Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults
Anno: 2025
Rivista: NUTRIENTS
Autori/autrici: Godos, Justyna; Giampieri, Francesca; Frias-Toral, Evelyn; Zambrano-Villacres, Raynier; Olider Rojas Vistorte, Angel; Yélamos Torres, Vanessa; Battino, Maurizio; Galvano, Fabio; Castellano, Sabrina; Grosso, Giuseppe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/339873
Citazioni:
Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults / Godos, Justyna; Giampieri, Francesca; Frias-Toral, Evelyn; Zambrano-Villacres, Raynier; Olider Rojas Vistorte, Angel; Yélamos Torres, Vanessa; Battino, Maurizio; Galvano, Fabio; Castellano, Sabrina; Grosso, Giuseppe. - In: NUTRIENTS. - ISSN 2072-6643. - 17:3(2025). [10.3390/nu17030521]
Abstract:
Background: Nut consumption has been considered a potential protective factor against cognitive decline. The aim of this study was to test whether higher total and specific nut intake was associated with better cognitive status in a sample of older Italian adults. Methods: A cross-sectional analysis... on 883 older adults (>50 y) was conducted. A 110-item food frequency questionnaire was used to collect information on the consumption of various types of nuts. The Short Portable Mental Status Questionnaire was used to assess cognitive status. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between nut intake and cognitive status after adjusting for potential confounding factors. Results: The median intake of total nuts was 11.7 g/day and served as a cut-off to categorize low and high consumers (mean intake 4.3 g/day vs. 39.7 g/day, respectively). Higher total nut intake was significantly associated with a lower prevalence of impaired cognitive status among older individuals (OR = 0.35, CI 95%: 0.15, 0.84) after adjusting for potential confounding factors. Notably, this association remained significant after additional adjustment for adherence to the Mediterranean dietary pattern as an indicator of diet quality, (OR = 0.32, CI 95%: 0.13, 0.77). No significant associations were found between cognitive status and specific types of nuts. Conclusions: Habitual nut intake is associated with better cognitive status in older adults.
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Pyroptosis: A Novel Therapeutic Target for Bioactive Compounds in Human Disease Treatment? A Narrative Review
Anno: 2025
Rivista: NUTRIENTS
Autori/autrici: Yang, B; Qi, Z; Armas Diaz, Y; Cassotta, M; Grosso, G; Cianciosi, D; Zhang, D; Zou, X; Quiles, Jl; Battino, M; Giampieri, F
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/339693
Citazioni:
Pyroptosis: A Novel Therapeutic Target for Bioactive Compounds in Human Disease Treatment? A Narrative Review / Yang, B; Qi, Z; Armas Diaz, Y; Cassotta, M; Grosso, G; Cianciosi, D; Zhang, D; Zou, X; Quiles, Jl; Battino, M; Giampieri, F. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 17:3(2025). [10.3390/nu17030461]
Abstract:
Background/Objectives: Bioactive compounds possess the ability to maintain health and improve diseases by regulating inflammation and cell death processes. Pyroptosis is programmed cell death related to inflammation and exerts a critical role in the development and progression of different types of ...diseases. This narrative review aims to investigate and discuss the effects of dietary bioactive compounds on pyroptosis in different common human pathologies, such as inflammatory disease, bacterial infection, injury disease, cancer, diabetes and heart disease, etc. Method: Studies published in the major databases until December 2024 in English were considered, for a total of 50 papers. Results: The current evidence demonstrated that the bioactive compounds are able to regulate the pyroptosis process by modulating different inflammasome sensors (NLRP1, NLRP3, and AIM2), caspase family proteins (caspase-1, caspase-3, and caspase-11), and gasdermins (GSDMD and GSDME) in many pathological conditions related to inflammation, including cancer and cardiovascular diseases. Conclusions: Bioactive compounds have powerful potential to be the candidate drug for pyroptosis modulation in inflammatory diseases, even if more clinical studies are needed to confirm the effects and establish efficient doses for humans.
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Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice
Anno: 2024
Rivista: FOOD CHEMISTRY
Autori/autrici: Luo, Peihuan; Ai, Jian; Wang, Qiongyao; Lou, Yihang; Liao, Zhiwei; Giampieri, Francesca; Battino, Maurizio; Sieniawska, Elwira; Bai, Weibin; Tian, Lingmin
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/338456
Citazioni:
Enzymatic treatment shapes in vitro digestion pattern of phenolic compounds in mulberry juice / Luo, Peihuan; Ai, Jian; Wang, Qiongyao; Lou, Yihang; Liao, Zhiwei; Giampieri, Francesca; Battino, Maurizio; Sieniawska, Elwira; Bai, Weibin; Tian, Lingmin. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 469:(2024). [10.1016/j.foodchem.2024.142555]
Abstract:
The health benefits of mulberry fruit are closely associated with its phenolic compounds. However, the effects of enzymatic treatments on the digestion patterns of these compounds in mulberry juice remain largely unknown. This study investigated the impact of pectinase (PE), pectin lyase (PL), and c...ellulase (CE) on the release of phenolic compounds in whole mulberry juice. The digestion patterns were further evaluated using an in vitro simulated digestion model. The results revealed that PE significantly increased chlorogenic acid content by 77.8 %, PL enhanced cyanidin-3-O-glucoside by 20.5 %, and CE boosted quercetin by 44.5 %. Following in vitro digestion, the phenolic compound levels decreased differently depending on the treatment, while cyanidin-3-O-rutinoside content increased across all groups. In conclusion, the selected enzymes effectively promoted the release of phenolic compounds in mulberry juice. However, during gastrointestinal digestion, the degradation of phenolic compounds surpassed their enhanced release, with effects varying based on the compound's structure.
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Aging, age-related diseases, oxidative stress and plant polyphenols: Is this a true relationship?
Anno: 2024
Rivista: MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM
Autori/autrici: Cassotta, M; Quiles, Jl; Giampieri, F; Battino, M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/336489
Citazioni:
Aging, age-related diseases, oxidative stress and plant polyphenols: Is this a true relationship? / Cassotta, M; Quiles, Jl; Giampieri, F; Battino, M. - In: MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM. - ISSN 1973-798X. - 17:3(2024), pp. 255-259. [10.3233/MNM-240057]

Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: "A review"
Anno: 2024
Rivista: FRONTIERS IN PHARMACOLOGY
Autori/autrici: Al-Naqeb, Ghanya; Kalmpourtzidou, Aliki; Giampieri, Francesca; De Giuseppe, Rachele; Cena, Hellas
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/338333
Citazioni:
Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: "A review" / Al-Naqeb, Ghanya; Kalmpourtzidou, Aliki; Giampieri, Francesca; De Giuseppe, Rachele; Cena, Hellas. - In: FRONTIERS IN PHARMACOLOGY. - ISSN 1663-9812. - 15:(2024). [10.3389/fphar.2024.1448731]
Abstract:
Many medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic. Therefore, evaluation of the genotoxicity effects of plant extracts that are used as traditional... medicine is essential to ensure they are safe for use and in the search for new medication. This review summarizes 52 published studies on the genotoxicity of 28 plant extracts used in traditional medicine. A brief overview of the selected plant extracts, including, for example, their medicinal uses, pharmacological effects, and primary identified compounds, as well as plant parts used, the extraction method, genotoxic assay, and phytochemicals responsible for genotoxicity effect were provided. The genotoxicity effect of selected plant extracts in most of the reviewed articles was based on the experimental conditions. Among different reviewed studies, A total of 6 plant extracts showed no genotoxic effect, other 14 plant extracts showed either genotoxic or mutagenic effect and 14 plant extracts showed anti-genotoxic effect against different genotoxic induced agents. In addition, 4 plant extracts showed both genotoxic and non-genotoxic effects and 6 plant extracts showed both genotoxic and antigenotoxic effects. While some suggestions on the responsible compounds of the genotoxicity effects were proposed, the proposed responsible phytochemicals were not individually tested for the genotoxicity potential to confirm the findings. In addition, the mechanisms by which most plant extracts exert their genotoxicity effect remain unidentified. Therefore, more research on the genotoxicity of medicinal plant extracts and their genotoxicity mechanisms is required.
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Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action
Anno: 2024
Rivista: NUTRIENTS
Autori/autrici: Godos, J.; Romano, G. L.; Laudani, S.; Gozzo, L.; Guerrera, I.; Dominguez Azpiroz, I.; Martinez Diaz, R.; Quiles, J. L.; Battino, M.; Drago, F.; Giampieri, F.; Galvano, F.; Grosso, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/336488
Citazioni:
Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action / Godos, J.; Romano, G. L.; Laudani, S.; Gozzo, L.; Guerrera, I.; Dominguez Azpiroz, I.; Martinez Diaz, R.; Quiles, J. L.; Battino, M.; Drago, F.; Giampieri, F.; Galvano, F.; Grosso, G.. - In: NUTRIENTS. - ISSN 2072-6643. - 16:15(2024). [10.3390/nu16152471]
Abstract:
Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for... their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota.
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Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project
Anno: 2024
Rivista: NUTRIENTS
Autori/autrici: Giampieri, Francesca; Alice, Rosi; Francesca, Scazzina; Evelyn, Frias-Toral; Osama, Abdelkarim; Mohamed, Aly; Raynier, Zambrano-Villacres; Juancho, Pons; Laura, Vázquez-Araújo; Sandra Sumalla, Cano; Iñaki, Elio; Lorenzo, Monasta; Ana, Mata; María Isabel, Pardo; Pablo, Busó; Giuseppe, Grosso
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/337258
Citazioni:
Youth Healthy Eating Index (YHEI) and Diet Adequacy in Relation to Country-Specific National Dietary Recommendations in Children and Adolescents in Five Mediterranean Countries from the DELICIOUS Project / Giampieri, Francesca; Alice, Rosi; Francesca, Scazzina; Evelyn, Frias-Toral; Osama, Abdelkarim; Mohamed, Aly; Raynier, Zambrano-Villacres; Juancho, Pons; Laura, Vázquez-Araújo; Sandra Sumalla, Cano; Iñaki, Elio; Lorenzo, Monasta; Ana, Mata; María Isabel, Pardo; Pablo, Busó; Giuseppe, Grosso. - In: NUTRIENTS. - ISSN 2072-6643. - 16:22(2024). [10.3390/nu16223907]
Abstract:
Background/Objectives: The diet quality of younger individuals is decreasing globally, with alarming trends also in the Mediterranean region. The aim of this study was to assess diet quality and adequacy in relation to country-specific dietary recommendations for children and adolescents living in t...he Mediterranean area. Methods: A cross-sectional survey was conducted of 2011 parents of the target population participating in the DELICIOUS EU-PRIMA project. Dietary data and cross-references with food-based recommendations and the application of the youth healthy eating index (YHEI) was assessed through 24 h recalls and food frequency questionnaires. Results: Adherence to recommendations on plant-based foods was low (less than ∼20%), including fruit and vegetables adequacy in all countries, legume adequacy in all countries except for Italy, and cereal adequacy in all countries except for Portugal. For animal products and dietary fats, the adequacy in relation to the national food-based dietary recommendations was slightly better (∼40% on average) in most countries, although the Eastern countries reported worse rates. Higher scores on the YHEI predicted adequacy in relation to vegetables (except Egypt), fruit (except Lebanon), cereals (except Spain), and legumes (except Spain) in most countries. Younger children (p < 0.005) reporting having 8–10 h adequate sleep duration (p < 0.001), <2 h/day screen time (p < 0.001), and a medium/high physical activity level (p < 0.001) displayed a better diet quality. Moreover, older respondents (p < 0.001) with a medium/high educational level (p = 0.001) and living with a partner (p = 0.003) reported that their children had a better diet quality. Conclusions: Plant-based food groups, including fruit, vegetables, legumes, and even (whole-grain) cereals are underrepresented in the diets of Mediterranean children and adolescents. Moreover, the adequate consumption of other important dietary components, such as milk and dairy products, is rather disregarded, leading to substantially suboptimal diets and poor adequacy in relation to dietary guidelines.
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Manuka honey's anti-metastatic impact on colon cancer stem-like cells: unveiling its effects on epithelial–mesenchymal transition, angiogenesis and telomere length
Anno: 2024
Rivista: FOOD & FUNCTION
Autori/autrici: Cianciosi, Danila; Forbes-Hernandez, Tamara; Armas Diaz, Yasmany; Elexpuru-Zabaleta, Maria; Quiles, José L.; Battino, Maurizio; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/332072
Citazioni:
Manuka honey's anti-metastatic impact on colon cancer stem-like cells: unveiling its effects on epithelial–mesenchymal transition, angiogenesis and telomere length / Cianciosi, Danila; Forbes-Hernandez, Tamara; Armas Diaz, Yasmany; Elexpuru-Zabaleta, Maria; Quiles, José L.; Battino, Maurizio; Giampieri, Francesca. - In: FOOD & FUNCTION. - ISSN 2042-6496. - 15:13(2024), pp. 7200-7213. [10.1039/d4fo00943f]
Abstract:
Colorectal cancer often leads to metastasis, with cancer stem cells (CSCs) playing a pivotal role in this process. Two closely linked mechanisms, epithelial-mesenchymal transition and angiogenesis, contribute to metastasis and recent research has also highlighted the impact of telomere replication o...n this harmful tumor progression. Standard chemotherapy alone can inadvertently promote drug-resistant CSCs, posing a challenge. Combining chemotherapy with other compounds, including natural ones, shows promise in enhancing effectiveness while minimizing side effects. This study investigated the anti-metastatic potential of Manuka honey, both alone and in combination with 5-fluorouracil, using a 3D model of colonospheres enriched with CSC-like cells. In summary, it was observed that the treatment reduced migration ability by downregulating the transcription factors Slug, Snail, and Twist, which are key players in epithelial-mesenchymal transition. Additionally, Manuka honey downregulated pro-angiogenic factors and shortened CSC telomeres by downregulating c-Myc - demonstrating an effective anti-metastatic potential. This study suggests new research opportunities for studying the impact of natural compounds when combined with pharmaceuticals, with the potential to enhance effectiveness and reduce side effects.
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Modulatory effect of Andean blackberry polyphenols on genes related to antioxidant and inflammatory responses, the NLRP3 inflammasome, and autophagy
Anno: 2024
Rivista: JOURNAL OF BERRY RESEARCH
Autori/autrici: Castejón-Vega, Beatriz; Kyriakidis, Nikolaos C.; Alcócer-Gómez, Elizabet; Giampieri, Francesca; González-Paramás, Ana M.; Cordero, Mario D.; Alvarez-Suarez, José M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327467
Citazioni:
Modulatory effect of Andean blackberry polyphenols on genes related to antioxidant and inflammatory responses, the NLRP3 inflammasome, and autophagy / Castejón-Vega, Beatriz; Kyriakidis, Nikolaos C.; Alcócer-Gómez, Elizabet; Giampieri, Francesca; González-Paramás, Ana M.; Cordero, Mario D.; Alvarez-Suarez, José M.. - In: JOURNAL OF BERRY RESEARCH. - ISSN 1878-5093. - 14:1(2024), pp. 41-59. [10.3233/jbr-230058]
Abstract:
BACKGROUND: The Andean blackberry (Rubus glaucus Benth) is one of Ecuador’s most iconic Andean berries for which a high anthocyanin content has been described. OBJECTIVE: The aim of the present study was to determine the chemical composition and anti-inflammatory potential of the Andean blackbe...rry from Ecuador, with an emphasis on its effects on NLRP3 inflammasome activation and autophagy processes. RESULTS: Andean blackberry extracts were rich in hydroxycinnamates (coumaric acid and derivates), in addition to quercetin and kaempferol as principal flavonols. Cyanidin and its glycosides were identified as the main anthocyanins present. Andean blackberry extracts efficiently reduced oxidative stress markers in the lipopolysaccharide-stimulated RAW 264.7 cells. The extracts also caused a moderate decrease in the expression of the pro-inflammatory and antioxidant genes NFκB1, TNF, IL-1 , IL-6, and NOS2 expression, while they significantly increased the mRNA levels of both SOD1 and NFE2L2 genes. Andean blackberry extracts significantly decreased the activation of the NLRP3 inflammasome complex, as well as p62 levels, and the LC3I/LC3II ratio increased, suggesting a direct action of Andean blackberry compounds on the inflammatory response and restoration of the autophagy process. CONCLUSION: These results suggest that Andean blackberries potentially have an anti-inflammatory effect through their ability to regulate genes related to the inflammatory and antioxidant response, as well as modulate the activation of the NLRP3 inflammasome complex and autophagy processes.
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From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products
Anno: 2024
Rivista: FRONTIERS IN NUTRITION
Autori/autrici: Regolo, Lucia; Giampieri, Francesca; Battino, Maurizio; Armas Diaz, Yasmany; Mezzetti, Bruno; Elexpuru-Zabaleta, Maria; Mazas, Cristina; Tutusaus, Kilian; Mazzoni, Luca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/332053
Citazioni:
From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products / Regolo, Lucia; Giampieri, Francesca; Battino, Maurizio; Armas Diaz, Yasmany; Mezzetti, Bruno; Elexpuru-Zabaleta, Maria; Mazas, Cristina; Tutusaus, Kilian; Mazzoni, Luca. - In: FRONTIERS IN NUTRITION. - ISSN 2296-861X. - 11:(2024). [10.3389/fnut.2024.1083759]
Abstract:
In the last decades, the world population and demand for any kind of product have grown exponentially. The rhythm of production to satisfy the request of the population has become unsustainable and the concept of the linear economy, introduced after the Industrial Revolution, has been replaced by a ...new economic approach, the circular economy. In this new economic model, the concept of "the end of life" is substituted by the concept of restoration, providing a new life to many industrial wastes. Leaves are a by-product of several agricultural cultivations. In recent years, the scientific interest regarding leaf biochemical composition grew, recording that plant leaves may be considered an alternative source of bioactive substances. Plant leaves' main bioactive compounds are similar to those in fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. Bioactive compounds can positively influence human health; in fact, it is no coincidence that the leaves were used by our ancestors as a natural remedy for various pathological conditions. Therefore, leaves can be exploited to manufacture many products in food (e.g., being incorporated in food formulations as natural antioxidants, or used to create edible coatings or films for food packaging), cosmetic and pharmaceutical industries (e.g., promising ingredients in anti-aging cosmetics such as oils, serums, dermatological creams, bath gels, and other products). This review focuses on the leaves' main bioactive compounds and their beneficial health effects, indicating their applications until today to enhance them as a harvesting by-product and highlight their possible reuse for new potential healthy products.
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Human-based new approach methodologies to accelerate advances in nutrition research
Anno: 2024
Rivista: FOOD FRONTIERS
Autori/autrici: Cassotta, Manuela; Cianciosi, Danila; Elexpuru-Zabaleta, Maria; Elio Pascual, Inaki; Sumalla Cano, Sandra; Giampieri, Francesca; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327398
Citazioni:
Human-based new approach methodologies to accelerate advances in nutrition research / Cassotta, Manuela; Cianciosi, Danila; Elexpuru-Zabaleta, Maria; Elio Pascual, Inaki; Sumalla Cano, Sandra; Giampieri, Francesca; Battino, Maurizio. - In: FOOD FRONTIERS. - ISSN 2643-8429. - 5:3(2024), pp. 1031-1062. [10.1002/fft2.369]
Abstract:
Much of nutrition research has been conventionally based on the use of simplistic in vitro systems or animal models, which have been extensively employed in an effort to better understand the relationships between diet and complex diseases as well as to evaluate food safety. Although these models ha...ve undeniably contributed to increase our mechanistic understanding of basic biological processes, they do not adequately model complex human physiopathological phenomena, creating concerns about the translatability to humans. During the last decade, extraordinary advancement in stem cell culturing, three-dimensional cell cultures, sequencing technologies, and computer science has occurred, which has originated a wealth of novel human-based and more physiologically relevant tools. These tools, also known as “new approach methodologies,” which comprise patient-derived organoids, organs-on-chip, multi-omics approach, along with computational models and analysis, represent innovative and exciting tools to forward nutrition research from a human-biology-oriented perspective. After considering some shortcomings of conventional in vitro and vivo approaches, here we describe the main novel available and emerging tools that are appropriate for designing a more human-relevant nutrition research. Our aim is to encourage discussion on the opportunity to explore innovative paths in nutrition research and to promote a paradigm-change toward a more human biology-focused approach to better understand human nutritional pathophysiology, to evaluate novel food products, and to develop more effective targeted preventive or therapeutic strategies while helping in reducing the number and replacing animals employed in nutrition research.
