRY
Autori/autrici: Aloisi, G.; Marengoni, A.; Morandi, A.; Zucchelli, A.; Cherubini, A.; Mossello, E.; Bo, M.; Di Santo, S. G.; Mazzone, A.; Trabucchi, M.; Cappa, S.; Fimognari, F. L.; Incalzi, R. A.; Gareri, P.; Perticone, F.; Campanini, M.; Montorsi, M.; Latronico, N.; Zambon, A.; on behalf of the Italian Study Group on Delirium (ISGoD): Boffelli, S; Di Stefano, F; De Filippi, F; Guerini, F; Bertoletti, E; March, A; Margiotta, A; Mecocci, P; Ruggiero, C; Addesi, D; Fantò, F; Isaia, G; Dijik, B; Porrino, P; Cotroneo, Am; Galli, G; Bruni, Ac; Bernardini, B; Corsini, C; Cagnin, A; Zurlo, G; Barbagallo, G; Lunardelli, Ml; Martini, E; Battaglia, G; Latella, R; Petritola, D; Sinforiani, E; Cester, A; Formilan, M; Carbone, P; Appollonio, I; Cereda, D; Tremolizzo, L; Bottacchi, E; Lucchetti, L; Mariani, C; Rapazzini, P; Romanelli, G; Marengoni, A; Zuliani, G; Bianchi, L; Suardi, T; Muti, E; Bottura, R; Sgrò, G; Mandas, A; Serchisu, L; Crippa, P; Ivaldi, C; Ungar, A; Villani, D; Raimondi, C; Mussi, C; Isaia, G; Provenzano, G; Mari, D; Odetti, P; Monacelli, F; Antonelli Incalzi, R; Pluderi, A; Bellamoli, C; Terranova, L; Scarpini, E; D’Amico, F; Cavallini, Mc; Guerrini, G; Scotuzzi, Am; Chiarello, A; Pilotto, A; Tognini, S; Dell’Aquila, G; Toigo, G; Ceschia, G; Piccinini, M; Fabbo, A; Zoli, M; Forti, P; Wenter, C; Basile, G; Lasagni, A; Padovani, A; Rozzini, L; Cottino, M; Vitali, S; Tripi, G; Avanzi, S; Umidi, S; Moretti, D; Ruotolo, G; Boschi, F; Bonino, P; Marchionni, N; Cavallini, Mc; Fascendini, S; Noro, G; Turco, R; Ubezio, Mc; Serrati, C; Infante, M; Gentile, S; Pernigotti, Lm; Biagini, Ca; Canonico, E; Bonati, P; Gareri, P; Caffarra, P; Castagna, A; Ceretti, A; Castiglia, R; Gabelli, C; Lo Storto, M; Putzu, P; Bellelli, G; Morandi, A; Di Santo, S; Mazzone, A; Rozzini, R; Zanetti, E; Bianchetti, A; Bo, M; Mossello, E; Cherubini, A; Ferrara, N; Ferrari, A; Musicco, M; Trabucchi, M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330352
Citazioni:
Drug prescription and delirium in older inpatients: Results from the nationwide multicenter Italian Delirium Day 2015-2016 / Aloisi, G., Marengoni, A., Morandi, A., Zucchelli, A., Cherubini, A., Mossello, E., Bo, M., Di Santo, S.G., Mazzone, A., Trabucchi, M., Cappa, S., Fimognari, F.L., Incalzi, R.A., Gareri, P., Perticone, F., Campanini, M., Montorsi, M., Latronico, N., Zambon, A., on behalf of the Italian Study Group on Delirium (ISGoD): Boffelli, S., et al.. - In: JOURNAL OF CLINICAL PSYCHIATRY. - ISSN 0160-6689. - STAMPA. - 80:2(2019), p. 18m12430. [10.4088/JCP.18m12430]
Abstract:
Objective: This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods: Data were collected ...during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy was defined as a prescription of drugs from 5 or more classes. Results: Of 4,133 participants, 969 (23.4%) had delirium. The general prevalence of polypharmacy was higher in patients with delirium (67.6% vs 63.0%, P =.009) but varied according to clinical settings. After adjustment for confounders, polypharmacy was associated with delirium only in patients admitted to surgical units (OR = 2.9; 95% CI, 1.4-6.1). Insulin, antibiotics, antiepileptics, antipsychotics, and atypical antidepressants were associated with delirium, whereas statins and angiotensin receptor blockers