Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade
Anno:
2017
Rivista: FOOD CHEMISTRY
Autori/autrici: Giampieri, Francesca; Alvarez-Suarez, Josè M.; Cordero, Mario D.; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Afrin, Sadia; Santos-Buelga, Celestino; González-Paramás, Ana M.; Astolfi, Paola; Rubini, Corrado; Zizzi, Antonio; Tulipani, Sara; Quiles, Josè L.; Mezzetti, Bruno; Battino, Maurizio
Lingua: ENG
Classificazione IRIS: 1.1 Articolo in rivista
Scheda completa IRIS: https://iris.univpm.it/handle/11566/255284
Citazioni:Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade / Giampieri, Francesca; Alvarez-Suarez, Josè M.; Cordero, Mario D.; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Afrin, Sadia; Santos-Buelga, Celestino; González-Paramás, Ana M.; Astolfi, Paola; Rubini, Corrado; Zizzi, Antonio; Tulipani, Sara; Quiles, Josè L.; Mezzetti, Bruno; Battino, Maurizio. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 234:(2017), pp. 464-471. [10.1016/j.foodchem.2017.05.017]
Abstract:Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of s
...trawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8 weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P < 0.05). Furthermore, a significant (P < 0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.
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