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Differences in carotid to femoral pulse wave velocity and carotid intima media thickness between vegetarian and omnivorous diets in healthy subjects: a systematic review and meta-analysis
Anno: 2024
Rivista: FOOD & FUNCTION
Autori/autrici: Saz-Lara, Alicia; Battino, Maurizio; del Saz Lara, Andrea; Cavero-Redondo, Iván; Dávalos, Alberto; López de Las Hazas, María-Carmen; Visioli, Francesco; Lucerón-Lucas-Torres, Maribel; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326692
Citazioni:
Differences in carotid to femoral pulse wave velocity and carotid intima media thickness between vegetarian and omnivorous diets in healthy subjects: a systematic review and meta-analysis / Saz-Lara, Alicia; Battino, Maurizio; del Saz Lara, Andrea; Cavero-Redondo, Iván; Dávalos, Alberto; López de Las Hazas, María-Carmen; Visioli, Francesco; Lucerón-Lucas-Torres, Maribel; Giampieri, Francesca. - In: FOOD & FUNCTION. - ISSN 2042-6496. - 15:3(2024), pp. 1135-1143. [10.1039/D3FO05061K]
Abstract:
Background: Arterial stiffness and atherosclerosis are known risk factors for cardiovascular morbidity and mortality. Vegetarian diets have been associated with cardiovascular benefits, including improvements in metabolic parameters. However, the impact of a vegetarian diet on cardiovascular paramet...ers, specifically arterial stiffness and atherosclerosis, in healthy individuals remains unclear. Thus, this study aims to analyze differences in arterial stiffness and atherosclerosis between vegetarian and omnivorous diets in healthy subjects. Methods: A systematic review and meta-analysis were conducted following established guidelines. PubMed, Scopus, Web of Science, and Cochrane Library databases were searched for studies examining the association between vegetarian and omnivorous diets with arterial stiffness and atherosclerosis. Cross-sectional studies reporting carotid to femoral pulse wave velocity (cf-PWv) as a measure of arterial stiffness and carotid intima media thickness (c-IMT) as a measure of atherosclerosis were included. Data were synthesized using random effects models, and sensitivity analyses, meta-regressions, and assessment of publication bias were performed. Results: Ten studies were included in the systematic review, and seven studies were included in the meta-analysis. The pooled analysis demonstrated that individuals following a vegetarian diet had differences in the levels of arterial stiffness (cf-PWv) compared to those following an omnivorous diet (MD: -0.43 m s-1; 95% CI: -0.63, -0.23). Similarly, atherosclerosis (c-IMT) was found to be different in individuals adhering to a vegetarian dietary pattern (MD = -29.86 mm; 95% CI: -58.41, -1.32). Conclusions: Our findings suggest that a vegetarian diet is associated with improved arterial stiffness and reduced atherosclerosis in healthy individuals. These results support the inclusion of a well-balanced vegetarian dietary pattern in the prevention and management of cardiovascular diseases. However, further research is needed to explore the effects of a vegetarian diet on arterial health in diverse populations and to assess long-term cardiovascular outcomes.
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Establishment of 3D Cultures of Myometrium, Leiomyoma, and Leiomyosarcoma Cells: Advantages and Disadvantages of Two Different Models
Anno: 2024
Rivista: REPRODUCTIVE SCIENCES
Autori/autrici: Pellegrino, P; Greco, S; Gonzalez, Ad; Giampieri, F; Giannubilo, Sr; Delli Carpini, G; Capocasa, F; Mezzetti, B; Battino, M; Ciavattini, A; Ciarmela, P
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/337259
Citazioni:
Establishment of 3D Cultures of Myometrium, Leiomyoma, and Leiomyosarcoma Cells: Advantages and Disadvantages of Two Different Models / Pellegrino, P; Greco, S; Gonzalez, Ad; Giampieri, F; Giannubilo, Sr; Delli Carpini, G; Capocasa, F; Mezzetti, B; Battino, M; Ciavattini, A; Ciarmela, P. - In: REPRODUCTIVE SCIENCES. - ISSN 1933-7191. - 31:(2024), pp. 3729-3742. [10.1007/s43032-024-01724-3]
Abstract:
Uterine leiomyomas are the most common benign, monoclonal, gynaecological tumors in a woman's uterus, while leiomyosarcoma is a rare but aggressive condition caused by the malignant transformation of the myometrium. To overcome the common obstacles related to the methods usually used to study these ...pathologies, we aimed to devise three-dimensional models of myometrium, uterine leiomyoma and leiomyosarcoma cell lines, using two different types of biocompatible scaffolds. Specifically, we exploited the agarose gel matrix in common 6-well plates and the alginate matrix using Bioprinting INKREDIBLE + (CELLINK), a pneumatic extruded base equipped with a system with double printheads, and a UV printer LED curing system. Both methods allowed the development of 3D spheroids of all three cell types, that were also suitable for morphological investigations. We showed that all cell types embedded in both agarose and alginate formed spheroids in their growth medium. The spheroids successfully proliferated and self-organized into complex structures, developing a sustainable system that emulated the condition of the tissues through the accumulation of extracellular matrix. These models could be useful for a better understanding of pathophysiology, etiopathogenesis, and testing new methods or molecules from a preventive and therapeutic point of view.
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Nutritional, functional, and safety characterization of the edible larva of the South American palm weevil (chontacuro) Rhynchophorus palmarum L. from Amazonian Ecuador
Anno: 2024
Rivista: JOURNAL OF FOOD COMPOSITION AND ANALYSIS
Autori/autrici: Chimbo-Gándara, Luis F.; Granda-Albuja, Genoveva; Mora, José R.; Llumiquinga, Erika; Ruiz-Uriguen, Melany; Machado, António; Cisneros-Heredia, Diego F.; Abreu-Naranjo, Reinier; Giampieri, Francesca; Tejera, Eduardo; Álvarez-Suárez, José M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/333057
Citazioni:
Nutritional, functional, and safety characterization of the edible larva of the South American palm weevil (chontacuro) Rhynchophorus palmarum L. from Amazonian Ecuador / Chimbo-Gándara, Luis F.; Granda-Albuja, Genoveva; Mora, José R.; Llumiquinga, Erika; Ruiz-Uriguen, Melany; Machado, António; Cisneros-Heredia, Diego F.; Abreu-Naranjo, Reinier; Giampieri, Francesca; Tejera, Eduardo; Álvarez-Suárez, José M.. - In: JOURNAL OF FOOD COMPOSITION AND ANALYSIS. - ISSN 0889-1575. - 134:(2024). [10.1016/j.jfca.2024.106507]
Abstract:
Edible insects represent a viable option to address the current need for nutritious, safe, and eco-friendly foods. People native to the Amazon region have a long-standing tradition of consuming edible insects that are relatively unknown elsewhere. This research aimed to characterize the chemical, nu...tritional, and microbiological composition of the edible larva of the palm weevil Rhynchophorus palmarum L. (chontacuro) from the Amazonian lowlands of Ecuador. The larvae proved to be rich in lipids (∼50 %), proteins (∼20 %), fiber (∼6 %), and oleic acid, one of their predominant fatty acids along with palmitic acid. The larvae are also rich in vitamins (B6, B9, A, and E) and are a source of β-carotene, calcium, potassium, magnesium, and phosphorus. No evidence of toxic elements (metals) or pathogenic microorganisms was observed. In general, chontacuro larvae proved to be a safe and nutritious food, managing to fully or partially cover several of the Dietary Reference Intakes for several nutrients.
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Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota
Anno: 2024
Rivista: FRONTIERS IN PHARMACOLOGY
Autori/autrici: Godos, J; Romano, Gl; Gozzo, L; Laudani, S; Paladino, N; Dominguez Azpíroz, I; Martínez López, Nm; Giampieri, F; Quiles, Jl; Battino, M; Galvano, F; Drago, F; Grosso, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327851
Citazioni:
Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota / Godos, J; Romano, Gl; Gozzo, L; Laudani, S; Paladino, N; Dominguez Azpíroz, I; Martínez López, Nm; Giampieri, F; Quiles, Jl; Battino, M; Galvano, F; Drago, F; Grosso, G.. - In: FRONTIERS IN PHARMACOLOGY. - ISSN 1663-9812. - 15:(2024). [10.3389/fphar.2024.1368949]
Abstract:
Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained p...articular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted.
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Association between diagnostic imaging and biochemical markers: a possible tool for monitoring metabolic disorders
Anno: 2024
Rivista: CURRENT OPINION IN FOOD SCIENCE
Autori/autrici: Cianciosi, Danila; Armas Diaz, Yasmany; Grosso, Giuseppe; Quiles, José L; Giampieri, Francesca; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/325131
Citazioni:
Association between diagnostic imaging and biochemical markers: a possible tool for monitoring metabolic disorders / Cianciosi, Danila; Armas Diaz, Yasmany; Grosso, Giuseppe; Quiles, José L; Giampieri, Francesca; Battino, Maurizio. - In: CURRENT OPINION IN FOOD SCIENCE. - ISSN 2214-7993. - 55:(2024). [10.1016/j.cofs.2023.101109]
Abstract:
Metabolic syndrome (MetS), obesity, and diabetes mellitus (DM) are the most common metabolic disorders (MDs) in the world, characterized by abnormalities in body's metabolic processes. The typical diagnosis of MDs is usually executed by monitoring the levels of specific biochemical markers, but diag...nostic imaging may provide valuable complementary information in MDs, offering advantages in diagnosis, target organ monitoring, follow-up, and development of new therapeutic approaches. The aim of this review is to summarize and discuss the studies published in the literature about the connection between images deriving from the diagnostic techniques and the key biochemical markers in the main MDs, in order to gain a comprehensive view of the different disorders.
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Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?
Anno: 2024
Rivista: PHARMACEUTICALS
Autori/autrici: Laudani, Samuele; Godos, Justyna; Romano Giovanni, Luca; Gozzo, Lucia; Di Domenico Federica, Martina; Dominguez Azpíroz, Irma; Martínez Diaz, Raquel; Giampieri, Francesca; Quiles, José; Battino, Maurizio; Drago, Filippo; Galvano, Fabio; Grosso, Giuseppe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/326772
Citazioni:
Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? / Laudani, Samuele; Godos, Justyna; Romano Giovanni, Luca; Gozzo, Lucia; Di Domenico Federica, Martina; Dominguez Azpíroz, Irma; Martínez Diaz, Raquel; Giampieri, Francesca; Quiles, José; Battino, Maurizio; Drago, Filippo; Galvano, Fabio; Grosso, Giuseppe. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 17:2(2024). [10.3390/ph17020236]
Abstract:
Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence... of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.
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Lifestyle Factors Associated with Children’s and Adolescents’ Adherence to the Mediterranean Diet Living in Mediterranean Countries: The DELICIOUS Project
Anno: 2024
Rivista: NUTRIENTS
Autori/autrici: Rosi, Alice; Scazzina, Francesca; Giampieri, Francesca; Álvarez-Córdova, Ludwig; Abdelkarim, Osama; Ammar, Achraf; Aly, Mohamed; Frias-Toral, Evelyn; Pons, Juancho; Vázquez-Araújo, Laura; Rodríguez Velasco, Carmen Lili; Brito Ballester, Julién; Monasta, Lorenzo; Mata, Ana; Chacón, Adrián; Busó, Pablo; Grosso, Giuseppe
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/338552
Citazioni:
Lifestyle Factors Associated with Children’s and Adolescents’ Adherence to the Mediterranean Diet Living in Mediterranean Countries: The DELICIOUS Project / Rosi, Alice; Scazzina, Francesca; Giampieri, Francesca; Álvarez-Córdova, Ludwig; Abdelkarim, Osama; Ammar, Achraf; Aly, Mohamed; Frias-Toral, Evelyn; Pons, Juancho; Vázquez-Araújo, Laura; Rodríguez Velasco, Carmen Lili; Brito Ballester, Julién; Monasta, Lorenzo; Mata, Ana; Chacón, Adrián; Busó, Pablo; Grosso, Giuseppe. - In: NUTRIENTS. - ISSN 2072-6643. - 17:1(2024). [10.3390/nu17010026]
Abstract:
Background/Objectives. Traditional dietary patterns are being abandoned in Mediterranean countries, especially among younger generations. This study aimed to investigate the potential lifestyle determinants that can increase adherence to the Mediterranean diet in children and adolescents. Methods. T...his study is a cross-sectional analysis of data from five Mediterranean countries (Italy, Spain, Portugal, Egypt, and Lebanon) within the context of the EU-funded project DELICIOUS (UnDErstanding consumer food choices & promotion of healthy and sustainable Mediterranean Diet and LIfestyle in Children and adolescents through behavIOUral change actionS). This study comprised information on 2011 children and adolescents aged 6–17 years old collected during 2023. The main background characteristics of both children and parents, including age, sex, education, and family situation, were collected. Children’s eating (i.e., breakfast, place of eating, etc.) and lifestyle habits (i.e., physical activity level, sleep, and screen time) were also investigated. The level of adherence to the Mediterranean diet was assessed using the KIDMED index. Logistic regression analyses were performed to test for likelihood of higher adherence to the Mediterranean diet. Results. Major determinants of higher adherence to the Mediterranean diet were younger age, higher physical activity level, adequate sleep duration, and, among dietary habits, having breakfast and eating with family members and at school. Parents’ younger age and higher education were also determinants of higher adherence. Multivariate adjusted analyses showed that an overall healthier lifestyle and parents’ education were the factors independently associated with higher adherence to the Mediterranean diet. Conclusions. Higher adherence to the Mediterranean diet in children and adolescents living in the Mediterranean area is part of an overall healthy lifestyle possibly depending on parents’ cultural background.
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The preventive and inhibitory effects of red raspberries on cancer
Anno: 2024
Rivista: JOURNAL OF BERRY RESEARCH
Autori/autrici: Qi, Zexiu; Yang, Bei; Giampieri, Francesca; Cianciosi, Danila; Alvarez-Suarez, José Miguel; Elexpuru-Zabaleta, Maria; Quiles, Josè L.; Forbes-Hernandez, Tamara Y.; Zhang, Di; Bai, Weibin; Tian, Lingmin; Mezzetti, Bruno; Battino, Maurizio; Armas Diaz, Yasmany
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/327468
Citazioni:
The preventive and inhibitory effects of red raspberries on cancer / Qi, Zexiu; Yang, Bei; Giampieri, Francesca; Cianciosi, Danila; Alvarez-Suarez, José Miguel; Elexpuru-Zabaleta, Maria; Quiles, Josè L.; Forbes-Hernandez, Tamara Y.; Zhang, Di; Bai, Weibin; Tian, Lingmin; Mezzetti, Bruno; Battino, Maurizio; Armas Diaz, Yasmany. - In: JOURNAL OF BERRY RESEARCH. - ISSN 1878-5093. - 14:1(2024), pp. 61-71. [10.3233/jbr-240004]
Abstract:
Red raspberries are gaining attention more and more for their nutritional and bioactive components, with potential health effects such as antitumor properties. This review aims to describe the antioxidant activities of red raspberries, emphasizing the role of anthocyanins and ellagitannins as primar...y contributors among red raspberry polyphenols; it also outlined the connection between red raspberries and their role in inhibiting cancer cell growth by regulating oxidative stress. Numerous studies suggest that red raspberries are able to block cancer cell progression by inhibiting proliferation, migration, and autophagy, as well as regulating the cell cycle, angiogenesis, and DNA damage repair. This review sheds light to the growing evidence supporting antioxidants as a crucial link between fruit consumption and cancer prevention.
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Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet
Anno: 2024
Rivista: JOURNAL OF TRANSLATIONAL MEDICINE
Autori/autrici: Godos, J.; Scazzina, F.; Paterno Castello, C.; Giampieri, F.; Quiles, J. L.; Briones Urbano, M.; Battino, M.; Galvano, F.; Iacoviello, L.; de Gaetano, G.; Bonaccio, M.; Grosso, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/328852
Citazioni:
Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet / Godos, J.; Scazzina, F.; Paterno Castello, C.; Giampieri, F.; Quiles, J. L.; Briones Urbano, M.; Battino, M.; Galvano, F.; Iacoviello, L.; de Gaetano, G.; Bonaccio, M.; Grosso, G.. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - 22:1(2024). [10.1186/s12967-024-05095-w]
Abstract:
Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity. Researchers have investigated the role of Mediterranean-type dietary patterns on human he...alth all around the world, reporting consistent findings concerning its benefits. However, what does truly define the Mediterranean diet? The myriad of dietary scores synthesizes the nutritional content of a Mediterranean-type diet, but a variety of aspects are generally unexplored when studying the adherence to this dietary pattern. Among dietary factors, the main characteristics of the Mediterranean diet, such as consumption of fruit and vegetables, olive oil, and cereals should be accompanied by other underrated features, such as the following: (i) specific reference to whole-grain consumption; (ii) considering the consumption of legumes, nuts, seeds, herbs and spices often untested when exploring the adherence to the Mediterranean diet; (iii) consumption of eggs and dairy products as common foods consumed in the Mediterranean region (irrespectively of the modern demonization of dietary fat intake). Another main feature of the Mediterranean diet includes (red) wine consumption, but more general patterns of alcohol intake are generally unmeasured, lacking specificity concerning the drinking occasion and intensity (i.e., alcohol drinking during meals). Among other underrated aspects, cooking methods are rather simple and yet extremely varied. Several underrated aspects are related to the quality of food consumed when the Mediterranean diet was first investigated: foods are locally produced, minimally processed, and preserved with more natural methods (i.e., fermentation), strongly connected with the territory with limited and controlled impact on the environment. Dietary habits are also associated with lifestyle behaviors, such as sleeping patterns, and social and cultural values, favoring commensality and frugality. In conclusion, it is rather reductive to consider the Mediterranean diet as just a pattern of food groups to be consumed decontextualized from the social and geographical background of Mediterranean culture. While the methodologies to study the Mediterranean diet have demonstrated to be useful up to date, a more holistic approach should be considered in future studies by considering the aforementioned underrated features and values to be potentially applied globally through the concept of a “Planeterranean” diet.
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Could Celiac Disease and Overweight/Obesity Coexist in School-Aged Children and Adolescents? A Systematic Review
Anno: 2023
Rivista: CHILDHOOD OBESITY
Autori/autrici: De Giuseppe, Rachele; Bergomas, Francesca; Loperfido, Federica; Giampieri, Francesca; Preatoni, Giorgia; Calcaterra, Valeria; Cena, Hellas
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323201
Citazioni:
Could Celiac Disease and Overweight/Obesity Coexist in School-Aged Children and Adolescents? A Systematic Review / De Giuseppe, Rachele; Bergomas, Francesca; Loperfido, Federica; Giampieri, Francesca; Preatoni, Giorgia; Calcaterra, Valeria; Cena, Hellas. - In: CHILDHOOD OBESITY. - ISSN 2153-2168. - (2023). [10.1089/chi.2022.0035]
Abstract:
Background: Celiac disease (CD) is a multifactorial, immune-mediated enteropathic disorder that may occur at any age with heterogeneous clinical presentation. In the last years, unusual manifestations have become very frequent, and currently, it is not so uncommon to diagnose CD in subjects with ove...rweight or obesity, especially in adults; however, little is known in the pediatric population. This systematic review aims to evaluate the literature regarding the association between CD and overweight/obesity in school-age children.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. An electronic database search of articles published in the last 20 years in English was carried out in Web of Sciences, PubMed, and Medline. The quality of the included studies was assessed by using the STrengthening the Reporting of OBservational studies in Epidemiology statement.Results: Of the 1396 articles identified, 9 articles, investigating overweight/obesity in children/adolescents affected by CD or screening CD in children/adolescents with overweight/obesity, met the inclusion criteria. Overall, the results showed that the prevalence of overweight or obesity in school-age children (6-17 years) affected by CD ranged between 3.5% and 20%, highlighting that the coexistence of CD with overweight/obesity in children is not uncommon as previously thought.Conclusion: Although CD has been historically correlated with being underweight due to malabsorption, it should be evaluated also in children with overweight and obesity, especially those who have a familiar predisposition to other autoimmune diseases and/or manifest unusual symptoms of CD.