exhibited an inverse association. A stronger association was seen between typical and atypical antipsychotics and delirium in subjects free from dementia compared to individuals with dementia (typical: OR = 4.31; 95% CI, 2.94-6.31 without dementia vs OR = 1.64; 95% CI, 1.19-2.26 with dementia; atypical: OR = 5.32; 95% CI, 3.44-8.22 without dementia vs OR = 1.74; 95% CI, 1.26-2.40 with dementia). The absence of antipsychotics among the prescribed drugs was inversely associated with delirium in the whole sample and in both of the hospital settings, but only in patients without dementia. Conclusions: Polypharmacy is significantly associated with delirium only in surgical units, raising the issue of the relevance of medication review in different clinical settings. Specific drug classes are associated with delirium depending on the clinical setting and dementia diagnosis, suggesting the need to further explore this relationship.
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The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the “Delirium Day 2015”
Anno: 2019
Rivista: AGING CLINICAL AND EXPERIMENTAL RESEARCH
Autori/autrici: Bo, M; Porrino, P; Di Santo, Sg; Mazzone, A; Cherubini, A; Mossello, E; Bianchetti, A; Musicco, M; Ferrari, A; Ferrara, N; Filippini, C; Trabucchi, M; Morandi, A; Bellelli, G; on behalf of the Italian Study Group on Delirium (ISGoD): Boffelli, S; Di Stefano, F; De Filippi, F; Guerini, F; Bertoletti, E; March, A; Margiotta, A; Mecocci, P; Ruggiero, C; Addesi, D; Fantò, F; Isaia, G; Dijik, B; Porrino, P; Cotroneo, Am; Galli, G; Bruni, Ac; Bernardini, B; Corsini, C; Cagnin, A; Zurlo, G; Barbagallo, G; Lunardelli, Ml; Martini, E; Battaglia, G; Latella, R; Petritola, D; Sinforiani, E; Cester, A; Formilan, M; Carbone, P; Appollonio, I; Cereda, D; Tremolizzo, L; Bottacchi, E; Lucchetti, L; Mariani, C; Rapazzini, P; Romanelli, G; Marengoni, A; Zuliani, G; Bianchi, L; Suardi, T; Muti, E; Bottura, R; Sgrò, G; Mandas, A; Serchisu, L; Crippa, P; Ivaldi, C; Ungar, A; Villani, D; Raimondi, C; Mussi, C; Isaia, G; Provenzano, G; Mari, D; Odetti, P; Monacelli, F; Antonelli Incalzi, R; Pluderi, A; Bellamoli, C; Terranova, L; Scarpini, E; D’Amico, F; Cavallini, Mc; Guerrini, G; Scotuzzi, Am; Chiarello, A; Pilotto, A; Tognini, S; Dell’Aquila, G; Toigo, G; Ceschia, G; Piccinini, M; Fabbo, A; Zoli, M; Forti, P; Wenter, C; Basile, G; Lasagni, A; Padovani, A; Rozzini, L; Cottino, M; Vitali, S; Tripi, G; Avanzi, S; Umidi, S; Moretti, D; Ruotolo, G; Boschi, F; Bonino, P; Marchionni, N; Cavallini, Mc; Fascendini, S; Noro, G; Turco, R; Ubezio, Mc; Serrati, C; Infante, M; Gentile, S; Pernigotti, Lm; Biagini, Ca; Canonico, E; Bonati, P; Gareri, P; Caffarra, P; Castagna, A; Ceretti, A; Castiglia, R; Gabelli, C; Lo Storto, M; Putzu, P; Bellelli, G; Morandi, A; Di Santo, S; Mazzone, A; Rozzini, R; Zanetti, E; Bianchetti, A; Bo, M; Mossello, E; Cherubini, A; Ferrara, N; Ferrari, A; Musicco, M; Trabucchi, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330354
Citazioni:
The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the “Delirium Day 2015” / Bo, M., Porrino, P., Di Santo, S.g., Mazzone, A., Cherubini, A., Mossello, E., Bianchetti, A., Musicco, M., Ferrari, A., Ferrara, N., Filippini, C., Trabucchi, M., Morandi, A., Bellelli, G., on behalf of the Italian Study Group on Delirium (ISGoD): Boffelli, S., Di Stefano, F., De Filippi, F., Guerini, F., Bertoletti, E., March, A., et al.. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - STAMPA. - 31:3(2019), pp. 411-420. [10.1007/s40520-018-0974-1]
