Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?
Anno:
2018
Rivista: FOOD AND CHEMICAL TOXICOLOGY
Autori/autrici: Giampieri, Francesca; Quiles, José L.; Orantes-Bermejo, Francisco J.; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Sánchez-González, Cristina; Llopis, Juan; Rivas-García, Lorenzo; Afrin, Sadia; Varela-López, Alfonso; Cianciosi, Danila; Reboredo-Rodriguez, Patricia; Fernández-Piñar, Cristina Torres; Iglesias, Ruben Calderón; Ruiz, Roberto; Aparicio, Silvia; Crespo, Jorge; Dzul Lopez, Luis; Xiao, Jianbo; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/255285
Citazioni:Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties? / Giampieri, F., Quiles, J.L., Orantes-Bermejo, F.J., Gasparrini, M., Forbes-Hernandez, T.Y., Sánchez-González, C., Llopis, J., Rivas-García, L., Afrin, S., Varela-López, A., Cianciosi, D., Reboredo-Rodriguez, P., Fernández-Piñar, C.T., Iglesias, R.C., Ruiz, R., Aparicio, S., Crespo, J., Dzul Lopez, L., Xiao, J., Battino, M.. - In: FOOD AND CHEMICAL TOXICOLOGY. - ISSN 0278-6915. - 112:(2018), pp. 126-133. [10.1016/j.fct.2017.12.041]
Abstract:During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the anti
...oxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P < .05) fiber, protein, carbohydrate, polyphenol and flavonoid concentration, as well as the highest (P < .05) total antioxidant capacity than the MUD 2 samples. MUD1 exerted also anticancer activity on HepG2 cells, by reducing cellular viability, increasing intracellular ROS levels and affecting mitochondrial functionality in a dose-dependent manner.
We showed for the first time that by-products from beeswax recycling process can represent a rich source of phytochemicals with high total antioxidant capacity and anticancer activity; however, further researches are necessary to evaluate their potentiality for human health by in vivo studies.
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