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The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
Anno: 2023
Rivista: PHYTOMEDICINE
Autori/autrici: Singla, Rajeev K; De, Ronita; Efferth, Thomas; Mezzetti, Bruno; Sahab Uddin, Md; Sanusi, Null; Ntie-Kang, Fidele; Wang, Dongdong; Schultz, Fabien; Kharat, Kiran R; Devkota, Hari Prasad; Battino, Maurizio; Sur, Daniel; Lordan, Ronan; Patnaik, Sourav S; Tsagkaris, Christos; Sai, Chandragiri Siva; Tripathi, Surya Kant; Găman, Mihnea-Alexandru; Ahmed, Mosa E O; González-Burgos, Elena; Babiaka, Smith B; Paswan, Shravan Kumar; Odimegwu, Joy Ifunanya; Akram, Faizan; Simal-Gandara, Jesus; Urquiza, Mágali S; Tikhonov, Aleksei; Mondal, Himel; Singla, Shailja; Lonardo, Sara Di; Mulholland, Eoghan J; Cenanovic, Merisa; Maigoro, Abdulkadir Yusif; Giampieri, Francesca; Lee, Soojin; Tzvetkov, Nikolay T; Louka, Anna Maria; Verma, Pritt; Chopra, Hitesh; Olea, Scarlett Perez; Khan, Johra; Alvarez Suarez, José M; Zheng, Xiaonan; Tomczyk, Michał; Sabnani, Manoj Kumar; Medina, Christhian Delfino Villanueva; Khalid, Garba M; Boyina, Hemanth Kumar; Georgiev, Milen I; Supuran, Claudiu T; Sobarzo-Sánchez, Eduardo; Fan, Tai-Ping; Pittala, Valeria; Sureda, Antoni; Braidy, Nady; Russo, Gian Luigi; Vacca, Rosa Anna; Banach, Maciej; Lizard, Gérard; Zarrouk, Amira; Hammami, Sonia; Orhan, Ilkay Erdogan; Aggarwal, Bharat B; Perry, George; Miller, Mark Js; Heinrich, Michael; Bishayee, Anupam; Kijjoa, Anake; Arkells, Nicolas; Bredt, David; Wink, Michael; Fiebich, Bernd L; Kiran, Gangarapu; Yeung, Andy Wai Kan; Gupta, Girish Kumar; Santini, Antonello; Lucarini, Massimo; Durazzo, Alessandra; El-Demerdash, Amr; Dinkova-Kostova, Albena T; Cifuentes, Alejandro; Souto, Eliana B; Zubair, Muhammad Asim Masoom; Badhe, Pravin; Echeverría, Javier; Horbańczuk, Jarosław Olav; Horbanczuk, Olaf K; Sheridan, Helen; Sheshe, Sadeeq Muhammad; Witkowska, Anna Maria; Abu-Reidah, Ibrahim M; Riaz, Muhammad; Ullah, Hammad; Oladipupo, Akolade R; Lopez, Víctor; Sethiya, Neeraj Kumar; Shrestha, Bhupal Govinda; Ravanan, Palaniyandi; Gupta, Subash Chandra; Alzahrani, Qushmua E; Dama Sreedhar, Preethidan; Xiao, Jianbo; Moosavi, Mohammad Amin; Subramani, Parasuraman Aiya; Singh, Amit Kumar; Chettupalli, Ananda Kumar; Patra, Jayanta Kumar; Singh, Gopal; Karpiński, Tomasz M; Al-Rimawi, Fuad; Abiri, Rambod; Ahmed, Atallah F; Barreca, Davide; Vats, Sharad; Amrani, Said; Fimognari, Carmela; Mocan, Andrei; Hritcu, Lucian; Semwal, Prabhakar; Shiblur Rahaman, Md; Emerald, Mila; Akinrinde, Akinleye Stephen; Singh, Abhilasha; Joshi, Ashima; Joshi, Tanuj; Khan, Shafaat Yar; Balla, Gareeballah Osman Adam; Lu, Aiping; Pai, Sandeep Ramchandra; Ghzaiel, Imen; Acar, Niyazi; Es-Safi, Nour Eddine; Zengin, Gokhan; Kureshi, Azazahemad A; Sharma, Arvind Kumar; Baral, Bikash; Rani, Neeraj; Jeandet, Philippe; Gulati, Monica; Kapoor, Bhupinder; Mohanta, Yugal Kishore; Emam-Djomeh, Zahra; Onuku, Raphael; Depew, Jennifer R; Atrooz, Omar M; Goh, Bey Hing; Andrade, Jose Carlos; Konwar, Bikramjit; Shine, V J; Ferreira, João Miguel Lousa Dias; Ahmad, Jamil; Chaturvedi, Vivek K; Skalicka-Woźniak, Krystyna; Sharma, Rohit; Gautam, Rupesh K; Granica, Sebastian; Parisi, Salvatore; Kumar, Rishabh; Atanasov, Atanas G; Shen, Bairong
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314777
Citazioni:
The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis / Singla, Rajeev K; De, Ronita; Efferth, Thomas; Mezzetti, Bruno; Sahab Uddin, Md; Sanusi, Null; Ntie-Kang, Fidele; Wang, Dongdong; Schultz, Fabien; Kharat, Kiran R; Devkota, Hari Prasad; Battino, Maurizio; Sur, Daniel; Lordan, Ronan; Patnaik, Sourav S; Tsagkaris, Christos; Sai, Chandragiri Siva; Tripathi, Surya Kant; Găman, Mihnea-Alexandru; Ahmed, Mosa E O; González-Burgos, Elena; Babiaka, Smith B; Paswan, Shravan Kumar; Odimegwu, Joy Ifunanya; Akram, Faizan; Simal-Gandara, Jesus; Urquiza, Mágali S; Tikhonov, Aleksei; Mondal, Himel; Singla, Shailja; Lonardo, Sara Di; Mulholland, Eoghan J; Cenanovic, Merisa; Maigoro, Abdulkadir Yusif; Giampieri, Francesca; Lee, Soojin; Tzvetkov, Nikolay T; Louka, Anna Maria; Verma, Pritt; Chopra, Hitesh; Olea, Scarlett Perez; Khan, Johra; Alvarez Suarez, José M; Zheng, Xiaonan; Tomczyk, Michał; Sabnani, Manoj Kumar; Medina, Christhian Delfino Villanueva; Khalid, Garba M; Boyina, Hemanth Kumar; Georgiev, Milen I; Supuran, Claudiu T; Sobarzo-Sánchez, Eduardo; Fan, Tai-Ping; Pittala, Valeria; Sureda, Antoni; Braidy, Nady; Russo, Gian Luigi; Vacca, Rosa Anna; Banach, Maciej; Lizard, Gérard; Zarrouk, Amira; Hammami, Sonia; Orhan, Ilkay Erdogan; Aggarwal, Bharat B; Perry, George; Miller, Mark Js; Heinrich, Michael; Bishayee, Anupam; Kijjoa, Anake; Arkells, Nicolas; Bredt, David; Wink, Michael; Fiebich, Bernd L; Kiran, Gangarapu; Yeung, Andy Wai Kan; Gupta, Girish Kumar; Santini, Antonello; Lucarini, Massimo; Durazzo, Alessandra; El-Demerdash, Amr; Dinkova-Kostova, Albena T; Cifuentes, Alejandro; Souto, Eliana B; Zubair, Muhammad Asim Masoom; Badhe, Pravin; Echeverría, Javier; Horbańczuk, Jarosław Olav; Horbanczuk, Olaf K; Sheridan, Helen; Sheshe, Sadeeq Muhammad; Witkowska, Anna Maria; Abu-Reidah, Ibrahim M; Riaz, Muhammad; Ullah, Hammad; Oladipupo, Akolade R; Lopez, Víctor; Sethiya, Neeraj Kumar; Shrestha, Bhupal Govinda; Ravanan, Palaniyandi; Gupta, Subash Chandra; Alzahrani, Qushmua E; Dama Sreedhar, Preethidan; Xiao, Jianbo; Moosavi, Mohammad Amin; Subramani, Parasuraman Aiya; Singh, Amit Kumar; Chettupalli, Ananda Kumar; Patra, Jayanta Kumar; Singh, Gopal; Karpiński, Tomasz M; Al-Rimawi, Fuad; Abiri, Rambod; Ahmed, Atallah F; Barreca, Davide; Vats, Sharad; Amrani, Said; Fimognari, Carmela; Mocan, Andrei; Hritcu, Lucian; Semwal, Prabhakar; Shiblur Rahaman, Md; Emerald, Mila; Akinrinde, Akinleye Stephen; Singh, Abhilasha; Joshi, Ashima; Joshi, Tanuj; Khan, Shafaat Yar; Balla, Gareeballah Osman Adam; Lu, Aiping; Pai, Sandeep Ramchandra; Ghzaiel, Imen; Acar, Niyazi; Es-Safi, Nour Eddine; Zengin, Gokhan; Kureshi, Azazahemad A; Sharma, Arvind Kumar; Baral, Bikash; Rani, Neeraj; Jeandet, Philippe; Gulati, Monica; Kapoor, Bhupinder; Mohanta, Yugal Kishore; Emam-Djomeh, Zahra; Onuku, Raphael; Depew, Jennifer R; Atrooz, Omar M; Goh, Bey Hing; Andrade, Jose Carlos; Konwar, Bikramjit; Shine, V J; Ferreira, João Miguel Lousa Dias; Ahmad, Jamil; Chaturvedi, Vivek K; Skalicka-Woźniak, Krystyna; Sharma, Rohit; Gautam, Rupesh K; Granica, Sebastian; Parisi, Salvatore; Kumar, Rishabh; Atanasov, Atanas G; Shen, Bairong. - In: PHYTOMEDICINE. - ISSN 0944-7113. - ELETTRONICO. - 108:(2023). [10.1016/j.phymed.2022.154520]
Abstract:
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences T...askforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events.
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Exploring the Chemistry of Ocimum Species under Specific Extractions and Chromatographic Methods: A Systematic Review
Anno: 2023
Rivista: ACS OMEGA
Autori/autrici: Beltrán-Noboa, Andrea; Jordan-Álvarez, Alejandro; Guevara-Terán, Mabel; Gallo, Blanca; Berrueta, Luis A; Giampieri, Francesca; Battino, Maurizio; Álvarez-Suarez, José M; Tejera, Eduardo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314793
Citazioni:
Exploring the Chemistry of Ocimum Species under Specific Extractions and Chromatographic Methods: A Systematic Review / Beltrán-Noboa, Andrea; Jordan-Álvarez, Alejandro; Guevara-Terán, Mabel; Gallo, Blanca; Berrueta, Luis A; Giampieri, Francesca; Battino, Maurizio; Álvarez-Suarez, José M; Tejera, Eduardo. - In: ACS OMEGA. - ISSN 2470-1343. - ELETTRONICO. - 8:12(2023), pp. 10747-10756. [10.1021/acsomega.3c00043]
Abstract:
Ocimum is considered the largest genus in the Lamiacea family. The genus includes basil, a group of aromatic plants with a wide range of culinary uses that nowadays draws attention for its medicinal and pharmaceutical potential. This systematic review intends to explore the chemical composition of n...onessential oils and their variation across different Ocimum species. Moreover, we aimed to identify the state of knowledge regarding the molecular space in this genus as well as the different methods of extraction/identification and geographical location. Seventy-nine eligible articles were selected for the final analysis, from which we extracted more than 300 molecules. We found that the countries with the highest number of studies into Ocimum species are India, Nigeria, Brazil, and Egypt. However, from all known species of Ocimum, only 12 were found to have an extensive chemical characterization, particularly Ocimum basilicum and Ocimum tenuiflorum. Our study focused especially on alcoholic, hydroalcoholic, and water extracts, in which the main techniques for compound identifications are GC-MS, LC-MS, and LC-UV. Across the compiled molecules, we found a wide variety of compounds, especially flavonoids, phenolic acids, and terpenoids, suggesting that this genus could be a very useful source of possible bioactive compounds. The information collected in this review also emphasizes the huge gap between the vast number of Ocimum species discovered and the number of studies in each of them that determined the chemical characterization.
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Oleuropein Attenuates Oxidative Stress in Human Trophoblast Cells
Anno: 2023
Rivista: ANTIOXIDANTS
Autori/autrici: Pirković, Andrea; Vilotić, Aleksandra; Borozan, Sunčica; Nacka-Aleksić, Mirjana; Bojić-Trbojević, Žanka; Krivokuća, Milica Jovanović; Battino, Maurizio; Giampieri, Francesca; Dekanski, Dragana
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314788
Citazioni:
Oleuropein Attenuates Oxidative Stress in Human Trophoblast Cells / Pirković, Andrea; Vilotić, Aleksandra; Borozan, Sunčica; Nacka-Aleksić, Mirjana; Bojić-Trbojević, Žanka; Krivokuća, Milica Jovanović; Battino, Maurizio; Giampieri, Francesca; Dekanski, Dragana. - In: ANTIOXIDANTS. - ISSN 2076-3921. - ELETTRONICO. - 12:1(2023), p. 197. [10.3390/antiox12010197]
Abstract:
Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells in vitro, by examining the changes in several markers implicated in oxidative stress interactions in the placenta. Trophoblast HTR-8/SVneo cells were preincubated with OLE... at 10 and 100 mu M and exposed to H2O2, as a model of oxidative stress. Protein and lipid peroxidation, as well as antioxidant enzymes' activity, were determined spectrophotometrically, and DNA damage was evaluated by comet assay. iNOS protein expression was assessed by Western blot, while the mRNA expression of pro- and anti-apoptotic genes BAX and BCL2 and transcription factor NFE2L2, as well as cytokines IL-6 and TNF alpha were determined by qPCR. Oleuropein demonstrated cytoprotective effects against H2O2 in trophoblast cells by significantly improving the antioxidant status and preventing protein and lipid damage, as well as reducing the iNOS levels. OLE reduced the mRNA expression of IL-6 and TNF alpha, however, it did not influence the expression of NFE2L2 or the BAX/BCL2 ratio after H2O2 exposure. Oleuropein per se did not lead to any adverse effects in HTR-8/SVneo cells under the described conditions, confirming its safety in vitro. In conclusion, it significantly attenuated oxidative damage and restored antioxidant functioning, confirming its protective role in trophoblast.
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In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain
Anno: 2023
Rivista: ANTIOXIDANTS
Autori/autrici: Romero-Márquez, Jose M; Navarro-Hortal, María D; Orantes, Francisco J; Esteban-Muñoz, Adelaida; Pérez-Oleaga, Cristina M; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Giampieri, Francesca; Quiles, José L; Forbes-Hernández, Tamara Y
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314791
Citazioni:
In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain / Romero-Márquez, Jose M; Navarro-Hortal, María D; Orantes, Francisco J; Esteban-Muñoz, Adelaida; Pérez-Oleaga, Cristina M; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Giampieri, Francesca; Quiles, José L; Forbes-Hernández, Tamara Y. - In: ANTIOXIDANTS. - ISSN 2076-3921. - ELETTRONICO. - 12:2(2023), p. 404. [10.3390/antiox12020404]
Abstract:
There is growing evidence that Alzheimer's disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has bee...n tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-beta aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effects.
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Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms
Anno: 2023
Rivista: CRITICAL REVIEWS IN FOOD SCIENCE & NUTRITION
Autori/autrici: Sun, Yu; Mehmood, Arshad; Giampieri, Francesca; Battino, Maurizio; Chen, Xiumin
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323199
Citazioni:
Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms / Sun, Yu; Mehmood, Arshad; Giampieri, Francesca; Battino, Maurizio; Chen, Xiumin. - In: CRITICAL REVIEWS IN FOOD SCIENCE & NUTRITION. - ISSN 1549-7852. - 118(2023), pp. 1-18. [10.1080/10408398.2023.2255666]
Abstract:
: Diabetes is a metabolic disease due to impaired or defective insulin secretion and is considered one of the most serious chronic diseases worldwide. Gamma-aminobutyric acid (GABA) is a naturally occurring non-protein amino acid commonly present in a wide range of foods. A number of studies documen...ted that GABA has good anti-diabetic potential. This review summarized the available dietary sources of GABA as well as animal and human studies on the anti-diabetic properties of GABA, while also discussing the underlying mechanisms. GABA may modulate diabetes through various pathways such as inhibiting the activities of α-amylase and α-glucosidase, promoting β-cell proliferation, stimulating insulin secretion from β-cells, inhibiting glucagon secretion from α-cells, improving insulin resistance and glucose tolerance, and increasing antioxidant and anti-inflammatory activities. However, further mechanistic studies on animals and human are needed to confirm the therapeutic effects of GABA against diabetes.
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Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States
Anno: 2023
Rivista: NUTRIENTS
Autori/autrici: D’Andrea, Patrizia; Giampieri, Francesca; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/325113
Citazioni:
Nutritional Modulation of Hepcidin in the Treatment of Various Anemic States / D’Andrea, Patrizia; Giampieri, Francesca; Battino, Maurizio. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 15:24(2023). [10.3390/nu15245081]
Abstract:
Twenty years after its discovery, hepcidin is still considered the main regulator of iron homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of iron, which can come from one’s diet, from iron stores, and from erythrophagocytosis. Many anemic conditions are cause...d by non-physiologic increases in hepcidin. The sequestration of iron in the intestine and in other tissues poses worrying premises in view of discoveries about the mechanisms of ferroptosis. The nutritional treatment of these anemic states cannot ignore the nutritional modulation of hepcidin, in addition to the bioavailability of iron. This work aims to describe and summarize the few findings about the role of hepcidin in anemic diseases and ferroptosis, as well as the modulation of hepcidin levels by diet and nutrients
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The VegPlate for Sports: A Plant-Based Food Guide for Athletes
Anno: 2023
Rivista: NUTRIENTS
Autori/autrici: Baroni, Luciana; Pelosi, Ettore; Giampieri, Francesca; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314794
Citazioni:
The VegPlate for Sports: A Plant-Based Food Guide for Athletes / Baroni, Luciana; Pelosi, Ettore; Giampieri, Francesca; Battino, Maurizio. - In: NUTRIENTS. - ISSN 2072-6643. - 15:7(2023), p. 1746. [10.3390/nu15071746]
Abstract:
Background: Nutrition strategies improve physiological and biochemical adaptation to training, facilitate more intense workouts, promote faster recoveries after a workout in anticipation of the next, and help to prepare for a race and maintain the body's hydration status. Although vegetarianism (i.e...., lacto-ovo and veganism) has become increasingly popular in recent years, the number of vegetarian athletes is not known, and no specific recommendations have been made for vegetarian dietary planning in sports. Well-planned diets are mandatory to obtain the best performance, and the available literature reports that those excluding all types of flesh foods (meat, poultry, game, and seafood) neither find advantages nor suffer from disadvantages, compared to omnivorous diets, for strength, anaerobic, or aerobic exercise performance; additionally, some benefits can be derived for general health. Methods: We conceived the VegPlate for Sports, a vegetarian food guide (VFG) based on the already-validated VegPlate facilitating method, designed according to the Italian dietary reference intakes (DRIs). Results: The VegPlate for Sports is suitable for men and women who are active in sports and adhere to a vegetarian (i.e., lacto-ovo and vegan) diet, and provides weight-based, adequate dietary planning. Conclusions: The VegPlate for Sports represents a practical tool for nutrition professionals and gives the possibility to plan diets based on energy, carbohydrate (CHO), and protein (PRO) necessities, from 50 to 90 Kg body weight (BW).
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Prevalence of undiagnosed diabetes and prediabetes related to periodontitis and its risk factors in elderly individuals
Anno: 2023
Rivista: JOURNAL OF DENTISTRY
Autori/autrici: Portes, Juliana; Bullón, Beatriz; Gallardo, Isabel; Fernandez-Riejos, Patricia; Quiles, Jose Luis; Giampieri, Francesca; Bullón, Pedro
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323197
Citazioni:
Prevalence of undiagnosed diabetes and prediabetes related to periodontitis and its risk factors in elderly individuals / Portes, Juliana; Bullón, Beatriz; Gallardo, Isabel; Fernandez-Riejos, Patricia; Quiles, Jose Luis; Giampieri, Francesca; Bullón, Pedro. - In: JOURNAL OF DENTISTRY. - ISSN 0300-5712. - 132:(2023), p. 104480. [10.1016/j.jdent.2023.104480]
Abstract:
Objective: The prevalence of undiagnosed diabetes was estimated to increase with age and can reach 3.5%. The purpose of the study was to evaluate the prevalence of undiagnosed diabetes and prediabetes in the elderly patients who attended a dental clinic and to find common risk factors.Methods: Male ...patients, older than 50 years, attended their first dental visit to the School of Dentistry for a period of two years, and it was proposed to evaluate undiagnosed type 2 diabetes mellitus. Periodontal, biochemical, microbiological examinations, nutritional profile, and physical activity were performed.Results: A total of 106 patients were examined, 6 (5.6%) had diabetes, and 37 (34.9%) had prediabetes without prior diagnosis. The severity of periodontitis was greater in patients with diabetes. Most of the patients were overweight and had increased systolic blood pressure. Patients with prediabetes and periodontitis had a low adherence to the Mediterranean diet. Tannerella forsythia was present in more patients with periodontitis, and the prevalence of Aggregatibacter actinomycetemcomitans is practically absent in groups with periodontitis, except for the group with diabetes.Conclusions: In the population studied, the prevalence of patients without a diagnosis of diabetes and prediabetes was very high and underestimated. The increased severity of periodontitis in patients with diabetes and in conjunction with the high level of cortisol seen in patients with periodontitis, especially those with diabetes, emphasize the dysregulation of the immunoinflammatory system. Clinical significance: It is essential to add all this data to our dental practice to cover patient health with a broader landscape.
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Anthocyanins: What do we know until now?
Anno: 2023
Rivista: JOURNAL OF BERRY RESEARCH
Autori/autrici: Giampieri, F; Cianciosi, D; Alvarez-Suarez, Jm; Quiles, Jl; Forbes-Hernández, Ty; Navarro-Hortal, Md; Machì, M; Casanova, Rdp; Espinosa, Jcm; Chen, Xm; Di, Z; Bai, Wb; Tian, Lm; Mezzetti, B; Battino, M; Diaz, Ya
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323203
Citazioni:
Anthocyanins: What do we know until now? / Giampieri, F; Cianciosi, D; Alvarez-Suarez, Jm; Quiles, Jl; Forbes-Hernández, Ty; Navarro-Hortal, Md; Machì, M; Casanova, Rdp; Espinosa, Jcm; Chen, Xm; Di, Z; Bai, Wb; Tian, Lm; Mezzetti, B; Battino, M; Diaz, Ya. - In: JOURNAL OF BERRY RESEARCH. - ISSN 1878-5093. - 13:1(2023), pp. 1-6. [10.3233/JBR-220087]
Abstract:
Diets enriched in plant-based foods are associated with the maintenance of a good well-being and with the prevention of many non-communicable diseases. The health effects of fruits and vegetables consumption are mainly due to the presence of micronutrients, including vitamins and minerals, and polyp...henols, plant secondary metabolites. One of the most important classes of phenolic compounds are anthocyanins, that confer the typical purple-red color to many foods, such as berries, peaches, plums, red onions, purple corn, eggplants, as well as purple carrots, sweet potatoes and red cabbages, among others. This commentary aims to briefly highlight the progress made by science in the last years, focusing on some unexpected aspects related with anthocyanins, such as their bioavailability, their health effects and their relationship with gut microbiota.
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Plant-Based Milk Alternatives in Child Nutrition
Anno: 2023
Rivista: FOODS
Autori/autrici: Brusati, M; Baroni, L; Rizzo, G; Giampieri, F; Battino, M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314795
Citazioni:
Plant-Based Milk Alternatives in Child Nutrition / Brusati, M; Baroni, L; Rizzo, G; Giampieri, F; Battino, M. - In: FOODS. - ISSN 2304-8158. - ELETTRONICO. - 12:7(2023), p. 1544. [10.3390/foods12071544]
Abstract:
Plant-based milk alternatives can be distinguished in two main categories, differing in production processes and regulation: plant-based formulas and plant-based drinks. They are now a widely accepted class of products on the international market. The various plant-based milk alternatives differ in ...nutritional characteristics due to their origin and manufacturing; more importantly, whereas formulas from plant and cow origin can be used interchangeably, plant-based drinks are nutritionally different from cow's milk and can be consumed by children subsequently to the use of formula. Several scientific organizations have expressed differing opinions on the use of these products in the diets of children. In the face of unanimous conclusions regarding the use of these products during the first year of life, in subsequent ages there were conflicting opinions regarding the timing, quantities, and type of product to be used. From the viewpoint of the child's overall diet and health, it could be suggested that these foods be considered not as simple substitutes for cow's milk, but as part of a varied diet, within individual advice of use. We suggest accepting the presence of these products in a baby's diet (omnivores included), planning their use correctly in the context of a balanced diet, according to the specific product and the needs of the individual.