Abstract:
Backround: Use of indwelling urinary catheter (IUC) in older adults has negative consequences, including delirium. Aim: This analysis, from the “Delirium Day 2015”, a nationwide multicenter prevalence study, aim to evaluate the association of IUC with delirium in hospitalized and Nursing... Homes (NHs) patients. Methods: Patients underwent a comprehensive geriatric assessment, including the presence of IUC; inclusion criteria were age > 65 years, being Italian speaker and providing informed consent; exclusion criteria were coma, aphasia, end-of-life status. Delirium was assessed using the 4AT test (score ≥ 4: possible delirium; scores 1–3: possible cognitive impairment). Results: Among 1867 hospitalized patients (mean age 82.0 ± 7.5 years, 58% female), 539 (28.9%) had IUC, 429 (22.9%) delirium and 675 (36.1%) cognitive impairment. IUC was significantly associated with cognitive impairment (OR 1.60, 95% CI 1.19–2.16) and delirium (2.45, 95% CI 1.73–3.47), this latter being significant also in the subset of patients without dementia (OR 2.28, 95% CI 1.52–3.43). Inattention and impaired alertness were also independently associated with IUC. Among 1454 NHs residents (mean age 84.4 ± 7.4 years, 70.% female), 63 (4.3%) had IUC, 535 (36.8%) a 4AT score ≥ 4, and 653 (44.9%) a 4AT score 1–3. The multivariate logistic regression analysis did not show a significant association between 4AT test or its specific items with IUC, neither in the subset of patients without dementia. Discussion: We confirmed a significant association between IUC and delirium in hospitalized patients but not in NHs residents. Conclusion: Environmental and clinical factors of acute setting might contribute to IUC-associated delirium occurrence.
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Calcium metabolism and vitamin D in the extreme longevity
Anno: 2008
Rivista: EXPERIMENTAL GERONTOLOGY
Autori/autrici: Passeri, G; Vescovini, R; Sansoni, P; Galli, C; Franceschi, C; Passeri, M; Italian Multicentric Study on Centenarians 87, Collaborators; Motta, M; Franceschi, C; Motta, L; Capurso, A; Panza, F; Solfrizzi, V; D'Introno, A; Colacicco, Am; Capurso, S; Capri, M; Salvioli, S; Valensin, S; Bennati, E; Malaguarnera, M; Maugeri, D; Rapisarda, R; Franzone, A; Ferlito, L; De Benedictis, G; Berardelli, M; Masotti, G; Petruzzi, E; Petruzzi, I; Pinzani, P; Monti, D; Antonini, Fm; Capurso, C; Nicita Mauro, V; Lo Balbo, C; Mento, A; Nicita Mauro, C; Maltese, G; Basile, G; Mari, D; Coppola, R; Provenzano, R; Salvioli, G; Baldelli, Mv; Mussi, C; Varricchio, M; Barbieri, M; Gambardella, A; Paolisso, G; Caruso, C; Candore, G; Colonna Romano, G; Lio, D; Sansoni, P; Vescovini, R; Galli, C; Biasini, C; Telera, A; Passeri, G; Passeri, M; Ferrari, E; Cravello, L; Barili, L; Solerte, Sb; Fioravanti, M; Magri, F; Fagnoni, F; Senin, Umberto; Mecocci, Patrizia; Cherubini, Antonio; Marigliano, V; Tafaro, L; Cicconetti, P; Tombesi, F; Tombolillo, Mt; Ettore, E; Forconi, S; Boschi, S; Righi, Ga; Guerrini, M; Giarelli, L; Stanta, G; Ferrucci, L; Ble, A; Metter, Ej; Guralnik, Jm; Pacifici, R; Zuccaro, P; Palmi, I; Branca, S; Fradà, G; Motta, F; Crimi, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/330291