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Evaluation of the polyphenolic profile of native Ecuadorian stingless bee honeys (Tribe: Meliponini) and their antibiofilm activity on susceptible and multidrug-resistant pathogens: An exploratory analysis
Anno: 2023
Rivista: CURRENT RESEARCH IN FOOD SCIENCE
Autori/autrici: Cabezas-Mera, Fausto Sebastián; Atiencia-Carrera, María Belén; Villacrés-Granda, Irina; Proaño, Adrian Alexander; Debut, Alexis; Vizuete, Karla; Herrero-Bayo, Lorena; Gonzalez-Paramás, Ana M; Giampieri, Francesca; Abreu-Naranjo, Reinier; Tejera, Eduardo; Álvarez-Suarez, José M; Machado, António
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323200
Citazioni:
Evaluation of the polyphenolic profile of native Ecuadorian stingless bee honeys (Tribe: Meliponini) and their antibiofilm activity on susceptible and multidrug-resistant pathogens: An exploratory analysis / Cabezas-Mera, Fausto Sebastián; Atiencia-Carrera, María Belén; Villacrés-Granda, Irina; Proaño, Adrian Alexander; Debut, Alexis; Vizuete, Karla; Herrero-Bayo, Lorena; Gonzalez-Paramás, Ana M; Giampieri, Francesca; Abreu-Naranjo, Reinier; Tejera, Eduardo; Álvarez-Suarez, José M; Machado, António. - In: CURRENT RESEARCH IN FOOD SCIENCE. - ISSN 2665-9271. - 7:(2023), p. 100543. [10.1016/j.crfs.2023.100543]
Abstract:
: Biofilms are associated with infections that are resistant to conventional therapies, contributing to the antimicrobial resistance crisis. The need for alternative approaches against biofilms is well-known. Although natural products like stingless bee honeys (tribe: Meliponini) constitute an alter...native treatment, much is still unknown. Our main goal was to evaluate the antibiofilm activity of stingless bee honey samples against multidrug-resistant (MDR) pathogens through biomass assays, fluorescence (cell count and viability), and scanning electron (structural composition) microscopy. We analyzed thirty-five honey samples at 15% (v/v) produced by ten different stingless bee species (Cephalotrigona sp., Melipona sp., M. cramptoni, M. fuscopilosa, M. grandis, M. indecisa, M. mimetica, M. nigrifacies, Scaptotrigona problanca, and Tetragonisca angustula) from five provinces of Ecuador (Tungurahua, Pastaza, El Oro, Los Ríos, and Loja) against 24-h biofilms of Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, and Candida tropicalis. The present honey set belonged to our previous study, where the samples were collected in 2018-2019 and their physicochemical parameters, chemical composition, mineral elements, and minimal inhibitory concentration (MIC) were screened. However, the polyphenolic profile and their antibiofilm activity on susceptible and multidrug-resistant pathogens were still unknown. According to polyphenolic profile of the honey samples, significant differences were observed according to their geographical origin in terms of the qualitative profiles. The five best honey samples (OR24.1, LR34, LO40, LO48, and LO53) belonging to S. problanca, Melipona sp., and M. indecisa were selected for further analysis due to their high biomass reduction values, identification of the stingless bee specimens, and previously reported physicochemical parameters. This subset of honey samples showed a range of 63-80% biofilm inhibition through biomass assays. Fluorescence microscopy (FM) analysis evidenced statistical log reduction in the cell count of honey-treated samples in all pathogens (P <0.05), except for S. aureus ATCC 25923. Concerning cell viability, C. tropicalis, K. pneumoniae ATCC 33495, and K. pneumoniae KPC significantly decreased (P <0.01) by 21.67, 25.69, and 45.62%, respectively. Finally, scanning electron microscopy (SEM) analysis demonstrated structural biofilm disruption through cell morphological parameters (such as area, size, and form). In relation to their polyphenolic profile, medioresinol was only found in the honey of Loja, while scopoletin, kaempferol, and quercetin were only identified in honey of Los Rios, and dihydrocaffeic and dihydroxyphenylacetic acids were only detected in honey of El Oro. All the five honey samples showed dihydrocoumaroylhexose, luteolin, and kaempferol rutinoside. To the authors' best knowledge, this is the first study to analyze stingless bees honey-treated biofilms of susceptible and/or MDR strains of S. aureus, K. pneumoniae, and Candida species.
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House cricket (Acheta domesticus): A review based on its nutritional composition, quality, and potential uses in the food industry
Anno: 2023
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Pilco-Romero, Gabriela; Chisaguano-Tonato, Aida M.; Herrera-Fontana, María E.; Chimbo-Gándara, Luis F.; Sharifi-Rad, Majid; Giampieri, Francesca; Battino, Maurizio; Vernaza, María Gabriela; Álvarez-Suárez, José M.
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/324352
Citazioni:
House cricket (Acheta domesticus): A review based on its nutritional composition, quality, and potential uses in the food industry / Pilco-Romero, Gabriela; Chisaguano-Tonato, Aida M.; Herrera-Fontana, María E.; Chimbo-Gándara, Luis F.; Sharifi-Rad, Majid; Giampieri, Francesca; Battino, Maurizio; Vernaza, María Gabriela; Álvarez-Suárez, José M.. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - ELETTRONICO. - (2023), p. 104226. [10.1016/j.tifs.2023.104226]

Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease
Anno: 2023
Rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Autori/autrici: Romero-Márquez, Jose M; Forbes-Hernández, Tamara Y; Navarro-Hortal, María D; Quirantes-Piné, Rosa; Grosso, Giuseppe; Giampieri, Francesca; Lipari, Vivian; Sánchez-González, Cristina; Battino, Maurizio; Quiles, José L
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314792
Citazioni:
Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease / Romero-Márquez, Jose M; Forbes-Hernández, Tamara Y; Navarro-Hortal, María D; Quirantes-Piné, Rosa; Grosso, Giuseppe; Giampieri, Francesca; Lipari, Vivian; Sánchez-González, Cristina; Battino, Maurizio; Quiles, José L. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 24:5(2023), p. 4353. [10.3390/ijms24054353]
Abstract:
Alzheimer's Disease (AD) is the cause of around 60-70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have ...been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-beta formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-kappa B and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD.
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Food knowledge level among Tanzanian women of childbearing age: developing a score for the food knowledge questionnaire
Anno: 2023
Rivista: JOURNAL OF NUTRITIONAL SCIENCE
Autori/autrici: Conti, Maria Vittoria; Gnesi, Marco; Mshanga, Naelijwa; De Giuseppe, Rachele; Giampieri, Francesca; Cena, Hellas
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323198
Citazioni:
Food knowledge level among Tanzanian women of childbearing age: developing a score for the food knowledge questionnaire / Conti, Maria Vittoria; Gnesi, Marco; Mshanga, Naelijwa; De Giuseppe, Rachele; Giampieri, Francesca; Cena, Hellas. - In: JOURNAL OF NUTRITIONAL SCIENCE. - ISSN 2048-6790. - 12:(2023), p. e42. [10.1017/jns.2023.28]
Abstract:
Food knowledge (FK) is one of the factors that contribute to malnutrition conditions in developing countries, together with food safety, food security and food access. FK is defined as 'the competence to understand healthy nutrition concepts'; it impacts individuals' life due to its relationship wit...h food behaviour and eating habits. Therefore, acting on FK can represent a starting point for improving the health status of vulnerable populations. The authors present a total score of an FK questionnaire (FKQ) and its relation to the socio-demographic characteristics of a specific target population: Tanzanian women of childbearing age. The results of the manuscript complement evidence of construct validity of the FKQ by providing an algorithm to compute a total score as a measure of FK. The strength of this tool, and its score, lies in the fact that the questionnaire has been validated and is easy to administer.
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Muscular involvement in long-term type 1 diabetes: Does it represent an underestimated complication?
Anno: 2023
Rivista: NUTRITION
Autori/autrici: Pollakova, D; Tubili, C; Di Folco, U; De Giuseppe, R; Battino, M; Giampieri, F
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323196
Citazioni:
Muscular involvement in long-term type 1 diabetes: Does it represent an underestimated complication? / Pollakova, D; Tubili, C; Di Folco, U; De Giuseppe, R; Battino, M; Giampieri, F. - In: NUTRITION. - ISSN 0899-9007. - ELETTRONICO. - 112:(2023), p. 112060. [10.1016/j.nut.2023.112060]
Abstract:
Objectives: Structural, metabolic, and functional signs of skeletal muscle damage have been identified in indi-viduals affected by type 1 diabetes (T1D), but, to our knowledge, no guidelines for the diagnosis and treat-ment of muscle impairment exist and studies on T1D and muscle health remain limit...ed. The aim of this study was to evaluate the prevalence of sarcopenia in a long-term T1D population and to assess the effects of some clinical parameters on muscle mass and function.Methods: Thirty-nine patients affected by T1D were enrolled. Body mass index (BMI), body composition (appendicular lean mass index [ALMI] and fat mass [FM]), and muscle strength were measured. Additionally, the relationship between Mediterranean diet adherence and sarcopenia was assessed.Results: In the present sample (mean age 49.32 & PLUSMN; 13.49 y, 41.1% women, mean duration of diabetes 30.13 & PLUSMN; 12.28 y), the prevalence of sarcopenia was 7.7% (12.5 % in women and 4.35% in men). The prevalence of low ALMI was 23.1% (25% in women and 21.74% in men). Significant inverse correlations were found between ALMI and duration of diabetes and ALMI and FM; and significant positive correlations between ALMI and BMI, physical activity level, and muscle strength. At the same time, significant inverse correlations were observed between muscle strength and duration of diabetes and muscle strength and FM.Conclusions: We observed a high prevalence of low muscle mass, similar to those found in the older age groups of the general population (25 years in advance) and our findings suggest a possible pathogenetic role of T1D duration on muscle trophism and function.& COPY; 2023 Elsevier Inc. All rights reserved.
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The In Vitro Effects of Romina Strawberry Extract on 3D Uterine Leiomyosarcoma Cells
Anno: 2023
Rivista: NUTRIENTS
Autori/autrici: Greco, Stefania; Pellegrino, Pamela; Giampieri, Francesca; Capocasa, Franco; Delli Carpini, Giovanni; Battino, Maurizio; Mezzetti, Bruno; Giannubilo, Stefano Raffaele; Ciavattini, Andrea; Ciarmela, Pasquapina
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/316811
Citazioni:
The In Vitro Effects of Romina Strawberry Extract on 3D Uterine Leiomyosarcoma Cells / Greco, Stefania; Pellegrino, Pamela; Giampieri, Francesca; Capocasa, Franco; Delli Carpini, Giovanni; Battino, Maurizio; Mezzetti, Bruno; Giannubilo, Stefano Raffaele; Ciavattini, Andrea; Ciarmela, Pasquapina. - In: NUTRIENTS. - ISSN 2072-6643. - 15:11(2023). [10.3390/nu15112557]
Abstract:
Leiomyosarcoma is an aggressive soft tissue sarcoma derived from the smooth muscle cells of the uterus. We tested the effect of Romina strawberry extract treatment on three-dimensional cultured uterine leiomyosarcoma cells. We established 3D cultures in agarose gel, where the cells seeded were able ...to form spheroids. We performed the observation and counting of the spheroids with a phase-contrast optical microscope, finding a decrease in the number of spheroids formed in the plates after 24 and 48 h treatment with 250 µg/mL of cultivar Romina strawberry extract. We also characterized the spheroids morphology by DNA binding fluorescent-stain observation, hematoxylin and eosin stain, and Masson’s trichrome stain. Finally, the real-time PCR showed a reduced expression of extracellular matrix genes after strawberry treatment. Overall, our data suggest that the fruit extract of this strawberry cultivar may be a useful therapeutic adjuvant for the management of uterine leiomyosarcoma.
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Possible role of nutrition in the prevention of inflammatory bowel disease-related colorectal cancer: A focus on human studies
Anno: 2023
Rivista: NUTRITION
Autori/autrici: Cassotta, Manuela; Cianciosi, Danila; De Giuseppe, Rachele; Navarro-Hortal, Maria Dolores; Armas Diaz, Yasmany; Forbes-Hernández, Tamara Yuliett; Pifarre, Kilian Tutusaus; Pascual Barrera, Alina Eugenia; Grosso, Giuseppe; Xiao, Jianbo; Battino, Maurizio; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314796
Citazioni:
Possible role of nutrition in the prevention of inflammatory bowel disease-related colorectal cancer: A focus on human studies / Cassotta, Manuela; Cianciosi, Danila; De Giuseppe, Rachele; Navarro-Hortal, Maria Dolores; Armas Diaz, Yasmany; Forbes-Hernández, Tamara Yuliett; Pifarre, Kilian Tutusaus; Pascual Barrera, Alina Eugenia; Grosso, Giuseppe; Xiao, Jianbo; Battino, Maurizio; Giampieri, Francesca. - In: NUTRITION. - ISSN 1873-1244. - ELETTRONICO. - 110:(2023), p. 111980. [10.1016/j.nut.2023.111980]
Abstract:
: Patients with inflammatory bowel disease (IBD) are at substantially high risk for colorectal cancer (CRC). IBD-associated CRC accounts for roughly 10% to 15% of the annual mortality in patients with IBD. IBD-related CRC also affects younger patients compared with sporadic CRC, with a 5-y survival ...rate of 50%. Regardless of medical therapies, the persistent inflammatory state characterizing IBD raises the risk for precancerous changes and CRC, with additional input from several elements, including genetic and environmental risk factors, IBD-associated comorbidities, intestinal barrier dysfunction, and gut microbiota modifications. It is well known that nutritional habits and dietary bioactive compounds can influence IBD-associated inflammation, microbiome abundance and composition, oxidative stress balance, and gut permeability. Additionally, in recent years, results from broad epidemiologic and experimental studies have associated certain foods or nutritional patterns with the risk for colorectal neoplasia. The present study aimed to review the possible role of nutrition in preventing IBD-related CRC, focusing specifically on human studies. It emerges that nutritional interventions based on healthy, nutrient-dense dietary patterns characterized by a high intake of fiber, vegetables, fruit, ω-3 polyunsaturated fatty acids, and a low amount of animal proteins, processed foods, and alcohol, combined with probiotic supplementation have the potential of reducing IBD-activity and preventing the risk of IBD-related CRC through different mechanisms, suggesting that targeted nutritional interventions may represent a novel promising approach for the prevention and management of IBD-associated CRC.
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Can alpha-linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS-CoV-2 infection?
Anno: 2023
Rivista: FOOD FRONTIERS
Autori/autrici: Cianciosi, D.; Diaz, Y. A.; Gaddi, A. V.; Capello, F.; Savo, M. T.; Pali Casanova, R. D. J.; Martinez Espinosa, J. C.; Pascual Barrera, A. E.; Navarro-Hortal, M. -D.; Tian, L.; Bai, W.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323931
Citazioni:
Can alpha-linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS-CoV-2 infection? / Cianciosi, D.; Diaz, Y. A.; Gaddi, A. V.; Capello, F.; Savo, M. T.; Pali Casanova, R. D. J.; Martinez Espinosa, J. C.; Pascual Barrera, A. E.; Navarro-Hortal, M. -D.; Tian, L.; Bai, W.; Giampieri, F.; Battino, M.. - In: FOOD FRONTIERS. - ISSN 2643-8429. - ELETTRONICO. - (2023). [10.1002/fft2.319]

Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal
Anno: 2023
Rivista: FOOD CHEMISTRY
Autori/autrici: Cianciosi, Danila; Armas Diaz, Yasmany; Alvarez-Suarez, José M; Chen, Xiumin; Zhang, Di; Martínez López, Nohora Milena; Briones Urbano, Mercedes; Quiles, José L; Amici, Adolfo; Battino, Maurizio; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323194
Citazioni:
Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal / Cianciosi, Danila; Armas Diaz, Yasmany; Alvarez-Suarez, José M; Chen, Xiumin; Zhang, Di; Martínez López, Nohora Milena; Briones Urbano, Mercedes; Quiles, José L; Amici, Adolfo; Battino, Maurizio; Giampieri, Francesca. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 427:(2023), p. 136684. [10.1016/j.foodchem.2023.136684]
Abstract:
ABSTR A C T Manuka honey, which is rich in pinocembrin, quercetin, naringenin, salicylic, p-coumaric, ferulic, syringic and 3,4-dihydroxybenzoic acids, has been shown to have pleiotropic effects against colon cancer cells. In this study, potential chemosensitizing effects of Manuka honey against 5-F...luorouracil were investigated in colonspheres enriched with cancer stem cells (CSCs), which are responsible for chemoresistance. Results showed that 5-Fluo-rouracil increased when it was combined with Manuka honey by downregulating the gene expression of both ATP-binding cassette sub-family G member 2, an efflux pump and thymidylate synthase, the main target of 5-Fluorouracil which regulates the ex novo DNA synthesis. Manuka honey was associated with decreased self-renewal ability by CSCs, regulating expression of several genes in Wnt/& beta;-catenin, Hedgehog and Notch path-ways. This preliminary study opens new areas of research into the effects of natural compounds in combination with pharmaceuticals and, potentially, increase efficacy or reduce adverse effects.
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Using the experimental model C. elegans to in vivo deepen into the biomedical properties of the Romina strawberry (Fragaria x ananassa) cultivar: A look into tau protein-related Alzheimer's disease, aging and redox biology
Anno: 2023
Rivista: JOURNAL OF BERRY RESEARCH
Autori/autrici: Navarro-Hortal, Md; Forbes-Hernández, Ty; Romero-Márquez, Jm; Armas Díaz, Y; Pascual-Barrera, Ae; Giampieri, F; Rivas-García, L; Sánchez-González, C; Battino, M; Quiles, Jl
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323202
Citazioni:
Using the experimental model C. elegans to in vivo deepen into the biomedical properties of the Romina strawberry (Fragaria x ananassa) cultivar: A look into tau protein-related Alzheimer's disease, aging and redox biology / Navarro-Hortal, Md; Forbes-Hernández, Ty; Romero-Márquez, Jm; Armas Díaz, Y; Pascual-Barrera, Ae; Giampieri, F; Rivas-García, L; Sánchez-González, C; Battino, M; Quiles, Jl. - In: JOURNAL OF BERRY RESEARCH. - ISSN 1878-5093. - 13:1(2023), pp. 81-94. [10.3233/JBR-230009]
Abstract:
BACKGROUND: Romina strawberry cultivar is rich in bioactive compounds. Healthy properties of Romina have been only partially investigated. There are almost no information concerning aging and age-related diseases like Alzheimer's Disease (AD).OBJECTIVE: To evaluate about the effects of a methanolic ...extract of the strawberry Romina cultivar on aging, redox biology, and tau protein-related aspects of AD in Caenorhabditis elegans.METHODS: Caenorhabditis elegans strains were treated with 100, 500 or 1000 mu g/mL of a methanolic extract of the Romina cultivar and evaluated for toxicity, lifespan, tau protein expression and redox biology markers.RESULTS: No toxicity was found. Tau expression was lower in nematodes treated with 500 and 1000 mu g/mL. All treatments induced higher lifespan than control. Lipofuscin expression was higher in old nematodes and the treatments led to a lower expression in young and old animals. Redox biology markers were improved by strawberry treatment in young and old animals, but the best results were found for different dosages depending on age.CONCLUSIONS: Romina cultivar presented promising effects concerning tau-related AD and longevity. Romina might be considered from the point of view of a proper regulation of redox biology, but considering that treatment conditions should be adjusted by age.
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The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment
Anno: 2023
Rivista: DISEASES
Autori/autrici: Salinari, Alessia; Machì, Michele; Armas Diaz, Yasmany; Cianciosi, Danila; Qi, Zexiu; Yang, Bei; Ferreiro Cotorruelo, Maria Soledad; Villar, Santos Gracia; Dzul Lopez, Luis Alonso; Battino, Maurizio; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323195
Citazioni:
The Application of Digital Technologies and Artificial Intelligence in Healthcare: An Overview on Nutrition Assessment / Salinari, Alessia; Machì, Michele; Armas Diaz, Yasmany; Cianciosi, Danila; Qi, Zexiu; Yang, Bei; Ferreiro Cotorruelo, Maria Soledad; Villar, Santos Gracia; Dzul Lopez, Luis Alonso; Battino, Maurizio; Giampieri, Francesca. - In: DISEASES. - ISSN 2079-9721. - 11:3(2023), p. 97. [10.3390/diseases11030097]
Abstract:
\In the last decade, artificial intelligence (AI) and AI-mediated technologies have undergone rapid evolution in healthcare and medicine, from apps to computer software able to analyze medical images, robotic surgery and advanced data storage system. The main aim of the present commentary is to brie...fly describe the evolution of AI and its applications in healthcare, particularly in nutrition and clinical biochemistry. Indeed, AI is revealing itself to be an important tool in clinical nutrition by using telematic means to self-monitor various health metrics, including blood glucose levels, body weight, heart rate, fat percentage, blood pressure, activity tracking and calorie intake trackers. In particular, the application of the most common digital technologies used in the field of nutrition as well as the employment of AI in the management of diabetes and obesity, two of the most common nutrition-related pathologies worldwide, will be presented.
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Mechanisms of action of berry bioactives on Obesity-induced inflammation
Anno: 2022
Autori/autrici: Giampieri, F.; Cianciosi, D.; Ansary, J.; FORBES-HERNANDEZ, T. Y.; ALVAREZ-SUAREZ, J. M.; Battino, M.
Lingua: ENG
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/295484
Citazioni:
Mechanisms of action of berry bioactives on Obesity-induced inflammation / Giampieri, F.; Cianciosi, D.; Ansary, J.; FORBES-HERNANDEZ, T. Y.; ALVAREZ-SUAREZ, J. M.; Battino, M.. - STAMPA. - (2022).

Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Cianciosi, D.; Forbes-Hernandez, T. Y.; Regolo, L.; Alvarez-Suarez, J. M.; Quinzi, D.; Sargenti, A.; Bai, W.; Tian, L.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297645
Citazioni:
Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis / Cianciosi, D.; Forbes-Hernandez, T. Y.; Regolo, L.; Alvarez-Suarez, J. M.; Quinzi, D.; Sargenti, A.; Bai, W.; Tian, L.; Giampieri, F.; Battino, M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 374:(2022), p. 131753. [10.1016/j.foodchem.2021.131753]
Abstract:
The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon ade...nocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.