Citazioni:
Calcium metabolism and vitamin D in the extreme longevity / Passeri, G., Vescovini, R., Sansoni, P., Galli, C., Franceschi, C., Passeri, M., Italian Multicentric Study on Centenarians 87, C., Motta, M., Franceschi, C., Motta, L., Capurso, A., Panza, F., Solfrizzi, V., D'Introno, A., Colacicco, A.m., Capurso, S., Capri, M., Salvioli, S., Valensin, S., Bennati, E., et al.. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - STAMPA. - 43:(2008), pp. 79-87.
Abstract:
Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if consid...ering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence. Calcium metabolism is regulated at cellular/molecular level by a network of cytokines, growth factors, systemic hormones that act on bone in paracrine/autocrine/systemic fashion. Among the molecules involved in bone metabolism, parathyroid hormone (PTH) and vitamin D present some peculiar aspects during senescence. The osteometabolic features in a consistent group of centenarians have been evaluated. It results that a severe hypovitaminosis D was present in 99 out of 104 centenarians (25-OH vitamin D below 5 nmol/L), and that it plays an important role as a factor inducing a vicious circle involving hypocalcemia, secondary hyperparathyroidism, together with biochemical features indicating a consistent bone loss. Serum C-terminal cross-linking telopeptide, a specific marker of bone resorption was elevated in 92% of these subjects. Moreover, it has been found that several femoral fractures had occurred after 90 years of age. These data offer a rational for the possible prevention of elevated bone turnover, bone loss and consequently the reduction of osteoporotic fractures and fractures-induced disability, in the oldest olds, through the simple supplementation with calcium and vitamin D.
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A Neural Network Approach to the Pitch Dynamics Identification for a Light Aircraft
Anno: 1998
Autori/autrici: Basile, G.; Piazza, Francesco; Pirani, Stefano
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/47172
Citazioni:
A Neural Network Approach to the Pitch Dynamics Identification for a Light Aircraft / Basile, G., Piazza, F., Pirani, S.. - (1998).
Abstract:
Daytona, Florida – USA

A novel method for aircraft attitude estimation using magnetic field sensors and dynamic modeling
Anno: 1996
Autori/autrici: Basile, G.; Pirani, Stefano; Rinaldi, M.; Varosi, S.
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/46387
Citazioni:
A novel method for aircraft attitude estimation using magnetic field sensors and dynamic modeling / Basile, G., Pirani, S., Rinaldi, M., Varosi, S.. - (1996).
Abstract:
Orlando, Florida - USA.

Solid state device for the measurement of light aircraft roll attitude
Anno: 1993
Autori/autrici: Basile, G.; Latchman, H. A.; Pirani, Stefano; Rinaldi, M.
Classificazione IRIS: 4.1 Contributo in Atti di convegno
Scheda completa IRIS: https://iris.univpm.it/handle/11566/46640
Citazioni:
Solid state device for the measurement of light aircraft roll attitude / Basile, G., Latchman, H.A., Pirani, S., Rinaldi, M.. - (1993).
Abstract:
Irvine, California – USA