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Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Sumalla-Cano, S.; Forbes-Hernandez, T.; Aparicio-Obregon, S.; Crespo, J.; Elexpuru-Zabaleta, M.; Gracia-Villar, M.; Giampieri, F.; Elio, I.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299174
Citazioni:
Changes in the Lifestyle of the Spanish University Population during Confinement for COVID-19 / Sumalla-Cano, S.; Forbes-Hernandez, T.; Aparicio-Obregon, S.; Crespo, J.; Elexpuru-Zabaleta, M.; Gracia-Villar, M.; Giampieri, F.; Elio, I.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1661-7827. - 19:4(2022), p. 2210. [10.3390/ijerph19042210]
Abstract:
The aim of this study was to evaluate the influence of the lockdown due to the COVID-19 pandemic, on eating and physical activity behavior, in a university population. A healthy diet such as the Mediterranean Diet (MD) pattern, rich in fruit and vegetables, can prevent degenerative diseases such as ...obesity, diabetes, cardiovascular diseases, etc. We conducted a cross-sectional study and data were collected by an anonymous online questionnaire. Participants completed a survey consisting of 3 sections: sociodemographic data; dietary behavior and physical activity; the Mediterranean Diet questionnaire (MEDAS-14) and the Emotional Eater Questionnaire (EEQ). A total of 168 participants completed the questionnaire: 66.7% were women, 79.2% were from Spain, 76.8% were students, 76.2% lived in their family home and 66.1% were of normal weight. During lock-down our population shopped for groceries 1 time or less per week (76.8%); maintained the same consumption of fruits (45.2%), vegetables (50.6%), dairy products (61.9%), pulses (64.9%), fish/sea-food (57.7%), white meat (77.4%), red and processed meat (71.4%), pastries and snacks (48.2%), rice/pasta/potatoes (70.2%) and nuts (62.5%), spirits (98.8%) and sugary drinks (91.7%). Cooking time increased (73.2%) and the consumption decreased of low alcohol drinks (60.1%), spirits (75%) and sugary drinks (57.1%), and physical activity also diminished (49.4%). University Employees (UE) gained more weight (1.01 ± 0.02) than students (0.99 ± 0.03) (p < 0.05) during the confinement period. A total of 79.8% of the participants obtained a Medium/High Adherence to the MD during lockdown. Emotional and very emotional eaters were higher in the female group (p < 0.01). In the event of further confinement, strategies should be implemented to promote a balanced and healthy diet together with the practice of physical activity, taking special care of the female and UE groups.
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Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures: A Dose–Response Meta-Analysis
Anno: 2022
Rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Autori/autrici: Godos, J.; Giampieri, F.; Chisari, E.; Micek, A.; Paladino, N.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Battino, M.; La Vignera, S.; Musumeci, G.; Grosso, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297651
Citazioni:
Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures: A Dose–Response Meta-Analysis / Godos, J.; Giampieri, F.; Chisari, E.; Micek, A.; Paladino, N.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Battino, M.; La Vignera, S.; Musumeci, G.; Grosso, G.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1661-7827. - ELETTRONICO. - 19:3(2022), p. 1515. [10.3390/ijerph19031515]
Abstract:
Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits— mostly related to the cardiovascular system. Nevertheless, there is no univocal agreement on this matter, and r...esearch is still ongoing to clarify whether there might be other potential outcomes affected by alcohol intake. In this regard, there is evidence that excess alcohol intake may negatively influence the risk of osteoporotic fractures. However, there is no comprehensive evidence of literature assessing the role of alcohol consumption in bone mineral density (BMD) and the risk of oste-oporotic fractures. Thus, the aim of this study was to quantitatively assess the dose–response relationship between alcohol intake and BMD and risk of osteoporotic fractures. The Embase and MED-LINE electronic databases were searched from their inception to December 2021 for articles provid-ing a quantifiable measurement of alcohol consumption for at least three categories and (1) a measurement of BMD (and dispersion as continuous variables) in some area of the body or (2) risk of osteoporotic fracture provided as relative risk (RR) or hazard ratio (HR), with a 95% confidence interval (CI) as the measure of the association of each category with alcohol intake. A total of 11 studies including 46,916 individuals with BMD assessment and 8 studies including 240,871 individuals with risk of fracture analysis were included. Compared to non-drinkers, consumption of up to two standard drinks of alcohol per day was correlated with higher lumbar and femur neck BMD values, while up to one standard drink of alcohol was correlated with higher hip BMD compared to no alcohol consumption. Higher risk of hip fractures was found starting from three standard drinks of alcohol per day (RR = 1.33, 95% CI: 1.04; 1.69 for three alcoholic drinks/d, and RR = 1.59, 95% CI: 1.23; 2.05 for four alcoholic drinks/d) compared to no alcohol consumption, with no evidence of heterogeneity. Concerning the risk of any osteoporotic fractures, the risk steadily increased with higher intake of alcohol, although never reaching statistical significance. In conclusion, there is consistent evidence that increased alcohol consumption is associated with higher risk of osteopo-rotic hip fracture; however, the role of alcohol at lower doses is uncertain, as BMD was even higher in light drinkers compared to abstainers.
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Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise
Anno: 2022
Rivista: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Autori/autrici: Navarro-Hortal, María D; Romero-Márquez, Jose M; Jiménez-Trigo, Victoria; Xiao, Jianbo; Giampieri, Francesca; Forbes-Hernández, Tamara Y; Grosso, Giuseppe; Battino, Maurizio; Sánchez-González, Cristina; Quiles, José L
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314751
Citazioni:
Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise / Navarro-Hortal, María D; Romero-Márquez, Jose M; Jiménez-Trigo, Victoria; Xiao, Jianbo; Giampieri, Francesca; Forbes-Hernández, Tamara Y; Grosso, Giuseppe; Battino, Maurizio; Sánchez-González, Cristina; Quiles, José L. - In: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. - ISSN 1040-8398. - ELETTRONICO. - (2022), pp. 1-20. [10.1080/10408398.2022.2098244]
Abstract:
As the number of older people has grown in recent decades, the search for new approaches to manage or delay aging is also growing. Among the modifiable factors, diet plays a crucial role in healthy aging and in the prevention of age-related diseases. Thus, the interest in the use of foods, which are... rich in bioactive compounds such as functional foods with anti-aging effects is a growing market. This review summarizes the current knowledge about the molecular mechanisms of action of foods considered as functional foods in aging, namely berries, curcumin, and virgin olive oil. Moreover, honey is also analyzed as a food with well-known healthy benefits, but which has not been deeply evaluated from the point of view of aging. The effects of these foods on aging are analyzed from the point of view of molecular mechanisms including oxidative stress, mitochondrial dysfunction, inflammation, genomic stability, telomere attrition, cellular senescence, and deregulated nutrient-sensing. A comprehensive study of the scientific literature shows that the aforementioned foods have demonstrated positive effects on certain aspects of aging, which might justify their use as functional foods in elderly. However, more research is needed, especially in humans, designed to understand in depth the mechanisms of action through which they act.
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The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders
Anno: 2022
Rivista: NUTRIENTS
Autori/autrici: Nacka-Aleksić, Mirjana; Pirković, Andrea; Vilotić, Aleksandra; Bojić-Trbojević, Žanka; Jovanović Krivokuća, Milica; Giampieri, Francesca; Battino, Maurizio; Dekanski, Dragana
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314775
Citazioni:
The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders / Nacka-Aleksić, Mirjana; Pirković, Andrea; Vilotić, Aleksandra; Bojić-Trbojević, Žanka; Jovanović Krivokuća, Milica; Giampieri, Francesca; Battino, Maurizio; Dekanski, Dragana. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 14:24(2022), p. 5246. [10.3390/nu14245246]
Abstract:
Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also ...led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.
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The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Cianciosi, D.; Forbes-Hernandez, T. Y.; Regolo, L.; Alvarez-Suarez, J. M.; Navarro-Hortal, M. D.; Xiao, J.; Quiles, J. L.; Battino, M.; Giampieri, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297644
Citazioni:
The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters / Cianciosi, D.; Forbes-Hernandez, T. Y.; Regolo, L.; Alvarez-Suarez, J. M.; Navarro-Hortal, M. D.; Xiao, J.; Quiles, J. L.; Battino, M.; Giampieri, F.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 375:(2022), p. 131904. [10.1016/j.foodchem.2021.131904]
Abstract:
Polyphenols are plant secondary metabolites, whose biological activity has been widely demonstrated. However, the research in this field is a bit reductive, as very frequently the effect of individual compound is investigated in different experimental models, neglecting more complex, but common, rel...ationships that are established in the diet. This review summarizes the data that highlighted the interaction between polyphenols and other food components, especially macro- (lipids, proteins, carbohydrates and fibers) and micronutrients (minerals, vitamins and organic pigments), paying particular attention on their bioavailability, antioxidant capacity and chemical, physical, organoleptic and nutritional characteristics. The topic of food interaction has yet to be extensively studied because a greater knowledge of the food chemistry behind these interactions and the variables that modify their effects, could offer innovations and improvements in various fields ranging from organoleptic, nutritional to health and economic field.
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Recovery of value-added anthocyanins from mulberry by a cation exchange chromatography
Anno: 2022
Rivista: CURRENT RESEARCH IN FOOD SCIENCE
Autori/autrici: Liao, Zhiwei; Zhang, Xuan; Chen, Xi; Battino, Maurizio; Giampieri, Francesca; Bai, Weibin; Tian, Lingmin
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314756
Citazioni:
Recovery of value-added anthocyanins from mulberry by a cation exchange chromatography / Liao, Zhiwei; Zhang, Xuan; Chen, Xi; Battino, Maurizio; Giampieri, Francesca; Bai, Weibin; Tian, Lingmin. - In: CURRENT RESEARCH IN FOOD SCIENCE. - ISSN 2665-9271. - ELETTRONICO. - 5:(2022), pp. 1445-1451. [10.1016/j.crfs.2022.08.022]
Abstract:
Anthocyanins are often targets in polyphenol analysis. However, it's hard to effectively separate anthocyanin from copigments such as phenolic acid and flavanols due to their similar structure. Thus, a cation exchange chromatography with 001 x 7 has been developed, which is available for anthocyanin...s isolation both on a small and large scale. The optimal process condition of anthocyanins isolation was determined. Compared to the macroporous adsorbent resins and Strong Cation Exchange resin (SCX), 001X7 shows greater economic advantages in large-scale purification of anthocyanins. More than 95% purity of the anthocyanin fraction can be achieved through this approach. This method shows a path to provide large quantities of copigments-free anthocyanins from mulberry polyphenols for the further study of its biological effects and may be extended to other analytical methods of polyphenol isolation from other plant materials.
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The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods
Anno: 2022
Rivista: MOLECULES
Autori/autrici: Ramos-Vivas, José; Tapia, Olga; Elexpuru-Zabaleta, María; Pifarre, Kilian Tutusaus; Armas Diaz, Yasmany; Battino, Maurizio; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314767
Citazioni:
The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods / Ramos-Vivas, José; Tapia, Olga; Elexpuru-Zabaleta, María; Pifarre, Kilian Tutusaus; Armas Diaz, Yasmany; Battino, Maurizio; Giampieri, Francesca. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 27:17(2022), p. 5585. [10.3390/molecules27175585]
Abstract:
Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The prod...uction of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives.
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Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Gil-Martin, E.; Forbes-Hernandez, T.; Romero, A.; Cianciosi, D.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297643
Citazioni:
Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products / Gil-Martin, E.; Forbes-Hernandez, T.; Romero, A.; Cianciosi, D.; Giampieri, F.; Battino, M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 378:(2022). [10.1016/j.foodchem.2021.131918]
Abstract:
Agro-foodindustries generate colossal amounts of non-edible waste and by-products, easily accessible as raw materials for up-cycling active phytochemicals. Phenolic compounds are particularly relevant in this field given their abundance in plant residues and the market interest of their functionalit...ies (e.g. natural antioxidant activity) as part of nutraceutical, cosmetological and biomedical formulations. In “bench-to-bedside” achievements, sample extraction is essential because valorization benefits from matrix desorption and solubilization of targeted phytocompounds. Specifically, the composition and polarity of the extractant, the optimal sample particle size and sample:solvent ratio, as well as pH, pressure and temperature are strategic for the release and stability of mobilized species. On the other hand, current green chemistry environmental rules require extraction approaches that eliminate polluting consumables and reduce energy needs. Thus, the following pages provide an update on advanced technologies for the sustainable and efficient recovery of phenolics from plant matrices.
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Unravelling potential biomedical applications of the edible flower Tulbaghia violacea
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Rivas-Garcia, L.; Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Esteban-Munoz, A.; Giampieri, F.; Sumalla-Cano, S.; Battino, M.; Quiles, J. L.; Llopis, J.; Sanchez-Gonzalez, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297642
Citazioni:
Unravelling potential biomedical applications of the edible flower Tulbaghia violacea / Rivas-Garcia, L.; Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Esteban-Munoz, A.; Giampieri, F.; Sumalla-Cano, S.; Battino, M.; Quiles, J. L.; Llopis, J.; Sanchez-Gonzalez, C.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 381:(2022), p. 132096. [10.1016/j.foodchem.2022.132096]
Abstract:
Traditionally, edible flowers have been used as foods and for therapeutic purposes, today they have gained importance due to their bioactive compounds such as flavonols, anthocyanins or other phenolic compounds, which give them potential for biomedical applications. This work evaluated a methanolic ...extract of Tulbaghia violacea. Eleven individual phenolic compounds were found and quantified by mass spectrometry in the extract. Antioxidant activity tests (TEAC, FRAP and DPPH) and other characterization parameters were assayed (total phenolic content and total flavonoid content). In vitro studies showed antitumoral activity against ovarian tumoral cells mediated by the induction of non-dependent caspase cell death and by the activation of reactive oxygen species. The effect of the extract against features of Alzheimer disease was in vivo assayed in Caenorhabditis elegans. Tulbaghia extract led to a reduction in the 1–42 beta amyloid peptide formation and prevented oxidative stress. These results suggested that Tulbaghia violacea could be a new source of phenolic compounds for nutraceuticals and functional food development.
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Development of a Short Questionnaire for the Screening for Vitamin D Deficiency in Italian Adults: The EVIDENCe-Q Project
Anno: 2022
Rivista: NUTRIENTS
Autori/autrici: De Giuseppe, Rachele; Tomasinelli, Chiara; Cena, Hellas; Braschi, V; Giampieri, Francesca; Preatoni, G; Centofanti, D; Princis, M; Bartoletti, E; Biino, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/298764
Citazioni:
Development of a Short Questionnaire for the Screening for Vitamin D Deficiency in Italian Adults: The EVIDENCe-Q Project / De Giuseppe, Rachele; Tomasinelli, Chiara; Cena, Hellas; Braschi, V; Giampieri, Francesca; Preatoni, G; Centofanti, D; Princis, M; Bartoletti, E; Biino, G.. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 14:(2022), p. 1772. [10.3390/nu14091772]

Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies
Anno: 2022
Rivista: NUTRIENTS
Autori/autrici: Gastaldello, A; Giampieri, F; Quiles, Jl; Navarro-Hortal, Md; Aparicio, S; García Villena, E; Tutusaus Pifarre, K; De Giuseppe, R; Grosso, G; Cianciosi, D; Forbes-Hernández, Tf; Nabavi, Sm; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299671
Citazioni:
Adherence to the Mediterranean-Style Eating Pattern and Macular Degeneration: A Systematic Review of Observational Studies / Gastaldello, A; Giampieri, F; Quiles, Jl; Navarro-Hortal, Md; Aparicio, S; García Villena, E; Tutusaus Pifarre, K; De Giuseppe, R; Grosso, G; Cianciosi, D; Forbes-Hernández, Tf; Nabavi, Sm; Battino, M.. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 14:(2022), p. 2028. [10.3390/nu14102028]
Abstract:
Age-related macular degeneration (AMD) is a serious degenerative disease affecting the eyes, and is the main cause of severe vision loss among people >55 years of age in developed countries. Its onset and progression have been associated with several genetic and lifestyle factors, with diet appearin...g to play a pivotal role in the latter. In particular, dietary eating patterns rich in plant foods have been shown to lower the risk of developing the disease, and to decrease the odds of progressing to more advanced stages in individuals already burdened with early AMD. We systematically reviewed the literature to analyse the relationship between the adherence to a Mediterranean diet, a mainly plant-based dietary pattern, and the onset/progression of AMD. Eight human observational studies were analysed. Despite some differences, they consistently indicate that higher adherence to a Mediterranean eating pattern lowers the odds of developing AMD and decreases the risk of progression to more advanced stages of the disease, establishing the way for preventative measures emphasizing dietary patterns rich in plant-foods.
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Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease
Anno: 2022
Rivista: FOOD & FUNCTION
Autori/autrici: Navarro-Hortal, María D; Romero-Márquez, Jose M; Muñoz-Ollero, Pedro; Jiménez-Trigo, Victoria; Esteban-Muñoz, Adelaida; Tutusaus, Kilian; Giampieri, Francesca; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Llopis, Juan; Forbes-Hernández, Tamara Y; Quiles, José L
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314769
Citazioni:
Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey via HSP-16.2 and SKN-1/Nrf2 pathways in an in vivo model of Alzheimer's disease / Navarro-Hortal, María D; Romero-Márquez, Jose M; Muñoz-Ollero, Pedro; Jiménez-Trigo, Victoria; Esteban-Muñoz, Adelaida; Tutusaus, Kilian; Giampieri, Francesca; Battino, Maurizio; Sánchez-González, Cristina; Rivas-García, Lorenzo; Llopis, Juan; Forbes-Hernández, Tamara Y; Quiles, José L. - In: FOOD & FUNCTION. - ISSN 2042-6496. - ELETTRONICO. - 13:21(2022), pp. 11185-11199. [10.1039/d2fo01739c]
Abstract:
Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of beta-amyloid peptide and the formation of neurofibrillary tangles of h...yperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease. However, despite its potential, there is no scientific evidence about Manuka honey (MH) in this regard. In the present work we evaluated the effect of MH on the toxicity induced by A beta aggregation and Tau in a Caenorhabditis elegans model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed A beta-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms.
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Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer's beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Navarro-Hortal, M. D.; Romero-Marquez, J. M.; Esteban-Munoz, A.; Sanchez-Gonzalez, C.; Rivas-Garcia, L.; Llopis, J.; Cianciosi, D.; Giampieri, F.; Sumalla-Cano, S.; Battino, M.; Quiles, J. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297654
Citazioni:
Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer's beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans / Navarro-Hortal, M. D.; Romero-Marquez, J. M.; Esteban-Munoz, A.; Sanchez-Gonzalez, C.; Rivas-Garcia, L.; Llopis, J.; Cianciosi, D.; Giampieri, F.; Sumalla-Cano, S.; Battino, M.; Quiles, J. L.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 372:(2022), p. 131272. [10.1016/j.foodchem.2021.131272]
Abstract:
Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additio...nally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved.
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Influence of altitude on the physicochemical composition and antioxidant capacity of strawberry: a preliminary systematic review and meta-analysis
Anno: 2022
Rivista: PHYTOCHEMISTRY REVIEWS
Autori/autrici: Guevara-Teran, M; Gonzalez-Paramas, Am; Beltran-Noboa, A; Giampieri, F; Battino, M; Tejera, E; Alvarez-Suarez, Jm
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314753
Citazioni:
Influence of altitude on the physicochemical composition and antioxidant capacity of strawberry: a preliminary systematic review and meta-analysis / Guevara-Teran, M; Gonzalez-Paramas, Am; Beltran-Noboa, A; Giampieri, F; Battino, M; Tejera, E; Alvarez-Suarez, Jm. - In: PHYTOCHEMISTRY REVIEWS. - ISSN 1568-7767. - ELETTRONICO. - (2022). [10.1007/s11101-022-09834-z]
Abstract:
Several climatic trends are generally associated with altitude, that may influence the nutritional and phytochemical composition of plants. Strawberry is considered a functional food due to biological activities and health benefits. This systematic review and meta-analysis intend to expose possible ...variations on physicochemical composition and antioxidant capacity of strawberries in regard to altitude. Thirty eligible studies were included for the final meta-analysis. Two altitude ranges were established: 0 - 1000 and 1000-2000 m above sea level. A random-effects model was used to obtain the results. It was discovered that total soluble solids significantly decreased with altitude. Total titratable acidity increased with altitude. Vitamin C and total anthocyanins showed a significant difference between the groups before we discarded some studies. The analysis of altitude for phenolics and antioxidant capacity evaluated for the DPPH radical scavenging method did not identify any significant differences between the studies. The findings suggest that altitude does not affect the physicochemical composition and antioxidant capacity of strawberries; nonetheless, a more exhaustive study is recommended.[GRAPHICS].
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The rise of processed meat alternatives: A narrative review of the manufacturing, composition, nutritional profile and health effects of newer sources of protein, and their place in healthier diets
Anno: 2022
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Gastaldello, A; Giampieri, F; De Giuseppe, R; Grosso, G; Baroni, L; Battino, M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314766
Citazioni:
The rise of processed meat alternatives: A narrative review of the manufacturing, composition, nutritional profile and health effects of newer sources of protein, and their place in healthier diets / Gastaldello, A; Giampieri, F; De Giuseppe, R; Grosso, G; Baroni, L; Battino, M. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - ELETTRONICO. - 127:(2022), pp. 263-271. [10.1016/j.tifs.2022.07.005]
Abstract:
Background: The drive to reduce the negative impact of the global food system on the environment and human health, and to feed a growing global population, has led to the rapid development of meat alternatives, including plant-based and mycoprotein-based products such as burgers, cured meat and nugg...ets. These are generally food items manufactured with highly refined ingredients, so health professionals interested in promoting plant-based diets, or a reduction in meat consumption, need a deeper understanding about the potential health effects of these products in order to present them to the public in an objective and helpful manner.Scope and approaches: In this narrative review, a search of the current available scientific literature was performed with the aim of exploring all these foods by delving into the way they are manufactured, their nutritional characteristics, their impact on health, as well as trying to understand their place in modern, diets.Key findings and conclusion: Processed meat alternatives, despite being highly refined products, can be a good source of healthy food groups and nutrients often underrepresented in omnivores diets such as grains, legumes, plant protein and fibre, although attention must be paid to their salt and saturated fat content. For people wanting to move away from a meat-heavy diet, the consumption of these items can represent a stepping stone towards the adoption of more healthful dietary patterns centred on whole plant-foods. In addition, they might help to increase compliance with the new lifestyle as they tend to replicate some of the organoleptic properties of meat.
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Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry (Vaccinium floribundum Kunth)
Anno: 2022
Rivista: MOLECULES
Autori/autrici: Guevara-Terán, Mabel; Padilla-Arias, Katherine; Beltrán-Novoa, Andrea; González-Paramás, Ana M; Giampieri, Francesca; Battino, Maurizio; Vásquez-Castillo, Wilson; Fernandez-Soto, Paulina; Tejera, Eduardo; Alvarez-Suarez, José M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314771
Citazioni:
Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry (Vaccinium floribundum Kunth) / Guevara-Terán, Mabel; Padilla-Arias, Katherine; Beltrán-Novoa, Andrea; González-Paramás, Ana M; Giampieri, Francesca; Battino, Maurizio; Vásquez-Castillo, Wilson; Fernandez-Soto, Paulina; Tejera, Eduardo; Alvarez-Suarez, José M. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 27:21(2022), p. 7525. [10.3390/molecules27217525]
Abstract:
The chemical composition and biological capacities of berries depend on environmental parameters, maturity, and location. The Andean blueberry (Vaccinium floribundum Kunth), also known as mortino, presents a unique combination of several phytochemicals, which play a synergistic role in its character...ization as a functional food. We aimed to expose the possible variations that exist in the profile of the phenolic compounds as well as the antioxidant and antimicrobial capacity of the wild Andean blueberry with respect to three ripeness stages and two different altitudes. We found that polyphenols are the predominant compounds in the berry during the early ripeness stage and are the main bioactive compounds that give rise to the antioxidant capacity and inhibition effect on the growth of gram-positive and gram-negative bacteria. Moreover, the accumulation of ascorbic acid, free amino acids, and anthocyanins increases as the ripening process progresses, and they were the main bioactive compounds in the ripe berry. The latter compounds influence the production of the typical bluish or reddish coloration of ripe blueberries. In addition, it was determined that environmental conditions at high altitudes could have a positive influence in all cases. Overall, our data provide evidence regarding the high functional value of the wild Andean blueberry.
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Computational modeling predicts potential effects of the herbal infusion “horchata” against COVID-19
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Tejera, E.; Perez-Castillo, Y.; Toscano, G.; Noboa, A. L.; Ochoa-Herrera, V.; Giampieri, F.; Alvarez-Suarez, J. M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299176
Citazioni:
Computational modeling predicts potential effects of the herbal infusion “horchata” against COVID-19 / Tejera, E.; Perez-Castillo, Y.; Toscano, G.; Noboa, A. L.; Ochoa-Herrera, V.; Giampieri, F.; Alvarez-Suarez, J. M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 366:(2022), p. 130589. [10.1016/j.foodchem.2021.130589]
Abstract:
Bioactive plant-derived molecules have emerged as therapeutic alternatives in the fight against the COVID-19 pandemic. In this investigation, principal bioactive compounds of the herbal infusion “horchata” from Ecuador were studied as potential novel inhibitors of the SARS-CoV-2 virus. The chemi...cal composition of horchata was determined through a HPLC-DAD/ESI-MSn and GC–MS analysis while the inhibitory potential of the compounds on SARS-CoV-2 was determined by a computational prediction using various strategies, such as molecular docking and molecular dynamics simulations. Up to 51 different compounds were identified. The computational analysis of predicted targets reveals the compounds’ possible anti-inflammatory (no steroidal) and antioxidant effects. Three compounds were identified as candidates for Mpro inhibition: benzoic acid, 2-(ethylthio)-ethyl ester, l-Leucine-N-isobutoxycarbonyl-N-methyl-heptyl and isorhamnetin and for PLpro: isorhamnetin-3-O-(6-Orhamnosyl-galactoside), dihydroxy-methoxyflavanone and dihydroxyphenyl)-5-hydroxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid. Our results suggest the potential of Ecuadorian horchata infusion as a starting scaffold for the development of new inhibitors of the SARS-CoV-2 Mpro and PLpro enzymes.
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Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules
Anno: 2022
Rivista: ACS OMEGA
Autori/autrici: Guerra, Yasel; Celi, Diana; Cueva, Paul; Perez-Castillo, Yunierkis; Giampieri, Francesca; Alvarez-Suarez, José Miguel; Tejera, Eduardo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/323204
Citazioni:
Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules / Guerra, Yasel; Celi, Diana; Cueva, Paul; Perez-Castillo, Yunierkis; Giampieri, Francesca; Alvarez-Suarez, José Miguel; Tejera, Eduardo. - In: ACS OMEGA. - ISSN 2470-1343. - 7:49(2022), pp. 44542-44555. [10.1021/acsomega.2c05766]
Abstract:
Ever since coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, was declared a pandemic on March 11, 2020, by the WHO, a concerted effort has been made to find compounds capable of acting on the virus and preventing its replication. In this context, researchers have refocused part of their att...ention on certain natural compounds that have shown promising effects on the virus. Considering the importance of this topic in the current context, this study aimed to present a critical review and analysis of the main reports of plant-derived compounds as possible inhibitors of the two SARS-CoV-2 proteases: main protease (Mpro) and Papain-like protease (PLpro). From the search in the PubMed database, a total of 165 published articles were found that met the search patterns. A total of 590 unique molecules were identified from a total of 122 articles as potential protease inhibitors. At the same time, 114 molecules reported as natural products and with annotation of theoretical support and antiviral effects were extracted from the COVID-19 Help database. After combining the molecules extracted from articles and those obtained from the database, we identified 648 unique molecules predicted as potential inhibitors of Mpro and/or PLpro. According to our results, several of the predicted compounds with higher theoretical confidence are present in many plants used in traditional medicine and even food, such as flavonoids, carboxylic acids, phenolic acids, triterpenes, terpenes phytosterols, and triterpenoids. These are potential inhibitors of Mpro and PLpro. Although the predictions of several molecules against SARS-CoV-2 are promising, little experimental information was found regarding certain families of compounds. Only 45 out of the 648 unique molecules have experimental data validating them as inhibitors of Mpro or PLpro, with the most frequent scaffold present in these 45 compounds being the flavone. The novelty of this work lies in the analysis of the structural diversity of the chemical space among the molecules predicted as inhibitors of SARS-CoV-2 Mpro and PLpro proteases and the comparison to those molecules experimentally validated. This work emphasizes the need for experimental validation of certain families of compounds, preferentially combining classical enzymatic assays with interaction-based methods. Furthermore, we recommend checking the presence of Pan-Assay Interference Compounds (PAINS) and the presence of molecules previously reported as inhibitors of Mpro or PLpro to optimize resources and time in the discovery of new SARS-CoV-2 antivirals from plant-derived molecules.
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An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans
Anno: 2022
Rivista: FOOD AND CHEMICAL TOXICOLOGY
Autori/autrici: Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Jimenez-Trigo, V.; Vera-Ramirez, L.; Forbes-Hernandez, T. J.; Esteban-Munoz, A.; Giampieri, F.; Bullon, P.; Battino, M.; Sanchez-Gonzalez, C.; Quiles, J. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297646
Citazioni:
An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans / Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Jimenez-Trigo, V.; Vera-Ramirez, L.; Forbes-Hernandez, T. J.; Esteban-Munoz, A.; Giampieri, F.; Bullon, P.; Battino, M.; Sanchez-Gonzalez, C.; Quiles, J. L.. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - ELETTRONICO. - 162:(2022), p. 112914. [10.1016/j.fct.2022.112914]
Abstract:
Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, includin...g oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved.
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Dietary phytoestrogen intake and cognitive status in Southern Italian older adults
Anno: 2022
Rivista: BIOMOLECULES
Autori/autrici: Giampieri, F; Godos, G; Caruso, G; Owczarek, M; Jurek, J; Castellano, S; Ferri, R; Caraci, F; Grosso, G
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/301901
Citazioni:
Dietary phytoestrogen intake and cognitive status in Southern Italian older adults / Giampieri, F; Godos, G; Caruso, G; Owczarek, M; Jurek, J; Castellano, S; Ferri, R; Caraci, F; Grosso, G. - In: BIOMOLECULES. - ISSN 2218-273X. - 12:6(2022), p. 760. [10.3390/biom12060760]

The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action
Anno: 2022
Rivista: NUTRIENTS
Autori/autrici: Grosso, G.; Godos, J.; Currenti, W.; Micek, A.; Falzone, L.; Libra, M.; Giampieri, F.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Battino, M.; La Vignera, S.; Galvano, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297649
Citazioni:
The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action / Grosso, G.; Godos, J.; Currenti, W.; Micek, A.; Falzone, L.; Libra, M.; Giampieri, F.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Battino, M.; La Vignera, S.; Galvano, F.. - In: NUTRIENTS. - ISSN 2072-6643. - 14:3(2022), p. 545. [10.3390/nu14030545]
Abstract:
The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms of action of dietary polyphenols on vascular health, blood pressure and hypertension. There is evidence that some polyphenol-rich foods, including berry fruits rich in anthocyanins, ...cocoa and green tea rich in flavan-3-ols, almonds and pistachios rich in hydroxycinnamic acids, and soy products rich in isoflavones, are able to improve blood pressure levels. A variety of mechanisms can elucidate the observed effects. Some limitations of the evidence, including variability of polyphenol content in plant-derived foods and human absorption, difficulty disentangling the effects of polyphenols from other dietary compounds, and discrepancy of doses between animal and human studies should be taken into account. While no single food counteracts hypertension, adopting a plant-based dietary pattern including a variety of polyphenol-rich foods is an advisable practice to improve blood pressure.
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Three Amazonian palms as underestimated and little-known sources of nutrients, bioactive compounds and edible insects
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Jaramillo-Vivanco, T.; Balslev, H.; Montufar, R.; Camara, R. M.; Giampieri, F.; Battino, M.; Camara, M.; Alvarez-Suarez, J. M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297647
Citazioni:
Three Amazonian palms as underestimated and little-known sources of nutrients, bioactive compounds and edible insects / Jaramillo-Vivanco, T.; Balslev, H.; Montufar, R.; Camara, R. M.; Giampieri, F.; Battino, M.; Camara, M.; Alvarez-Suarez, J. M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 372:(2022), p. 131273. [10.1016/j.foodchem.2021.131273]
Abstract:
Mauritia flexuosa, Bactris gasipaes, and Oenocarpus bataua are among the main palms in the Amazon used for food and medicinal purposes. The food most commonly derived from these are fruits, oil, and the larvae of the insect Rhynchophorus palmarum reared in their trunks. Palm fruits are used for oil ...extraction as they are rich in saturated fatty acids, fiber, pro-vitamin A, carotenoids, tocopherols, macro and microelements, and polyphenols. Furthermore, the larvae of R. palmarum are rich in lipids, vitamin E, and proteins. This review analyzes the chemical composition of the fruit and oil of these palm species, as well as the R. palmarum larvae that breed in them. Our aim is to present information that is not widely known in order to demonstrate the potential of these palms as sources of plant-based and animal food with high nutritional and functional values.
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Recovering high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction
Anno: 2022
Rivista: FOOD CHEMISTRY X
Autori/autrici: Zhang, Xuan; Wang, Songen; Wu, Qixia; Battino, Maurizio; Giampieri, Francesca; Bai, Weibin; Tian, Lingmin
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314776
Citazioni:
Recovering high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction / Zhang, Xuan; Wang, Songen; Wu, Qixia; Battino, Maurizio; Giampieri, Francesca; Bai, Weibin; Tian, Lingmin. - In: FOOD CHEMISTRY X. - ISSN 2590-1575. - ELETTRONICO. - 16:(2022), p. 100476. [10.1016/j.fochx.2022.100476]
Abstract:
Food waste is a potential source to replace fresh materials for obtaining functional ingredients. Blueberry pomace contains considerable amounts of anthocyanins. In this study, we investigated ultrasonic-assisted extraction (UAE) of anthocyanins from blueberry pomace. We used a Box-Behnken design (B...BD) to screen and optimize the important factors influencing yield. The optimum extraction conditions were a temperature of 40 degrees C, an ultra-sonic power of 400 W and an extraction time of 40 min. The optimum yield was 108.23 mg/100 g DW. In addition, we used a cation column to separate anthocyanins, and optimized the chromatographic conditions of HPLC to analyze and identify the main anthocyanins. Thirteen anthocyanins were found in blueberry pomace, of which Malvidin-3-Galactoside (22.65 %) was the highest. These findings provide a theoretical basis and opti-mized process parameters for the recovery of high value-added anthocyanins from blueberry pomace with ultrasound-assisted extraction, thus facilitating the comprehensive utilization of blueberry pomace.
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Edible insects: A novel nutritious, functional, and safe food alternative
Anno: 2022
Rivista: FOOD FRONTIERS
Autori/autrici: Giampieri, F; Alvarez-Suarez, Jm; Machi, M; Cianciosi, D; Navarro-Hortal, Md; Battino, M
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314765
Citazioni:
Edible insects: A novel nutritious, functional, and safe food alternative / Giampieri, F; Alvarez-Suarez, Jm; Machi, M; Cianciosi, D; Navarro-Hortal, Md; Battino, M. - In: FOOD FRONTIERS. - ISSN 2643-8429. - ELETTRONICO. - 3:3(2022), pp. 358-365. [10.1002/fft2.167]
Abstract:
In a world where 1 billion people suffer from hunger, lands and seas are overexploited and production systems are unsustainable, and there is an urgent need to find alternative foods. In this context, insects represent a good source of macro- and micronutrients and even bioactive compounds that coul...d contribute to reducing nutritional deficiency and preventing some human diseases. However, some aspects related to their consumption, including health risks, need to be clarified. This communication aims to summarize the nutritional/phytochemical profile of common edible insects and the main safety concerns, highlighting the possible strategies to promote entomophagy in a more conscious way.
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Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum
Anno: 2022
Rivista: FOOD AND CHEMICAL TOXICOLOGY
Autori/autrici: Beltrán-Noboa, Andrea; Proaño-Ojeda, John; Guevara, Mabel; Gallo, Blanca; Berrueta, Luis A; Giampieri, Francesca; Perez-Castillo, Yunierkis; Battino, Maurizio; Álvarez-Suarez, José M; Tejera, Eduardo
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/314761
Citazioni:
Metabolomic profile and computational analysis for the identification of the potential anti-inflammatory mechanisms of action of the traditional medicinal plants Ocimum basilicum and Ocimum tenuiflorum / Beltrán-Noboa, Andrea; Proaño-Ojeda, John; Guevara, Mabel; Gallo, Blanca; Berrueta, Luis A; Giampieri, Francesca; Perez-Castillo, Yunierkis; Battino, Maurizio; Álvarez-Suarez, José M; Tejera, Eduardo. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - ELETTRONICO. - 164:(2022), p. 113039. [10.1016/j.fct.2022.113039]
Abstract:
Ocimum basilicum and Ocimum tenuiflorum are two basil species widely used medicinally as an anti-inflammatory, antimicrobial and cardioprotective agent. This study focuses on the chemical characterization of the majoritarian compounds of both species and their anti-inflammatory potential. Up to 22 c...ompounds such as various types of salvianolic acids, derivatives of rosmaniric acid and flavones were identified in both plants. The identified compounds were very similar between both plants and are consistent with previous finding in other studies in Portugal and Italy. Based on the identified molecules a consensus target prediction was carried out. Among the main predicted target proteins, we found a high representation of the carbonic anhydrase family (CA2, CA7 and CA12) and several key proteins from the arachidonic pathway (LOX5, PLA2, COX1 and COX2). Both pathways are well related to inflammation. The interaction between the compounds and these targets were explored through molecular docking and molecular dynamics simulation. Our results suggest that some molecules present in both plants can induce an anti-inflammatory response through a non-steroidal mechanism of action connected to the carbon dioxide metabolism.
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Organic vs conventional plant-based foods: A review
Anno: 2022
Rivista: FOOD CHEMISTRY
Autori/autrici: Giampieri, F.; Mazzoni, L.; Cianciosi, D.; Alvarez-Suarez, J. M.; Regolo, L.; Sanchez-Gonzalez, C.; Capocasa, F.; Xiao, J.; Mezzetti, B.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297650
Citazioni:
Organic vs conventional plant-based foods: A review / Giampieri, F.; Mazzoni, L.; Cianciosi, D.; Alvarez-Suarez, J. M.; Regolo, L.; Sanchez-Gonzalez, C.; Capocasa, F.; Xiao, J.; Mezzetti, B.; Battino, M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 383:(2022). [10.1016/j.foodchem.2022.132352]
Abstract:
Organic farming is characterized by the prohibition of the use of chemical synthetic fertilizers, pesticides, feed additives and genetically modified organisms and by the application of sustainable agricultural technologies based on ecological principles and natural rules. Organic products are belie...ved to be more nutritious and safer foods compared to the conventional alternatives by consumers, with the consequent increase of demand and price of these foodstuffs. However, in academic circles there is much debate on these issues, since there is not a clear scientific evidence of the difference on the environmental impact and on the nutritional quality, safety and health effects between conventional and organic foods. Therefore, this work aims to describe and update the most relevant data on organic foods, by describing the impact of this practice on environment, producers, consumers and society, as well as by comparing the physicochemical, nutritional and phytochemical quality of conventional and organic plant foods.
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Effect of Brazil Nuts on Selenium Status, Blood Lipids, and Biomarkers of Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Anno: 2022
Rivista: ANTIOXIDANTS
Autori/autrici: Godos, J.; Giampieri, F.; Micek, A.; Battino, M.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Paladino, N.; Falzone, L.; Grosso, G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299173
Citazioni:
Effect of Brazil Nuts on Selenium Status, Blood Lipids, and Biomarkers of Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials / Godos, J.; Giampieri, F.; Micek, A.; Battino, M.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Paladino, N.; Falzone, L.; Grosso, G.. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 11:2(2022), p. 403. [10.3390/antiox11020403]
Abstract:
Tree nuts, including Brazil nuts, have been hypothesized to impact cardiovascular health through the modulation of oxidative stress and inflammation. Nonetheless, a quantitative analysis of these effects has not been performed. Therefore, the aim of this study was to systematically revise and quanti...fy the effect of Brazil nut intervention on selenium status, blood lipids, and biomarkers of oxidative stress and inflammation using a meta-analytical approach. To meet the goals of this study, a systematic search of PubMed, EMBASE, and Web of Science databases of published randomised clinical trials reporting on dietary interventions with Brazil nuts and their effects on selenium status, blood lipids, and markers of oxidative stress and inflammation was performed. Eight articles were included for systematic review and meta-analysis. Based on the conducted analysis, a significant positive effect of Brazil nuts on selenium blood concentration (SMD = 6.93, 95% CI: 3.99; 9.87) was found. Additionally, a positive effect of Brazil nut intervention on glutathione peroxidase activity (SMD = 0.53, 95% CI: 0.07; 0.99) was observed. However, no significant results were found when considering blood lipid levels, including results for total cholesterol (SMD = −0.22, 95% CI: −0.57; 0.14), HDL cholesterol (SMD = −0.04, 95% CI: −0.28; 0.19) and LDL cholesterol (SMD = −0.15; 95% CI: −0.43; 0.13). In conclusion, the findings from this study suggest that Brazil nut consumption improves selenium status and exerts antioxidant effects, which could be considered a potential pathway for the prevention of metabolic disorders related to altered blood lipid profiles. However, further studies are needed to elucidate the effect of Brazil nuts toward blood lipid profile, also preferably controlling for other biomarkers.
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An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans
Anno: 2022
Rivista: ANTIOXIDANTS
Autori/autrici: Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Jimenez-Trigo, V.; Munoz-Ollero, P.; Forbes-Hernandez, T. Y.; Esteban-Munoz, A.; Giampieri, F.; Noya, I. D.; Bullon, P.; Vera-Ramirez, L.; Battino, M.; Sanchez-Gonzalez, C.; Quiles, J. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299171
Citazioni:
An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans / Romero-Marquez, J. M.; Navarro-Hortal, M. D.; Jimenez-Trigo, V.; Munoz-Ollero, P.; Forbes-Hernandez, T. Y.; Esteban-Munoz, A.; Giampieri, F.; Noya, I. D.; Bullon, P.; Vera-Ramirez, L.; Battino, M.; Sanchez-Gonzalez, C.; Quiles, J. L.. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 11:4(2022), p. 629. [10.3390/antiox11040629]
Abstract:
Olive milling produces olive oil and different by-products, all of them very rich in different bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim of the present study was to investigate the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms as...sociated with Alzheimer disease features like Aβ-and tau-induced toxicity, as well as on oxidative stress in Caenorhabditis elegans. Moreover, characterization of the extracts, regarding the profile and content of phenolics, as well as total antioxidant ability, was investigated. The study of lethality, growth, pharyngeal pumping, and longevity in vivo demonstrated the lack of toxicity of the extract. One hundred µg/mL of extract treatment revealed prevention of oxidative stress and a delay in Aβ-induced paralysis related with a lower presence of Aβ aggregates. Indeed, the extract showed the ability to avoid a certain degree of proteotoxicity associated with aggregation of the tau protein. According to RNAi tests, SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2 were mechanistically associated in the observed effects.
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Validation of a Food Knowledge Questionnaire on Tanzanian Women of Childbearing Age
Anno: 2022
Rivista: NUTRIENTS
Autori/autrici: Conti, M. V.; Gnesi, M.; De Giuseppe, R.; Giampieri, F.; Monti, M. C.; Mshanga, N.; Kinabo, J.; Msuya, J.; Cena, H.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299175
Citazioni:
Validation of a Food Knowledge Questionnaire on Tanzanian Women of Childbearing Age / Conti, M. V.; Gnesi, M.; De Giuseppe, R.; Giampieri, F.; Monti, M. C.; Mshanga, N.; Kinabo, J.; Msuya, J.; Cena, H.. - In: NUTRIENTS. - ISSN 2072-6643. - 14:3(2022), p. 691. [10.3390/nu14030691]
Abstract:
The present manuscript describes the validation of a food knowledge questionnaire (FKQ) for Tanzanian childbearing age women. The FKQ was derived from the Ugandan version and was adapted according to Tanzanian culture and food habits, including 114 closed-ended questions, divided into five different... sections. The FKQ was administered to 671 Tanzanian childbearingage women who were eligible if they: (i) were aged between 14 and 49 years old, (ii) had not been diagnosed with any disease and (iii) lived in the urban or peri-urban area of the Arusha and Morogoro region. The validation process of the FKQ was conducted in Tanzania and the recruitment occurred between August and October 2020. The final version of the validated questionnaire was characterized by a total of 88 questions, divided into ten different sections; each section aimed to investigate a different aspect of food knowledge, except for section A, which collected information related to the social and demographic characteristics of the respondent. The food knowledge questionnaire showed good construct validity and content validity to assess knowledge and food practices in Tanzanian women of childbearing age and could be used in future studies to identify women at higher risk of unhealthy eating habits and food choices.
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Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells
Anno: 2021
Autori/autrici: Afrin, S.; Forbes-Hernandez, T. Y.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 2.1 Contributo in volume (Capitolo o Saggio)
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299281
Citazioni:
Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells / Afrin, S.; Forbes-Hernandez, T. Y.; Giampieri, F.; Battino, M.. - (2021), pp. 407-415. [10.1016/B978-0-12-819547-5.00036-5]
Abstract:
Manuka honey (MH) is a rich source of several biological and pharmacological bioactive compounds, as well as natural antioxidants. The phenolic compounds of MH are significantly correlated with its antioxidant capacity and its beneficial effect in human health is becoming more apparent. This chapter... focuses on the antioxidant and anticancer activity of MH in in vitro and in vivo models. A rising amount of evidence indicates that MH exerts protective effects against oxidative damage through scavenging or quenching of oxygen free radicals, protecting biomolecules, activating antioxidant enzymes, and increasing antioxidant responsive element expressions both in in vitro and in vivo models. In colon cancer cells, MH induced preventive and therapeutic effects by suppressing cancer cells proliferation, activating apoptosis, inducing oxidative stress, and inhibiting metastatic processes through altering multiple molecular targets. Additionally, the anticancer effectiveness of 5-fluorouracil chemotherapy was augmented in the presence of MH at less doses.
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Ultra-small iron nanoparticles target mitochondria inducing autophagy, acting on mitochondrial dna and reducing respiration
Anno: 2021
Rivista: PHARMACEUTICS
Autori/autrici: Rivas-Garcia, L.; Quiles, J. L.; Varela-Lopez, A.; Giampieri, F.; Battino, M.; Bettmer, J.; Montes-Bayon, M.; Llopis, J.; Sanchez-Gonzalez, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286970
Citazioni:
Ultra-small iron nanoparticles target mitochondria inducing autophagy, acting on mitochondrial dna and reducing respiration / Rivas-Garcia, L.; Quiles, J. L.; Varela-Lopez, A.; Giampieri, F.; Battino, M.; Bettmer, J.; Montes-Bayon, M.; Llopis, J.; Sanchez-Gonzalez, C.. - In: PHARMACEUTICS. - ISSN 1999-4923. - 13:1(2021), pp. 1-18. [10.3390/pharmaceutics13010090]
Abstract:
The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dy...sfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2–4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies.
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Health-promoting properties as a target for selecting strawberry cultivars in breeding programmes
Anno: 2021
Rivista: ACTA HORTICULTURAE
Autori/autrici: Martinez-Ferri, E.; Cervantes, L.; Soria, C.; Forbes-Hernandez, T.; Giampieri, F.; Reboredo-Rodriguez, P.; Battino, M.; Ariza, M. T.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290757
Citazioni:
Health-promoting properties as a target for selecting strawberry cultivars in breeding programmes / Martinez-Ferri, E.; Cervantes, L.; Soria, C.; Forbes-Hernandez, T.; Giampieri, F.; Reboredo-Rodriguez, P.; Battino, M.; Ariza, M. T.. - In: ACTA HORTICULTURAE. - ISSN 0567-7572. - ELETTRONICO. - 1309:1309(2021), pp. 865-868. [10.17660/ActaHortic.2021.1309.123]
Abstract:
Strawberries are among the most valuable fruits for fresh consumption in the world. Besides their pleasant taste, fruits are highly appreciated by consumers because of their health benefits, which have been related to the antioxidant capacity of the polyphenolic compounds they contain. However, stra...wberry cultivars present different amount and type of this antioxidants. This, joined to the fact that the digestion process can affect their release and alter their composition, could result in differences on the health effects (i.e., bioactivity; BA) of these cultivars, and therefore, it could be important to consider the digestion process for selecting a bioactivity indicator. Thus, the antioxidant capacity (TEAC) of the fruits of five strawberry cultivars was determined before (i.e., fresh fruit material) and after being subjected to an in vitro digestion process (i.e., digested fractions). Thus, on each cultivar, an effect of in vitro digestion was observed, decreasing the TEAC of potentially absorbed extracts (i.e., bioavailable; TEACBA) with respect to the TEAC of the fruit (TEACF), although the decrease in antioxidant capacity was not in the same proportion in all cultivars, there being no correlation between TEACF and TEACBA. To evaluate the correlation between TEACBA and its BA, a ROS (reactive oxygen species) quantification in hepatic cells treated with bioavailable extracts of two strawberry cultivars, previously selected for their higher and lower TEACBA, ('Marquis' and 'Primoris', respectively) was carried out, showing a higher BA in 'Marquis' (i.e., cultivar with higher TEACBA). These results show the importance of performing the in vitro digestion process to reveal the health potential of strawberry cultivars. Besides, TEACBA is proposed as an indicator of BA. However, for selecting parents in breeding programmes, more efforts must be done in order to find a BA indicator that can be determined by faster and more direct techniques.
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Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine
Anno: 2021
Rivista: CURRENT RESEARCH IN BIOTECHNOLOGY
Autori/autrici: Kletecka-Pulker, M.; Mondal, H.; Wang, D.; Parra, R. G.; Maigoro, A. Y.; Lee, S.; Garg, T.; Mulholland, E. J.; Devkota, H. P.; Konwar, B.; Patnaik, S. S.; Lordan, R.; Nawaz, F. A.; Tsagkaris, C.; Rayan, R. A.; Louka, A. M.; De, R.; Badhe, P.; Schaden, E.; Willschke, H.; Maleczek, M.; Boyina, H. K.; Khalid, G. M.; Uddin, M. S.; Sanusi, ; Khan, J.; Odimegwu, J. I.; Yeung, A. W. K.; Akram, F.; Sai, C. S.; Bucher, S.; Paswan, S. K.; Singla, R. K.; Shen, B.; Di Lonardo, S.; Tosevska, A.; Simal-Gandara, J.; Zec, M.; Gonzalez-Burgos, E.; Habijan, M.; Battino, M.; Giampieri, F.; Tikhonov, A.; Cianciosi, D.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Mezzetti, B.; Babiaka, S. B.; Ahmed, M. E. O.; Piccard, P.; Urquiza, M. S.; Depew, J. R.; Schultz, F.; Sur, D.; Pai, S. R.; Gaman, M. -A.; Cenanovic, M.; Tzvetkov, N. T.; Tripathi, S. K.; Kharat, K. R.; Garcia-Sosa, A. T.; Sieber, S.; Atanasov, A. G.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/300668
Citazioni:
Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine / Kletecka-Pulker, M.; Mondal, H.; Wang, D.; Parra, R. G.; Maigoro, A. Y.; Lee, S.; Garg, T.; Mulholland, E. J.; Devkota, H. P.; Konwar, B.; Patnaik, S. S.; Lordan, R.; Nawaz, F. A.; Tsagkaris, C.; Rayan, R. A.; Louka, A. M.; De, R.; Badhe, P.; Schaden, E.; Willschke, H.; Maleczek, M.; Boyina, H. K.; Khalid, G. M.; Uddin, M. S.; Sanusi, ; Khan, J.; Odimegwu, J. I.; Yeung, A. W. K.; Akram, F.; Sai, C. S.; Bucher, S.; Paswan, S. K.; Singla, R. K.; Shen, B.; Di Lonardo, S.; Tosevska, A.; Simal-Gandara, J.; Zec, M.; Gonzalez-Burgos, E.; Habijan, M.; Battino, M.; Giampieri, F.; Tikhonov, A.; Cianciosi, D.; Forbes-Hernandez, T. Y.; Quiles, J. L.; Mezzetti, B.; Babiaka, S. B.; Ahmed, M. E. O.; Piccard, P.; Urquiza, M. S.; Depew, J. R.; Schultz, F.; Sur, D.; Pai, S. R.; Gaman, M. -A.; Cenanovic, M.; Tzvetkov, N. T.; Tripathi, S. K.; Kharat, K. R.; Garcia-Sosa, A. T.; Sieber, S.; Atanasov, A. G.. - In: CURRENT RESEARCH IN BIOTECHNOLOGY. - ISSN 2590-2628. - ELETTRONICO. - 3:(2021), pp. 146-153. [10.1016/j.crbiot.2021.04.004]
Abstract:
The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study..., we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives.
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Antioxidant effects of strawberry extract on HepG2 stressed with an oxidant agent
Anno: 2021
Rivista: ACTA HORTICULTURAE
Autori/autrici: Giampieri, F.; Cianciosi, D.; Ansary, J.; Regolo, L.; Forbes-Hernandez, T. Y.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290766
Citazioni:
Antioxidant effects of strawberry extract on HepG2 stressed with an oxidant agent / Giampieri, F.; Cianciosi, D.; Ansary, J.; Regolo, L.; Forbes-Hernandez, T. Y.; Battino, M.. - In: ACTA HORTICULTURAE. - ISSN 0567-7572. - ELETTRONICO. - 1309:1309(2021), pp. 903-909. [10.17660/ActaHortic.2021.1309.129]
Abstract:
A common denominator in the pathogenesis of most common chronic diseases is the involvement of oxidative stress, defined as a persistent imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses. When the production of ROS exceeds the capacity of antioxidant defenses..., oxidative stress may arise, damaging the functional and structural integrity of cellular macromolecules, such as lipids, proteins and DNA. A strategy to alleviate oxidative damage could be the use of natural antioxidants derived from diet. In this context, strawberries (Fragaria ~ ananassa Duch.) possess a remarkable nutritional composition in terms of micronutrients such as minerals, vitamin C and folates, and non-nutrient elements, like phenolic compounds, that are essential for human health by exerting antioxidant effects. The overall goal of the present study was to investigate the potential of a polyphenol-rich strawberry extract to protect against oxidative stress. The strawberry extract was characterized for its nutritional and phytochemical contents, as well as for its antioxidant capacity. HepG2 cells were treated with 100 μg mL-1strawberry extract and then were stressed with 10 mM AAPH for 24 h to induce oxidative stress and cell viability, apoptosis rate, intracellular ROS and nitric oxide (NO) levels were assessed. Results showed that strawberry extract had a high content of total polyphenols, flavonoids and anthocyanins and a relevant total antioxidant capacity. In addition, a significant improvement in cell viability and apoptosis rate was found in cells treated with strawberry and stressed with AAPH, as well as a relevant decrease in intracellular ROS and NO levels. Our results confirm the capacity of strawberry extract to counteract oxidative stress, highlighting the utmost importance to plan and develop an in vivo study, in order to obtain a comprehensive description of the efficacy of strawberry bioactive compounds in oxidative stress-related diseases and elucidate their mechanisms of action.
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Natural products in drug discovery: advances and opportunities
Anno: 2021
Rivista: NATURE REVIEWS DRUG DISCOVERY
Autori/autrici: Atanasov, A. G.; Zotchev, S. B.; Dirsch, V. M.; Supuran, C. T.; the International Natural Product Sciences, Taskforce; Battino, M.; Giampieri, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/287569
Citazioni:
Natural products in drug discovery: advances and opportunities / Atanasov, A. G.; Zotchev, S. B.; Dirsch, V. M.; Supuran, C. T.; the International Natural Product Sciences, Taskforce; Battino, M.; Giampieri, F.. - In: NATURE REVIEWS DRUG DISCOVERY. - ISSN 1474-1776. - ELETTRONICO. - 20:3(2021), pp. 200-216. [10.1038/s41573-020-00114-z]
Abstract:
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterizati...on and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
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The central role of mitochondria in the relationship between dietary lipids and cancer progression
Anno: 2021
Rivista: SEMINARS IN CANCER BIOLOGY
Autori/autrici: Varela-Lopez, A.; Vera-Ramirez, L.; Giampieri, F.; Navarro-Hortal, M. D.; Forbes-Hernandez, T. Y.; Battino, M.; Quiles, J. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286971
Citazioni:
The central role of mitochondria in the relationship between dietary lipids and cancer progression / Varela-Lopez, A.; Vera-Ramirez, L.; Giampieri, F.; Navarro-Hortal, M. D.; Forbes-Hernandez, T. Y.; Battino, M.; Quiles, J. L.. - In: SEMINARS IN CANCER BIOLOGY. - ISSN 1044-579X. - ELETTRONICO. - (2021). [10.1016/j.semcancer.2021.01.001]
Abstract:
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment... affecting cancer cell metabolism. Clinical trials have shown that diets rich in polyunsaturated fatty acids (PUFA) can negatively affect tumor growth. However, certain n-6 PUFAs can also contribute to cancer progression. Identifying the molecular mechanisms through which lipids affect cancer progression will provide an opportunity for focused dietary interventions that could translate into the development of personalized diets for cancer control. However, the effective mechanisms of action of PUFAs have not been fully clarified yet. Mitochondria controls ATP generation, redox homeostasis, metabolic signaling, apoptotic pathways and many aspects of autophagy, and it has been recognized to play a key role in cancer. The purpose of this review is to summarize the current evidence linking dietary lipids effects on mitochondrial aspects with consequences for cancer progression and the molecular mechanisms that underlie this association.
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A review of mushrooms in human nutrition and health
Anno: 2021
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Rizzo, G.; Goggi, S.; Giampieri, F.; Baroni, L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299408
Citazioni:
A review of mushrooms in human nutrition and health / Rizzo, G.; Goggi, S.; Giampieri, F.; Baroni, L.. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - 117:(2021), pp. 60-73. [10.1016/j.tifs.2020.12.025]
Abstract:
Background: mushrooms are traditionally used as a food ingredient and in folk medicine. Many in vitro and animal studies have reported their potential health effects, but without any clear application in human health. Although they have a worldwide history of use in dishes and folk medicine, mushroo...m extracts are commonly taken as supplements but need to be evaluated regarding clinical effects and safety, in particular among patients searching for further efficacy for their disease beside pharmacological treatments already prescribed. Scope and approach: this review summarizes available data from the scientific literature about the nutritional and effects of mushrooms on human health by selecting clinical studies on humans in English. At the same time, the safety profile and unwanted effects were highlighted. Key findings and conclusions: in spite of their wide use among populations, data on humans were scant and did not justify extensive use without more well-designed trials on mushroom efficacy. Overall, their use seems to be safe, but with some side effects, easily reversible after intake interruption. Nutritional use seems promising for coping with the energy surplus of the Western countries and could be useful for some nutritional aspects.
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The anticancer activity of strawberry
Anno: 2021
Rivista: ACTA HORTICULTURAE
Autori/autrici: Ansary, J.; Forbes-Hernandez, T. Y.; Regolo, L.; Cianciosi, D.; Giampieri, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/295482
Citazioni:
The anticancer activity of strawberry / Ansary, J.; Forbes-Hernandez, T. Y.; Regolo, L.; Cianciosi, D.; Giampieri, F.. - In: ACTA HORTICULTURAE. - ISSN 0567-7572. - ELETTRONICO. - 1309:1309(2021), pp. 925-932. [10.17660/ActaHortic.2021.1309.132]
Abstract:
Cancer is the second leading cause of death worldwide and the failure of chemo- A nd radiotherapy is most responsible for this, due to drug resistance or adverse reactions. For this reason, investigating the antitumour effect of natural compounds alone or in combination with common chemotherapy drug...s is getting really interesting. During carcinogenesis, the neoplastic formation process is attributable to different events, many of which are related to phenomena of chronic inflammation, oxidative stress and thus to damages to biological macromolecules, especially nucleic acids. Therefore, studying the effect of some food matrices that have anti-inflammatory and antioxidant properties is a goal for many researchers. Among the different fruits, strawberry has several bioactive phenolic compounds, especially flavonoids, anthocyanins and ellagitannins, with proven biological activities; their presence has led many researches to investigate its antitumour activity in different types of cancer, both in in vitro and in vivo models. The purpose of this work is therefore to show the latest finding about this topic.
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Novel approaches in anthocyanin research - Plant fortification and bioavailability issues
Anno: 2021
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Alvarez-Suarez, J. M.; Cuadrado, C.; Redondo, I. B.; Giampieri, F.; Gonzalez-Paramas, A. M.; Santos-Buelga, C.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/299283
Citazioni:
Novel approaches in anthocyanin research - Plant fortification and bioavailability issues / Alvarez-Suarez, J. M.; Cuadrado, C.; Redondo, I. B.; Giampieri, F.; Gonzalez-Paramas, A. M.; Santos-Buelga, C.. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - 117:(2021), pp. 92-105. [10.1016/j.tifs.2021.01.049]
Abstract:
Background: Anthocyanins are a major class of plant phenolic pigments, responsible for the red, purple or blue color of leaves, flowers, tubers, fruits and certain vegetables. They are considered the largest and most important group of water-soluble pigments in nature and have been described to have... multiple health-promoting properties. However, the bioavailability of anthocyanins is reportedly extremely low, affected by factors inherent to the molecule's characteristics, as well as by the effect of food processing, transformations during the digestive process and their levels in fruits. Scope and approach: This review aims to discuss current knowledge regarding the effects of technological processes used in the food industry on the stability, bioavailability and biological effect of anthocyanins. In addition, a review of new trends in the improvement of anthocyanin production in plants is presented, which outlines what has been reported about genes involved in the regulation and its expression. Key findings and conclusions: The alterations that anthocyanins suffer, which can affect their bioavailability and biological effects, do not take place solely during the digestion process, caused mainly by pH and intrinsic and bacterial enzymes, but also during the different processing methods that food-containing anthocyanins can undergo. Factors such as thermal and non-thermal processing, storage, oxidative degradation and encapsulation systems have been shown to closely influence anthocyanins' stability and biological effects. In recent times, genetic manipulation aiming at upregulating the gene expression of metabolic pathways has been used to improve fruit quality and anthocyanin content in plant foods, and may also contribute towards counteracting some of the indicated limitations.
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Plant-based bioactive compounds: Healthy promoters and protective agents
Anno: 2021
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Battino, Maurizio; Forbes-Hernandez, Tamara Y.; Giampieri, Francesca
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290763
Citazioni:
Plant-based bioactive compounds: Healthy promoters and protective agents / Battino, Maurizio; Forbes-Hernandez, Tamara Y.; Giampieri, Francesca. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - ELETTRONICO. - (2021). [10.1016/j.tifs.2021.03.055]

Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells
Anno: 2021
Rivista: FOOD AND CHEMICAL TOXICOLOGY
Autori/autrici: Afrin, S.; Giampieri, F.; Cianciosi, D.; Alvarez-Suarez, J. M.; Bullon, B.; Amici, A.; Quiles, J. L.; Forbes-Hernandez, T. Y.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297659
Citazioni:
Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells / Afrin, S.; Giampieri, F.; Cianciosi, D.; Alvarez-Suarez, J. M.; Bullon, B.; Amici, A.; Quiles, J. L.; Forbes-Hernandez, T. Y.; Battino, M.. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - ELETTRONICO. - 156:(2021), p. 112484. [10.1016/j.fct.2021.112484]
Abstract:
Colorectal cancer remains a challenging health burden worldwide. This study aimed to assess the potentiality of Strawberry tree honey (STH), a polyphenol-enriched food, to increase the effectiveness of 5-Fluorouracil (5-FU) in adenocarcinoma (HCT-116) and metastatic (LoVo) colon cancer cell lines. T...he combined treatment reduced cell viability and caused oxidative stress, by increasing oxidative biomarkers and decreasing antioxidant defence, in a more potent way compared to 5-FU alone. The expression of endoplasmic reticulum (ATF-6, XBP-1) and MAPK (p-p38 MAPK, p-ERK1/2) markers were also elevated after the combined treatment, enhancing the cell cycle arrest through the modulation of regulatory genes (i.e., cyclins and CDKs). Apoptotic gene (i.e., caspases) expressions were also increased after the combined treatment, while those of proliferation (i.e., EGFR), cell migration, invasion (i.e., matrix metallopeptidase) and epithelial–mesenchymal transition (N-cadherin, β-catenin) were suppressed. Finally, the combined treatment led cell metabolism towards a quiescent stage, by reducing mitochondrial respiration and glycolysis. In conclusion, this work represents an initial step to highlight the possibility to use STH in combination with 5-FU in the treatment of colon cancer, even if further in vitro an in vivo studies are strongly needed to confirm the possible chemo-sensitizing effects of STH.
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Phages and enzybiotics in food biopreservation
Anno: 2021
Rivista: MOLECULES
Autori/autrici: Ramos-Vivas, J.; Elexpuru-Zabaleta, M.; Samano, M. L.; Barrera, A. P.; Forbes-Hernandez, T. Y.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297657
Citazioni:
Phages and enzybiotics in food biopreservation / Ramos-Vivas, J.; Elexpuru-Zabaleta, M.; Samano, M. L.; Barrera, A. P.; Forbes-Hernandez, T. Y.; Giampieri, F.; Battino, M.. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 26:17(2021), p. 5138. [10.3390/molecules26175138]
Abstract:
Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophage...s or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives.
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Nutritional value and preventive role of nigella sativa l. And its main component thymoquinone in cancer: An evidenced-based review of preclinical and clinical studies
Anno: 2021
Rivista: MOLECULES
Autori/autrici: Ansary, J.; Giampieri, F.; Forbes-Hernandez, T. Y.; Regolo, L.; Quinzi, D.; Villar, S. G.; Villena, E. G.; Pifarre, K. T.; Alvarez-Suarez, J. M.; Battino, M.; Cianciosi, D.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290759
Citazioni:
Nutritional value and preventive role of nigella sativa l. And its main component thymoquinone in cancer: An evidenced-based review of preclinical and clinical studies / Ansary, J.; Giampieri, F.; Forbes-Hernandez, T. Y.; Regolo, L.; Quinzi, D.; Villar, S. G.; Villena, E. G.; Pifarre, K. T.; Alvarez-Suarez, J. M.; Battino, M.; Cianciosi, D.. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 26:8(2021), p. 2108. [10.3390/molecules26082108]
Abstract:
In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent a...nticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.
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The molecular basis of different approaches for the study of cancer stem cells and the advantages and disadvantages of a three-dimensional culture
Anno: 2021
Rivista: MOLECULES
Autori/autrici: Cianciosi, D.; Ansary, J.; Forbes-Hernandez, T. Y.; Regolo, L.; Quinzi, D.; Villar, S. G.; Villena, E. G.; Pifarre, K. T.; Alvarez-Suarez, J. M.; Battino, M.; Giampieri, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290764
Citazioni:
The molecular basis of different approaches for the study of cancer stem cells and the advantages and disadvantages of a three-dimensional culture / Cianciosi, D.; Ansary, J.; Forbes-Hernandez, T. Y.; Regolo, L.; Quinzi, D.; Villar, S. G.; Villena, E. G.; Pifarre, K. T.; Alvarez-Suarez, J. M.; Battino, M.; Giampieri, F.. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 26:9(2021), p. 2615. [10.3390/molecules26092615]
Abstract:
Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, pro-liferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in ...this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+ /CD38− ). In the following years, different strategies and projects have been developed for the study of CSCs, which are basically divided into surface markers assays and functional assays; some of these techniques also allow working with a cellular model that better mimics the tumor architecture. The purpose of this mini review is to summarize and briefly describe all the current methods used for the identification, isolation and enrichment of CSCs, describing, where possible, the molecular basis, the advantages and disadvantages of each technique with a particular focus on those that offer a three-dimensional culture.
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The preventive effect of strawberries against the onset of common human diseases induced by oxidative stress
Anno: 2021
Rivista: ACTA HORTICULTURAE
Autori/autrici: Cianciosi, D.; Ansary, J.; Regolo, L.; Giampieri, F.; Forbes-Hernandez, T. Y.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/295483
Citazioni:
The preventive effect of strawberries against the onset of common human diseases induced by oxidative stress / Cianciosi, D.; Ansary, J.; Regolo, L.; Giampieri, F.; Forbes-Hernandez, T. Y.. - In: ACTA HORTICULTURAE. - ISSN 0567-7572. - ELETTRONICO. - 1309:1309(2021), pp. 917-924. [10.17660/ActaHortic.2021.1309.131]
Abstract:
A diet rich in fruits and vegetables is closely related with the prevention against the development of various pathologies such as cancer, cardiovascular diseases, ageing-related disorders, especially thanks to the high content of bioactive compounds with a high antioxidant activity. Strawberry poss...esses numerous micronutrients such as vitamins (vitamin C, folate) and minerals (K, P, Ca), but also a high amount of non-nutrients components such as polyphenols, especially flavonoids (anthocyanins and ellagitannins are the most common). The biological activity of phytochemical compounds has been widely demonstrated both in vitro and in vivo; the preventive role of these are mainly due to their capacity to protect biological macromolecules against oxidative damage, limiting the production of free radicals or detoxifying them. The main purpose of this work is to summarize the latest findings about the potential preventive effect of strawberry against the onset of neoplastic, cardiovascular and neuro-degenerative diseases.
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Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds
Anno: 2021
Rivista: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Autori/autrici: Giampieri, F.; Quiles, J. L.; Cianciosi, D.; Forbes-Hernandez, T. Y.; Orantes-Bermejo, F. J.; Alvarez-Suarez, J. M.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297652
Citazioni:
Bee Products: An Emblematic Example of Underutilized Sources of Bioactive Compounds / Giampieri, F.; Quiles, J. L.; Cianciosi, D.; Forbes-Hernandez, T. Y.; Orantes-Bermejo, F. J.; Alvarez-Suarez, J. M.; Battino, M.. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - ELETTRONICO. - (2021). [10.1021/acs.jafc.1c05822]
Abstract:
Beside honey, honeybees (Apis mellifera L.) are able to produce many byproducts, including bee pollen, propolis, bee bread, royal jelly, and beeswax. Even if the medicinal properties of these byproducts have been recognized for thousands of years by the ancient civilizations, in the modern era, they... have a limited use, essentially as nutritional supplements or health products. However, these natural products are excellent sources of bioactive compounds, macro- and micronutrients, that, in a synergistic way, confer multiple biological activities to these byproducts, such as, for example, antimicrobial, antioxidant, and anti-inflammatory properties. This work aims to update the chemical and phytochemical composition of bee pollen, propolis, bee bread, royal jelly, and beeswax and to summarize the main effects exerted by these byproducts on human health, from the anticancer and immune-modulatory activities to the antidiabetic, hypolipidemic, hypotensive, and anti-allergic properties.
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Nutrition and rheumatoid arthritis in the ‘omics’ era
Anno: 2021
Rivista: NUTRIENTS
Autori/autrici: Cassotta, M.; Forbes-Hernandez, T. Y.; Cianciosi, D.; Zabaleta, M. E.; Cano, S. S.; Dominguez, I.; Bullon, B.; Regolo, L.; Alvarez-Suarez, J. M.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290760
Citazioni:
Nutrition and rheumatoid arthritis in the ‘omics’ era / Cassotta, M.; Forbes-Hernandez, T. Y.; Cianciosi, D.; Zabaleta, M. E.; Cano, S. S.; Dominguez, I.; Bullon, B.; Regolo, L.; Alvarez-Suarez, J. M.; Giampieri, F.; Battino, M.. - In: NUTRIENTS. - ISSN 2072-6643. - ELETTRONICO. - 13:3(2021), pp. 1-25. [10.3390/nu13030763]
Abstract:
Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to... more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed.
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The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer's Disease
Anno: 2021
Rivista: CELLS
Autori/autrici: Magi, Simona; Preziuso, Alessandra; Piccirillo, Silvia; Giampieri, Francesca; Cianciosi, Danila; Orciani, Monia; Amoroso, Salvatore
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/291830
Citazioni:
The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer's Disease / Magi, Simona; Preziuso, Alessandra; Piccirillo, Silvia; Giampieri, Francesca; Cianciosi, Danila; Orciani, Monia; Amoroso, Salvatore. - In: CELLS. - ISSN 2073-4409. - STAMPA. - 10:8(2021), p. 2109. [10.3390/cells10082109]
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive regression and memory loss. Dysfunctions of both glucose metabolism and mitochondrial dynamics have been recognized as the main upstream events of the degenerative processes leading to AD. It has been rec...ently found that correcting cell metabolism by providing alternative substrates can prevent neuronal injury by retaining mitochondrial function and reducing AD marker levels. Here, we induced an AD-like phenotype by using the glycolysis inhibitor glyceraldehyde (GA) and explored whether L-carnitine (4-N-trimethylamino-3-hydroxybutyric acid, LC) could mitigate neuronal damage, both in SH-SY5Y neuroblastoma cells and in rat primary cortical neurons. We have already reported that GA significantly modified AD marker levels; here we demonstrated that GA dramatically compromised cellular bioenergetic status, as revealed by glycolysis and oxygen consumption rate (OCR) evaluation. We found that LC ameliorated cell survival, improved OCR and ATP synthesis, prevented the loss of the mitochondrial membrane potential (Delta psi(m)) and reduced the formation of reactive oxygen species (ROS). Of note, the beneficial effect of LC did not rely on the glycolytic pathway rescue. Finally, we noticed that LC significantly reduced the increase in pTau levels induced by GA. Overall, these findings suggest that the use of LC can promote cell survival in the setting of the metabolic impairments commonly observed in AD. Our data suggest that LC may act by maintaining mitochondrial function and by reducing the pTau level.
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Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages
Anno: 2021
Rivista: JOURNAL OF FUNCTIONAL FOODS
Autori/autrici: Cianciosi, D.; Forbes-Hernandez, T. Y.; Alvarez-Suarez, J. M.; Ansary, J.; Quinzi, D.; Amici, A.; Navarro-Hortal, M. D.; Esteban-Munoz, A.; Quiles, J. L.; Battino, M.; Giampieri, F.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297668
Citazioni:
Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages / Cianciosi, D.; Forbes-Hernandez, T. Y.; Alvarez-Suarez, J. M.; Ansary, J.; Quinzi, D.; Amici, A.; Navarro-Hortal, M. D.; Esteban-Munoz, A.; Quiles, J. L.; Battino, M.; Giampieri, F.. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - ELETTRONICO. - 87:(2021), p. 104752. [10.1016/j.jff.2021.104752]
Abstract:
The aim of this study was to evaluate for the first time the anti-inflammatory effects of chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with the bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment with t...he two honeys markedly decreased apoptosis and stimulated wound healing in macrophages stressed with LPS, where they also reduced the intracellular levels of ROS and nitrite. Additionally, treatment with LPS decreased the levels of glutathione and suppressed the antioxidant enzyme activities, which were significantly (p < 0.05) increased in the presence of the two honeys, through the modulation of Nrf2 expression; in LPS-stressed macrophages, Chestnut or Eucalyptus honeys protected against inflammation by regulating the main inflammatory biomarkers, including TNF-α, IL-10 and iNOS, through the decrease of NF-кB expression. Finally, they improved mitochondrial respiration and the main related parameters.
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Effect of thermal liquefaction on quality, chemical composition and antibiofilm activity against multiresistant human pathogens of crystallized eucalyptus honey
Anno: 2021
Rivista: FOOD CHEMISTRY
Autori/autrici: Villacres-Granda, I.; Proano, A.; Coello, D.; Debut, A.; Vizuete, K.; Ballesteros, I.; Granda-Albuja, G.; Rosero-Mayanquer, H.; Battino, M.; Giampieri, F.; Alvarez-Suarez, J. M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297661
Citazioni:
Effect of thermal liquefaction on quality, chemical composition and antibiofilm activity against multiresistant human pathogens of crystallized eucalyptus honey / Villacres-Granda, I.; Proano, A.; Coello, D.; Debut, A.; Vizuete, K.; Ballesteros, I.; Granda-Albuja, G.; Rosero-Mayanquer, H.; Battino, M.; Giampieri, F.; Alvarez-Suarez, J. M.. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - ELETTRONICO. - 365:(2021), p. 130519. [10.1016/j.foodchem.2021.130519]
Abstract:
Thermal liquefaction is a conventional method used by beekeepers to liquefy crystallized honey. However, an abusive use of heat may affect its quality, chemical composition and bioactivity. The purpose of this study was to investigate the effect of thermal liquefaction on the quality, chemical compo...sition and antibiofilm properties of eucalyptus honey. Thermal liquefaction (at 45 and 60 °C) did not affect the honey's quality; however, a significant reduction in the reducing capacity, total phenolic content and hydrogen peroxide content was observed. At 60 °C, a significant reduction in the honey's ability to inhibit biofilm formation was observed in Pseudomonas aeruginosa, as well as a reduction in its ability to remove preformed biofilms in both Staphylococcus aureus and Pseudomonas aeruginosa. Structural changes in biofilm architecture caused by honey were not affected by thermal treatment. Therefore, we recommend liquefaction at 45 °C as the most convenient for honey liquefaction without affecting its characteristics.
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The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota
Anno: 2021
Rivista: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Autori/autrici: Annunziata, G.; Sureda, A.; Orhan, I. E.; Battino, M.; Arnone, A.; Jimenez-Garcia, M.; Capo, X.; Cabot, J.; Sanadgol, N.; Giampieri, F.; Tenore, G. C.; Kashani, H. R. K.; Silva, A. S.; Habtemariam, S.; Nabavi, S. F.; Nabavi, S. M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297662
Citazioni:
The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota / Annunziata, G.; Sureda, A.; Orhan, I. E.; Battino, M.; Arnone, A.; Jimenez-Garcia, M.; Capo, X.; Cabot, J.; Sanadgol, N.; Giampieri, F.; Tenore, G. C.; Kashani, H. R. K.; Silva, A. S.; Habtemariam, S.; Nabavi, S. F.; Nabavi, S. M.. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - ELETTRONICO. - 128:(2021), pp. 437-453. [10.1016/j.neubiorev.2021.07.004]
Abstract:
Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked t...o the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.
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The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation
Anno: 2021
Rivista: PHYTOMEDICINE
Autori/autrici: Battino, M.; Giampieri, F.; Cianciosi, D.; Ansary, J.; Chen, X.; Zhang, D.; Gil, E.; Forbes-Hernandez, T.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286400
Citazioni:
The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation / Battino, M.; Giampieri, F.; Cianciosi, D.; Ansary, J.; Chen, X.; Zhang, D.; Gil, E.; Forbes-Hernandez, T.. - In: PHYTOMEDICINE. - ISSN 0944-7113. - 86:(2021), pp. 153170.1-153170.18. [10.1016/j.phymed.2020.153170]
Abstract:
Background: Oxidative stress and inflammation contribute to the etiopathogenesis of several human chronic diseases, such as cancer, diabetes, cardiovascular diseases and metabolic syndrome. Besides classic stimuli, such as reactive oxidant species, endotoxins (i.e., bacteria lipopolysaccharide), cyt...okines or carcinogens, oxidative stress and inflammation can be triggered by a poor diet and an excess of body fat and energy intake. Strawberry and honey are common rich sources of nutrients and bioactive compounds, widely studied for their roles exerted in health maintenance and disease prevention. Purpose: This review aims to summarize and update the effects of strawberry and honey against oxidative stress and inflammation, with emphasis on metabolism and on the main molecular mechanisms involved in these effects. Methods: A wide range of literature, published in the last 10 years, elucidating the effects of strawberry and honey in preventing oxidative stress and inflammation both in vitro (whole matrix and digested fractions) and in vivo was collected from online electronic databases (PubMed, Scopus and Web of Science) and reviewed. Results: Strawberry and honey polyphenols may potentially prevent the chronic diseases related to oxidative stress and inflammation. Several in vitro and in vivo studies reported the effects of these foods in suppressing the oxidative stress, by decreasing ROS production and oxidative biomarkers, restoring the antioxidant enzyme activities, ameliorating the mitochondrial antioxidant status and functionality, among others, and the inflammatory process, by modulating the mediators of acute and chronic inflammation essential for the onset of several human diseases. These beneficial properties are mediated in part through their ability to target multiple signaling pathways, such as p38 MAPK, AMPK, PI3K/Akt, NF-κB and Nrf2. Conclusions: Available scientific literature show that strawberry and honey may be effective in preventing oxidative stress and inflammation. The deep evaluation of the factors that affect their metabolism as well as the assessment of the main molecular mechanisms involved are of extreme importance for the possible therapeutic and preventive benefit against the most common human diseases. However, published literature is still scarce so that deeper studies should be performed in order to evaluate the bioavailability of these food matrices and their effects after digestion.
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Strawberry-derived exosome-like nanoparticles prevent oxidative stress in human mesenchymal stromal cells
Anno: 2021
Rivista: BIOMOLECULES
Autori/autrici: Perut, F.; Roncuzzi, L.; Avnet, S.; Massa, A.; Zini, N.; Sabbadini, S.; Giampieri, F.; Mezzetti, B.; Baldini, N.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/290750
Citazioni:
Strawberry-derived exosome-like nanoparticles prevent oxidative stress in human mesenchymal stromal cells / Perut, F.; Roncuzzi, L.; Avnet, S.; Massa, A.; Zini, N.; Sabbadini, S.; Giampieri, F.; Mezzetti, B.; Baldini, N.. - In: BIOMOLECULES. - ISSN 2218-273X. - 11:1(2021), pp. 87.1-87.14. [10.3390/biom11010087]
Abstract:
Plant-derived exosome-like nanovesicles (EPDENs) have recently been isolated and eval-uated as potential bioactive nutraceutical biomolecules. It has been hypothesized that EPDENs may exert their activity on mammalian cells through their specific cargo. In this study, we isolated and purified EPDENs... from the strawberry juice of Fragaria x ananassa (cv. Romina), a new culti-var characterized by a high content of anthocyanins, folic acid, flavonols, and vitamin C and an elevated antioxidant capacity. Fragaria-derived EPDENs were purified by a series of centrifugation and filtration steps. EPDENs showed size and morphology similar to mammalian extracellular nanovesicles. The internalization of Fragaria-derived EPDENs by human mesenchymal stromal cells (MSCs) did not negatively affect their viability, and the pretreatment of MSCs with Fragaria-derived EPDENs prevented oxidative stress in a dose-dependent manner. This is possibly due to the presence of vitamin C inside the nanovesicle membrane. The analysis of EPDEN cargo also revealed the presence of small RNAs and miRNAs. These findings suggest that Fragaria-derived EPDENs may be considered nanoshuttles contained in food, with potential health-promoting activity.
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Molecular interactions between dietary lipids and bone tissue during aging
Anno: 2021
Rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Autori/autrici: Romero-Marquez, J. M.; Varela-Lopez, A.; Navarro-Hortal, M. D.; Badillo-Carrasco, A.; Forbes-Hernandez, T. Y.; Giampieri, F.; Dominguez, I.; Madrigal, L.; Battino, M.; Quiles, J. L.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297664
Citazioni:
Molecular interactions between dietary lipids and bone tissue during aging / Romero-Marquez, J. M.; Varela-Lopez, A.; Navarro-Hortal, M. D.; Badillo-Carrasco, A.; Forbes-Hernandez, T. Y.; Giampieri, F.; Dominguez, I.; Madrigal, L.; Battino, M.; Quiles, J. L.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - ELETTRONICO. - 22:12(2021), p. 6473. [10.3390/ijms22126473]
Abstract:
Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater finan...cial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research.
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The efficacy of berries against lipopolysaccharide-induced inflammation: A review
Anno: 2021
Rivista: TRENDS IN FOOD SCIENCE & TECHNOLOGY
Autori/autrici: Gasparrini, M.; Forbes-Hernandez, T. Y.; Cianciosi, D.; Quiles, J. L.; Mezzetti, B.; Xiao, J.; Giampieri, F.; Battino, M.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/286973
Citazioni:
The efficacy of berries against lipopolysaccharide-induced inflammation: A review / Gasparrini, M.; Forbes-Hernandez, T. Y.; Cianciosi, D.; Quiles, J. L.; Mezzetti, B.; Xiao, J.; Giampieri, F.; Battino, M.. - In: TRENDS IN FOOD SCIENCE & TECHNOLOGY. - ISSN 0924-2244. - ELETTRONICO. - 117:(2021), pp. 74-91. [10.1016/j.tifs.2021.01.015]
Abstract:
Background: an increasing number of epidemiological studies highlights a remarkable association between a diet rich in fruits and vegetables and a lower incidence of different inflammatory-related pathologies. Berries represent an interesting source of phytochemicals and nutrients, widely investigat...ed for their role in health promotion and disease prevention. Scope and approach: the aim of this review was to summarize and update the effect of different berry extracts, their fractions and single bioactive compounds against the inflammatory status promoted by the Gram-negative bacteria endotoxin lipopolysaccharide (LPS). The main molecular mechanisms involved have been elucidated, focusing particular attention on the biological response evoked in different in vitro and in vivo models. Key findings and cocnlusions: the inhibition of inflammatory response mediated by MAPK and NF-kB is the main molecular pathway involved in berries anti-inflammatory role, especially in grape and blueberry which represent the main investigated fruits, improving antioxidant defence and exerting beneficial effects in the maintenance of healthy conditions in LPS-treated models.
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Recent advances on bioactive polysaccharides from mulberry
Anno: 2021
Rivista: FOOD & FUNCTION
Autori/autrici: Ai, J.; Bao, B.; Battino, M.; Giampieri, F.; Chen, C.; You, L.; Cespedes-Acuna, C. L.; Ognyanov, M.; Tian, L.; Bai, W.
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/297666
Citazioni:
Recent advances on bioactive polysaccharides from mulberry / Ai, J.; Bao, B.; Battino, M.; Giampieri, F.; Chen, C.; You, L.; Cespedes-Acuna, C. L.; Ognyanov, M.; Tian, L.; Bai, W.. - In: FOOD & FUNCTION. - ISSN 2042-6496. - ELETTRONICO. - 12:12(2021), pp. 5219-5235. [10.1039/d1fo00682g]
Abstract:
Mulberry (Moraceae family), commonly considered as a folk remedy, has a long history of usage in many regions of the world. Polysaccharides regarded as one of the major components in mulberry plants, and they possess antioxidant, antidiabetic, hepatoprotective, prebiotic, immunomodulatory and antitu...mor properties, among others. In recent decades, mulberry polysaccharides have been widely studied for their multiple health benefits and potential economic value. However, there are few reviews providing updated information on polysaccharides from mulberry. In this review, recent advances in the study of isolation, purification, structural characterization, biological activity and the structure-activity relationship of mulberry polysaccharides are summarized and discussed. Furthermore, a thorough analysis of the current trends and perspectives on mulberry polysaccharides is also proposed. Hopefully, these findings can provide a useful reference value for the development and application of natural polysaccharides in the field of functional food and medicine in the future.
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